Article
Cell & Tissue Engineering
Ju-Fang Liu, Po-Chun Chen, Thai-Yen Ling, Chun-Han Hou
Summary: This study demonstrates that heat shock induces the expression of HSPs in hPDMCs through the activation of ROS, p38 MAPK, Akt signaling, and HSF1, which plays a protective role.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Gastroenterology & Hepatology
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon-Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley
Summary: c-Rel plays an important role in hepatocellular carcinoma by limiting genotoxic injury and subsequent tumor burden. Inhibiting c-Rel can enhance the effectiveness of DNA damaging agents and reduce HCC growth.
Article
Oncology
Wenbin Liu, Shiliang Cai, Rui Pu, Zixiong Li, Donghong Liu, Xinyu Zhou, Jianhua Yin, Xi Chen, Liping Chen, Jianfeng Wu, Xiaojie Tan, Xin Wang, Guangwen Cao
Summary: Mutations in the preS region of hepatitis B virus (HBV) are associated with an increased risk of hepatocellular carcinoma (HCC). In this study, several specific preS mutations were found to significantly increase the risk of HCC by promoting inflammation and altering gene expression in inflammation- and metabolism-related pathways. These findings highlight the importance of monitoring these mutations for HCC prevention.
Review
Plant Sciences
Baptiste Bourgine, Anthony Guihur
Summary: Heat stress events limit crop productivity, leading plants to accumulate heat-shock proteins (HSPs) for thermal protection. HSP chaperones play a critical role in regulating protein folding and preventing misfolded protein formation, thereby avoiding heat-induced cell death. The HSP20 family is tightly repressed at low temperatures, suggesting a costly mechanism that can become detrimental under unnecessary conditions.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Michael Y. Sherman, Vladimir Gabai
Summary: Bag3 plays a crucial role in various physiological processes by acting as a scaffold in cell signaling, recruiting components of different signaling pathways, responding to various stimuli, and controlling multiple physiological processes.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Food Science & Technology
Simeng Chen, Jie Zhou, Chidimma Juliet Igbokwe, Yuqing Duan, Meihong Cai, Yuanqing He, Haihui Zhang
Summary: This study investigated the effect and potential mechanism of RDPEER, an antioxidant oligopeptide derived from watermelon seeds, on heat stress-induced liver injury and cell damage. The results showed that supplementation with RDPEER attenuated hepatocyte injury by increasing cell viability, reducing ROS production, improving antioxidant enzyme activity, and decreasing MDA content. RDPEER also inhibited HPA axis hyperactivity, transaminase activity, and inflammatory factor levels, while activating the endogenous antioxidant pathway and reducing inflammatory factor transcription and heat shock protein expression. Overall, RDPEER supplementation enhanced antioxidant capacity and alleviated liver damage caused by heat stress, suggesting its potential use in nutritional interventions.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Malak Fouani, Charbel A. Basset, Giuseppe D. Mangano, Lavinia G. Leone, Nada B. Lawand, Angelo Leone, Rosario Barone
Summary: This review sheds light on the neuroimmune function of different members of the heat shock protein (HSPs) family and the complex manifold actions that they exert during the course of rheumatoid arthritis (RA).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sisi Huang, Kaiyue Wang, Dongyan Huang, Xin Su, Rongfu Yang, Congcong Shao, Juan Jiang, Jianhui Wu
Summary: This study found that lower doses of BPAF can promote dorsal prostatic hyperplasia in rats by interfering with multiple biomarkers in the NF-kappa B signaling pathway. These findings further confirm the toxic effect of BPAF on prostate health and provide important clues to the underlying mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Nian Wang, Xiehon Liu, K. E. Liu, Kangkai Wang, Huali Zhang
Summary: This study reveals that heat shock protein beta-1 (HSPB1) plays a crucial role in maintaining the redox state and antioxidant activity in cardiomyocytes. HSPB1 undergoes homo-oxidation in response to hydrogen peroxide (H2O2), which is dependent on the Cys137 residue. Cys137 residue not only protects cardiomyocytes against oxidative injury but also regulates HSPB1's oxidation, phosphorylation at Ser15, and distribution to insoluble cell components after H2O2 treatment.
Review
Cell Biology
Ariadni Androvitsanea, Kostas Stylianou, Eleni Drosataki, Ioannis Petrakis
Summary: Research has shown that heat-shock proteins can have varying effects on the immune system, either triggering immune responses or alleviating them, which is important for studying and treating autoimmune diseases.
