Review
Biochemistry & Molecular Biology
Richard M. Lucas, Lin Luo, Jennifer L. Stow
Summary: This article summarizes the important role of ERK1/2 in cell signaling, particularly in immune responses in immune cells. Additionally, it discusses the dysfunctional signaling of ERK1/2 in inflammatory diseases and explores the potential therapeutic benefits of targeting this pathway in inflammation.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2022)
Article
Cell Biology
Cheng Wei, Xiaoyang Zhang, Dazhao Peng, Xu Zhang, Haizhen Guo, Yalin Lu, Lin Luo, Bo Wang, Zesheng Li, Yingjie He, Xuezhi Du, Shu Zhang, Hao Liang, Shenghui Li, Sheng Wang, Lei Han, Jianning Zhang
Summary: This study revealed that upregulation of HOXA11-AS in glioma is associated with poor prognosis. Its ectopic expression promotes proliferation, migration, and invasion of glioma cells, acting as a molecular sponge for let-7b-5p to regulate CTHRC1 expression and activate the beta-catenin/c-Myc pathway.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Masanobu Tsubaki, Tomoya Takeda, Yuuichi Koumoto, Takehiro Usami, Takuya Matsuda, Shiori Seki, Kazuko Sakai, Kazuto Nishio, Shozo Nishida
Summary: The development of BCR::ABL1 tyrosine kinase inhibitors has greatly improved survival in chronic myeloid leukaemia (CML) patients. However, resistance to these inhibitors is a clinical problem. This study investigated the mechanism of resistance to dasatinib, a BCR::ABL1 tyrosine kinase inhibitor, and found that elevated expression and activation of MOS, TPL2 and ERK1/2 were involved in dasatinib resistance. Inhibition of these proteins overcame the resistance.
CELL PROLIFERATION
(2023)
Article
Biochemistry & Molecular Biology
Hyo-Jin Park, Bokyung Kim, Deog-Bon Koo, Dong-Seok Lee
Summary: This study revealed that PRDX1 is expressed in the ovary and during ovulation, controlling the TLR4/P38/ERK1/2 signaling activity in ovulated mice and its interaction with COCs during ovulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Atsuto Naruke, Rei Nakano, Junichi Nunomura, Yoko Suwabe, Masumi Nakano, Shinichi Namba, Taku Kitanaka, Nanako Kitanaka, Hiroshi Sugiya, Tomohiro Nakayama
Summary: Fibroblasts play a significant role in autoimmune skin diseases by producing and secreting cytokines under inflammatory conditions, particularly by inducing the expression of the chemokine IL-8 through IL-1β. Understanding the signaling pathways involved, such as MAPK signaling mediated by Tpl2, is crucial for the pathogenesis of autoimmune diseases like atopic dermatitis.
Article
Biology
Serkan Ismail Goktuna
Summary: IKBKE is associated with various cancers and has emerged as a potential target for cancer therapy. It orchestrates tumor cell survival by regulating MEK/ERK activation in tumors. The interaction between IKBKE and TPL2 leads to TPL2 phosphorylation, providing a novel regulatory link between IKBKE and constitutive ERK1/2 activation in tumor cells.
Article
Biology
Concetta Anna Germano, Giuseppe Clemente, Antonello Storniolo, Maria Anele Romeo, Elisabetta Ferretti, Mara Cirone, Livia Di Renzo
Summary: mTOR is activated in AML cells, and quercetin and rapamycin inhibit its substrates, P70S6K and 4EBP1. ERK1/2 inhibition enhances the dephosphorylation of mTORC1 substrates and activates AKT. The combined inhibition of ERK1/2 and AKT further enhances the dephosphorylation of 4EBP1 and increases cytotoxicity of quercetin or rapamycin. Additionally, quercetin or rapamycin reduces autophagy, which is related to eIF2a phosphorylation. Therefore, the combined inhibition of mTORC1, ERK1/2, and AKT should be considered in AML treatment.
