Article
Biochemistry & Molecular Biology
Robert Walmsley, Derek S. Steele, Georgina M. Ellison-Hughes, Sotiris Papaspyros, Andrew J. Smith
Summary: This study investigated the effects of imatinib, a receptor tyrosine kinase inhibitor, on human cardiac progenitor cells. It was found that imatinib reduced cell viability, depolarized mitochondria, increased lysosome and autophagosome content, and induced cell death through necroptosis. However, the toxicity could be rescued by RIP1 inhibition and autophagy played a partial role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Jihoon Nah, Daniela Zablocki, Junichi Sadoshima
Summary: Understanding the mechanisms of cell death in cardiomyocytes is crucial for the treatment of heart failure, with a focus on autophagy-related cell death. Autophagy plays a key role in cellular quality control for survival, but dysregulation can lead to cell death.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Review
Cell Biology
Lawrence M. Schwartz
Summary: Cell death is a normal and essential component of development and homeostasis, but dysregulation of this process underlies most human diseases. Autophagy is a process mediated by the formation of double membrane vesicles, which allows cells to survive stresses and may also mediate cell death during development and pathogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhiyuan Yin, Danyu Shen, Yaning Zhao, Hao Peng, Jinding Liu, Daolong Dou
Summary: Transmembrane kinases (TMKs) play important roles in cellular signaling. The kinase domains of most metazoan and plant TMKs belong to the S/T/Y-kinase superfamily. TMKs in protists have diverse origins and functional diversity. Despite belonging to different kinase subfamilies, protist LRR and GPCR-type TMKs share similar sensory domain architectures with plant and animal TMKs.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Medicine, Research & Experimental
Emilia A. Korhonen, Aino Murtomaki, Sawan Kumar Jha, Andrey Anisimov, Anne Pink, Yan Zhang, Simon Stritt, Inam Liaqat, Lukas Stanczuk, Laura Alderfer, Zhiliang Sun, Emmi Kapiainen, Abhishek Singh, Ibrahim Sultan, Anni Lantta, Veli-Matti Leppanen, Lauri Eklund, Yulong He, Hellmut G. Augustin, Kari Vaahtomeri, Pipsa Saharinen, Taija Makinen, Kari Alitalo
Summary: This study reveals the involvement of Ang2 in VEGF-C-induced lymphangiogenesis through the PI3K/Akt signaling pathway in lymphatic endothelial cells. Blockade of Ang2 or deletion of Tie receptors in LECs inhibits lymphangiogenesis. The study highlights the important crosstalk between VEGF-C and Ang signaling pathways and suggests potential therapeutic approaches targeting Ang2/Tie/PI3K signaling for lymphangiogenesis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Microbiology
Marina Valente Navarro, Yasmin Nascimento de Barros, Wilson Dias Segura, Alison Felipe Alencar Chaves, Grasielle Pereira Jannuzzi, Karen Spadari Ferreira, Patricia Xander, Wagner Luiz Batista
Summary: The study revealed the crucial role of PbDrk1 in cell wall modulation of P. brasiliensis, affecting fungal resistance to different cell wall-disturbing agents and influencing cell wall morphogenesis by regulating various genes associated with cell wall modulation. It also showed an increased phagocytic index and proinflammatory cytokine levels in response to PbDrk1, suggesting its significance as a potential target for antifungal molecular activity.
Article
Biochemistry & Molecular Biology
Lilli Gerstenmaier, Ombretta Colasanti, Hannah Behrens, Margot Kolonko, Christian Hammann, Monica Hagedorn
Summary: In this study, it was found that Mycobacterium marinum can be ejected from host cells in a non-lytic fashion, with the involvement of both autophagic machinery and ESCRT machinery. These processes may be part of a response to protect host cell integrity and respond to membrane damage.
