Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy

HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation

(2016) Lavinia Nardinocchi et al.   Aging-US

Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation

(2015) Michal Sheffer et al.   Oncotarget

Dietary downregulation of mutant p53 levels via glucose restriction

(2012) Olga Catalina Rodriguez et al.   CELL CYCLE

Autophagy and cancer

(2012) Kyeong Sook Choi   EXPERIMENTAL AND MOLECULAR MEDICINE

Updates on HIPK2: a resourceful oncosuppressor for clearing cancer

(2012) Gabriella D’Orazi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Dietary Glycemic Load and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings From CALGB 89803

(2012) Jeffrey A. Meyerhardt et al.   JNCI-Journal of the National Cancer Institute

Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death

(2012) Nicholas A Graham et al.   Molecular Systems Biology

Cancer metabolism: current perspectives and future directions

(2012) C Muñoz-Pinedo et al.   Cell Death & Disease

A Low Carbohydrate, High Protein Diet Slows Tumor Growth and Prevents Cancer Initiation

(2011) V. W. Ho et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs

(2011) Rosa Puca et al.   CELL CYCLE

Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy

(2011) D Vara et al.   CELL DEATH AND DIFFERENTIATION

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

(2011) J-H Mao et al.   ONCOGENE

The Loss of the p53 Activator HIPK2 Is Responsible for Galectin-3 Overexpression in Well Differentiated Thyroid Carcinomas

(2011) Luca Lavra et al.   PLoS One

Metformin inhibits melanoma development through autophagy and apoptosis mechanisms

(2011) T Tomic et al.   Cell Death & Disease

Activation of Phosphatidylcholine Cycle Enzymes in Human Epithelial Ovarian Cancer Cells

(2010) E. Iorio et al.   CANCER RESEARCH

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

(2010) I. Ben Sahra et al.   CANCER RESEARCH

Autophagy: assays and artifacts

(2010) Sandra Barth et al.   JOURNAL OF PATHOLOGY

The missing Zinc: p53 misfolding and cancer

(2010) Stewart N. Loh   Metallomics

Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells

(2010) R Puca et al.   ONCOGENE

Zinc Downregulates HIF-1α and Inhibits Its Activity in Tumor Cells In Vitro and In Vivo

(2010) Lavinia Nardinocchi et al.   PLoS One

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

Negative Regulation of  4 Integrin Transcription by Homeodomain-Interacting Protein Kinase 2 and p53 Impairs Tumor Progression

(2009) G. Bon et al.   CANCER RESEARCH

From bench to bedside: current and future applications of molecular profiling in renal cell carcinoma

(2009) Androu Arsanious et al.   Molecular Cancer

HIPK2 modulates p53 activity towards pro-apoptotic transcription

(2009) Rosa Puca et al.   Molecular Cancer

Cancer's insatiable appetite

(2009) Jason W Locasale et al.   NATURE BIOTECHNOLOGY

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Targeting Hypoxia in Cancer Cells by Restoring Homeodomain Interacting Protein-Kinase 2 and p53 Activity and Suppressing HIF-1α

(2009) Lavinia Nardinocchi et al.   PLoS One

Spectroscopic and Statistical Techniques for Information Recovery in Metabonomics and Metabolomics

(2008) John C. Lindon et al.   Annual Review of Analytical Chemistry

Transcriptional regulation of hypoxia-inducible factor 1α by HIPK2 suggests a novel mechanism to restrain tumor growth

(2008) Lavinia Nardinocchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Reversible Dysfunction of Wild-Type p53 following Homeodomain-Interacting Protein Kinase-2 Knockdown

(2008) R. Puca et al.   CANCER RESEARCH

Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc

(2008) Rosa Puca et al.   EXPERIMENTAL CELL RESEARCH

Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells

(2008) Rosa Puca et al.   GYNECOLOGIC ONCOLOGY

An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response

(2008) Marco A. Calzado et al.   NATURE CELL BIOLOGY