A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signaling

Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells

(2014) Ummuhan Demir et al.   BMC CANCER

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

Anterior gradient 2and3- two prototype androgen-responsive genes transcriptionally upregulated by androgens and by oestrogens in prostate cancer cells

(2013) Huajie Bu et al.   FEBS Journal

Posttranslational Modification of the Androgen Receptor in Prostate Cancer

(2013) Travis Van der Steen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity

(2013) Adam Collison et al.   NATURE MEDICINE

Novel therapeutics for the management of castration-resistant prostate cancer (CRPC)

(2011) Daniel J. Lee et al.   BJU INTERNATIONAL

Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

(2011) Brett S. Carver et al.   CANCER CELL

Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

(2011) C. Cai et al.   CANCER RESEARCH

Targeting PDK1 in Cancer

(2011) C. Raimondi et al.   CURRENT MEDICINAL CHEMISTRY

Protein Phosphatase 2A (PP2A)-specific Ubiquitin Ligase MID1 Is a Sequence-dependent Regulator of Translation Efficiency Controlling 3-Phosphoinositide-dependent Protein Kinase-1 (PDPK-1)

(2011) Beatriz Aranda-Orgillés et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Protein Phosphatase 2A Activity Alters Androgen-Independent Growth of Prostate Cancer Cells: Therapeutic Implications

(2011) A. Bhardwaj et al.   MOLECULAR CANCER THERAPEUTICS

Mutant CAG repeats of Huntingtin transcript fold into hairpins, form nuclear foci and are targets for RNA interference

(2011) Mateusz de Mezer et al.   NUCLEIC ACIDS RESEARCH

Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer

(2011) A Urbanucci et al.   ONCOGENE

Overexpression of immunoglobulin (CD79a) binding protein1 (IGBP-1) in small lung adenocarcinomas and its clinicopathological significance

(2011) Shingo Sakashita et al.   PATHOLOGY INTERNATIONAL

Control of mTORC1 signaling by the Opitz syndrome protein MID1

(2011) E. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Somatic Mutations throughout the Entire Mitochondrial Genome Are Associated with Elevated PSA Levels in Prostate Cancer Patients

(2010) Anita Kloss-Brandstätter et al.   AMERICAN JOURNAL OF HUMAN GENETICS

46,XY disorders of sex development – the undermasculinised male with disorders of androgen action

(2010) Ralf Werner et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Inhibition of cyclin D1 expression by androgen receptor in breast cancer cells--identification of a novel androgen response element

(2010) M. Lanzino et al.   NUCLEIC ACIDS RESEARCH

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An in vitro model for preclinical testing of endocrine therapy combinations for prostate cancer

(2010) Minja J. Pfeiffer et al.   PROSTATE

3-Phosphoinositide-Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma

(2009) M. Maurer et al.   CANCER RESEARCH

Castration-Resistant Prostate Cancer: Locking Up the Molecular Escape Routes

(2009) R. M. Attar et al.   CLINICAL CANCER RESEARCH

NF-κB and cancer: how intimate is this relationship

(2009) Sahdeo Prasad et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Protein Phosphatase 2A and Rapamycin Regulate the Nuclear Localization and Activity of the Transcription Factor GLI3

(2008) S. Krauss et al.   CANCER RESEARCH

Smith–Lemli–Opitz syndrome: pathogenesis, diagnosis and management

(2008) Forbes D Porter   EUROPEAN JOURNAL OF HUMAN GENETICS

A Feedback Loop between the Androgen Receptor and a NEDD4-binding Protein, PMEPA1, in Prostate Cancer Cells

(2008) Hongyun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Active Transport of the Ubiquitin Ligase MID1 along the Microtubules Is Regulated by Protein Phosphatase 2A

(2008) Beatriz Aranda-Orgillés et al.   PLoS One

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY