标题
PP2A inhibition overcomes acquired resistance to HER2 targeted therapy
作者
关键词
HER2, lapatinib, Resistance, eEF2, PP2A
出版物
Molecular Cancer
Volume 13, Issue 1, Pages 157
出版商
Springer Nature
发表日期
2014-06-24
DOI
10.1186/1476-4598-13-157
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Durable complete response following chemotherapy and trastuzumab for metastatic HER2-positive breast cancer
- (2012) G. Gullo et al. ANNALS OF ONCOLOGY
- PI3K independent activation of mTORC1 as a target in lapatinib-resistant ERBB2+ breast cancer cells
- (2012) Anna-Maria Jegg et al. BREAST CANCER RESEARCH AND TREATMENT
- Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis
- (2012) Sahar A. Saddoughi et al. EMBO Molecular Medicine
- Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial
- (2012) José Baselga et al. LANCET
- Phosphorylation of Eukaryotic Elongation Factor 2 (eEF2) by Cyclin A–Cyclin-Dependent Kinase 2 Regulates Its Inhibition by eEF2 Kinase
- (2012) Asli A. Hizli et al. MOLECULAR AND CELLULAR BIOLOGY
- Protein Phosphatase 2A Mediates Dormancy of Glioblastoma Multiforme-Derived Tumor Stem-Like Cells during Hypoxia
- (2012) Christoph P. Hofstetter et al. PLoS One
- Evaluation of the association of PIK3CA mutations and PTEN loss with efficacy of trastuzumab therapy in metastatic breast cancer
- (2011) E. Razis et al. BREAST CANCER RESEARCH AND TREATMENT
- Growth of the pancreatic cancer cell line PANC-1 is inhibited by protein phosphatase 2A inhibitors through overactivation of the c-Jun N-terminal kinase pathway
- (2011) Wei Li et al. EUROPEAN JOURNAL OF CANCER
- 2D-DIGE analysis of phospho-enriched fractions from dasatinib-treated melanoma cell lines
- (2011) Alex J. Eustace et al. Journal of Proteomics
- Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition
- (2011) B N Rexer et al. ONCOGENE
- Pharmacologic Modulation of Serine/Threonine Phosphorylation Highly Sensitizes PHEO in a MPC Cell and Mouse Model to Conventional Chemotherapy
- (2011) Lucia Martiniova et al. PLoS One
- Inhibition of IGF1R activity enhances response to trastuzumab in HER-2-positive breast cancer cells
- (2010) B. C. Browne et al. ANNALS OF ONCOLOGY
- A synthetic cantharidin analog for the enhancement of doxorubicin suppression of stem cell-derived aggressive sarcoma
- (2010) Chao Zhang et al. BIOMATERIALS
- Synergistic interaction between trastuzumab and EGFR/HER-2 tyrosine kinase inhibitors in HER-2 positive breast cancer cells
- (2010) Norma O’Donovan et al. INVESTIGATIONAL NEW DRUGS
- Resistance to ErbB2 Tyrosine Kinase Inhibitors in Breast Cancer Is Mediated by Calcium-Dependent Activation of RelA
- (2010) W. Xia et al. MOLECULAR CANCER THERAPEUTICS
- Activated Phosphoinositide 3-Kinase/AKT Signaling Confers Resistance to Trastuzumab but not Lapatinib
- (2010) N. A. O'Brien et al. MOLECULAR CANCER THERAPEUTICS
- X-Linked Inhibitor of Apoptosis Protein Inhibits Apoptosis in Inflammatory Breast Cancer Cells with Acquired Resistance to an ErbB1/2 Tyrosine Kinase Inhibitor
- (2010) K. M. Aird et al. MOLECULAR CANCER THERAPEUTICS
- Novel Mechanism of Lapatinib Resistance in HER2-Positive Breast Tumor Cells: Activation of AXL
- (2009) L. Liu et al. CANCER RESEARCH
- The effect of a PP2A inhibitor on the nuclear receptor corepressor pathway in glioma
- (2009) Jie Lu et al. JOURNAL OF NEUROSURGERY
- Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms
- (2009) Jie Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphatidylinositol 3-Kinase Hyperactivation Results in Lapatinib Resistance that Is Reversed by the mTOR/Phosphatidylinositol 3-Kinase Inhibitor NVP-BEZ235
- (2008) P. J.A. Eichhorn et al. CANCER RESEARCH
- Lapatinib Resistance in HCT116 Cells Is Mediated by Elevated MCL-1 Expression and Decreased BAK Activation and Not by ERBB Receptor Kinase Mutation
- (2008) A. P. Martin et al. MOLECULAR PHARMACOLOGY
- Multiple pathways regulated by the tumor suppressor PP2A in transformation
- (2008) Jukka Westermarck et al. TRENDS IN MOLECULAR MEDICINE
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