Article
Chemistry, Applied
Diming Tan, Weiwen Chen, Zixin Yang, Minjing Rong, Rui Huang, Xiyang Wu, Weibin Bai, Lingmin Tian
Summary: This study aimed to link propionic acid (PA) and fructooligosaccharides (FOS) to form propionyl-FOS capable of delivering PA to the colon. Chemically synthesized propionyl-FOS (AP-FOS) showed higher esterification degree than enzymatically synthesized ones (P-FOS). AP-FOS also exhibited higher diversity. In vitro fermentation experiments showed that both AP-FOS and P-FOS groups had higher levels of PA and butyric acid compared to FOS group. However, P-FOS showed better fermentability and prebiotic effects through gut microbiota modulation compared to FOS.
FOOD HYDROCOLLOIDS
(2023)
Article
Food Science & Technology
Di Yao, Mengna Wu, Ying Dong, Lixue Ma, Xiaoyu Wang, Lei Xu, Qiaoru Yu, Xiqun Zheng
Summary: This study investigated the fermentation characteristics of fructooligosaccharides (FOS) and galactooligosaccharides (GOS) with infant fecal inoculum. The results showed that FOS and GOS significantly influenced the composition and metabolism of the intestinal microbiota, leading to increased production of short-chain fatty acids (SCFAs) and lactate.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Zhihua Niu, Meijuan Zou, Tingting Bei, Na Zhang, Dongyao Li, Miaoshu Wang, Chen Li, Hongtao Tian
Summary: The study found that L. rhamnosus can increase specific bands in the ERIC-PCR and enhance their brightness in the later stage of recovery in the mice intestine. High-throughput results confirmed that Lactobacillus and Akkermansia had different changes over time, but both showed an upward trend. Additionally, FOS had a positive effect on L. rhamnosus colonization in the gut.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Review
Nutrition & Dietetics
Yuqi Dou, Xue Yu, Yuanli Luo, Botian Chen, Defu Ma, Jing Zhu
Summary: This study is the first meta-analysis to explore the effect of FOS on gut microbiota and to evaluate the adverse effects of FOS intake on the gastrointestinal tract. FOS supplementation could increase the number of colonic Bifidobacterium spp. while higher dose (7.5-15 g/d) and longer duration (>4 weeks) showed more distinct effects and was well tolerated.
Review
Agriculture, Dairy & Animal Science
Muhammad Akhtar, Yan Chen, Ziyu Ma, Xiaolong Zhang, Deshi Shi, Jawaria A. Khan, Huazhen Liu
Summary: This review summarizes the role of short chain fatty acids (SCFA) in modulating gut inflammation and highlights their potential and applications in the treatment of inflammatory bowel disease (IBD).
Review
Nutrition & Dietetics
Peng Zhao, Suhong Zhao, Jinwei Tian, Xinxin Liu
Summary: This review primarily focuses on the relationship between the gut microbiota and its major metabolites, such as short-chain fatty acids (SCFAs), and heart failure (HF), aiming to explore effective treatments for HF by targeting SCFAs and improve patients' quality of life.
Article
Environmental Sciences
Maowang Jiang, Wencheng Xiao, Jingtao Ye, Liting Xu, Ruibing Peng, Qingxi Han, Zhenming Lu, Huilai Shi, Xiamin Jiang
Summary: This study investigates the changes in digestive physiology, intestinal morphology, and microbial composition during feed transition in Sepia pharaonis. The results show significant changes in digestive enzymes and microbiota, highlighting the importance of understanding these changes for aquaculture production.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Cell Biology
Kenneth J. O'Riordan, Michael K. Collins, Gerard M. Moloney, Emily G. Knox, Maria R. Aburto, Christine Fulling, Shane J. Morley, Gerard Clarke, Harriet Schellekens, John F. Cryan
Summary: The role of the intestinal microbiota in regulating gut-brain axis signaling has gained attention in recent years. Understanding the relationship between the gut microbiota, its metabolites, and the brain is crucial for developing new therapeutic approaches, including identifying psychobiotics. Current research focuses on the effects of short-chain fatty acids (SCFAs), such as butyrate, acetate, and propionate, on brain function, behavior, and physiology, and how these SCFAs enter the systemic circulation and can potentially impact the brain.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Immunology
Xiran Lou, Jinfang Xue, Ruifei Shao, Yan Yang, Deyuan Ning, Chunyan Mo, Fuping Wang, Guobing Chen
Summary: This study found significant differences in gut microbiota between sepsis patients and healthy individuals. Fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) were found to regulate the abundance of bacteria and improve survival rate and systemic inflammatory response in a mouse model of sepsis. These findings suggest that FMT and SCFAs may be a potential treatment for sepsis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Geriatrics & Gerontology
Xiao-hang Qian, Ru-yan Xie, Xiao-li Liu, Sheng-di Chen, Hui-dong Tang
Summary: Short-chain fatty acids (SCFAs) are important metabolites derived from the gut microbiota through fermentation of dietary fiber. They play a role in various physiological and pathological processes in the human body, including potential roles and mechanisms in neurodegenerative diseases such as Alzheimer's disease.