Article
Immunology
Raissa Timmerman, Ella A. Zuiderwijk-Sick, Jeffrey J. Bajramovic
Summary: TLR-induced signaling triggers inflammatory responses, and the P2Y6 receptor enhances pro-inflammatory cytokine levels, especially in microglia. Through transcriptome analysis, P2Y6 signaling amplifies pro-inflammatory responses in microglia by regulating the expression of target genes through modulation of transcription factors. Additionally, inhibition of P2Y6 signaling strongly induces heat shock protein expression. These findings shed new light on the specific pro-inflammatory role of P2Y6 signaling in neuroinflammation and may provide novel approaches to control brain inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Physiology
Parya Behzadi, Nicholas Ravanelli, Hugo Gravel, Hadiatou Barry, Amelie Debray, Georgia K. Chaseling, Vincent Jacquemet, Paul-Eduard Neagoe, Anil Nigam, Andre C. Carpentier, Martin G. Sirois, Daniel Gagnon
Summary: The study evaluated the acute physiological responses to hot water immersion in adults with type 2 diabetes mellitus and found that while it increased core temperature, heart rate, and IL-6 concentration, it did not significantly affect insulin sensitivity, vascular function, or inflammatory markers. Heat therapy did not acutely improve markers of cardiometabolic function in adults with T2DM.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Review
Immunology
Fatima Kanso, Alia Khalil, Hiba Noureddine, Yolla El-Makhour
Summary: NF kappa B-COX-PGs pathway mediates inflammation leading to chronic inflammation, requiring treatment. Anti-inflammatory drugs are effective but come with side effects, hence the need for new safer options like thiosemicarbazones derivatives.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kaiyue Wang, Dongyan Huang, Ping Zhou, Xin Su, Rongfu Yang, Congcong Shao, Aicui Ma, Jianhui Wu
Summary: BPA and BPAF can induce prostatic hyperplasia in rats and modulate the regulation of the NF-kB signaling pathway. In addition, combined exposure to BPA and BPAF can also increase proliferation and reduce apoptosis in human prostate cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Tsukasa Aoki, Fumitaka Hiura, Aonan Li, Nan Yang, Nana Takakura-Hino, Satoru Mukai, Miho Matsuda, Fusanori Nishimura, Eijiro Jimi
Summary: Periodontal disease is an infectious disease that affects many people worldwide. In this study, it was found that aly/aly mice, which have a mutation in the map3k14 gene, exhibited a decreased number of osteoclasts and suppressed alveolar bone resorption, indicating the potential of targeting the NF-kappa B pathway for periodontal disease treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Food Science & Technology
Larissa Naomi Takeda, Lucas Fornari Laurindo, Elen Landgraf Guiguer, Anupam Bishayee, Adriano Cressoni Araujo, Lara Cristina Casadei Ubeda, Ricardo de Alvares Goulart, Sandra Maria Barbalho
Summary: Guava has medicinal properties that can be used in the treatment of various diseases and contribute to reducing the risk of chronic diseases. It also has economic importance for producing countries. The by-products of guava have potential applications in the food and cosmetic industries.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Oncology
Alisha Sachdeva, Dimple Dhawan, Gaurav K. Jain, Muekerrem Betuel Yerer, Taylor E. Collignon, Devesh Tewari, Anupam Bishayee
Summary: Oral cancer is a global cause of death, and traditional treatment methods face challenges of cancer recurrence and adverse reactions to chemotherapy drugs. Natural products play a significant role in drug discovery and have potential effects against various cancers, including oral cancer. The limited bioavailability of natural products is a major obstacle to their therapeutic application. Therefore, comprehensive utilization of various formulation strategies to improve bioavailability is important. This work presents recent advancements in novel strategies for natural product delivery that significantly enhance bioavailability and reduce adverse events in the prevention and treatment of oral cancer.
Review
Chemistry, Medicinal
Suneel Kumar, Stephen O. Mathew, Ravindra Prasad Aharwal, Hardeep Singh Tulli, Chakrabhavi Dhananjaya Mohan, Gautam Sethi, Kwang-Seok Ahn, Kassidy Webber, Sardul Singh Sandhu, Anupam Bishayee
Summary: Cancer is a highly significant global health concern, and current treatment options, such as surgery, chemotherapy, radiation therapy, and immune therapy, have limitations and may lead to disease recurrence. Withaferin A, a natural bioactive compound found in the Indian medicinal plant Withania somnifera, has shown promising anticancer activities by modulating the expression and activity of oncogenic proteins. This article comprehensively discusses the biosynthesis, antineoplastic activities, mode-of-action, and clinical potential of withaferin A, as well as its effect on miRNA expression, combinational use with other cytotoxic agents, formulations, and safety profiles.
Review
Pathology
Amitabha Ray, Melissa J. L. Bonorden, Rajashree Pandit, Katai J. Nkhata, Anupam Bishayee
Summary: About one-fourth of the global population is overweight or obese, increasing the risk of insulin resistance, cardiovascular diseases, and infections. Obesity is connected to the severity of COVID-19 and can lead to metabolic disorders. Diabetes is associated with persistent viral infections and affects vaccine effectiveness. Monitoring inflammatory and energy homeostasis markers is important in preventing obesity-related diseases.
