Model-driven experimental analysis of the function of SHP-2 in IL-6-induced Jak/STAT signaling

A simple work flow for biologically inspired model reduction - application to early JAK-STAT signaling

(2011) Tom Quaiser et al.   BMC Systems Biology

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

(2011) Emilie A. Bard-Chapeau et al.   CANCER CELL

The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3

(2011) M. Vogt et al.   JOURNAL OF CELL SCIENCE

Rapid Phospho-Turnover by Receptor Tyrosine Kinases Impacts Downstream Signaling and Drug Binding

(2011) Laura B. Kleiman et al.   MOLECULAR CELL

Theoretical Analysis of Time-to-Peak Responses in Biological Reaction Networks

(2010) Fabian J. Theis et al.   BULLETIN OF MATHEMATICAL BIOLOGY

Protein Tyrosine Phosphatases, TC-PTP, SHP1, and SHP2, Cooperate in Rapid Dephosphorylation of Stat3 in Keratinocytes Following UVB Irradiation

(2010) Dae Joon Kim et al.   PLoS One

Systematic identifiability testing for unambiguous mechanistic modeling – application to JAK-STAT, MAP kinase, and NF-κB signaling pathway models

(2009) Tom Quaiser et al.   BMC Systems Biology

Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2

(2009) Boris R. A. Blechacz et al.   HEPATOLOGY

Negative Regulation of Stat3 by ActivatingPTPN11Mutants Contributes to the Pathogenesis of Noonan Syndrome and Juvenile Myelomonocytic Leukemia

(2009) Wenjun Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY