Review
Oncology
Anna Wawruszak, Lidia Borkiewicz, Estera Okon, Wirginia Kukula-Koch, Syeda Afshan, Marta Halasa
Summary: Breast cancer remains a challenging malignancy with varying responses to therapy, requiring the development of new active agents to improve the current treatment regimens. Vorinostat (SAHA) shows promise in the therapy of different histological subtypes of breast cancer, either alone or in combination with other anticancer agents, based on preclinical and clinical trials data.
Review
Cardiac & Cardiovascular Systems
Gang Zhou, Yanfang Liu, Hui Wu, Dong Zhang, Qingzhuo Yang, Yi Li
Summary: This paper provides an overview of the role of histone deacetylases (HDACs) in atherosclerosis and further explores their mechanisms in regulating apoptosis, autophagy, and programmed necrosis. The findings contribute to new measures and theoretical basis for preventing and treating atherosclerosis.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Review
Cell Biology
Yin Shi, Han-Ming Shen, Vidya Gopalakrishnan, Nancy Gordon
Summary: Autophagy is a highly conserved catabolic process that protects cells from harm and allows survival under stress conditions. The regulation of autophagy is complex, involving various signaling pathways including AMPK and mTOR. Understanding these regulatory mechanisms can lead to the discovery of new therapeutic targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Min Xie, Geoffrey W. Cho, Yongli Kong, Dan L. Li, Francisco Altamirano, Xiang Luo, Cyndi R. Morales, Nan Jiang, Gabriele G. Schiattarella, Herman May, Jessica Medina, John M. Shelton, Anwarul Ferdous, Thomas G. Gillette, Joseph A. Hill
Summary: The study tested the use of an autophagy-inducing peptide, TB, to protect against reperfusion injury by reducing reactive oxygen species. It was found that TB reduced infarct size, improved contractile function, and decreased oxidative stress by increasing autophagic flux.
CIRCULATION RESEARCH
(2021)
Article
Dermatology
Liat Samuelov, Ron Bochner, Lee Magal, Kiril Malovitski, Nadav Sagiv, Janna Nousbeck, Aviad Keren, Dana Fuchs-Telem, Ofer Sarig, Amos Gilhar, Eli Sprecher
Summary: The study showed that the histone deacetylase inhibitor Vorinostat can effectively inhibit hyperproliferation of keratinocytes and induce their differentiation and apoptosis. In a chimeric mouse model, Vorinostat demonstrated significant improvement in psoriasis-like symptoms, indicating its potential use in treating psoriasis and other hyperproliferative skin disorders.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Cell Biology
Namin Duan, Xiaohui Hu, Huiran Qiu, Rui Zhou, Yuru Li, Wenxia Lu, Yamin Zhu, Shuang Shen, Wenhui Wu, Feifei Yang, Ning Liu
Summary: In this study, a novel and efficient HDAC1 inhibitor called HR488B was found to exhibit effective anti-colorectal cancer (CRC) activity. HR488B induced cell cycle arrest and apoptosis in CRC cells by causing mitochondrial dysfunction, reactive oxygen species (ROS) generation, and DNA damage accumulation. Furthermore, HR488B suppressed the growth of CRC cells by decreasing the expression of E2F1 and preventing its release from the E2F1/Rb/HDAC1 complex. Therefore, HR488B may be a potential candidate for CRC therapy and targeting the E2F1/Rb/HDAC1 axis shows promise as a therapeutic approach for CRC.