Article
Cell Biology
Yanqin Qin, Binghua Li, Suyavaran Arumugam, Qiuxia Lu, Salah M. Mankash, Junzi Li, Beicheng Sun, Jiansheng Li, Richard A. Flavell, Hua-Bing Li, Xinshou Ouyang
Summary: The study demonstrates that m(6)A modification plays a crucial role in NAFLD and obesity, with METTL3 regulating the m(6)A modification of DDIT4 mRNA, influencing macrophage metabolic reprogramming.
Article
Biology
Brittany L. Dunkerly-Eyring, Shi Pan, Miguel Pinilla-Vera, Desirae McKoy, Sumita Mishra, Maria I. Grajeda Martinez, Christian U. Oeing, Mark J. Ranek, David A. Kass
Summary: Serine 1364 on TSC2 plays a role in regulating mTORC1 activation through ERK1/2 phosphorylation but not Akt activation. Phospho-mimetic and phospho-silenced mutations at S1364 both affect mTORC1 activation. S1364 has negligible impact on mTORC1 regulation by energy and nutrient status.
LIFE SCIENCE ALLIANCE
(2022)
Article
Multidisciplinary Sciences
Yanting Zhu, Shifeng Wang, Peiguang Niu, Huajiao Chen, Jintuo Zhou, Li Jiang, Danyun Li, Daohua Shi
Summary: The study found that cardamonin inhibits the proliferation of ovarian cancer cells by inducing oxidative stress. Proteomic analysis and Western blotting revealed that cardamonin affects cellular redox homeostasis and cell proliferation through the MAPK pathway and the mTORC1 and ERK1/2 pathways.
Article
Chemistry, Multidisciplinary
Teng Xue, Xiaoqiu Liu, Mei Zhang, Qiukai E, Shuting Liu, Maosheng Zou, Ying Li, Zhinan Ma, Yun Han, Paul Thompson, Xuesen Zhang
Summary: The study found that PADI2 plays a role in promoting the progression of endometrial cancer (EC) by facilitating the expression of IGF2BP1 and preventing SOX2 mRNA degradation. Inhibiting PADI2/MEK1 signaling could be a potential therapeutic approach for EC.
Review
Biochemistry & Molecular Biology
Maurizio Federico
Summary: COVID-19 pathogenesis develops in two phases. mRNA vaccines have shown efficacy in containing the development of severe disease possibly by inhibiting alveolar macrophages and counteracting cytokine storm.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Karsten Grote, Marina Nicolai, Uwe Schubert, Bernhard Schieffer, Christian Troidl, Klaus T. Preissner, Stefan Bauer, Silvia Fischer
Summary: The study demonstrated that self-extracellular RNA can interact with TLR2 ligands and enhance innate immune responses under pathological conditions, suggesting it as a new target for the treatment of bacterial and viral infections.
Article
Cell Biology
Richard M. Lucas, Liping Liu, James E. B. Curson, Yvette W. H. Koh, Neeraj Tuladhar, Nicholas D. Condon, Kaustav Das Gupta, Sabrina S. Burgener, Kate Schroder, Evan Ingley, Matthew J. Sweet, Jennifer L. Stow, Lin Luo
Summary: The immune-specific transmembrane adaptor SCIMP acts as a scaffold for Erk1/2 in TLR pathways, guiding the spatial and temporal recruitment of Erk2 for pro-inflammatory TLR4 signaling. SCIMP deficiency results in defects in Erk1/2 recruitment, c-Fos activation, and pro-inflammatory cytokine production, with these effects being phenocopied by Erk1/2 signaling inhibition. This highlights a specific role for SCIMP in membrane recruitment of Erk1/2 kinase to initiate TLR-mediated pro-inflammatory responses in macrophages.
Article
Cell Biology
Daofeng You, Qiuge Qiao, Katsushige Ono, Mei Wei, Wenyun Tan, Cuihua Wang, Yangong Liu, Gang Liu, Mingqi Zheng
Summary: This study reveals that miR-223-3p plays a negative regulatory role in inflammatory responses in atherosclerosis, possibly through the MEK1/ERK1/2 signaling pathway. MiR-223-3p can alleviate the formation of atherosclerotic plaques and reduce the number of inflammatory cells, providing new therapeutic prospects for the treatment of atherosclerosis.
