Article
Medicine, Research & Experimental
Qian Wu, Rui Li, Qing-Xiang Wang, Meng-Yu Zhang, Ting-Ting Liu, Yi-Qing Qu
Summary: Our study revealed the oncogenic role of JAML in LUAD, showing that elevated JAML expression is positively correlated with pT and pTNM. Silencing JAML significantly inhibited malignant behaviors of LUAD cells, induced cell cycle arrest at G(0)/G(1) phase, and promoted apoptosis, possibly through inactivation of the Wnt/beta-catenin pathway in LUAD cells. Rescue experiments confirmed the effects of JAML could be reversed by Wnt/beta-catenin pathway activator in A549 cells. This suggests that JAML may serve as a predictive biomarker and potential therapeutic target for LUAD.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Cheng-Kuei Wu, Man-Ting Wei, Hung-Chang Wu, Cheng-Lin Wu, Cheng-Ju Wu, Hungjiun Liaw, Wen-Pin Su
Summary: This study revealed the overexpression of BMP2 in lung adenocarcinoma patients with lymph node metastasis. In an in vivo mouse model, BMP2 was shown to promote lung adenocarcinoma metastasis. The activation of the SMAD1/5/8 signaling pathway was found to be involved in BMP2-mediated cell migration. Therefore, targeting the BMP2 signaling pathway could be a potential therapeutic strategy for treating metastatic lung adenocarcinoma.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Jiayi Gu, Yingxue Qi, Yuxin Lu, Qianying Tao, Die Yu, Chunchun Jiang, Jianwen Liu, Xin Liang
Summary: This study demonstrates for the first time that lung adenocarcinoma cells can express vWF and promote tumor metastasis by regulating PHKG1 to promote glycogen metabolism. The findings suggest potential targets for inhibition of lung adenocarcinoma metastasis.
Article
Environmental Sciences
Huang-Ming Hu, Hsiang-Lin Lee, Chung-Jung Liu, Yi-Hsien Hsieh, Yong-Syuan Chen, Kuan-Chun Hsueh
Summary: The study found that MTA2 regulates HCC progression through the MTA2-FAK-MMP7 pathway. PTK7, as a downstream factor of MTA2, affects the migration and invasion abilities of HCC cells by regulating MMP7 expression. The expression level of PTK7 is correlated with tumor stage, grade, and overall survival in HCC patients, and may have diagnostic value for HCC patients.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Fangfang Cai, Huangru Xu, Daolong Zha, Xiaoyang Wang, Ping Li, Shihui Yu, Yingying Yao, Xiaoyao Chang, Jia Chen, Yanyan Lu, Zi-Chun Hua, Hongqin Zhuang
Summary: AK2 regulates tumor cell metastasis in lung adenocarcinoma, with its high expression associated with poor patient survival; AK2 is closely related to the migration and invasion ability of lung adenocarcinoma cells; AK2 may regulate epithelial-mesenchymal transition through Smad-related signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Ruijie Zhang, Shengjin Li, Jian Lan, Changyi Li, Xianzhi Du, Weijie Dong, Qian Yu, Daoxin Wang
Summary: This study found that low-dose cisplatin can activate the EMT process and promote malignant progression of lung adenocarcinoma cells through upregulating CNTN-1.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Jun Bai, Hongli Li, Xinlu Chen, Lin Chen, Yaqiong Hu, Lu Liu, Yanqiao Zhao, Wei Zuo, Baogang Zhang, Chonggao Yin
Summary: LncRNA-AC009948.5 is upregulated in lung adenocarcinoma tissues and cells, and its increased expression is associated with tumor size, lymph nodes, distant metastasis, histological grade, and poor prognosis. Knockdown of LncRNA-AC009948.5 inhibits cell proliferation, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo. Mechanistically, LncRNA-AC009948.5 directly binds to miR-186-5p and suppresses the expression of the target gene NCAPG2.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yueyu Dai, Fangyuan Zhong, Wenbin Liu, Qibin Song, Weiguo Hu
Summary: The study explored the relationship between Mycoplasma hyorhinis infection and TKI resistance in lung adenocarcinoma patients. Results showed that higher levels of M. hyorhinis infection were associated with shorter progression-free survival, potentially due to the hydrolysis of TKI. This study provides strong evidence for the correlation between M. hyorhinis infection and TKI resistance, suggesting potential strategies to improve TKI efficacy in cancer patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Xiangyu Zhao, Yuxing Chen, Xiaoqin Sun, Zaoke He, Tao Wu, Chenxu Wu, Jing Chen, Jinyu Wang, Kaixuan Diao, Xue-Song Liu
Summary: This study found that EFNA4, a member of the EPH family, is amplified and up-regulated in lung tumor patients, especially in those with lymph node metastases. Overexpression of EFNA4 promotes lung tumor cell proliferation and migration, while knockdown or knockout of EFNA4 inhibits cell proliferation and migration. These findings suggest that the amplification of the EFNA4 gene may play an oncogenic role in promoting lung cancer lymph node metastasis.
