Article
Microbiology
Nico Forraz, Cecile Bize, Anne-Laure Desroches, Clement Milet, Pauline Payen, Pauline Chanut, Catherine Kern, Christine Garcia, Colin Mcguckin
Summary: Acne-prone skin is associated with dysbiosis of the skin microbiota, leading to excessive sebum production and inflammation. We have developed a sebaceous gland model that mimics acne-prone skin by infecting with a specific strain of Cutibacterium acnes and inducing lipid overproduction.
Article
Biochemistry & Molecular Biology
Katharina Klas, Dragan Copic, Martin Direder, Maria Laggner, Patricia Sandee Prucksamas, Florian Gruber, Hendrik Jan Ankersmit, Michael Mildner
Summary: Although sebocytes from sebaceous glands and preputial glands share common lipid-producing properties, significant differences were found in the expression levels of enzymes involved in the biogenesis of specialized lipid classes. This suggests major developmental, functional, and biosynthetic differences between the two gland types.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Yi-Tzu Cho, Hung Su, Ching-Ying Wu, Tiao-Lai Huang, Jingyueh Jeng, Min-Zong Huang, Deng-Chyang Wu, Jentaie Shiea
Summary: This study investigated the distribution of squalene in the skin using an efficient analytical approach, revealing a higher distribution of squalene on the face compared to other body areas. It also noted the novelty of being the first study to analyze squalene distribution on whole-body skin using a high-throughput approach.
ANALYTICAL CHEMISTRY
(2021)
Article
Veterinary Sciences
G. Gajaila, M. Ghita, G. Zagrai, D. C. Cotor, A. M. Ionescu, A. M. Zagrai (Maierean), A. Damian, G. Cotor
Summary: A high incidence of cutaneous tumors is observed in domestic carnivorous in pet clinic, with sebaceous glands being the starting point. Hormonal imbalances are considered the most common cause. The effects of an androgenic like hormonal drug on sebaceous gland functionality were studied, and it was found that male dogs showed increased sebum secretion and decreased skin pH after administration, similar results were observed in females.
POLISH JOURNAL OF VETERINARY SCIENCES
(2022)
Review
Dermatology
Gelan Shamloul, Amor Khachemoune
Summary: Sebaceous glands are an essential component of the skin that develop during embryogenesis and do not develop further after birth but increase in size with age. They mainly secrete sebum, lubricate the skin, provide thermoregulation, and exhibit antimicrobial activity, with varying levels of sebum excretion at different stages of life.
DERMATOLOGIC THERAPY
(2021)
Article
Allergy
Huibin Yin, Zhuoqiong Qiu, Ronghui Zhu, Shangshang Wang, Chaoying Gu, Xu Yao, Wei Li
Summary: Patients with atopic dermatitis (AD) have deviated lipidome in sebum and aberrant lipid metabolism in sebaceous glands, indicating a possible role of sebaceous gland-derived lipids in the pathogenesis of AD.
Article
Biochemistry & Molecular Biology
XueMei Li, Xin Zeng, DoYeon Kim, Jian Jiang, Fen Wei, JingYu Zhang, Bao Chai, Li Fu, Young Lee, ChangDeok Kim, HongXiang Chen
Summary: This study investigated the role of KLF4 in lipid production in immortalized human sebocytes during calcium-induced lipogenesis. The results showed that overexpression of KLF4 increased lipid production and upregulated the expression of lipogenic genes, suggesting that KLF4 is a novel regulator of lipid production in sebocytes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Jin Zhou, Madhulika Tripathi, Jia Pei Ho, Anissa Anindya Widjaja, Shamini Guna Shekeran, Macalinao Dominique Camat, Anne James, Yajun Wu, Jianhong Ching, Jean-Paul Kovalik, Kiat-Hon Lim, Stuart Alexander Cook, Boon-Huat Bay, Brijesh Kumar Singh, Paul Michael Yen
Summary: This study found that thyroid hormone can treat NASH-associated hepatic inflammation and fibrosis by promoting autophagy and mitochondrial biogenesis, increasing the oxidation of fatty acids, and reducing lipotoxicity, oxidative stress, and inflammation.
Article
Chemistry, Medicinal
Fang Xie, Mark Reid Groseclose, Sara Tortorella, Gabriele Cruciani, Stephen Castellino
Summary: In this study, MALDI IMS was used to map specific lipids in minipig skin, identifying lipid markers associated with sebaceous glands and hair follicles. Biochemical pathway analysis revealed potential drug-targeting strategies for reducing sebum overproduction. This research highlights the ability of MALDI IMS to link molecular distribution with both morphological features and physiological state in skin tissue, providing a basis for drug discovery and dermatological research.