Article
Gastroenterology & Hepatology
Carlos Sanz-Garcia, Kyle L. Poulsen, Damien Bellos, Han Wang, Megan R. McMullen, Xiaoxia Li, Saurabh Chattopadhyay, Ganes Sen, Laura E. Nagy
JOURNAL OF HEPATOLOGY
(2019)
Article
Hematology
Shengjiang Tan, Laetitia Kermasson, Angela Hoslin, Pekka Jaako, Alexandre Faille, Abraham Acevedo-Arozena, Etienne Lengline, Dana Ranta, Maryline Poiree, Odile Fenneteau, Hubert Ducou le Pointe, Stefano Fumagalli, Blandine Beaupain, Patrick Nitschke, Christine Bole-Feysot, Jean-Pierre de Villartay, Christine Bellanne-Chantelot, Jean Donadieu, Caroline Kannengiesser, Alan J. Warren, Patrick Revy
Article
Endocrinology & Metabolism
Irene Lopez-Mateo, Elvira Alonso-Merino, Cristian Suarez-Cabrera, Jeong Won Park, Sheue-Yann Cheng, Susana Alemany, Jesus M. Paramio, Ana Aranda
Article
Endocrinology & Metabolism
Angela Sanchez, Constanza Contreras-Jurado, Diego Rodriguez, Javier Regadera, Susana Alemany, Ana Aranda
JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Gastroenterology & Hepatology
Xiaoqin Wu, Kyle L. Poulsen, Carlos Sanz-Garcia, Emily Huang, Megan R. McMullen, Sanjoy Roychowdhury, Srinivasan Dasarathy, Laura E. Nagy
JOURNAL OF HEPATOLOGY
(2020)
Article
Medicine, Research & Experimental
Tatsunori Miyata, Xiaoqin Wu, Xiude Fan, Emily Huang, Carlos Sanz-Garcia, Christina K. Cajigas-Du Ross, Sanjoy Roychowdhury, Annette Bellar, Megan R. McMullen, Jaividhya Dasarathy, Daniela S. Allende, Joan Caballeria, Pau Sancho-Bru, Craig J. McClain, Mack Mitchell, Arthur J. McCullough, Svetlana Radaeva, Bruce Barton, Gyongyi Szabo, Srinivasan Dasarathy, Laura E. Nagy
Summary: The study found that MLKL plays a different role in ALD and NAFL/NASH mouse models, and suggested that RIP1-RIP3-MLKL can be used as biomarkers to distinguish alcohol-associated hepatitis (AH) from NASH.
Correction
Gastroenterology & Hepatology
Xiaoqin Wu, Kyle L. Poulsen, Carlos Sanz-Garcia, Emily Huang, Megan R. McMullen, Sanjoy Roychowdhury, Srinivasan Dasarathy, Laura E. Nagy
JOURNAL OF HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Shengjiang Tan, Laetitia Kermasson, Christine Hilcenko, Vasileios Kargas, David Traynor, Ahmed Z. Boukerrou, Norberto Escudero-Urquijo, Alexandre Faille, Alexis Bertrand, Maxim Rossmann, Beatriz Goyenechea, Li Jin, Jonathan Moreil, Olivier Alibeu, Blandine Beaupain, Christine Bole-Feysot, Stefano Fumagalli, Sophie Kaltenbach, Jean-Alain Martignoles, Cecile Masson, Patrick Nitschke, Melanie Parisot, Aurore Pouliet, Isabelle Radford-Weiss, Frederic Tores, Jean-Pierre de Villartay, Mohammed Zarhrate, Ai Ling Koh, Kong Boo Phua, Bruno Reversade, Peter J. Bond, Christine Bellanne-Chantelot, Isabelle Callebaut, Francois Delhommeau, Jean Donadieu, Alan J. Warren, Patrick Revy
Summary: Acquired somatic EIF6 mutations are common in individuals with Shwachman-Diamond syndrome, providing a selective advantage over non-modified cells. These mutations may serve as a mechanism of somatic genetic rescue in inherited Mendelian disorders.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Olga Estevez-Vazquez, Raquel Benede-Ubieto, Feifei Guo, Beatriz Gomez-Santos, Patricia Aspichueta, Johanna Reissing, Tony Bruns, Carlos Sanz-Garcia, Svenja Sydor, Lars P. Bechmann, Eva Maranillo, Jose Ramon Sanudo, Maria Teresa Vazquez, Arantza Lamas-Paz, Laura Moran, Marina S. Mazariegos, Andreea Ciudin, Juan M. Pericas, Maria Isabel Peligros, Javier Vaquero, Eduardo Martinez-Naves, Christian Liedtke, Jose R. Regueiro, Christian Trautwein, Rafael Banares, Francisco Javier Cubero, Yulia A. Nevzorova
Summary: This study found that diets high in Palmitic Acid (PA), mainly sourced from palm oil, may lead to obesity, high cholesterol, more severe liver injury, and fibrosis, while diets high in trans-fat may result in glucose intolerance and elevated liver enzymes. Temporary withdrawal of these unhealthy diets can reverse symptoms of Metabolic Syndrome and Fatty Liver Disease, but mild hepatic inflammation remains detectable in the high PA diet groups.