CELL DEATH & DISEASE
(2023)
Article
Physiology
Tanya J. Applegate, Greta M. Krafsur, June A. Boon, Hui Zhang, Min Li, Timothy N. Holt, S. Kelly Ambler, Benjamin A. Abrams, Daniel L. Gustafson, Karsten Bartels, Franklyn B. Garry, Kurt R. Stenmark, R. Dale Brown
Summary: In this study, the histone deacetylase inhibitor vorinostat showed potential benefits in a severe neonatal bovine pulmonary hypertension model, suggesting a promising epigenetic-directed therapy for the treatment of the disease. The results provide novel insights into the modulation of gene expression and reduction of pulmonary vascular stiffening, highlighting the potential translational impact of epigenetic-directed therapy in a large animal model of severe pulmonary hypertension.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hyein Jo, Kyeonghee Shim, Dooil Jeoung
Summary: Senescence has the potential to be used in anticancer therapy as it has both tumor-suppressive and tumorigenic effects. Targeting senescence may help to overcome therapeutic resistance. This review discusses the mechanisms of senescence induction and the roles of the senescence-associated secretory phenotype (SASP) in various life processes, including therapeutic resistance and tumorigenesis. The review also explores the roles of autophagy, histone deacetylases (HDACs), and microRNAs in senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Jian-Li Chen, Xiao-Hui Jia, Xinyue Xia, Xuan Wu, Yan-Neng Xu, Gang Yuan, Ze-Yun Gu, Kathy Qian Luo, Ming-Heng Yuan, Ruibin Jiang, Jianfang Wang, Xiao-Ming Zhu
Summary: In this study, hollow ZrO2 nanoshells were synthesized to encapsulate both the autophagy inhibitor chloroquine (CQ) and the HDAC inhibitor vorinostat (Vor) for effective combinational cancer therapy. The ZrO2 nanoshells showed high loading capacities for both CQ and Vor and exhibited a controlled release profile. The codelivery system enhanced the autophagy inhibition and hyperacetylation level in the cells, resulting in a superior antitumor effect in 4T1 tumor-bearing mice.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Xue-Song Xiang, Peng-Cheng Li, Wen-Quan Wang, Liang Liu
Summary: Pancreatic cancer is the seventh leading cause of cancer death worldwide and novel treatment options for PDAC are urgently needed. The dysregulation of HDACs has been identified in association with PDAC and may represent a therapeutic breakthrough. However, the contributions of HDACs to PDAC remain controversial and pharmacokinetic challenges limit the application of HDACis in PDAC.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Review
Biochemistry & Molecular Biology
Monika Pieniawska, Katarzyna Izykowska
Summary: Histone deacetylases (HDACs) are enzymes that alter chromatin structure, affecting gene expression. They play important roles in T-cell development and function. This review summarizes the current understanding of the role of HDACs in early T-cell development and mature lymphocyte function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Mengjiao Zhou, Minjian Yuan, Meng Zhang, Chenyi Lei, Omer Aras, Xiaohong Zhang, Feifei An
Summary: Histone deacetylase inhibitors (HDACis) are considered key targets in cancer therapy, but their efficacy as a single therapeutic agent is limited, leading to drug resistance. Combination therapies involving HDACis with other antitumor therapies are being studied to enhance therapeutic efficacy and reduce drug resistance, with a focus on chemotherapy, radiotherapy, phototherapy, targeted therapy, and immunotherapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Long Xu, Xiaoyu Yan, Jian Wang, Yuanxin Zhao, Qingqing Liu, Jiaying Fu, Xinyi Shi, Jing Su
Summary: This article provides an overview of ovarian cancer metastasis and the dysregulated expression of HDACs in ovarian cancer. It discusses the roles of HDACs in the regulation of ovarian cancer metastasis and highlights the importance of developing compounds that target HDACs in the future of ovarian cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Bingyi Zhou, Deliang Liu, Yuyong Tan