Article
Dermatology
Enrica Flori, Arianna Mastrofrancesco, Monica Ottaviani, Miriam Maiellaro, Christos C. Zouboulis, Emanuela Camera
Summary: Sebum, a lipid-rich mixture secreted by sebaceous glands, plays a role in regulating skin cells and is involved in inflammation. Saturated and monounsaturated fatty acids found in sebum contribute to the inflammation in acne-prone skin. Limited research has been done on the interaction between saturated fatty acids, their transformation, and induction of pro-inflammatory cytokines in sebocytes.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bernardo Pinto, Raul Valente, Filipe Caramelo, Raquel Ruivo, L. Filipe C. Castro
Summary: The mammalian skin has evolved a diverse array of adaptations, with the pilosebaceous unit being a prominent feature. Pangolins, belonging to the order Pholidota, have keratin-derived scales as iconic skin appendages. While they have hair on their abdomens, the presence of sebaceous and sweat glands is uncertain. By studying pangolin genomes, researchers have found evolutionary changes in genes related to skin physiology, such as wax monoester formation and triacylglycerol synthesis, as well as genes involved in skin defense and structural integrity. The findings shed light on the complex evolutionary history of mammalian skin.
JOURNAL OF MOLECULAR EVOLUTION
(2023)
Article
Ophthalmology
Huifeng Wang, Qingjun Zhou, Luqin Wan, Menglong Guo, Chen Chen, Junfa Xue, Lingling Yang, Lixin Xie
Summary: This study found that lipids in the meibomian glands of type 1 diabetic mice decreased, with larger and irregular lipid droplets. Diabetes caused an increase in ceramides content but a decrease in sphingomyelin to ceramides ratio in the glands. Additionally, diabetes reduced cell quantity and proliferation activity in the glands, along with increased inflammation.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Tao Yang, Renyi Hei, Xiaosong Li, Tianhua Ma, Yifen Shen, Chao Liu, Wen He, Lin Zhu, Yongchun Gu, Yanping Hu, Wenbin Wei, Yihang Shen
Summary: Through RNA sequencing and proteomics analysis, a protein complex of NPY2R/NPY5R/NFATc1 was found to play a regulatory role in specific skin glands of SD rats. NFATc1 functions in dephosphorylation, nuclear localization, and transcription factor activity, and facilitates the transcription of distal gland and sebum-related genes by binding to enhancer regions.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Agriculture, Multidisciplinary
Yaxu Liang, Zhen Zhang, Jiayu Tu, Zhibo Wang, Xiaoxiao Gao, Kaiping Deng, M. A. El-Samahy, Peihua You, Yixuan Fan, Feng Wang
Summary: The study revealed that GLA can protect AML-12 cells from lipid metabolism disorder caused by PA by balancing autophagy and apoptosis mediated by the LKB1-AMPK-mTOR pathway, thus preventing and treating NAFLD.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Siqi Yu, Haisheng Wang, Ming Liu, Fei Pei, Huan Liu, Jiali Zhang, Lu Zhang, Qiuhui Li, Zhi Chen
Summary: Macroautophagy/autophagy plays a critical role in salivary gland diseases, and this study found that ATG5 deficiency may induce pyroptosis and impair the function of salivary glands.
Article
Allergy
Supawadee Sukseree, Latifa Bakiri, Marta Palomo-Irigoyen, Oezge Uluckan, Peter Petzelbauer, Erwin F. Wagner
Summary: The activation of p62 is associated with skin lesions in an AD-like mouse model, and inactivation of p62 significantly reduces defects in keratinocyte differentiation, epidermal thickening, skin infiltration by immune cells, and the development of macroscopic skin lesions in the model.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Veronika Mlitz, Marcela Hermann, Maria Buchberger, Erwin Tschachler, Leopold Eckhart
Summary: In this study, scaffoldin was found to play an important role in the development of the avian beak, particularly in the morphogenesis of the egg tooth. The mRNA levels of scaffoldin and cornulin were investigated in the beaks and other embryonic tissues of chickens and quails, showing that both proteins are expressed in these tissues. Immunohistochemistry revealed the localization of scaffoldin in the peridermal compartment of the egg tooth and a multilayered structure on the lower beak.
Article
Cell Biology
Heidemarie Rossiter, Dragan Copic, Martin Direder, Florian Gruber, Samuele Zoratto, Martina Marchetti-Deschmann, Christopher Kremslehner, Michaela Sochorova, Ionela-Mariana Nagelreiter, Veronika Mlitz, Maria Buchberger, Barbara Lengauer, Bahar Golabi, Supawadee Sukseree, Michael Mildner, Leopold Eckhart, Erwin Tschachler
Summary: Autophagy in preputial glands delays age-related ductal ectasia, influences lipid droplet morphology, contributes to the complete dissolution of mature sebocytes during holocrine secretion, and regulates phospholipid and fatty acid metabolism, as well as pheromone production.
