Article
Biotechnology & Applied Microbiology
Feng-Lian Yang, Yu-Xia Wei, Bi-Yun Liao, Gui-Jiang Wei, Hai-Mei Qin, Xiao-Xia Pang, Jun-Li Wang
Summary: The study revealed that HOTAIR and EZH2 are highly expressed in NPC, while E-cadherin is lowly expressed. By regulating trimethylation of H3K27, HOTAIR inhibits E-cadherin expression, promoting NPC cell progression and tumor growth.
Article
Biochemistry & Molecular Biology
Yang Yi, Yanqiang Li, Chao Li, Longxiang Wu, Dongyu Zhao, Fuxi Li, Ladan Fazli, Rui Wang, Long Wang, Xuesen Dong, Wei Zhao, Kaifu Chen, Qi Cao
Summary: CDCA8 overexpression is associated with poor clinical outcome in patients with prostate cancer, and EZH2 is responsible for CDCA8 activation in PCa.
Article
Dentistry, Oral Surgery & Medicine
Yue Yu, Hesham MohamedAl-Sharani, Bin Zhang
Summary: This study reveals the important role of EZH2 in inhibiting ferroptosis in TSCC cells by inhibiting miR-125b-5p and enhancing SLC7A11.
Article
Oncology
Shu-Guang Su, Qiu-Li Li, Mei-Fang Zhang, Peng-Wei Zhang, Huimin Shen, Chris Zhiyi Zhang
Summary: DDX11 is upregulated in HCC and correlates with poor patient outcomes, exerting oncogenic activity via the EZH2/p21 signaling pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Plant Sciences
Nan-Nan Tian, Yan-Biao Zheng, Zhi-Peng Li, Feng-Wei Zhang, Jin-Fang Zhang
Summary: This study aimed to investigate the anti-tumor effect of Curcumol on hepatocellular carcinoma (HCC) and elucidate its underlying mechanism from the perspective of epigenetic modification. The results demonstrated that Curcumol suppressed tumor growth and metastasis via an Hotair/EZH2/histone modification regulatory axis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
An-Na Bae, Soo-Jung Jung, Jae-Ho Lee, Hyunsu Lee, Seung Gyu Park
Summary: This study investigated the clinical and prognostic value of EZH2 in hepatocellular carcinoma (HCC) and found that EZH2 overexpression is associated with poor prognosis in HCC. Additionally, EZH2 was correlated with N stage and alpha-fetoprotein (AFP) levels in HCC. The study also revealed a negative correlation between EZH2 expression and STAT3 expression.
MEDICINA-LITHUANIA
(2022)
Article
Pharmacology & Pharmacy
Shuangshuang Yin, Shenshen Yang, Yanming Luo, Jia Lu, Gaoyong Hu, Kailong Wang, Yingying Shao, Shiyue Zhou, Sangho Koo, Yuling Qiu, Tao Wang, Haiyang Yu
Summary: The study identifies CDK1, CCNB1, and CCNB2 as potential diagnostic and prognostic biomarkers for HCC, with CDK1 being a promising therapeutic target for lycorine against HCC.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Fuwen Yao, Yongqiang Zhan, Changzheng Li, Ying Lu, Jiao Chen, Jing Deng, Zijing Wu, Qi Li, Yi'an Song, Binhua Chen, Jinjun Chen, Kuifeng Tian, Zuhui Pu, Yong Ni, Lisha Mou
Summary: Abnormal activation of protein kinases and phosphatases, implicated in various tumorigenesis including hepatocellular carcinoma (HCC), may contribute to the poor prognosis of HCC patients. Our study identified nine genes with high expression levels in HCC cancer stem cells, showing potential as therapeutic targets. Inhibitors targeting two hub genes, AURKA and EZH2, inhibited HCC cell proliferation, migration, and invasion, suggesting their potential as anti-cancer agents for HCC treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Ke Wang, Xunliang Jiang, Yu Jiang, Jun Liu, Yongtao Du, Zecheng Zhang, Yunlong Li, Xinhui Zhao, Jipeng Li, Rui Zhang
Summary: This study revealed the role of the EZH2/miR-139-5p/TOP2A axis in regulating cellular senescence and cell proliferation in HCC, enriching the molecular mechanisms of EZH2-mediated epigenetic regulation in HCC. Therapeutically targeting EZH2 to induce cellular senescence and destroy senescent cells could be a potential treatment strategy for HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Genetics & Heredity
Jim P. Fouracre, Jia He, Victoria J. Chen, Simone Sidoli, R. Scott Poethig
Summary: In plants, the VAL gene family members VAL1 and VAL2 regulate the transition from juvenile to adult vegetative growth by controlling the overall level of miR156 expression, rather than its temporal dynamics. This study highlights the complexity of temporal regulation in plants.
Article
Oncology
Jianguo Wei, Shuqian Hou, Minhua Li, Xiaofei Yao, Li Wang, Zhen Zheng, Haiqian Mo, Yu Chen, Xiaolu Yuan
Summary: In this study, we conducted a comprehensive analysis of necroptosis-related genes in HCC and found that the NEC score can be effectively used to predict the prognosis of HCC patients and is associated with the response to immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Bo Tang, Rui Sun, Dejie Wang, Haoyue Sheng, Ting Wei, Liguo Wang, Jun Zhang, Thai H. Ho, Lu Yang, Qiang Wei, Haojie Huang
Summary: Both the gene repressor and activator functions of EZH2 are implicated in cancer progression, with the histone reader protein ZMYND8 playing a role in modulating EZH2 function and cell migration and invasion. Depletion of ZMYND8 enhances EZH2's Polycomb-dependent function in certain cancer cells and suppresses the FOXM1 transcription program.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Luyao Zhang, Dan Xiong, Qian Liu, Yiling Luo, Yuhan Tian, Xi Xiao, Ye Sang, Yihao Liu, Shubin Hong, Shuang Yu, Jie Li, Weiming Lv, Yanbing Li, Zhonghui Tang, Rengyun Liu, Qian Zhong, Haipeng Xiao
Summary: The study compared the epigenomic features of papillary thyroid carcinoma (PTC) and benign thyroid nodule (BTN) tissues, revealing PTC-specific super-enhancer-associated genes related to immune response and cancer pathways, and identifying several genes associated with disease-free survival of PTC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
David Jeremie Birnbaum, Maelle Picard, Quentin Da Costa, Thomas Delayre, Pascal Finetti, Olivier Cabaud, Emilie Agavnian, Bernadette De Rauglaudre, Emilie Denicolai, Francois Bertucci, Emilie Mamessier
Summary: Hepatocellular carcinoma (HCC) is a common and deadly cancer, and new treatments are needed. Immune checkpoint inhibitors (ICIs) have shown promise for HCC. By analyzing a large transcriptomic database, we found that the TIGIT/DNAM-1 axis, particularly the PVRIG molecule, could be a potential therapeutic option for HCC.
Article
Genetics & Heredity
Xin Zhou, Jia-mi Huang, Tian-man Li, Jun-qi Liu, Zhong-liu Wei, Chen-lu Lan, Guang-zhi Zhu, Xi-wen Liao, Xin-ping Ye, Tao Peng
Summary: The diagnostic and prognostic significance of ATP binding cassette subfamily C (ABCC) genes in hepatocellular carcinoma (HCC) was assessed in this study. ABCC1, ABCC4, ABCC5, and ABCC6 were found to potentially serve as prognostic biomarkers in HCC, and prognostic models constructed with these genes showed satisfactory efficacy.
FRONTIERS IN GENETICS
(2022)