Article
Biochemistry & Molecular Biology
Sk. Kayum Alam, Yongchang Zhang, Li Wang, Zhu Zhu, Christina E. Hernandez, Yuling Zhou, Nong Yang, Jian Lei, Xiaoyan Chen, Liang Zeng, Mark A. Klein, Luke H. Hoeppner
Summary: The study reveals that DARPP-32 and kinase-activated EGFR and ERBB3 proteins are overexpressed in EGFR TKI-refractory LUAD, leading to the evasion of cell death through a specific mechanism.
Article
Biochemistry & Molecular Biology
Tao Fan, Shuofeng Li, Chu Xiao, He Tian, Yujia Zheng, Yu Liu, Chunxiang Li, Jie He
Summary: CCL20 plays a role in promoting lung adenocarcinoma progression, with high expression associated with poor prognosis and activation of EMT, inflammatory response, and TNF pathway. Knockdown of CCL20 inhibits EMT process and cell proliferation in lung adenocarcinoma. Low CCL20 expression improves response to anti-PD-L1 therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Oncology
Yuying Liu, Xinyue Dong, Tao Li, Yanke Xing, Na Liu
Summary: This article reports a case of lung adenocarcinoma metastatic to the bladder and includes a literature review to provide clinicians with diagnostic and treatment experience and help avoid misdiagnosis and mistreatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Xiaohui Liu, Lu Li, Chengjie Geng, Shiyuan Wen, Cuiqiong Zhang, Chunmiao Deng, Xuejuan Gao, Gong Zhang, Qing-Yu He, Langxia Liu
Summary: The RNA helicase DDX17 has been found to promote proliferation, migration, and invasion of lung adenocarcinoma cells. It interacts with the mRNA of MYL9 and MAGEA6, upregulating their levels. Moreover, DDX17 regulates cell function by controlling actin cytoskeleton rearrangement and cell adhesion. In LUAD cells, autophagy may be inhibited by DDX17 through the MAGEA6/AMPK alpha 1 axis.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Cheng Zeng, Jing Guo, Jiajia Wu, Tiantian Che, Xiaoping Huang, Huawen Liu, Zhenghong Lin
Summary: The E3 ubiquitin ligase HRD1 regulates autophagy and is involved in non-small cell lung carcinoma (NSCLC) metastasis. HRD1 inhibits autophagy by promoting ATG3 ubiquitination and degradation, leading to the release of MIEN1 and the promotion of NSCLC metastasis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Cell Biology
Xiaoli Liu, Zuwei Yin, Linping Xu, Huaimin Liu, Lifeng Jiang, Shuochuan Liu, Xu Sun
Summary: The study found that LINC01426 promotes LUAD progression by recruiting USP22 to stabilize SHH protein and activate the Hedgehog pathway.