Article
Neurosciences
Velma T. E. Aho, Madelyn C. Houser, Pedro A. B. Pereira, Jianjun Chang, Knut Rudi, Lars Paulin, Vicki Hertzberg, Petri Auvinen, Malu G. Tansey, Filip Scheperjans
Summary: This study found that intestinal inflammatory responses and reductions in fecal SCFAs occur in Parkinson's disease (PD), are related to the microbiota and to disease onset, and are not reflected in plasma inflammatory profiles. Some of these relationships are distinct in PD and are sex-dependent. This study revealed potential alterations in microbiota-host interactions and links between earlier PD onset and intestinal inflammatory responses and reduced SCFA levels.
MOLECULAR NEURODEGENERATION
(2021)
Article
Nutrition & Dietetics
Nor Adila Mhd Omar, Johan Dicksved, Johanita Kruger, Galia Zamaratskaia, Karl Michaelsson, Alicja Wolk, Jan Frank, Rikard Landberg
Summary: Recent studies have found that a diet high in sugars can affect the gut microbiota, but there is a lack of experimental evidence. This study investigated the effects of high fructose or galactose intake, with or without fructooligosaccharides (FOS), on gut microbiota composition in rats. The results showed that the intake of fructose or galactose did not have a coherent effect on gut microbiota composition, but the addition of FOS increased Bifidobacterium. However, gut microbiota composition was associated with metabolic factors and gut permeability markers, which warrant further investigations.
FRONTIERS IN NUTRITION
(2022)
Review
Oncology
Huiqin Hou, Danfeng Chen, Kexin Zhang, Wanru Zhang, Tianyu Liu, Xin Dai, Bangmao Wang, Weilong Zhong, Hailong Cao
Summary: Colorectal cancer is the third most common cancer worldwide, and its development is closely related to changes in the gut microbiota and metabolites. Short-chain fatty acids play a crucial role in promoting intestinal health, inhibiting tumor development, and enhancing responses to chemotherapy and immunotherapy.
Article
Microbiology
Weiping Xiao, Jiabin Su, Xinjie Gao, Heng Yang, Ruiyuan Weng, Wei Ni, Yuxiang Gu
Summary: This study demonstrates that modulating the gut microbiome via fecal microbiota transplantation (FMT) can improve cognitive impairment and depressive-like behaviors caused by chronic cerebral hypoperfusion. FMT increases the level of short-chain fatty acids (SCFAs), promotes gut function, and improves cognitive performance. Long-term SCFA supplementation also reduces inflammation and hippocampal neuronal apoptosis.
Article
Agriculture, Dairy & Animal Science
Bong-Seung Seo, Su-Jin Park, So-Yeon Hwang, Ye-In Lee, Seung-Han Lee, Sang-Woo Hur, Kyeong-Jun Lee, Taek-Jeong Nam, Jin-Woo Song, Jae-Sig Kim, Won-Je Jang, Youn-Hee Choi
Summary: The study evaluated the application of a low-fishmeal diet as feed to olive flounder raised in a fish farm. It found that reducing the fishmeal content of the feed by up to 35% does not adversely affect the growth and physiological characteristics of the fish under farm conditions.