Article
Genetics & Heredity
Attila Placido Sachslehner, Marta Surbek, Julia Lachner, Surya Paudel, Leopold Eckhart
Summary: The study identified the expression of TGM1 in the skin and esophagus of chickens, showing its role in protein cross-linking. Results suggest that TGM1 is conserved among birds and chicken keratinocytes may be a useful model for studying TGM1 in non-mammalian cornification.
Article
Biochemistry & Molecular Biology
Yiwen Yang, Christopher Kremslehner, Sophia Derdak, Christina Bauer, Sarah Jelleschitz, Ionela-Mariana Nagelreiter, Heidemarie Rossiter, Marie Sophie Narzt, Florian Gruber, Michaela Sochorova
Summary: Lack of autophagy in epidermal keratinocytes leads to alterations in lipid composition, including decreased accumulation of lipid storage materials and changes in chain length and saturation of fatty acids. These changes are associated with alterations in the expression and localization of lipid and fatty acid transporter proteins, indicating that maintaining autophagic activity may be essential for maintaining epidermal lipid homeostasis in mammals at an advanced age.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Dermatology
Florian Gruber, Mikolaj Ogrodnik
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lucia Nanic, Andrea Cedilak, Nikolina Skrobot Vidacek, Florian Gruber, Miljenko Huzak, Michael Bader, Ivica Rubelj
Summary: The study demonstrates that implantation of young fibroblasts in aging rats restores cell density, revitalizes cell proliferation, rejuvenates collagen I and III matrices, and boosts epidermal stem cell proliferation. The transplantation of skin stem cells also reduces blistering in rats with Dominant Dystrophic Epidermolysis Bulosa (DDEB). The findings suggest that this intervention can change tissue homeostasis, leading to overall skin restoration and rejuvenation as well as the healing of DDEB skin.
Article
Biochemistry & Molecular Biology
Attila Placido Sachslehner, Marta Surbek, Bahar Golabi, Miriam Geiselhofer, Karin Jaeger, Claudia Hess, Ulrike Kuchler, Reinhard Gruber, Leopold Eckhart
Summary: The study focuses on the localization of transglutaminase activity in various integumentary structures in mammals and birds. Transglutaminase activity was found in different layers of human epidermis, sweat glands, hair follicles, and nails. It was also present in claws, feathers, and keratinocytes of feathers in chickens. Additionally, transglutaminase activity was detected in tongue papillae of mice and chickens. The study suggests that transglutamination contributes to the cornification of hard skin appendages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Caterina Barresi, Heidemarie Rossiter, Maria Buchberger, Johannes Pammer, Supawadee Sukseree, Maria Sibilia, Erwin Tschachler, Leopold Eckhart
Summary: Autophagy is a degradation mechanism that plays a critical role in cellular homeostasis. Inhibition of autophagy has been found to slow down the growth of skin tumors.
Article
Dermatology
Deborah Minzaghi, Petra Pavel, Christopher Kremslehner, Florian Gruber, Sophie Oberreiter, Judith Hagenbuchner, Barbara Del Frari, Stefan Blunder, Robert Gruber, Sandrine Dubrac
Summary: Atopic dermatitis (AD) is a complex disease characterized by chronic recurring eczema and pruritus. This study found that AD patients have oxidative and mitochondrial stress in the skin, as well as reduced antioxidant response, which further exacerbates the pathological changes in the skin.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Immunology
Leopold Eckhart, Wolfgang Sipos
Summary: This study identified inactivating mutations of OAS genes in primates through comparative genomics and revealed a diversifying evolution pattern of the OAS gene family. The study also found that camelids lack OAS2 and OAS3 genes, Asian pangolins lack both OASL and OAS3 genes, and a new OAS gene (OAS5) is present in the bat suborder Yangochiroptera. These differences may affect innate immune responses to coronaviruses and other RNA viruses.
Article
Nutrition & Dietetics
Dora Kovacs, Emanuela Camera, Szilard Poliska, Alessia Cavallo, Miriam Maiellaro, Katalin Dull, Florian Gruber, Christos C. Zouboulis, Andrea Szegedi, Daniel Toerocsik
Summary: Linoleic acid (LA) is an essential omega-6 polyunsaturated fatty acid (PUFA) derived from the diet. Sebocytes, whose primary role is to moisturise the skin, process free fatty acids (FFAs) to produce the lipid-rich sebum. We assessed the specificity of sebocytes for LA and dissected the different roles of LA and AA in regulating sebocyte functions.
Review
Biochemistry & Molecular Biology
Marta Surbek, Supawadee Sukseree, Leopold Eckhart
Summary: The skin protects the body and its metabolism of iron is regulated by differentially expressed genes in the epidermal keratinocytes, supporting the recycling of iron and preventing its release from the skin surface.
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)