期刊
MOLECULAR BIOLOGY
卷 46, 期 3, 页码 335-348出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0026893312020069
关键词
RNA interference; siRNA; siRNA delivery
Gene-directed therapy with small interfering RNA (siRNA) has a tremendous potential and will undoubtedly occupy one of the leading positions among other therapeutic methods in the future. The lack of efficient and targeted delivery vectors delays a successful implementation of this method in medicine. To develop such systems, one needs a comprehensive insight into the interactions of siRNAs, its delivery systems, and an organism. The review covers the properties of therapeutic siRNAs and nonviral systems for their delivery.
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