Article
Endocrinology & Metabolism
Junpei Sanada, Fuminori Tatsumi, Shinji Kamei, Yoshiro Fushimi, Masashi Shimoda, Kenji Kohara, Shuhei Nakanishi, Kohei Kaku, Tomoatsu Mune, Hideaki Kaneto
Summary: Pituitary adenoma producing both growth hormone (GH) and thyroid-stimulating hormone (TSH) is rare but possible. This case study presented a 27-year-old woman with symptoms of acromegaly and simultaneous production of both GH and TSH by the pituitary adenoma. Treatment included pituitary tumor resection, cyber knife therapy, somatostatin analog, GH receptor antagonist, and anti-thyroid drug thiamazole.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yan Jin, Jessica S. Jarmasz, Peter A. Cattini
Summary: The study aimed to evaluate the effects of dexamethasone (DEX) on hGH-N expression in 171hGH/CS mice, showing that DEX treatment can increase or rescue hGH-N RNA levels. This is the first evidence for a direct effect of glucocorticoids (GCs) on hGH-N expression in vivo and the potential to limit the negative impact of overeating/obesity on hGH production during puberty.
DNA AND CELL BIOLOGY
(2021)
Review
Medicine, General & Internal
Gudmundur Johannsson, Oskar Ragnarsson
Summary: GH deficiency is common in patients with hypothalamic-pituitary disorders, and its replacement therapy can improve symptoms and quality of life while maintaining a good safety profile.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ichiro Yamauchi, Yoriko Sakane, Takafumi Yamashita, Takuro Hakata, Taku Sugawa, Haruka Fujita, Kentaro Okamoto, Daisuke Taura, Keisho Hirota, Yohei Ueda, Toshihito Fujii, Akihiro Yasoda, Nobuya Inagaki
Summary: This study aimed to investigate the effects of peripheral iodothyronine deiodinases (DIOs) on thyroid hormone economy. The results showed that D2 could enhance local thyroid hormone action and promote its circulation, while D3 could decrease circulating T3 and T4 levels with elevated reverse T3, leading to consumptive hypothyroidism. Additionally, the D3 mice are expected to be a novel hypothyroidism model.
Article
Cell Biology
S. Thierry Omouessi, Jeffrey R. Leipprandt, Marie-Yvonne Akoume, Raelene Charbeneau, Susan Wade, Richard R. Neubig
Summary: Mice with an RGS-insensitive Gait mutation exhibit alterations in the functional state of the GH-axis, resulting in growth retardation. These changes include decreased pituitary mRNA levels for various hormones and reduced responsiveness to GH-stimulating agents.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Jiun-Lin Yan, Mao-Yu Chen, Yao-Liang Chen, Chi-Cheng Chuang, Peng-Wei Hsu, Kuo-Chen Wei, Chen-Nen Chang
Summary: This study evaluated the outcomes of the endoscopic transsphenoidal approach as the primary treatment for somatotroph adenomas and investigated patients with suboptimal surgical results. Factors such as tumor size, preoperative GH level, and residual tumors were found to be associated with surgical failure. Octreotide showed good outcomes for treating DGSA patients, while SRS/EXRT generated good results for patients receiving secondary treatments when remission could not be reached after 6 months of TSA operation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Richard Sinko, Petra Mohacsik, Dora Kovari, Veronika Penksza, Gabor Wittmann, Lilla Macsai, Tatiana L. Fonseca, Antonio C. Bianco, Csaba Fekete, Balazs Gereben
Summary: The study in THAI mice mimicking NTIS induced by infection or fasting showed different patterns of TH signaling in different tissues, suggesting that TH levels alone may not be a reliable marker of tissue TH signaling.
Article
Biology
Chirine Toufaily, Jerome Fortin, Carlos A. Alonso, Evelyne Lapointe, Xiang Zhou, Yorgui Santiago-Andres, Yeu-Farn Lin, Yiming Cui, Ying Wang, Dominic Devost, Ferdinand Roelfsema, Frederik Steyn, Aylin C. Hanyaloglu, Terence E. Hebert, Tatiana Fiordelisio, Derek Boerboom, Daniel J. Bernard
Summary: Gonadotropin-releasing hormone (GnRH) controls reproduction by stimulating FSH and LH synthesis via its receptor GnRHR, but the lack of Ctail in mammalian GnRHR may not provide an advantage for LH surge generation. In transgenic mice, addition of Ctail resulted in reduced FSH production and fertility, suggesting a potential role of Ctail in normal reproductive function.
Article
Endocrinology & Metabolism
Deepali Gupta, Anna M. Patterson, Sherri Osborne-Lawrence, Angie L. Bookout, Salil Varshney, Kripa Shankar, Omprakash Singh, Nathan P. Metzger, Corine P. Richard, Steven C. Wyler, Joel K. Elmquist, Jeffrey M. Zigman
Summary: The study investigated the role of acyl-ghrelin on GH secretion and metabolic actions by selectively deleting GHSR from somatotrophs. Results suggest that the direct engagement of GHSR-expressing somatotrophs is essential for acyl-ghrelin to stimulate GH secretion and influence its metabolic actions.
MOLECULAR METABOLISM
(2021)
Article
Medicine, General & Internal
Xiaojing Li
Summary: The experiment showed that knockout of the SSTR2 gene can inhibit the secretion of growth hormone in mice and suppress the growth of mice. This could potentially be a target for therapy in the clinic.