MOLECULAR MICROBIOLOGY
(2023)
Article
Biology
Dasmanthie De Silva, Lucas Ferguson, Grant H. Chin, Benjamin E. Smith, Ryan A. Apathy, Theodore L. Roth, Franziska Blaeschke, Marek Kudla, Alexander Marson, Nicholas T. Ingolia, Jamie H. D. Cate
Summary: This study reveals that human translation initiation factor eIF3 interacts with specific immune-related mRNAs and regulates T cell receptor translation, enhancing T cell activation. Utilizing this mechanism for genetic engineering improves the efficacy of CAR-T cells in killing tumor cells.
Article
Biochemistry & Molecular Biology
Yuting Tang, Yao Tao, Lu Wang, Liyuan Yang, Yipei Jing, Xueke Jiang, Li Lei, Zailin Yang, Xin Wang, Meixi Peng, Qiaoling Xiao, Jun Ren, Ling Zhang
Summary: The study revealed the interaction between NPM1 mutant and ULK1, demonstrating that NPM1 mutant maintains autophagic cell survival by regulating ULK1 stability and activation. This extends our understanding of the role of NPM1 mutant in autophagy activation in NPM1-mutated AML.
Review
Pharmacology & Pharmacy
Srimanta Patra, Prakash P. Praharaj, Daniel J. Klionsky, Sujit K. Bhutia
Summary: HDACs inhibit the acetylation of crucial autophagy genes, leading to deregulated autophagy and ACD, facilitating cancer cell survival. Vorinostat interferes with ACD by inhibiting the deacetylation of key autophagic markers, with autophagy-mediated, -associated, or dependent mechanisms depending on the involvement of apoptosis.
DRUG DISCOVERY TODAY
(2022)
Article
Biochemistry & Molecular Biology
Wonbum Kim, Taeck Joong Jeon
Summary: Phosphatidylinositol 3-Kinase (PI3K) plays an important role in relaying chemoattractant signals and regulating cell motility. However, its role in electrotaxis varies depending on the state of the cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Changfu Yao, Stephanie A. Bora, Tanyalak Parimon, Tanzira Zaman, Oren A. Friedman, Joseph A. Palatinus, Nirmala S. Surapaneni, Yuri P. Matusov, Giuliana Cerro Chiang, Alexander G. Kassar, Nayan Patel, Chelsi E. R. Green, Adam W. Aziz, Harshpreet Suri, Jo Suda, Andres A. Lopez, Gislaine A. Martins, Barry R. Stripp, Sina A. Gharib, Helen S. Goodridge, Peter Chen
Summary: Recent studies have shown immunologic dysfunction in severely ill patients with COVID-19, particularly in those with ARDS, where defective antigen presentation and interferon responsiveness were observed in monocytes. There was also suppressed cytotoxic activity in NK cells and CD8 T lymphocytes, along with deficient B cell activation, indicating delayed viral clearance in severely ill patients. These findings suggest an immune imbalance in COVID-19 patients with ARDS, potentially contributing to a more severe disease course.
Article
Biochemistry & Molecular Biology
Ping Chen, Chun-Hua Dai, Zhi-Hao Shi, Yi Wang, Jian-Nong Wu, Kang Chen, Jin-Yu Su, Jian Li
Summary: The combination of BBR and icotinib has a synergistic inhibitory effect on non-small cell lung cancer cells by inducing autophagic cell death and apoptosis. The anti-tumor activities of this combination therapy were confirmed in xenograft mouse models, suggesting a potential effective strategy to overcome icotinib resistance in the treatment of NSCLC. This synergistic effect was achieved through intracellular ROS accumulation, mediated autophagy and apoptosis, and resulted in the suppression of cell migration and invasion.
Article
Biochemistry & Molecular Biology
Seong-Ryeong Lim, Do-Wan Kim, Junghee Sung, Tae Hoon Kim, Chang-Hyung Choi, Sei-Jung Lee
Summary: Astaxanthin has antioxidant properties and can inhibit autophagic cell death induced by BPA in human dermal fibroblasts by suppressing ROS production and regulating kinase phosphorylation.
