Histone deacetylase inhibition synergistically enhances pemetrexed cytotoxicity through induction of apoptosis and autophagy in non-small cell lung cancer

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Dissecting the pathways that destabilize mutant p53: The proteasome or autophagy?

(2013) Sujata Choundhury et al.   CELL CYCLE

Life in the balance – a mechanistic view of the crosstalk between autophagy and apoptosis

(2013) Assaf D. Rubinstein et al.   JOURNAL OF CELL SCIENCE

Thymidylate Synthase Expression and Outcome of Patients Receiving Pemetrexed for Advanced Nonsquamous Non–Small-Cell Lung Cancer in a Prospective Blinded Assessment Phase II Clinical Trial

(2013) Marianne C. Nicolson et al.   Journal of Thoracic Oncology

Thymidylate synthase and ERCC1 as predictive markers in patients with pulmonary adenocarcinoma treated with pemetrexed and cisplatin

(2013) Seung Hyeun Lee et al.   LUNG CANCER

The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells

(2013) M-C Chen et al.   Cell Death & Disease

Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma

(2013) G M Matthews et al.   Cell Death & Disease

Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy

(2013) A Garufi et al.   Cell Death & Disease

The thiazole derivative CPTH6 impairs autophagy

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Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells

(2012) Annette Romanski et al.   CELL CYCLE

Multi-Targeted Histone Deacetylase Inhibitors in Cancer Therapy

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Givinostat and hydroxyurea synergize in vitro to induce apoptosis of cells from JAK2V617F myeloproliferative neoplasm patients

(2012) Ariel Amaru Calzada et al.   EXPERIMENTAL HEMATOLOGY

Significance of Folate Receptor Alpha and Thymidylate Synthase Protein Expression in Patients with Non–Small-Cell Lung Cancer Treated with Pemetrexed

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Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death

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Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer

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Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Sorafenib Enhances Pemetrexed Cytotoxicity through an Autophagy-Dependent Mechanism in Cancer Cells

(2011) M. D. Bareford et al.   CANCER RESEARCH

Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis

(2011) Jennifer Jurkin et al.   CELL CYCLE

Mechanisms of mitochondria and autophagy crosstalk

(2011) Angelika S. Rambold et al.   CELL CYCLE

Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8

(2011) M A Laussmann et al.   CELL DEATH AND DIFFERENTIATION

Cell death by autophagy: facts and apparent artefacts

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CPTH6, a Thiazole Derivative, Induces Histone Hypoacetylation and Apoptosis in Human Leukemia Cells

(2011) D. Trisciuoglio et al.   CLINICAL CANCER RESEARCH

Thymidylate Synthase and Excision Repair Cross-Complementing Group-1 as Predictors of Responsiveness in Mesothelioma Patients Treated with Pemetrexed/Carboplatin

(2011) P. A. Zucali et al.   CLINICAL CANCER RESEARCH

Significance of Thymidylate Synthase and Thyroid Transcription Factor 1 Expression in Patients with Nonsquamous Non-small Cell Lung Cancer Treated with Pemetrexed-Based Chemotherapy

(2011) Jong-Mu Sun et al.   Journal of Thoracic Oncology

Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: The association with treatment efficacy of pemetrexed

(2011) Chung-Yu Chen et al.   LUNG CANCER

The Autophagy Protein Atg12 Associates with Antiapoptotic Bcl-2 Family Members to Promote Mitochondrial Apoptosis

(2011) Assaf D. Rubinstein et al.   MOLECULAR CELL

Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism

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Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non-Small Cell Lung Cancer

(2011) R. A. Juergens et al.   Cancer Discovery

Histone deacetylase inhibitors: A chemical genetics approach to understanding cellular functions

(2010) Paul A. Marks   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Histone deacetylase inhibitor enhances sensitivity of non-small-cell lung cancer cells to 5-FU/S-1 via down-regulation of thymidylate synthase expression and up-regulation of p21waf1/cip1 expression

(2010) Rintaro Noro et al.   CANCER SCIENCE

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

(2010) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thymidylate Synthase But Not Excision Repair Cross-Complementation Group 1 Tumor Expression Predicts Outcome in Patients With Malignant Pleural Mesothelioma Treated With Pemetrexed-Based Chemotherapy

(2010) Luisella Righi et al.   JOURNAL OF CLINICAL ONCOLOGY

Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1

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DNA microarray profiling of genes differentially regulated by the histone deacetylase inhibitors vorinostat and LBH589 in colon cancer cell lines

(2009) Melissa J LaBonte et al.   BMC Medical Genomics

Differential Thymidylate Synthase Expression in Different Variants of Large-Cell Carcinoma of the Lung

(2009) V. Monica et al.   CLINICAL CANCER RESEARCH

Carboplatin and Paclitaxel in Combination With Either Vorinostat or Placebo for First-Line Therapy of Advanced Non–Small-Cell Lung Cancer

(2009) Suresh S. Ramalingam et al.   JOURNAL OF CLINICAL ONCOLOGY

Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells

(2008) A. Yacoub et al.   MOLECULAR CANCER THERAPEUTICS

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Lung Cancer

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A natural histone deacetylase inhibitor, Psammaplin A, induces cell cycle arrest and apoptosis in human endometrial cancer cells

(2007) Mee Young Ahn et al.   GYNECOLOGIC ONCOLOGY