Article
Biochemistry & Molecular Biology
Olga V. Oskolkova, Alma Hodzic, Pratap Karki, Bernd Gesslbauer, Yunbo Ke, Dina C. Hofer, Juliane G. Bogner-Strauss, Jean-Marie Galano, Camille Oger, Anna Birukova, Thierry Durand, Konstantin Birukov, Valery Bochkov
Summary: This study presents a method for synthesizing oxidized phospholipids containing oxylipins via an amide bond, which allows for high yield activation and attachment of oxylipins under mild conditions without the need for additional protection steps. The synthesized alkyl-amide oxidized phospholipids exhibit similar biological activities to di-acyl oxidized phospholipids, making them a potentially useful tool for further analysis of the structure-activity relationship of OxPLs.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Endocrinology & Metabolism
Pratap Karki, Konstantin G. Birukov
Summary: Previous studies have focused on the pro-inflammatory and barrier disruptive effects of lipid oxidation products in chronic vascular inflammation related to atherosclerosis, but recent evidence suggests that certain oxidized phospholipids actually have barrier protective and anti-inflammatory properties in the lung vascular endothelium. Among these, oxidized 1-palmitoyl-2-arachdonyl-sn-glycero-3-phosphocholine has been shown to enhance endothelial cell barrier properties and protect against vascular permeability induced by various agonists. Additionally, signaling mechanisms involving cytoskeletal remodeling play a significant role in the regulation of endothelial barrier function by oxidized phospholipids.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cell Biology
Tao Wang, Yuru Wang, Xiao Zhang, Wenlong Xu, Kehan Jin, Yiyun Pang, Yujie Wu, Jichang Luo, Ran Xu, Liqun Jiao, Wenjing Li
Summary: Vascular ageing is closely related to atherosclerosis and enhanced vascular inflammation. Phospholipid oxidation products induce cellular inflammation and affect cell behavior through interactions with vascular cells and immune cells. Interventions in lipid metabolism and anti-inflammation are important pathways for treating atherosclerosis. This review aims to sort out the signaling pathway of oxidized phospholipids-induced inflammatory factors and changes in cell behavior, and summarize therapeutic targets for the development of atherosclerosis drugs.
AGEING RESEARCH REVIEWS
(2023)
Article
Biotechnology & Applied Microbiology
Yuehong Pu, Lei Zhao, Yao Xi, Yichun Xia, Yiming Qian
Summary: The study evaluated the therapeutic effects of Mirtazapine, a central presynaptic alpha 2 receptor antagonist, on LPS-induced blood-brain barrier disruption. The results showed that Mirtazapine could protect the blood-brain barrier from LPS-induced damage and reverse the inflammatory response.
Editorial Material
Hematology
Ravi K. Alluri, Keith R. McCrae
Summary: The study found a novel variant of thrombophilia independent of circulating coagulation proteins or their inhibitors, which is associated with deficient annexin A2 expression. This variant may play an important role in maintaining blood fluidity, suggesting a potential therapeutic target for thrombosis.
Article
Cell Biology
Han She, Yu Zhu, Haoyue Deng, Lei Kuang, He Fang, Zisen Zhang, Chenyang Duan, Jiaqing Ye, Jie Zhang, Liangming Liu, Yi Hu, Tao Li
Summary: The study demonstrated that Dex could effectively protect vascular endothelial barrier function in septic rats by reducing vascular leakage, increasing expression of intercellular junction proteins, and inhibiting mitochondrial fission through regulating ER-MITO contact sites and Drp1 phosphorylation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Masashi Kakae, Hiroki Nakajima, Shota Tobori, Ayaka Kawashita, Jun Miyanohara, Misa Morishima, Kazuki Nagayasu, Takayuki Nakagawa, Eiji Shigetomi, Schuichi Koizumi, Yasuo Mori, Shuji Kaneko, Hisashi Shirakawa
Summary: Vascular cognitive impairment (VCI) refers to cognitive alterations caused by vascular disease and is associated with various types of dementia. Using a CCH-induced VCI model, researchers investigated the role of TRPA1 in this condition and found that TRPA1 in astrocytes prevents cognitive impairment and white matter injury. Stimulation of TRPA1 with cinnamaldehyde improved the outcomes of VCI. The study also revealed that TRPA1-induced production of leukemia inhibitory factor (LIF) in astrocytes promoted myelination of oligodendrocyte precursor cells.
