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Medicine, Research & Experimental
Mu Yang, Shujin Li, Li Huang, Rulian Zhao, Erkuan Dai, Xiaoyan Jiang, Yunqi He, Jinglin Lu, Li Peng, Wenjing Liu, Zhaotian Zhang, Dan Jiang, Yi Zhang, Zhilin Jiang, Yeming Yang, Peiquan Zhao, Xianjun Zhu, Xiaoyan Ding, Zhenglin Yang
Summary: Familial exudative vitreoretinopathy (FEVR) is a hereditary disorder that causes vision loss. In this study, genetic analysis identified variants in the CTNND1 gene that are associated with FEVR. Further experiments revealed that these variants affect cell adhesion and Wnt signaling activity, leading to the development of FEVR.
Article
Biology
Elod Mehes, Enys Mones, Mate Varga, Aron Zsigmond, Beata Biri-Kovacs, Laszlo Nyitray, Vanessa Barone, Gabriel Krens, Carl-Philipp Heisenberg, Tamas Vicsek
Summary: In vertebrate tissue and zebrafish germ layer progenitors, the actomyosin contractile system plays a crucial role in regulating tissue surface tension, cell aggregation and segregation. By inhibiting actomyosin contractility, we observed a delay in segregation. Furthermore, reducing tissue surface tension through cell type-specific inhibition of non-muscle myosin2 activity resulted in decreased compaction during aggregation and abnormal geometry during segregation.
COMMUNICATIONS BIOLOGY
(2023)
Article
Medical Laboratory Technology
Andres M. Acosta, Justine Barletta, Guru Sonpavde, Stuart Schnitt, Michelle S. Hirsch
Summary: E-cadherin, B-Cat, and p-120 exhibit membranous staining in conventional and micropapillary UC, while abnormal staining of E-Cad and p-120 in PC-UC and SUC aids in diagnosis.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
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Biochemistry & Molecular Biology
Waruni C. Dissanayake, Peter R. Shepherd
Summary: This study demonstrates the importance of adherens junctions in insulin release and identifies the role of p120 catenin in regulating this process.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Lindy J. Pence, Antonis Kourtidis, Ryan W. Feathers, Mary T. Haddad, Sotiris Sotiriou, Paul A. Decker, Aziza Nassar, Idris T. Ocal, Sejal S. Shah, Panos Z. Anastasiadis
Summary: Inflammatory breast cancer expresses high levels of E-cadherin, which promotes tumor metastasis, while the apical adherens junction protein PLEKHA7 is frequently deregulated in this cancer, with re-expression leading to suppression of tumor growth. These findings highlight the potential therapeutic value of targeting the imbalance between apical and basolateral cadherin complexes in inflammatory breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
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Multidisciplinary Sciences
Wei Wei, Yuhuan Li, Myeongsang Lee, Nicholas Andrikopoulos, Sijie Lin, Chunying Chen, David Tai Leong, Feng Ding, Yang Song, Pu Chun Ke
Summary: The production of plastics has played a crucial role in modern society, but the accumulation of plastics in the environment poses a significant threat to environmental sustainability and human health. This study focuses on the biological effects of nanoplastics, specifically anionic polystyrene and poly(methyl methacrylate), and reports that their introduction disrupts the vascular endothelial cadherin junctions. The findings provide important insights into the behavior and impact of nanoplastics, which can guide innovations for a sustainable plastics industry and environmental remediation.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Romina Tokumon, Isabel Sebastian, Bruno M. Humbel, Nobuhiko Okura, Hidenori Yamanaka, Tetsu Yamashiro, Claudia Toma
Summary: Leptospira interrogans disrupts epithelial adherens junctions to induce leptospirosis. The degradation of p0071 and p120-catenin proteins are involved in the disassembly of the AJs. This study provides insights into the mechanisms of AJ disassembly, which may contribute to the development of vaccines and diagnostic methods.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vinh Vu, Taylor Light, Brendan Sullivan, Diana Greiner, Kalina Hristova, Deborah Leckband
Summary: The study presents a new mechanism of E-cadherin oligomerization and demonstrates that binding of p120ctn protein is essential for constitutive E-cadherin dimerization. This finding challenges the traditional model of cadherin assembly at cell surfaces and sheds light on the core building blocks of cadherin-mediated intercellular adhesions.