Article
Biochemistry & Molecular Biology
Yun Hee Jeong, Tae In Kim, You-Chang Oh, Jin Yeul Ma
Summary: The ethanol extract of Selaginella tamariscina (STE) has been found to exhibit neuroprotective effects by reducing oxidative stress and inhibiting autophagic cell death induced by glutamate in HT22 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Christoph Ammer-Herrmenau, Upasana Kulkarni, Nico Andreas, Martin Ungelenk, Sarina Ravens, Christian Huebner, Angela Kather, Ingo Kurth, Michael Bauer, Thomas Kamradt
Article
Oncology
Biagio Di Lorenzo, Andre E. Simoes, Francisco Caiado, Paola Tieppo, Daniel V. Correia, Tania Carvalho, Maria Gomes da Silva, Julie Dechanet-Merville, Ton N. Schumacher, Immo Prinz, Haakan Norell, Sarina Ravens, David Vermijlen, Bruno Silva-Santos
CANCER IMMUNOLOGY RESEARCH
(2019)
Letter
Hematology
Ivan Odak, Solaiman Raha, Christian Schultze-Florey, Saleh Tavil, Sarina Ravens, Arnold Ganser, Reinhold Forster, Immo Prinz, Christian Koenecke
Article
Cell Biology
Likai Tan, Inga Sandrock, Ivan Odak, Yuval Aizenbud, Anneke Wilharm, Joana Barros-Martins, Yaara Tabib, Alina Borchers, Tiago Amado, Lahiru Gangoda, Marco J. Herold, Marc Schmidt-Supprian, Jan Kisielow, Bruno Silva-Santos, Christian Koenecke, Avi-Hai Hovav, Christian Krebs, Immo Prinz, Sarina Ravens
Article
Multidisciplinary Sciences
Biagio Di Lorenzo, Sarina Ravens, Bruno Silva-Santos
Article
Cell Biology
Alina S. Fichtner, Anja Bubke, Francesca Rampoldi, Anneke Wilharm, Likai Tan, Lars Steinbrueck, Christian Schultze-Florey, Constantin Von Kaisenberg, Immo Prinz, Thomas Herrmann, Sarina Ravens
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
Article
Oncology
Anke Janssen, Jose Villacorta Hidalgo, Dennis X. Beringer, Sanne van Dooremalen, Febilla Fernando, Eline van Diest, Antonela R. Terrizi, Peter Bronsert, Sylvia Kock, Annette Schmitt-Graeff, Martin Werner, Kerstin Heise, Marie Follo, Trudy Straetemans, Zsolt Sebestyen, Dmitry M. Chudakov, Sofya A. Kasatskaya, Felix E. Frenkel, Sarina Ravens, Eric Spierings, Immo Prinz, Ralf Kueppers, Miroslav Malkovsky, Paul Fisch, Jurgen Kuball
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Fisheries
Sabine E. Hammer, Melanie Leopold, Lisa-Maria Prawits, Kerstin H. Mair, John C. Schwartz, John A. Hammond, Sarina Ravens, Wilhelm Gerner, Armin Saalmueller
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2020)
Review
Cell Biology
Alina Suzann Fichtner, Sarina Ravens, Immo Prinz
Article
Multidisciplinary Sciences
Sarina Ravens, Alina S. Fichtner, Maike Willers, Dennis Torkornoo, Sabine Pirr, Jennifer Schoening, Malte Deseke, Inga Sandrock, Anja Bubke, Anneke Wilharm, Daniel Dodoo, Beverly Egyir, Katie L. Flanagan, Lars Steinbrueck, Paul Dickinson, Peter Ghazal, Bright Adu, Dorothee Viemann, Immo Prinz
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Oncology
Emilie Coppin, Bala Sai Sundarasetty, Susann Rahmig, Jonas Blume, Nikita A. Verheyden, Franz Bahlmann, Sarina Ravens, Undine Schubert, Janine Schmid, Stefan Ludwig, Katharina Geissler, Orlando Guntinas-Lichius, Constantin von Kaisenberg, Tanja Groten, Alexander Platz, Ronald Naumann, Barbara Ludwig, Immo Prinz, Claudia Waskow, Andreas Krueger
Summary: This study successfully generated a novel NSGW41hIL7 mouse model by introducing human interleukin-7 gene, which enables the model to better mimic human T-cell differentiation and increase the number of functional human T cells in the periphery.