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
(2023)
Correction
Chemistry, Medicinal
Elina Khatoon, Mangala Hegde, Aviral Kumar, Uzini Devi Daimary, Gautam Sethi, Anupam Bishayee, Ajaikumar B. Kunnumakkara
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Review
Chemistry, Medicinal
Jack T. Burcher, Lindsay K. DeLiberto, Andrea M. Allen, Kaitlyn L. Kilpatrick, Anupam Bishayee
Summary: The high incidence of oral cancer and excessive treatment cost highlight the need for new oral cancer prevention and treatment options. The value of natural agents, including plant secondary metabolites, in preventing cancer and providing a wide range of anticancer drugs has been established. This study provides a comprehensive analysis of current preclinical and clinical results on the use of phytochemicals for oral cancer prevention and treatment. Phytochemicals exert their anticancer effects by modulating various signaling pathways and show promising effects in clinical trials. However, concerns about bioavailability may limit their clinical application. Future research should focus on in-depth mechanistic studies, novel formulations of phytochemicals, adjuvant use with conventional treatment, and randomized clinical trials.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Chemistry, Medicinal
Hui Li Ang, Chakrabhavi Dhananjaya Mohan, Muthu K. Shanmugam, Hin Chong Leong, Pooyan Makvandi, Kanchugarakoppal S. Rangappa, Anupam Bishyaee, Alan Prem Kumar, Gautam Sethi
Summary: Epithelial-mesenchymal transition (EMT) is a crucial process in which epithelial cells transform into mesenchymal cells, playing a significant role in tumor progression and resistance to therapy. Various factors, such as signaling pathways, transcriptional regulators, noncoding RNAs, and epigenetic alterations, are involved in the regulation of EMT. However, despite preclinical data, there is a lack of clinical translation in targeting EMT therapeutically. This review discusses the role of these factors in EMT regulation, the contribution of EMT to drug resistance, and potential therapeutic interventions using natural products and nano-formulations as EMT blockers.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Maryam Ghanbari-Movahed, Sahar Shafiee, Jack T. Burcher, Ricardo Lagoa, Mohammad Hosein Farzaei, Anupam Bishayee
Summary: It has been found that cancer stem cells exhibit altered metabolism compared to non-CSCs, which plays a crucial role in tumor initiation, progression, immunosuppression, and resistance to conventional therapy. Two natural flavonoids, apigenin and isovitexin, have been shown to enhance the efficacy of conventional chemotherapeutic drugs by sensitizing CSCs. This study aims to critically evaluate the potential of apigenin and isovitexin in targeting CSCs in different cancers as novel therapeutic agents.
Review
Oncology
Sajad Fakhri, Seyed Zachariah Moradi, Farahnaz Faraji, Tara Farhadi, Osman Hesami, Amin Iranpanah, Kassidy Webber, Anupam Bishayee
Summary: The tumor microenvironment (TME) plays a crucial role in cancer development and progression. The use of nanomedicine could be a promising approach to overcome barriers in tumor-targeted therapy. Nanoparticle formulations of natural compounds have shown potential in simultaneously targeting multiple dysregulated factors in TME and reducing tumor resistance mechanisms.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Oncology
Sajad Fakhri, Seyed Zachariah Moradi, Farahnaz Faraji, Leila Kooshki, Kassidy Webber, Anupam Bishayee
Summary: Tumor cells use multiple signaling mediators to escape hypoxia and promote angiogenesis and metastasis. HIF-1 plays a critical role in tumor conditions by stimulating target genes and dysregulated pathways in invasion and migration. Targeting the HIF-1 pathway and its cross-talk mediators may be a novel strategy for cancer prevention and treatment.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Food Science & Technology
Taylor E. Collignon, Kassidy Webber, Josh Piasecki, Austin S. W. Rahman, Arijit Mondal, Sandra Maria Barbalho, Anupam Bishayee
Summary: Avocado has shown anticancer properties and contains various phytochemicals that can induce cytotoxicity, reduce tumor size and volume, making it a potential option for cancer prevention and treatment. However, more research is needed before avocado-derived phytochemicals can be developed as cancer preventive agents.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Chemistry, Medicinal
Siddavaram Nagini, Manikandan Palrasu, Anupam Bishayee
MEDICINAL RESEARCH REVIEWS
(2023)
Editorial Material
Oncology
Anupam Bishayee
Review
Oncology
Neeraj Choudhary, Sweta Bawari, Jack T. Burcher, Dona Sinha, Devesh Tewari, Anupam Bishayee
Summary: Lung cancer, the leading cause of cancer-related deaths worldwide, needs the development of safe and effective treatment. Phytochemicals have shown anticancer potential against lung cancer through multiple mechanisms, making them promising chemotherapeutic agents. This review critically analyzes the evidence from in vitro, in vivo, and clinical studies to establish the potential role of phytochemicals in mitigating lung cancer by modulating signaling pathways.
Article
Biochemistry & Molecular Biology
Jose Diogo E. Reis, Paulo Wender P. Gomes, Paulo R. da C. Sa, Sonia das G. S. R. Pamplona, Consuelo Yumiko Y. e Silva, Maria Fatima das G. F. da Silva, Anupam Bishayee, Milton Nascimento da Silva
Summary: This study identified new potential mass spectrometry signatures for phragmalin-type limonoids in Swietenia macrophylla leaves, providing valuable information for future drug development efforts.