Summary: Cancer is the second leading cause of death worldwide, with digestive system cancers being a primary contributor. Acetylation and deacetylation play crucial roles in cancer development, with HDAC6 being a widely studied enzyme that is upregulated in various tumors and associated with clinicopathological characteristics. There is ongoing research on HDAC6 inhibitors and their potential in inhibiting tumor growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yi-Ching Tang, Reid T. Powell, Assaf Gottlieb
Summary: The study proposes a new transfer learning workflow to transfer drug sensitivity prediction models from cancer cell lines to tumors and patient derived xenografts. The use of feature importance highlights the association between certain pathways and drug response in breast cancer.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Srimanta Patra, Soumya R. Mishra, Bishnu P. Behera, Kewal K. Mahapatra, Debasna P. Panigrahi, Chandra S. Bhol, Prakash P. Praharaj, Gautam Sethi, Samir K. Patra, Sujit K. Bhutia
Summary: Autophagy is a self-degradation process that eliminates dysfunctional cytoplasmic cargos to maintain cellular homeostasis. It plays a dual role in cytoprotection and cytostasis during malignant transformation, and is regulated by phyto-products. Autophagy also regulates epigenetic modulation and inflammation, limiting tumor metastasis.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Soumya Ranjan Mishra, Kewal Kumar Mahapatra, Bishnu Prasad Behera, Chandra Sekhar Bhol, Prakash Priyadarshi Praharaj, Debasna Pritimanjari Panigrahi, Srimanta Patra, Amruta Singh, Shankargouda Patil, Rohan Dhiman, Samir Kumar Patra, Sujit Kumar Bhutia
Summary: Inflammasomes play a critical role in tumor development, and their components have significant effects on tumorigenesis in a tissue-specific and stage-dependent manner. The proinflammatory cytokines produced by inflammasome activation can regulate tissue homeostasis and induce antitumor immune responses, but they can also promote cancer growth and proliferation by directing oncogenic signaling pathways in cancer cells. Epigenetic mechanisms and autophagy control inflammasome activation and contribute to cancer development.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Prajna Paramita Naik, Subhadip Mukhopadhyay, Prakash Priyadarshi Praharaj, Chandra Sekhar Bhol, Debasna Pritimanjari Panigrahi, Kewal Kumar Mahapatra, Srimanta Patra, Sarbari Saha, Aditya Kumar Panda, Krupasindhu Panda, Subhankar Paul, Palok Aich, Samir Kumar Patra, Sujit Kumar Bhutia
Summary: Clusterin induces autophagy in oral cancer through the AMPK/Akt/mTOR signaling pathway, protecting cells from apoptosis, interacts with ULK1 to induce autophagy, and promotes mitophagy in nutrient deprivation conditions. High CLU expression is associated with therapy resistance and clusterin-mediated mitophagy inhibits cell death by cisplatin in cancer cells.
Article
Cell Biology
Srimanta Patra, Kewal Kumar Mahapatra, Prakash Priyadarshi Praharaj, Debasna Pritimanjari Panigrahi, Chandra Sekhar Bhol, Soumya Ranjan Mishra, Bishnu Prasad Behera, Amruta Singh, Mrutyunjay Jena, Sujit Kumar Bhutia
Summary: Mitochondrial Ca2+ plays a crucial role in maintaining cellular homeostasis by regulating mitochondrial dynamics, mitophagy, and mitochondrial biogenesis, while dysregulation of mitochondrial Ca2+ can lead to various pathological conditions, including cancer. This review discusses the interaction between mitochondrial Ca2+ and quality control, highlighting their importance in governing mitochondrial health and coordination in cancer development.
Review
Pharmacology & Pharmacy
Prakash Priyadarshi Praharaj, Birija Sankar Patro, Sujit Kumar Bhutia
Summary: Mitochondrial dynamics and mitophagy play crucial roles in enabling cancer stem cells to adapt to the stressful tumor microenvironment, with maintaining mitochondrial homeostasis being essential for CSCs growth and metabolic switching. Targeting these cellular processes pharmacologically can improve patient survival in aggressive cancer types when combined with current chemotherapeutic drugs.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Prakash Priyadarshi Praharaj, Debasna Pritimanjari Panigrahi, Chandra Sekhar Bhol, Srimanta Patra, Soumya Ranjan Mishra, Kewal Kumar Mahapatra, Bishnu Prasad Behera, Amruta Singh, Shankargouda Patil, Sujit Kumar Bhutia
Summary: Cancer stem cells (CSCs) utilize mitophagy as a key survival mechanism, while mitochondrial biogenesis is an interesting target due to the high resistance of CSCs.
