Article
Oncology
Shraddha Patkar, Amit Chopde, Nitin Shetty, Suyash Kulkarni, Kunal Bharat Gala, Daksh Chandra, Anant Ramaswamy, Vikas Ostwal, Mahesh Goel
Summary: The study analyzed the comprehensive management of liver-directed therapy in patients with colorectal liver metastasis and found that surgical treatment significantly improved the survival rate of patients, while adjuvant non-surgical treatment also improved the treatment effect.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
E. L. Carpenter, K. K. Thomas, A. M. Adams, F. A. Valdera, R. C. Chick, P. M. Kemp Bohan, H. Spitzer, G. T. Clifton, J. O. Bader, D. W. Nelson, T. J. Vreeland
Summary: This study aimed to characterize modern trends in open versus minimally invasive surgery (MIS) approaches for colorectal liver metastasis (CRLM). The results showed an increasing trend in MIS approaches, but they were selectively implemented for patients with less technically demanding disease characteristics. Greater efforts should be directed towards educating and disseminating parenchymal-sparing MIS techniques for more complex resections.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Bao Jin, Xiang'an Wu, Gang Xu, Jiali Xing, Yuxin Wang, Huayu Yang, Shunda Du, Yilei Mao
Summary: Bibliometric analysis of articles related to CRCLM treatment provides insights into the development trends in this field. The study identified the United States, Japan, and France as the countries with the highest number of published articles, and Memorial Sloan-Kettering Cancer Center, MD Anderson Cancer Center, and Oslo University Hospital as the institutions with the most publications.
Article
Surgery
Diamantis I. Tsilimigras, Kota Sahara, J. Madison Hyer, Adrian Diaz, Dimitrios Moris, Fabio Bagante, Alfredo Guglielmi, Andrea Ruzzenente, Sorin Alexandrescu, George Poultsides, Kazunari Sasaki, Federico Aucejo, Aslam Ejaz, Jordan M. Cloyd, Timothy M. Pawlik
Summary: The study found that the proportion of patients undergoing simultaneous resection for synchronous colorectal liver metastases increased over time, while the incidence of severe complications decreased over time. Survival rates were comparable between simultaneous and staged resection in the long term.
Article
Multidisciplinary Sciences
Charlotte Boyd, Andre E. Punt
Summary: Monitoring population dynamics and detecting changes is crucial for cetacean conservation. Integrating additional data into surveys can improve accuracy of population size estimates and assist in detecting changes in population trend. Simulation studies are recommended to assess the potential for detecting population changes in cetacean populations.
Review
Nanoscience & Nanotechnology
Yuhan Wang, Zhenyu Yin, Lei Gao, Bin Ma, Jianming Shi, Hao Chen
Summary: Metastasis to the liver, a common pattern with poor prognosis, poses challenges to conventional therapies. Poor metastatic targeting ability, systemic toxicities, and inability to modulate the tumor microenvironment are major drawbacks. Lipid nanoparticles-based strategies, such as galactosylated or active-targeting chemotherapeutics liposomes, show promise in liver metastasis management. This review summarizes the state-of-art lipid nanoparticles-based therapies, focusing on drug-encapsulated nanoparticles targeting cancer cells and the tumor microenvironment for future clinical oncology practice.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Juan Carlos Celis-Pinto, Adela Alonso Fernandez-Velasco, Maria Daniela Corte-Torres, Jorge Santos-Juanes, Noelia Blanco-Agudin, Kelvin Manuel Pina Batista, Jesus Merayo-Lloves, Luis M. Quiros, Ivan Fernandez-Vega
Summary: The study investigated the expression of PTEN-induced kinase-1 (PINK1) in surgical specimens from ninety patients with metastatic colorectal adenocarcinoma (CRC) to the liver. The results showed that positive PINK1 expression was observed in all tumoral tissues, and there were no differences between different CRCs. However, a significant under-expression of PINK1 was found in CRLMs derived from the rectum compared to other sites. Altered PINK1 expression in CRCs was associated with worse overall survival due to abnormal mitophagy function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Salman Chaudhry, Ryan C. Fields, Patrick M. Grierson, Kian-Huat Lim
Summary: This article reviews the use of HAIP as a liver-directed therapy and discusses its application in colorectal cancer patients with liver metastasis. It explores the benefits and drawbacks of combining systemic and HAIP therapies, and provides insights on the use of HAIP in the modern era for patients with colorectal liver metastases.