ACTA MEDICA MEDITERRANEA
(2021)
Article
Biochemistry & Molecular Biology
Joanna Smyczynska, Natalia Pawelak, Maciej Hilczer, Andrzej Lewinski
Summary: Growth hormone deficiency is a common component of combined pituitary hormone deficiency, often with unknown genetic causes, leading to severe symptoms depending on the deficient hormone type. MRI findings show abnormalities in anterior pituitary development, and delayed diagnosis and treatment can be life-threatening.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Amit Akirov, Hiba Masri-Iraqi, Idit Dotan, Ilan Shimon
Summary: The diagnosis, management, and treatment of acromegaly heavily rely on the levels of serum IGF-1, basal GH, and nadir GH following OGTT. However, these hormone concentrations can be influenced by various factors, leading to discordant levels that may require additional monitoring and data. New standards for GH and IGF-1 provide more accurate tools, but limitations should be considered along with clinical history and imaging studies when evaluating patients with acromegaly.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Anna Malgorzata Kucharska, Ewelina Witkowska-Sedek, Malgorzata Ruminska, Beata Pyrzak
Summary: This paper presents literature data describing changes in thyroid function related to rhGH therapy and provides a current explanation of the mechanisms involved in this phenomenon, emphasizing the importance of changes in central and peripheral regulation during treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Chenxing Ji, Wen Xu, Hong Ding, Zhengyuan Chen, Chengzhang Shi, Jie Han, Liang Yu, Nidan Qiao, Yichao Zhang, Xiaoyun Cao, Xiang Zhou, Haixia Cheng, Huijin Feng, Cheng Luo, Zhiyu Li, Bing Zhou, Zhao Ye, Yao Zhao
Summary: Our study found that the expression of p300 is elevated in GHPA tissues compared to normal pituitary tissues. Knockdown of p300 inhibits cell proliferation and clone formation. Treatment with A-485 can suppress cell growth and inhibit GH secretion both in vitro and in vivo. Mechanistic studies showed that A-485 can downregulate the expression or activity of several oncogenes involved in the Pttg1, c-Myc, cAMP, and PI3K/AKT/mTOR signaling pathways, which play crucial roles in PA tumorigenesis and progression.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Antonio Bianchi, Sabrina Chiloiro, Antonella Giampietro, Simona Gaudino, Rosalinda Calandrelli, Ciro Mazzarella, Carmelo Caldarella, Mario Rigante, Marco Gessi, Liverana Lauretti, Laura De Marinis, Alessandro Olivi, Alfredo Pontecorvi, Francesco Doglietto
Summary: Growth hormone-secreting adenomas exhibit a wide range of behaviors and outcomes, from mild disease to aggressive neoplasms. Treatment for patients who do not respond to surgery or first-generation somatostatin receptor ligands may involve multiple surgical, medical, and radiation treatments. Currently, there are no markers that can predict the prognosis or aggressiveness of acromegaly. A multidisciplinary approach is necessary to tailor treatment for difficult/aggressive cases, including radiation therapy, chemotherapy, and emerging treatments.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Neurosciences
J. I. Nagy, J. E. Rash
EUROPEAN JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
D. D. Tsao, S. G. Wang, B. D. Lynn, J. I. Nagy
EUROPEAN JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
S. G. Wang, D. D. Tsao, K. G. Vanderpool, T. Yasumura, J. E. Rash, J. I. Nagy
EUROPEAN JOURNAL OF NEUROSCIENCE
(2017)
Article
Endocrinology & Metabolism
Lingling Lu, Adam D. Hogan-Cann, Andrea K. Globa, Ping Lu, James Nagy, Shernaz X. Bamji, Christopher M. Anderson
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2019)
Review
Neurosciences
James I. Nagy, Alberto E. Pereda, John E. Rash
NEUROSCIENCE LETTERS
(2019)
Article
Oncology
Navid Koleini, Barbara E. Nickel, Jie Wang, Zeinab Roveimiab, Robert R. Fandrich, Lorrie A. Kirshenbaum, Peter A. Cattini, Elissavet Kardami
Article
Endocrinology & Metabolism
Yan Jin, Hana Vakili, Song Yan Liu, Savas Menticoglou, Margaret E. Bock, Peter A. Cattini
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2018)
Review
Biochemistry & Molecular Biology
James I. Nagy, Alberto E. Pereda, John E. Rash
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2018)
Article
Neurosciences
J. I. Nagy, B. D. Lynn, J. M. M. Senecal, K. Stecina
Article
Neurosciences
J. I. Nagy, B. D. Lynn
Article
Neurosciences
Bruce D. Lynn, Xinbo Li, Sheriar G. Hormuzdi, Emily K. Griffiths, C. Jane McGlade, James I. Nagy
EUROPEAN JOURNAL OF NEUROSCIENCE
(2018)
Article
Cardiac & Cardiovascular Systems
Navid Koleini, Jon-Jon Santiago, Barbara E. Nickel, Glen Lester Sequiera, Jie Wang, Robert R. Fandrich, Davinder S. Jassal, Sanjiv Dhingra, Lorrie A. Kirshenbaum, Peter A. Cattini, Elissavet Kardami
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2019)
Review
Endocrinology & Metabolism
Peter A. Cattini, Yan Jin, Jessica S. Jarmasz, Noshin Noorjahan, Margaret E. Bock
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Showall Moazzam, Noshin Noorjahan, Yan Jin, James I. Nagy, Elissavet Kardami, Peter A. Cattini
Summary: Maternal obesity increases the risks of neurological disorders and is associated with reduced placental lactogen gene expression. In mice, a high fat diet negatively affects placental structure and maternal behavior. Impaired neurogenesis and low levels of brain-derived neurotrophic factor have also been implicated in depression.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jie Wang, Yan Jin, Peter A. Cattini
DNA AND CELL BIOLOGY
(2017)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)