Article
Cardiac & Cardiovascular Systems
Yuxin Li, Haw-Chih Tai, Nikola Sladojevic, Hyung-Hwan Kim, James K. Liao
Summary: The study found that ROCK1 and ROCK2 play a role in age-related vascular dysfunction. Inhibition of ROCK2 may have therapeutic benefits in preventing age-related vascular stiffening.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biology
Lara Elis Alberici Delsin, Cedric Plutoni, Anna Clouvel, Sarah Keil, Lea Marpeaux, Lina Elouassouli, Adele Khavari, Allen J. Ehrlicher, Gregory Emery
Summary: Collective cell migration is crucial for development, tissue homeostasis, and cancer metastasis. A study using A431 carcinoma cells reveals that MAP4K4 plays a central role in regulating collective migration by controlling cellular dynamics, cytoskeleton remodeling, and adhesion stability.
LIFE SCIENCE ALLIANCE
(2023)
Article
Dermatology
Angelo Antiguas, Kris A. DeMali, Martine Dunnwald
Summary: IRF6 is a transcription factor that plays a critical role in craniofacial development and epidermal morphogenesis. Loss of IRF6 leads to the absence of terminally differentiated epidermal layers and mislocalization of cell adhesion proteins in the oral epithelium. This study demonstrates that IRF6 is involved in the delivery of adhesion proteins to the cell membrane and that its deficiency results in a breakdown of epidermal sheets under mechanical stress.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Oncology
Liwei Ma, Ting Shen, Hui Peng, Jianjun Wu, Wenjin Wang, Xing Gao
Summary: This study found that overexpression of PTPRZ1 promotes the malignancy of OSF by regulating the phosphorylation of p120/beta-catenin. This finding provides clues for the identification of novel drug targets.
JOURNAL OF ONCOLOGY
(2022)
Article
Cell Biology
Jingduo Li, Xiupeng Zhang, Zaiyu Hou, Siqi Cai, Yingxue Guo, Limei Sun, Ailin Li, Qingchang Li, Enhua Wang, Yuan Miao
Summary: This study reveals the important role of P130cas in FAK-YAP axis-mediated radioresistance in non-small cell lung cancer (NSCLC). P130cas promotes cell proliferation, alters the cell cycle profile, and enhances tumor growth. Furthermore, the study demonstrates that P130cas interacts with YAP and promotes its activation and nuclear translocation.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Weixiang Song, Danchen Zhang, Jiaqi Mi, Wenfei Du, Yang Yang, Rong Chen, Cong Tian, Xiaodong Zhao, Kang Zou
Summary: E-cadherin and Cadherin-22 synergistically maintain the undifferentiation of SPCs through the pivotal intermediate molecule beta-catenin. LEF1, TCF3, STAT3, and HDAC4 were identified as co-regulatory factors of beta-catenin in regulating SPC fate.
CELL AND BIOSCIENCE
(2022)
Article
Clinical Neurology
Alisa Foerster, Frank Brand, Rouzbeh Banan, Robert Hueneburg, Christine A. M. Weber, Wiebke Ewert, Jessica Kronenberg, Christopher Previti, Natalie Elyan, Ulrike Beyer, Helge Martens, Bujung Hong, Jan H. Braesen, Andreas Erbersdobler, Joachim K. Krauss, Martin Stangel, Amir Samii, Stephan Wolf, Matthias Preller, Stefan Aretz, Bettina Wiese, Christian Hartmann, Ruthild G. Weber
Summary: Rare germline variants in the E-cadherin gene CDH1 were identified in families with glioma and gastric cancer, suggesting a potential role in tumorigenesis through the WNT/beta-catenin signaling pathway. Functional studies showed that these CDH1 variants affect cell membrane expression, migration, and aggregation, highlighting the importance of these variants in the risk of brain tumors.
ACTA NEUROPATHOLOGICA
(2021)