Single-Cell RNA Sequencing Reveals the Role of Phosphorylation-Related Genes in Hepatocellular Carcinoma Stem Cells

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Exosomal miR-101-3p and miR-423-5p inhibit medulloblastoma tumorigenesis through targeting FOXP4 and EZH2

(2021) Ping Xue et al.   CELL DEATH AND DIFFERENTIATION

CancerSCEM: a database of single-cell expression map across various human cancers

(2021) Jingyao Zeng et al.   NUCLEIC ACIDS RESEARCH

Inhibition of EZH2 Attenuates Sorafenib Resistance by Targeting NOTCH1 Activation-Dependent Liver Cancer Stem Cells via NOTCH1-Related MicroRNAs in Hepatocellular Carcinoma

(2020) Shanshan Wang et al.   Translational Oncology

A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity

(2020) Louisa Nelson et al.   Nature Communications

LncRNA LEF1-AS1 silencing diminishes EZH2 expression to delay hepatocellular carcinoma development by impairing CEBPB-interaction with CDCA7

(2020) Jun Gao et al.   CELL CYCLE

Aurora A kinase and its activator TPX2 are potential therapeutic targets in KRAS-induced pancreatic cancer

(2020) Sandro Mascena Gomes-Filho et al.   CELLULAR ONCOLOGY

New insights into the pharmacological, immunological, and CAR-T-cell approaches in the treatment of hepatocellular carcinoma

(2020) Michele Dal Bo et al.   DRUG RESISTANCE UPDATES

RNA polymerase II subunit D is essential for zebrafish development

(2020) Masanari Maeta et al.   Scientific Reports

Sorafenib Resistance in Hepatocellular Carcinoma: The Relevance of Genetic Heterogeneity

(2020) Loraine Kay D. Cabral et al.   Cancers

Combinational Immunotherapy for Hepatocellular Carcinoma: Radiotherapy, Immune Checkpoint Blockade and Beyond

(2020) Yun Hua Lee et al.   Frontiers in Immunology

Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response

(2019) Stefano Caruso et al.   GASTROENTEROLOGY

Alkylaminophenol Induces G1/S Phase Cell Cycle Arrest in Glioblastoma Cells Through p53 and Cyclin-Dependent Kinase Signaling Pathway

(2019) Phuong Doan et al.   Frontiers in Pharmacology

Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer

(2019) Vladislav Korobeynikov et al.   BREAST CANCER RESEARCH AND TREATMENT

A human liver cell atlas reveals heterogeneity and epithelial progenitors

(2019) Nadim Aizarani et al.   NATURE

Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer

(2019) Lichun Ma et al.   CANCER CELL

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

(2019) Qiming Zhang et al.   CELL

Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC

(2019) Lai Wei et al.   Nature Communications

The application of single-cell sequencing technology in the diagnosis and treatment of hepatocellular carcinoma

(2019) Kai Kang et al.   Annals of Translational Medicine

Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing

(2018) Charissa Kim et al.   CELL

Single-cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma

(2018) Hongping Zheng et al.   HEPATOLOGY

Hepatocellular carcinoma

(2018) Alejandro Forner et al.   LANCET

Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors

(2018) Laleh Haghverdi et al.   NATURE BIOTECHNOLOGY

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

Comparative Transcriptomics Unravels Prodigiosin's Potential Cancer-Specific Activity Between Human Small Airway Epithelial Cells and Lung Adenocarcinoma Cells

(2018) Bala Davient et al.   Frontiers in Oncology

The biology of Hepatocellular carcinoma: implications for genomic and immune therapies

(2017) Galina Khemlina et al.   Molecular Cancer

Targeting glioma stem cells through combined BMI1 and EZH2 inhibition

(2017) Xun Jin et al.   NATURE MEDICINE

Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer

(2017) Hui Liu et al.   Cancer Discovery

Defining the role of Lgr5+ stem cells in colorectal cancer: from basic research to clinical applications

(2017) Masayuki Fujii et al.   Genome Medicine

Phase II study of MLN8237 (Alisertib) in advanced/metastatic sarcoma

(2016) M. A. Dickson et al.   ANNALS OF ONCOLOGY

A MYC–aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer

(2016) Daniel Dauch et al.   NATURE MEDICINE

Function of AURKA protein kinase in the formation of vasculogenic mimicry in triple-negative breast cancer stem cells

(2016) Baocun Sun et al.   OncoTargets and Therapy

Safety and activity of alisertib, an investigational aurora kinase A inhibitor, in patients with breast cancer, small-cell lung cancer, non-small-cell lung cancer, head and neck squamous-cell carcinoma, and gastro-oesophageal adenocarcinoma: a five-arm phase 2 study

(2015) Bohuslav Melichar et al.   LANCET ONCOLOGY

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

EZH2-mediated loss of miR-622 determines CXCR4 activation in hepatocellular carcinoma

(2015) Haiou Liu et al.   Nature Communications

Aurora-A promotes chemoresistance in hepatocelluar carcinoma by targeting NF-kappaB/microRNA-21/PTEN signaling pathway

(2015) Kai Zhang et al.   Oncotarget

Early Hepatocellular Carcinoma on the Procrustean Bed of Ablation, Resection, and Transplantation

(2014) Riccardo Lencioni et al.   SEMINARS IN LIVER DISEASE

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

Akt2 and acid ceramidase cooperate to induce cell invasion and resistance to apoptosis

(2013) Norbert Berndt et al.   CELL CYCLE

Antiproliferative activity of gambogic acid isolated from Garcinia hanburyi in Hep3B and Huh7 cancer cells

(2013) PARRY NGAN HON LEE et al.   ONCOLOGY REPORTS

Gambogenic acid induces G1 arrest via GSK3β-dependent cyclin D1 degradation and triggers autophagy in lung cancer cells

(2012) Xian-Jun Yu et al.   CANCER LETTERS

Cancer Angiogenesis Induced by Kaposi Sarcoma-Associated Herpesvirus Is Mediated by EZH2

(2012) M. He et al.   CANCER RESEARCH

Aurora A kinase (AURKA) in normal and pathological cell division

(2012) Anna S. Nikonova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma

(2012) Hashem B. El-Serag   GASTROENTEROLOGY

Histone Methyltransferase EZH2 Induces Akt-Dependent Genomic Instability and BRCA1 Inhibition in Breast Cancer

(2011) M. E. Gonzalez et al.   CANCER RESEARCH

Significance of Aurora B overexpression in hepatocellular carcinoma. Aurora B Overexpression in HCC

(2010) Zhong-Zhe Lin et al.   BMC CANCER

Overexpression of EZH2 contributes to acquired cisplatin resistance in ovarian cancer cells in vitro and in vivo

(2010) Sha Hu et al.   CANCER BIOLOGY & THERAPY

p27Kip1, a double-edged sword in Shh-mediated medulloblastoma

(2010) Bobby Bhatia et al.   CELL CYCLE

Gambogenic acid mediated apoptosis through the mitochondrial oxidative stress and inactivation of Akt signaling pathway in human nasopharyngeal carcinoma CNE-1 cells

(2010) Fenggen Yan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells

(2010) F. Orzan et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214

(2010) G Yin et al.   ONCOGENE

Targeting Aurora Kinase with MK-0457 Inhibits Ovarian Cancer Growth

(2008) Y. G. Lin et al.   CLINICAL CANCER RESEARCH