Review
Biochemistry & Molecular Biology
Prakash Priyadarshi Praharaj, Srimanta Patra, Debasna Pritimanjari Panigrahi, Samir Kumar Patra, Sujit Kumar Bhutia
Summary: Clusterin (CLU) is a significant cancer regulator that controls various cancer-associated cellular events, making it an ideal target for cancer therapy. Inhibition of CLU enhances the anticancer potential of chemotherapy drugs and improves patient survival.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Biochemistry & Molecular Biology
Soumya Ranjan Mishra, Kewal Kumar Mahapatra, Bishnu Prasad Behera, Srimanta Patra, Chandra Sekhar Bhol, Debasna Pritimanjari Panigrahi, Prakash Priyadarshi Praharaj, Amruta Singh, Shankargouda Patil, Rohan Dhiman, Sujit Kumar Bhutia
Summary: The NLRP3 inflammasome plays a crucial role in neuroinflammation and neural diseases. Dysfunctional mitochondria and accumulation of mitochondrial reactive oxygen species are key factors in the activation of NLRP3 inflammasome.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Oncology
Subhadip Mukhopadhyay, Kewal Kumar Mahapatra, Prakash Priyadarshi Praharaj, Shankargouda Patil, Sujit Kumar Bhutia
Summary: Autophagy plays a dual role in cancer, promoting tumor clearance and inhibiting tumorigenesis while also supporting cancer growth and progression. It has a critical role in regulating metabolism, tumor microenvironment, immune evasion, and cancer stem cell survival. Lysosomal inhibitors like chloroquine and hydroxychloroquine have been repurposed as autophagy inhibitors in cancer therapy. The development of autophagy-based cancer therapy faces challenges.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Ravi Prakash, Eram Fauzia, Abu Junaid Siddiqui, Santosh Kumar Yadav, Neha Kumari, Mohammad Tayyab Shams, Abdul Naeem, Prakash P. Praharaj, Mohsin Ali Khan, Sujit Kumar Bhutia, Miroslaw Janowski, Johannes Boltze, Syed Shadab Raza
Summary: This study investigated the impact of oxidative stress on dental pulp stem cells and mesenchymal stem cells. It was found that oxidative stress enhanced autophagy, which could be repressed by ROS scavengers. The involvement of the ROS-p38-Erk1/2 pathway and the depletion of SIRT3 were also discovered. Furthermore, inhibition of autophagy improved stem cell viability.
Article
Cell Biology
Prakash P. Praharaj, Srimanta Patra, Soumya R. Mishra, Subhadip Mukhopadhyay, Daniel J. Klionsky, Shankargouda Patil, Sujit K. Bhutia
Summary: This study found that cisplatin treatment activated higher mitophagy in oral cancer stem cells by regulating CLU levels. CLU regulated mitochondrial fission by activating AKT kinase, leading to mitochondrial fission. Furthermore, CLU-mediated mitophagy positively regulated oral cancer stem cells by degrading MSX2 and preventing its nuclear translocation, which suppressed SOX2 activity and inhibited cancer stemness and self-renewal ability.
Article
Cell Biology
Debasna P. Panigrahi, Prakash P. Praharaj, Bishnu P. Behera, Srimanta Patra, Shankargouda Patil, Birija S. Patro, Sujit K. Bhutia
Summary: MTP18, an inner mitochondrial membrane protein, is not only essential for maintaining mitochondrial morphology but also acts as a mitophagy receptor that targets dysfunctional mitochondria for elimination. It interacts with LC3 proteins to induce mitochondrial autophagy.
JOURNAL OF CELL SCIENCE
(2023)
Article
Cell Biology
Srimanta Patra, Amruta Singh, Prakash P. Praharaj, Nitish K. Mohanta, Mrutyunjay Jena, Birija S. Patro, Ali Abusharha, Shankargouda Patil, Sujit K. Bhutia
Summary: SIRT1 is downregulated in oral cancer cells, leading to drug resistance. Downregulation of SIRT1 inhibits mitochondrial fission and promotes hyperfused mitochondrial networks, suppressing apoptosis. Overexpression of SIRT1 reverses mitochondrial hyperfusion and induces apoptosis. Gallic acid can counteract CDDP-mediated apoptosis inhibition by inhibiting mitochondrial hyperfusion. SIRT1 overexpression resensitizes CDDP-resistant cells to apoptosis.
CELL DEATH & DISEASE
(2023)
Article
Cell & Tissue Engineering
Prajna Paramita Naik, Swagatika Panigrahi, Ratnakar Parida, Prakash Priyadarshi Praharaj, Chandra Sekhar Bhol, Shankargouda Patil, N. M. L. Manjunath, Dipanjan Ghosh, Samir Kumar Patra, Sujit Kumar Bhutia
Summary: Cancer stem cells (CSCs) are a rare subset of malignant cells with stem cell-like features that acquire stemness through metabolic rewiring and epigenetic reprogramming, influencing tumor progression. Specific drugs targeting the metaboloepigenetic circuitry of CSCs may serve as potential cancer therapeutics.
STEM CELL REVIEWS AND REPORTS
(2022)
Review
Pharmacology & Pharmacy
Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley
Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)