Article
Immunology
Likai Tan, Alina Suzann Fichtner, Elena Bruni, Ivan Odak, Inga Sandrock, Anja Bubke, Alina Borchers, Christian Schultze-Florey, Christian Koenecke, Reinhold Foerster, Michael Jarek, Constantin von Kaisenberg, Ansgar Schulz, Xiaojing Chu, Bowen Zhang, Yang Li, Ulf Panzer, Christian F. Krebs, Sarina Ravens, Immo Prinz
Summary: The study reveals distinct waves of human innate-like effector gamma delta T cells in early fetal thymus, with semi-invariant V gamma 9V delta 2(+) TCR. High heterogeneity of gamma delta T cells in neonatal and adult blood is correlated with TCR usage. Effector gamma delta T cells with type 1 and type 3 innate T cell signatures were detected in embryonic thymus organogenesis.
SCIENCE IMMUNOLOGY
(2021)
Article
Hematology
Christian R. Schultze-Florey, Leonie Kuhlmann, Solaiman Raha, Joana Barros-Martins, Ivan Odak, Likai Tan, Yankai Xiao, Sarina Ravens, Lothar Hambach, Letizia Venturini, Michael Stadler, Matthias Eder, Felicitas Thol, Michael Heuser, Reinhold Foerster, Arnold Ganser, Immo Prinz, Christian Koenecke
Summary: The study analyzed the dynamics of CD8(+) alpha beta T-cell clones in patients with DLI, revealing a preferential expansion of distinct CD8(+) TRB clones upon first occurrence of GVL. Early repertoire changes 15 days after DLI were found to predict durable remission for the 36-month study follow-up, while absence of clonal outgrowth of the CD8(+ )TRB repertoire after DLI was an early biomarker that predicted relapse ahead of diagnosis. This CD8(+) TRB analysis may provide a reliable tool for predicting the efficacy of DLI and identifying patients at risk for progression and relapse after DLI.
Article
Cell Biology
Valentina Cazzetta, Elena Bruni, Sara Terzoli, Claudia Carenza, Sara Franzese, Rocco Piazza, Paolo Marzano, Matteo Donadon, Guido Torzilli, Matteo Cimino, Matteo Simonelli, Lorenzo Bello, Anna Villa, Likai Tan, Sarina Ravens, Immo Prinz, Domenico Supino, Federico S. Colombo, Enrico Lugli, Emanuela Marcenaro, Eric Vivier, Silvia Della Bella, Joanna Mikulak, Domenico Mavilio
Summary: NKG2A expression identifies a subset of V delta 2 T cells with intrinsic hyper-responsiveness against cancer, which is counterbalanced by the inhibitory signaling delivered by HLA-E expressed on malignant cells. Removal of NKG2A restores the effector functions of V delta 2 T cells.
Article
Medicine, Research & Experimental
Joanna Mikulak, Ferdinando Oriolo, Elena Bruni, Alessandra Roberto, Federico S. Colombo, Anna Villa, Marita Bosticardo, Ileana Bortolomai, Elena Lo Presti, Serena Meraviglia, Francesco Dieli, Stefania Vetrano, Silvio Danese, Silvia Della Bella, Michele M. Carvello, Matteo Sacchi, Giovanni Cugini, Giovanni Colombo, Marco Klinger, Paola Spaggiari, Massimo Roncalli, Immo Prinz, Sarina Ravens, Biagio di Lorenzo, Emanuela Marcenaro, Bruno Silva-Santos, Antonino Spinelli, Domenico Mavilio