Correction
Multidisciplinary Sciences
Shengjiang Tan, Laetitia Kermasson, Christine Hilcenko, Vasileios Kargas, David Traynor, Ahmed Z. Boukerrou, Norberto Escudero-Urquijo, Alexandre Faille, Alexis Bertrand, Maxim Rossmann, Beatriz Goyenechea, Li Jin, Jonathan Moreil, Olivier Alibeu, Blandine Beaupain, Christine Bole-Feysot, Stefano Fumagalli, Sophie Kaltenbach, Jean-Alain Martignoles, Cecile Masson, Patrick Nitschke, Melanie Parisot, Aurore Pouliet, Isabelle Radford-Weiss, Frederic Tores, Jean-Pierre de Villartay, Mohammed Zarhrate, Ai Ling Koh, Kong Boo Phua, Bruno Reversade, Peter J. Bond, Christine Bellanne-Chantelot, Isabelle Callebaut, Francois Delhommeau, Jean Donadieu, Alan J. Warren, Patrick Revy
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Sara Ceccacci, Kevin Roger, Ines Metatla, Cerina Chhuon, Khaled Tighanimine, Stefano Fumagalli, Adriana De Lucia, Iwona Pranke, Corinne Cordier, Maria Chiara Monti, Ida Chiara Guerrera
Summary: This study demonstrates the biological effects of the hydrophilic extract of Oenothera biennis cell cultures (ObHEx) on senescent cells through deep proteomic analysis. The results show that ObHEx can restore levels of crucial mitotic proteins and reactivate senescent cell proliferation to a small but significant extent. The study also provides a comprehensive panel of deregulated proteins associated with stress-induced premature senescence (SIPS), which can contribute to further understanding of senescence and potential modulators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Substance Abuse
X. Q. Wu, T. Miyata, X. D. Fan, E. Huang, C. Sanz-Garcia, C. K. Cajigas-Du Ross, A. Bellar, M. R. McMullen, D. S. Allende, S. Dasarathy, L. E. Nagy
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Xiude Fan, Jianguo Wu, Kyle L. Poulsen, Adam Kim, Xiaoqin Wu, Emily Huang, Tatsunori Miyata, Carlos Sanz-Garcia, Laura E. Nagy
Summary: This study identified a miRNA-E3 ubiquitin ligase regulatory network for protein substrates enriched in cell death pathways. In the livers of patients with alcohol-associated hepatitis, miR-150-5p expression was significantly increased while CISH expression was decreased, reflecting the influence of this regulatory network on cell death pathways.
HEPATOLOGY COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Carlos Sanz-Garcia, Megan R. McMullen, Saurabh Chattopadhyay, Sanjoy Roychowdhury, Ganes Sen, Laura E. Nagy
HEPATOLOGY COMMUNICATIONS
(2019)
Letter
Hematology
Angela Sanchez, Eduardo Anguita, Alberto Chaparro, Juan Jose Roldan-Etcheverry, Alberto Lopez-Garcia, Carlos Ramos-Acosta, Raluca Oancea, Diego Rodriguez-Munoz, Susana Alemany