Review
Oncology
Carolina de la Pinta, Maria E. Castillo, Manuel Collado, Cristina Galindo-Pumarino, Cristina Pena
Summary: Colorectal cancer is the third leading cause of cancer globally, with the liver being the most common site of metastasis in CRC patients. Radiomics and radiogenomics are important tools for diagnosing, predicting, and managing cancer patients through analyzing imaging data. Studies on liver metastatic colorectal cancer patients have shown the potential for improved diagnosis, treatment decisions, and prognostic biomarkers through advanced radiomics and radiogenomics techniques.
Article
Medicine, General & Internal
Ahmad Mahamid, Omar Abu-Zaydeh, Esther Kazlow, Dvir Froylich, Muneer Sawaied, Natalia Goldberg, Yael Berger, Wissam Khoury, Eran Sadot, Riad Haddad
Summary: This study investigated the relationship between the primary tumor location and survival rate in patients with colorectal liver metastases. The results showed that the primary tumor location did not significantly affect patient survival after liver resection in the Mediterranean population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Rohin Gawdi, Cristian D. Valenzuela, Omeed Moaven, John A. Stauffer, Nico R. Del Piccolo, Tanto Cheung, Carlos U. Corvera, Andrew D. Wisneski, Charles Cha, Perry Shen, Greg Russell, Nima Zarandi, Justin Dourado
Summary: This study examined the impact of neoadjuvant, adjuvant, and perioperative chemotherapy on the outcomes of patients with resectable colorectal-liver metastases (CLM). The results showed that adjuvant and perioperative chemotherapy were independently associated with improved overall survival (OS) compared to surgery alone.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Qichen Chen, Yizhou Zhang, Yiqiao Deng, Zhen Huang, Hong Zhao, Jianqiang Cai
Summary: There is a lack of evidence on simultaneous resection for elderly patients with colorectal liver metastasis (CRLM). In this study, elderly patients had a significantly higher rate of post-operative complications and worse overall survival. Further research is needed to determine the optimal treatment for elderly patients with high-risk CRLM.
Article
Oncology
Vincenza Granata, Roberta Fusco, Federica De Muzio, Carmen Cutolo, Sergio Venanzio Setola, Federica Dell'Aversana, Alessandro Ottaiano, Guglielmo Nasti, Roberta Grassi, Vincenzo Pilone, Vittorio Miele, Maria Chiara Brunese, Fabiana Tatangelo, Francesco Izzo, Antonella Petrillo
Summary: This study aimed to evaluate the effectiveness of radiomics features obtained by EOB-MRI phase in predicting clinical outcomes and assessing various factors in patients with colorectal liver metastases. The results showed that radiomics can serve as biomarkers to identify prognostic features that may influence treatment choices in these patients.
Article
Oncology
Yinghao Cao, Songqing Ke, Shenghe Deng, Lizhao Yan, Junnan Gu, Fuwei Mao, Yifan Xue, Changmin Zheng, Wentai Cai, Hongli Liu, Han Li, Fumei Shang, Zhuolun Sun, Ke Wu, Ning Zhao, Kailin Cai
Summary: A novel nomogram based on significant clinicopathological characteristics was established to predict overall survival and cancer-specific survival in patients with colorectal cancer liver metastasis. The nomogram showed favorable sensitivity in predicting survival rates at different time points and was found to be more beneficial than other single methods.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Rongqiang Liu, Weihao Kong, Mingbin Deng, Guozhen Lin, Tianxing Dai, Linsen Ye
Summary: The study found an association between Hepatitis B Virus infection and colorectal liver metastasis, but no significant impact on extrahepatic metastasis or patient prognosis.
Article
Gastroenterology & Hepatology
Thomas L. Sutton, Kevin G. Billingsley, Brett S. Walker, Alice W. Fung, Erin Maynard, C. Kristian Enestvedt, Elizabeth N. Dewey, Brian T. Brinkerhoff, Charles D. Lopez, Susan L. Orloff, Skye C. Mayo
Summary: This study aimed to investigate the sensitivity of different cross-sectional imaging modalities for MTF in ICC and found that CT is inadequate for pre-operative diagnosis of MTF in resectable ICC. Liver-protocol MRI is recommended as the standard pre-operative imaging modality for non-metastatic ICC.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Surgery
Marina Affi Koprowski, Thomas L. Sutton, Brian T. Brinkerhoff, Aaron Grossberg, Brett C. Sheppard, Skye C. Mayo
Summary: Pathologic subtype and receipt of adjuvant therapy may impact survival in ampullary cancer patients, but stage remains the primary determinant of survival.