Article
Fisheries
Helena Fernandes, Carolina Castro, Diogo Filipe, Francisco Moyano, Patricia Ferreira, Aires Oliva-Teles, Isabel Belo, Helena Peres, Manuel Jose Salgado
Summary: This study evaluated the potential of a carbohydrases-rich extract produced from the fermentation of brewer's spent grain (BSG) to enhance the nutritional value of plant-based diets for European seabass juveniles. The results showed that the BSG extract did not affect the growth performance of the fish but increased feed efficiency and protein utilization. Pre-treating the plant feedstuffs with the BSG extract seemed to be more effective in improving protein utilization compared to directly adding it to the diet. This study demonstrated the feasibility of using BSG valorization through solid-state fermentation (SSF) to produce a functional additive for aquafeeds, contributing to resource sustainability and increasing the nutritional value of plant feedstuffs.
Article
Fisheries
Renan Rosa Paulino, Alexandre Firmino Diogenes, Katia Rodrigues Batista de Oliveira, Tamira Maria Orlando, Priscila Vieira Rosa, Helena Peres, Aires Oliva-Teles
Summary: The study aimed to evaluate the effect of dietary protein:energy ratio and non-protein energy source on metabolic responses in gilthead sea bream. It was found that non-protein energy sources mainly affected carbohydrate metabolism and lipogenesis, while the protein:energy ratio primarily influenced gluconeogenesis and amino acid catabolism in the fish.
AQUACULTURE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Catarina Basto-Silva, Ana Couto, Juliana Rodrigues, Aires Oliva-Teles, Isabel Navarro, Hiroyuki Kaiya, Encarnacion Capilla, Ines Guerreiro
Summary: The study evaluated the impact of feeding frequency and dietary protein/carbohydrate ratios on appetite regulation in gilthead seabream. The results showed that feeding fish 2 or 3 meals per day and providing a low protein and high carbohydrate diet led to increased feed intake and feed conversion ratio. The specific growth rate was also higher in fish fed multiple meals per day. However, the expression of appetite-related genes in the brain and gut was not affected by feeding frequency or diet composition. Overall, the study suggests that feeding gilthead seabream a low protein and high carbohydrate diet multiple times a day may decrease the feeling of satiation.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Helena Fernandes, Nicole Martins, Lucia Vieira, Jose Manuel Salgado, Carolina Castro, Aires Oliva-Teles, Isabel Belo, Helena Peres
Summary: The study found that solid-state fermentation (SSF) was the most effective processing method for Ulva rigida, as it improved feed efficiency without affecting the growth performance of fish.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Article
Biology
Fabio Rangel, Rafaela A. Santos, Marta Monteiro, Ana Sofia Lavrador, Laura Gasco, Francesco Gai, Aires Oliva-Teles, Paula Enes, Claudia R. Serra
Summary: As the demand for fish increases due to the growing human population, aquaculture has become one of the fastest growing industries. However, the use of unsustainable fish meal as the main protein source in aquafeeds needs to be replaced. Recently, seven insect species have been approved as potential ingredients for animal feeds in Europe. Unfortunately, chitin, a component found in insects, is indigestible for economically valuable fish species, leading to lower fish performance. This study aimed to isolate probiotic bacteria from the gastrointestinal tract of European sea bass that can produce chitinases to improve the use of diets containing high levels of insect meal.
Article
Fisheries
Rui Magalhaes, Francisco Abellan Guardiola, Ines Guerreiro, Filipa Fontinha, Sara Moutinho, Claudia Reis Serra, Rolf Erik Olsen, Helena Peres, Aires Oliva-Teles
Summary: This study evaluated the immunomodulatory effects of different ratios of ARA, EPA, and DHA in the diet of gilthead sea bream juveniles. The results showed that fish fed with high DHA diet exhibited increased immune activity after intraperitoneal injection, while fish fed with high ARA diet showed higher bactericidal activity against the pathogenic bacteria.
AQUACULTURE RESEARCH
(2022)
Article
Marine & Freshwater Biology
Marcelino Herrera, Ana Rodiles, Natalia Salamanca, Jose Ignacio Navas, Maria Luisa Cordero, Ismael Hachero
Summary: This study aims to describe and analyze the results of the first flatfish stock enhancements in Andalusia. The results show that it is possible to release and recover tagged Senegal soles in the Gulf of Cadiz, and future long-term enhancement programs could help recover fisheries stocks.
