Review
Biochemistry & Molecular Biology
Loic Benoit, Audrey Dieu, Maxime Foguenne, Eliano Bonaccorsi-Riani
Summary: Ischemia-reperfusion injury (IRI) is an inflammatory process in organ transplantation. Sevoflurane has shown potential benefits in reducing hepatic IRI (HIRI). Experimental studies support its protective effects, but clinical studies have conflicting results. Further clinical trials are needed to determine the clinical relevance of sevoflurane as a protective factor against HIRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jing Zhang, Xia Cai, Qin Zhang, Xiaozhong Li, Siyuan Li, Jianyong Ma, Wengen Zhu, Xiao Liu, Meilin Wei, Wei Tu, Yunfeng Shen, Jianping Liu, Xiaoyang Lai, Peng Yu
Summary: The study found that hydrogen sulfide can restore the cardioprotection induced by sevoflurane postconditioning in diabetic rats by enhancing and promoting the SIRT1/Nrf2 signaling pathway, thereby mediating mitochondrial dysfunction and oxidative stress.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Dou Huang, Changwei Chen, Yunxia Zuo, Lei Du, Ting Liu, Geoffrey W. Abbott, Zhaoyang Hu
Summary: This study found that RLIPost reduces pulmonary damage induced by ischemia-reperfusion in both non-diabetic and diabetic rats. The protective mechanism in non-diabetic rats is associated with STAT-3, while in diabetic rats it is independent of STAT-3.
Article
Immunology
Haiyun Guo, Ze Fan, Shiquan Wang, Lina Ma, Jin Wang, Doutong Yu, Zhen Zhang, Lin Wu, Zhengwu Peng, Wenming Liu, Wugang Hou, Yanhui Cai
Summary: The mobilization of astrocytic glycogen inhibits A1-like astrocytes and enhances A2-like astrocytes during reperfusion, leading to reduced reactive oxygen species levels and increased production of NADPH and glutathione. This neuroprotection is mediated through ROS-mediated NF-kappa B inhibition and STAT3 activation, presenting a promising metabolic target for brain reperfusion injury in ischemic stroke.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Medicine, Research & Experimental
Yushi Wu, Haiqiong Liu, Xianbao Wang
Summary: Acute myocardial infarction requires timely reperfusion to reduce myocardial damage, but reperfusion may lead to myocardial ischemia/reperfusion injury. Pharmacological postconditioning is an effective and flexible strategy to reduce myocardial injury by administering medication before or during early reperfusion.
Article
Veterinary Sciences
Nicole Verhaar, Nicole de Buhr, Maren von Koeckritz-Blickwede, Marion Hewicker-Trautwein, Christiane Pfarrer, Gemma Mazzuoli-Weber, Henri Schulte, Sabine Kaestner
Summary: The study found a reduced apoptotic cell count in the group subjected to Ischaemic postconditioning (IPoC), but none of the other tested variables were significantly affected by IPoC. The clinical relevance and possible protective mechanism of IPoC in equine intestinal ischaemia remain unclear, highlighting the need for further research on its mechanism of action and effects in clinical cases of strangulating colic.
BMC VETERINARY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Liying Xu, Feng Ge, Yan Hu, Ying Yu, Kefang Guo, Changhong Miao
Summary: Sevoflurane postconditioning exerts hepatoprotective effects by inhibiting apoptosis, oxidative stress, and inflammatory response, improving survival rates in HIRI mice. Regulation of miR-142 and HMGB1 expression, as well as blocking the TLR4/NF-kappa B pathway activation, contribute to the protective effects of sevoflurane in hepatic I/R injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Sumin Gao, Rong Wang, Siwei Dong, Jing Wu, Bartlomiej Perek, Zhengyuan Xia, Shanglong Yao, Tingting Wang
Summary: The cardioprotective effect of sevoflurane postconditioning (SPostC) is mediated by TOPK-induced activation of PTEN/PI3K/Akt signaling pathway in nondiabetic conditions, while its impairment in diabetic conditions leads to loss of cardioprotection by SPostC.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Pharmacology & Pharmacy
Lingling Jiang, Tao Zhang, Yang Zhang, Dexin Yu, Ye Zhang
Summary: This study demonstrates that dexmedetomidine postconditioning (DPOC) can alleviate renal ischemic/reperfusion injury in patients undergoing laparoscopic partial nephrectomy (LPN), at least on a short-term basis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Shoaib, Rishabh C. Choudhary, Rupesh K. Chillale, Nancy Kim, Santiago J. Miyara, Shabirul Haque, Tai Yin, Maya Frankfurt, Ernesto P. Molmenti, Stavros Zanos, Junhwan Kim, Lance B. Becker
Summary: Cardiac arrest causes severe multiorgan damage, especially brain injury, and metformin may serve as an effective intervention to improve survival, protect mitochondrial function, and mitigate brain damage.
Article
Cell Biology
Zijun Zhao, Yishuai Li, Fei Chi, Li Ma, Yanan Li, Zhiyong Hou, Qiujun Wang
Summary: In this study, we investigated the protective effect of sevoflurane postconditioning against cerebral ischemia reperfusion (I/R) injury and its potential mechanism. The results showed that sevoflurane postconditioning ameliorated neurological deficits induced by cerebral I/R and suppressed neuroinflammatory responses by inhibiting the TLR4/MyD88/TRAF6 signaling pathway.
Article
Critical Care Medicine
Cody A. Rutledge, Brett A. Kaufman, Cameron Dezfulian, Jonathan Elmer
Summary: This study found that metformin may provide cardiac and renal protection for diabetic patients during sudden cardiac arrest, as it was associated with lower peak serum troponin and peak serum creatinine levels.
Article
Biotechnology & Applied Microbiology
Guoning Su, Yan Qu, Gang Li, Min Deng
Summary: The study found that SEV has a protective effect on cerebral ischemia/reperfusion injury (CIRI) by modulating the miR-30 c-5p-HIPK1 axis. Inhibition of HIPK1 can reverse the effect of reduced miR-30 c-5p on CIRI.
Article
Biochemistry & Molecular Biology
Fangping Xiao, Lei Wang, Meng Liu, Mingyue Chen, Hao He, Zhiqiang Jia, Lai Zhang, Yaqing Yang, Qianfan Hu, Mei Hong, Hanwen Zhang
Summary: In this study, the therapeutic role of SAC/VAL in regulating the GSK3β/NF-κB signaling pathway to suppress the inflammatory response and apoptosis was reported. SAC/VAL was found to reduce infarct size, improve ventricular function, and reverse pathological ventricular remodeling in I/R injury.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Neurosciences
Pingping Xia, Murat Marjan, Zhuoyi Liu, Wanqing Zhou, Qian Zhang, Chen Cheng, Minxi Zhao, Yuanyuan Tao, Zhihua Wang, Zhi Ye
Summary: Individuals who suffer from post-CA brain injury often face higher mortality and severe functional disability. Neuroinflammation plays a critical role in cerebral ischemia-reperfusion injury (CIRI) following cardiac arrest. This study found that Chrysophanol, a compound found in Rhubarb, has strong anti-inflammatory properties and can protect against CIRI-induced pyroptotic cell death. The findings suggest that Chrysophanol postconditioning inhibits NLRP3-related pyroptosis in a TRAF6-dependent manner, providing a potential therapeutic target for post-CA brain injury.
EXPERIMENTAL NEUROLOGY
(2022)