AMERICAN JOURNAL OF SURGERY
(2021)
Editorial Material
Oncology
Thomas L. Sutton, Michael C. Heinrich, Skye C. Mayo
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Thomas L. Sutton, Brett S. Walker, Kevin G. Billingsley, Brett C. Sheppard, Christopher L. Corless, Michael C. Heinrich, Skye C. Mayo
Summary: Longer disease-free interval (DFI) exceeding 24 months in GIST patients is independently associated with higher post-recurrence survival rate and better progression-free survival rate at 10 years. DFI duration may be linked to tumor biology characteristics and treatment planning.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Thomas L. Sutton, Brett S. Walker, Nima Nabavizadeh, Aaron Grossberg, Charles R. Thomas, Charles D. Lopez, Adel Kardosh, Emerson Y. Chen, Brett C. Sheppard, Skye C. Mayo
Summary: The study showed that ICC patients treated at a referral center had better treatment and survival outcomes, and increasing distance to the referral center was associated with receiving treatment at a non-referral center.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Brett S. Walker, Thomas L. Sutton, Luai Zarour, John G. Hunter, Stephanie G. Wood, V. Liana Tsikitis, Daniel O. Herzig, Charles D. Lopez, Emerson Y. Chen, Skye C. Mayo, Melissa H. Wong
Summary: Circulating hybrid cells are a novel blood-based biomarker that can monitor treatment response and disease progression, aiding in guiding decisions for further treatment. Additional validation studies of CHCs are warranted.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Editorial Material
Oncology
Thomas L. Sutton, Skye C. Mayo
ANNALS OF SURGICAL ONCOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Stephanie Radu, Alice W. Fung, Skye C. Mayo
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Marina Affi Koprowski, Thomas L. Sutton, Nima Nabavizadeh, Charles Thomas, Emerson Chen, Adel Kardosh, Charles Lopez, Skye C. Mayo, Kim Lu, Daniel Herzig, V. Liana Tsikitis
Summary: The study found that early recurrence in rectal cancer is not associated with post-recurrence survival, while symptomatic recurrences and those with elevated CEA levels are related to worse survival. Metastatic disease confined to the liver or lung is associated with improved survival.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Oncology
Thomas L. Sutton, Brett S. Walker, Stephanie Radu, Elizabeth N. Dewey, C. Kristian Enestvedt, Erin Maynard, Susan L. Orloff, Nima Nabavizadeh, Brett C. Sheppard, Charles D. Lopez, Kevin G. Billingsley, Skye C. Mayo
Summary: The study revealed that biliary tract violations during cholecystectomy may increase the risk of peritoneal carcinomatosis in patients with gallbladder cancer. Different degrees of biliary tract violations were associated with significantly different peritoneal disease-free survival rates.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Liam H. Wong, German Ferrer, Skye C. Mayo
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Gastroenterology & Hepatology
Thomas L. Sutton, Brett S. Walker, Kevin G. Billingsley, Brett C. Sheppard, Christopher L. Corless, Michael C. Heinrich, Skye C. Mayo
Summary: Curative-intent hepatectomy is associated with improved overall survival in patients with liver metastatic gastrointestinal stromal tumors (mGIST). However, the oncologic benefit of resecting treatment-resistant lesions remains unclear compared to second-line TKI therapy.
Article
Oncology
Brett S. Walker, Kevin G. Billingsley, Thomas L. Sutton, Kenneth J. Kolbeck, Elena K. Korngold, Nima Nabavizadeh, Elizabeth N. Dewey, Daniel O. Herzig, Charles D. Lopez, Skye C. Mayo
Summary: Concurrent HAI and systemic therapy can be used effectively as a treatment option for advanced CRLM patients, both as an adjuvant therapy and to facilitate conversion of unresectable disease.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Thomas L. Sutton, Rodney F. Pommier, Skye C. Mayo, Erin W. Gilbert, Pavlos Papavasiliou, Michele Babicky, Jon Gerry, Brett C. Sheppard, Patrick J. Worth
Summary: This study compared the outcomes of open surgeries and minimally invasive surgeries for pancreatic neuroendocrine tumors (PNETs). It concluded that patients receiving minimally invasive surgery had similar survival rates and disease progression rates as patients receiving open surgery, with no significant differences in complications. Therefore, the routine use of minimally invasive surgery techniques for selected PNET patients is recommended.
Editorial Material
Surgery
Skye C. Mayo