Article
Fisheries
Maria Mastoraki, Lydia Katsika, Paula Enes, Ines Guerreiro, Yannis P. Kotzamanis, Laura Gasco, Stavros Chatzifotis, Efthimia Antonopoulou
Summary: This study investigated the possibility of using insect larvae meals to replace fish meal in gilthead sea bream feed. The results showed that the use of Tenebrio molitor larvae resulted in better growth performance, while Hermetia illucens meal had lower dry matter-fat retention.
Article
Agriculture, Dairy & Animal Science
Ines Guerreiro, Carolina Castro, Claudia R. Serra, Filipe Coutinho, Ana Couto, Helena Peres, Pedro Pousao-Ferreira, Laura Gasco, Francesco Gai, Aires Oliva-Teles, Paula Enes
Summary: Insect meal is being considered as a sustainable alternative to fishmeal in fish diets. However, chitin, a component of insect meal, has been identified as a potential limitation for the inclusion of high levels of insect meal in aquafeeds. This study evaluated the effects of Hermetia illucens meal dietary inclusion on meagre liver and intestine oxidative status and found that chitin or insect lipid composition did not greatly affect meagre antioxidant status. Overall, Hermetia illucens meal can be included as up to 30% of the diet without compromising meagre antioxidant status.
Article
Nutrition & Dietetics
Farzaneh Vakili, Zahra Roosta, Roghieh Safari, Mojtaba Raeisi, Md. Sakhawat Hossain, Ines Guerreiro, Arash Akbazadeh, Seyed Hossein Hoseinifar
Summary: This study evaluated the impact of nutmeg seed meal on the growth, immunity, and antioxidant defense of zebrafish. The results showed that nutmeg supplementation did not significantly affect the growth of zebrafish, but it significantly decreased their survival rate. Nutmeg supplementation enhanced the immune and antioxidant parameters of zebrafish and improved their resistance to cold-water shock.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Ines Guerreiro, Carolina Castro, Claudia R. Serra, Filipe Coutinho, Ana Couto, Helena Peres, Pedro Pousao-Ferreira, Genevieve Corraze, Aires Oliva-Teles, Paula Enes
Summary: This study aimed to investigate the effects of including yellow worm meal in the diet of meagre fish on their fatty acid profile and oxidative status of the liver and intestine. The results showed that increasing levels of yellow worm meal in the diet led to an increase in certain fatty acids and a decrease in others in the whole body of the fish. The activity of certain enzymes involved in antioxidant defense increased in the liver and intestine, while others decreased. However, there was no significant effect on oxidative stress or lipid peroxidation. In conclusion, it is recommended to limit the inclusion of yellow worm meal to 10% in meagre fish diets to avoid major changes in fatty acid composition and oxidative imbalance.
Article
Fisheries
Diogo Filipe, Mario Dias, Rui Magalhaes, Helena Fernandes, Jose Salgado, Isabel Belo, Aires Oliva-Teles, Helena Peres
Summary: Aquaculture requires new, economical, and eco-friendly protein sources to replace traditional fisheries and plant ingredients. Using agriculture by-products as protein sources would reduce land-based feed production pressure and waste production, promoting a circular economy and sustainable aquaculture.
Article
Fisheries
Claudia Teixeira, Rita Pedrosa, Carolina Castro, Rui Magalhaes, Elisabete Matos, Aires Oliva-Teles, Helena Peres, Amalia Perez-Jimenez
Summary: This study aimed to assess the potential role of dietary tryptophan supplementation in meagre juveniles in order to minimize the deleterious effect of potential stress conditions. The results indicated that tryptophan supplementation had a negative impact on the growth and feed utilization of the fish, but did not affect these parameters at doses below 0.5%.
Article
Multidisciplinary Sciences
Quentin Garrigues, Emmanuelle Apper, Ana Rodiles, Nicoletta Rovere, Sylvie Chastant, Hanna Mila
Summary: Low birth weight puppies have different gut microbiota composition compared to other groups, and birth weight impacts the establishment of gut microbiota in puppies.
SCIENTIFIC REPORTS
(2023)