Article
Pharmacology & Pharmacy
Ellis Nelissen, Melissa Schepers, Laura Ponsaerts, Sebastien Foulquier, Annelies Bronckaers, Tim Vanmierlo, Peter Sandner, Jos Prickaerts
Summary: Vascular cognitive impairment (VCI) is a neurodegenerative disorder characterized by a vascular component, involving decreased cerebral blood flow, white matter lesions, endothelial dysfunction, and blood-brain barrier impairments. Oxidative stress and inflammation are major underlying mechanisms. Modulation of soluble guanylate cyclase (sGC) activity can improve vascular and neural function, and has shown efficacy in cardiovascular diseases.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Laura Rue, Tom Jaspers, Isabelle M. S. Degors, Sam Noppen, Dominique Schols, Bart De Strooper, Maarten Dewilde
Summary: The blood-brain barrier poses a challenge for the treatment of neurological diseases. Researchers have discovered two nanobodies that can bind to both human and cynomolgus transferrin receptors, potentially increasing the brain permeability of therapeutic drugs.
Article
Biotechnology & Applied Microbiology
Dongdong Tong, Xiaofei Wang, Liying Liu, Ting Wen, QiaoYi Chen, Chen Huang
Summary: This study reveals a new regulatory mechanism of LAMC2 in promoting the expression and stability of EGFR protein by facilitating ER transport and preventing protein degradation via ubiquitination. Moreover, high LAMC2 expression is positively associated with response to EGFR-TKI treatment.
CANCER GENE THERAPY
(2023)
Review
Cell Biology
Jinfeng Liu, Xinyong He, Sicheng Zheng, Aisong Zhu, Junyan Wang
Summary: Mitochondrial protein homeostasis plays a crucial role in cardiomyocyte injury and its understanding is important for cardiovascular disease research. Modulating the mitochondrial unfolded protein response (UPRmt) may become a potential treatment strategy for myocardial protection, although there is currently a lack of therapeutic drugs targeting UPRmt.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cardiac & Cardiovascular Systems
Ying Sheng, Chenming Zhang, Yehong Liu, Baida Xu, Tianhui Jin, Ting Ye, Jie Liu, Gangyong Wu, Liang Chen, Gangjun Zong
Summary: GDF11 plays a crucial role in reducing vascular calcification and serves as a potential intervention target for vascular calcification.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shotaro Michinaga, Kiyomi Sonoda, Naoki Inazuki, Manae Ezaki, Hiroki Awane, Kahori Shimizu, Shigeru Hishinuma, Hiroyuki Mizuguchi
Summary: This study explores the effects of H-2 receptor agonists on blood-brain barrier disruption following traumatic brain injury. The results suggest that H-2 receptor agonists can alleviate BBB disruption by promoting the expression of vascular protective factors in astrocytes and BMECs.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Orsolya Toeroek, Bettina Schreiner, Johanna Schaffenrath, Hsing-Chuan Tsai, Upasana Maheshwari, Sebastian A. Stifter, Christina Welsh, Ana Amorim, Sucheta Sridhar, Sebastian G. Utz, Wiebke Mildenberger, Sina Nassiri, Mauro Delorenzi, Adriano Aguzzi, May H. Han, Melanie Greter, Burkhard Becher, Annika Keller
Summary: Pericytes regulate leukocyte infiltration in the adult central nervous system and play a role in neuroinflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Gastroenterology & Hepatology