CELL DEATH & DISEASE
(2021)
Article
Gastroenterology & Hepatology
N. Barlow, Y. Nasser, P. Zhao, N. Sharma, R. Guerrero-Alba, L. E. Edgington-Mitchell, T. Lieu, N. A. Veldhuis, D. P. Poole, J. W. Conner, E. Lindstrom, A. W. Craig, B. Graham, S. J. Vanner, N. W. Bunnett
NEUROGASTROENTEROLOGY AND MOTILITY
(2015)
Article
Oncology
Otto L. D. Cerqueira, Peter Truesdell, Tomas Baldassarre, Santiago A. Vilella-Arias, Kathleen Watt, Jalna Meens, Harish Chander, Cynthia A. B. Osorio, Fernando A. Soares, Eduardo M. Reis, Andrew W. B. Craig
Article
Biochemistry & Molecular Biology
Utpal K. Mukhopadhyay, Jamaica Cass, Leda Raptis, Andrew W. Craig, Veronique Bourdeau, Sonal Varma, Sandip SenGupta, Bruce E. Elliott, Gerardo Ferbeyre
Article
Oncology
Madison Black, Ivraym B. Barsoum, Peter Truesdell, Tiziana Cotechini, Shannyn K. Macdonald-Goodfellow, Margaret Petroff, D. Robert Siemens, Madhuri Koti, Andrew W. B. Craig, Charles H. Graham
Article
Oncology
Katrina K. Au, Nichole Peterson, Peter Truesdell, Gillian Reid-Schachter, Kasra Khalaj, Runhan Ren, Julie-Ann Francis, Charles H. Graham, Andrew W. Craig, Madhuri Koti
GYNECOLOGIC ONCOLOGY
(2017)
Article
Oncology
Binbing Ling, Kathleen Watt, Sunandan Banerjee, Daniel Newsted, Peter Truesdell, Jarrett Adams, Sachdev S. Sidhu, Andrew W. B. Craig
Article
Cell Biology
Kathleen Watt, Daniel Newsted, Elena Voorand, Robert J. Gooding, Adrianna Majewski, Peter Truesdell, Binchen Yao, Thomas Tuschl, Neil Renwick, Andrew W. Craig
CELLULAR SIGNALLING
(2018)
Article
Biochemistry & Molecular Biology
P. Truesdell, J. Ahn, H. Chander, J. Meens, K. Watt, X. Yang, A. W. B. Craig
Article
Multidisciplinary Sciences
Sarah Nersesian, Rodette Williams, Daniel Newsted, Kavan Shah, Stephanie Young, P. Andrew Evans, John S. Allingham, Andrew W. Craig
SCIENTIFIC REPORTS
(2018)
Article
Oncology
Daniel Newsted, Sunandan Banerjee, Kathleen Watt, Sarah Nersesian, Peter Truesdell, Levi L. Blazer, Lia Cardarelli, Jarrett J. Adams, Sachdev S. Sidhu, Andrew W. Craig
Article
Multidisciplinary Sciences
J. L. Mackeil, P. Brzezinska, J. Burke-Kleinman, A. W. Craig, C. J. B. Nicol, D. H. Maurice
SCIENTIFIC REPORTS
(2019)
Article
Cell Biology
Stephanie Young, Namit Sharma, Jae Hoon Lee, Violeta Chitu, Volker Neumeister, Elisabeth Sohr, E. Richard Stanley, Christian M. Hedrich, Andrew W. B. Craig
DISEASE MODELS & MECHANISMS
(2019)
Article
Oncology
Kathleen Watt, Kathrin Tyryshkin, Neil Renwick, Andrew W. B. Craig
TRANSLATIONAL ONCOLOGY
(2020)
Article
Pathology
Katrina K. Au, Cecile Le Page, Runhan Ren, Liliane Meunier, Isabelle Clement, Kathrin Tyrishkin, Nichole Peterson, Jennifer Kendall-Dupont, Timothy Childs, Julie-Ann Francis, Charles H. Graham, Andrew W. Craig, Jeremy A. Squire, Anne-Marie Mes-Masson, Madhuri Koti
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2016)
Article
Multidisciplinary Sciences
Utpal K. Mukhopadhyay, Jamaica Cass, Leda Raptis, Andrew W. Craig, Veronique Bourdeau, Sonal Varma, Sandip Sen Gupta, Bruce E. Elliott, Gerardo Ferbeyre