Ilaria Marsilio, Valentina Caputi, Eva Latorre, Silvia Cerantola, Andrea Paquola, Ana I. Alcalde, Jose E. Mesonero, Siobhain M. O'Mahony, Antonella Bertazzo, Cristina Giaroni, Maria Cecilia Giron
Summary: The study found that treatment with OxPAPCs can disrupt the structural and functional integrity of the enteric nervous system (ENS), leading to changes in serotoninergic pathways and 5-HT tissue levels, potentially increasing the risk of developing functional gastrointestinal disorders during adolescence.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Medicine, Research & Experimental
Tobias Rothe, Florian Gruber, Stefan Uderhardt, Natacha Ipseiz, Susanne Roessner, Olga Oskolkova, Stephan Blueml, Norbert Leitinger, Wolfgang Bicker, Valery N. Bochkov, Masayuki Yamamoto, Alexander Steinkasserer, Georg Schett, Elisabeth Zinser, Gerhard Kroenke
JOURNAL OF CLINICAL INVESTIGATION
(2015)
Article
Medicine, Research & Experimental
Valery Bochkov, Andreas W. Schoenenberger, Olga Oskolkova, Ursula Toth, Johannes Stoeckl, Otto Majdic, Armond Daci, Therese J. Resink, Paul Erne, Maria Philippova
BIOMARKERS IN MEDICINE
(2016)
Article
Biochemistry & Molecular Biology
Olga Oskolkova, Grzegorz Gawlak, Yufeng Tian, Yunbo Ke, Nicolene Sarich, Sophia Son, Katrin Andreasson, Valery N. Bochkov, Anna A. Birukova, Konstantin G. Birukov
Review
Biochemistry & Molecular Biology
Valery Bochkov, Bernd Gesslbauer, Christina Mauerhofer, Maria Philippova, Paul Erne, Olga V. Oskolkova
FREE RADICAL BIOLOGY AND MEDICINE
(2017)
Article
Cell Biology
Olga V. Oskolkova, Viktoria Godschachner, Valery N. Bochkov
Article
Peripheral Vascular Disease
Taras Afonyushkin, Olga V. Oskolkova, Valery N. Bochkov
Article
Multidisciplinary Sciences
Olga Oskolkova, Nicolene Sarich, Yufeng Tian, Grzegorz Gawlak, Fanyong Meng, Valery N. Bochkov, Evgeny Berdyshev, Anna A. Birukova, Konstantin G. Birukov
SCIENTIFIC REPORTS
(2018)
Article
Dermatology
Heidemarie Rossiter, Gerald Stuebiger, Marion Groeger, Ulrich Koenig, Florian Gruber, Supawadee Sukseree, Veronika Mlitz, Maria Buchberger, Olga Oskolkova, Valery Bochkov, Leopold Eckhart, Erwin Tschachler
EXPERIMENTAL DERMATOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Marie-Sophie Narzt, Ionela-Mariana Nagelreiter, Olga Oskolkova, Valery N. Bochkov, Julie Latreilie, Maria Fedorova, Zhixu Ni, Fernando J. Sialana, Gert Lubec, Manuel Filzwieser, Maria Laggner, Martin Bilban, Michael Mildner, Erwin Tschachler, Johannes Grillari, Florian Gruber
Article
Biochemistry & Molecular Biology
Maria Philippova, Olga V. Oskolkova, Wolfgang Bicker, Andreas W. Schoenenberger, Therese J. Resink, Paul Erne, Valery N. Bochkov
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Review
Food Science & Technology
Maria Philippova, Olga V. Oskolkova, Valery N. Bochkov
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
(2019)
Review
Food Science & Technology
Konstantin G. Birukov, Olga V. Oskolkova
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
(2019)
Article
Physiology
Yunbo Ke, Olga V. Oskolkova, Nicolene Sarich, Yufeng Tian, Albert Sitikov, Mohan E. Tulapurkar, Sophia Son, Anna A. Birukova, Konstantin G. Birukov
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Yunbo Ke, Noureddine Zebda, Olga Oskolkova, Taras Afonyushkin, Evgeny Berdyshev, Yufeng Tian, Fanyong Meng, Nicolene Sarich, Valery N. Bochkov, Ji Ming Wang, Anna A. Birukova, Konstantin G. Birukov
CIRCULATION RESEARCH
(2017)