Article
Endocrinology & Metabolism
Jung Soo Lim, Samuel W. Plaska, Juilee Rege, William E. Rainey, Adina F. Turcu
Summary: Somatic gene mutations that promote inappropriate intracellular calcium entrance have been found in most aldosterone-producing adenomas (APAs). Angiotensin II and ACTH have been shown to increase aldosterone production from APAs, but responses to hormonal stimuli may vary based on different aldosterone-driver mutations. Transcript expression of AGTR1, MC2R, and MRAP differed in APAs with different mutations, suggesting that ATPase-mutated APAs may be more responsive to ACTH than KCNJ5-mutated APAs.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yuta Tezuka, Kae Ishii, Lili Zhao, Yuto Yamazaki, Ryo Morimoto, Hironobu Sasano, Aaron M. Udager, Fumitoshi Satoh, Adina F. Turcu
Summary: Dynamic HPA testing revealed significant differences in plasma steroid levels between patients with APA and BPA, with APA patients showing higher concentrations of specific steroids both at baseline and in response to ACTH stimulation. The discriminatory power of steroid measurements taken 15 minutes post-ACTH stimulation was particularly high, suggesting it could potentially replace adrenal vein sampling in some PA patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Valeria Hasenmajer, Ilaria Bonaventura, Marianna Minnetti, Valentina Sada, Emilia Sbardella, Andrea M. Isidori
Summary: This review provides an overview on the current knowledge regarding the adrenal and extra-adrenal effects of ACTH. It focuses on the role of ACTH in adrenal rhythmicity, steroidogenesis, mineralocorticoids, and adrenal growth, as well as its effects on various extra-adrenal organs and tissues. The review suggests re-evaluating the role of ACTH in potential treatment strategies due to its noncanonical effects, which have been overlooked in previous studies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hui Zhao, Zhe Chen, Hao Li, Yue-Hong Zhao, Qun Wang, Wei-Wei Li
Summary: This study demonstrates that bacteria can induce hemocyte proliferation in Chinese mitten crabs, and EsCsn5 plays a negative regulatory role in this process by controlling the degradation of EsCyclin E. Knockdown of EsCsn5 enhances hemocyte proliferation and reduces survival rate in crabs, leading to increased bacterial concentration in the hemolymph.
Article
Endocrinology & Metabolism
Lucyna Papierska, Michal Rabijewski, Bartosz Migda, Dorota Leszczynska, Karolina Nowak, Agnieszka Lebek-Szatanska, Piotr Glinicki, Wojciech Zgliczynski
Summary: The study aimed to determine whether a single measurement of ACTH is sufficient to confirm or rule out secondary adrenal insufficiency in the short Metyrapone test. The results showed that the readily available plasma ACTH assay cannot replace the measurement of 11-deoxycortisol concentrations for evaluating the results of the Metyrapone test.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Moeber Mahzari, Abdullah AlSohaim, Abdulrhman Al Mulla, Abdullah AlAssaf, Khalid Al Amri, Syed D. Hussain, Shaun Sabico, Naser M. Al Daghri, Yousef Saleh
Summary: This study aimed to investigate the cortisol response after the standard ACTH stimulation test in a group of Saudi Arabian patients. The study found that cortisol levels were significantly lower in patients who received corticosteroid replacement therapy, and the cortisol cutoff values were useful in diagnosing AI in patients with vague symptoms and signs.
Review
Endocrinology & Metabolism
Nada Younes, Isabelle Bourdeau, Andre Lacroix
Summary: Primary adrenal insufficiency is a rare but potentially fatal disease characterized by destruction of the adrenal cortex leading to hormone deficiencies. Patients often present with fatigue, weight loss, melanoderma, and hypotension. Diagnosis requires testing hormone levels and concentrations.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Maria Francesca Birtolo, Simone Antonini, Andrea Saladino, Benedetta Zampetti, Elisabetta Lavezzi, Iacopo Chiodini, Gherardo Mazziotti, Andrea G. A. Lania, Renato Cozzi
Summary: Secondary Adrenal Insufficiency (SAI) is a condition characterized by low ACTH secretion due to hypothalamus or pituitary disease or injury. The evaluation of SAI is challenging due to non-specific symptoms, rarity, and pitfalls associated with laboratory tests. The gold standard test for assessing the HPA axis is the insulin tolerance test, but the ACTH stimulation test is safer and well-tolerated, although its diagnostic accuracy varies.
Article
Immunology
Hanna F. Nowotny, Thomas Marchant Seiter, Jing Ju, Adrian Gottschlich, Holger Schneider, Stephanie Zopp, Frederick Vogel, Lea Tschaidse, Matthias K. Auer, Christian Lottspeich, Sebastian Kobold, Simon Rothenfusser, Felix Beuschlein, Martin Reincke, Leah Braun, Nicole Reisch
Summary: Patients with primary adrenal insufficiency (PAI) due to different causes show distinct differences in T and NK cell-phenotypes, despite receiving the same glucocorticoid replacement therapy. These findings highlight the variations in immune cell composition and function among PAI patients and suggest the need for disease-specific treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Salomi Shaikh, Lakshmi Nagendra, Shehla Shaikh, Joseph M. Pappachan
Summary: The diagnosis of adrenal insufficiency requires a high index of suspicion, detailed clinical assessment, and appropriate laboratory evaluation. The clinical characteristics vary depending on the cause and can range from insidious onset to a potentially life-threatening adrenal crisis. Testing the basal serum cortisol coupled with adrenocorticotrophin remains the initial tests of choice, while newer cortisol assays and salivary cortisol test are also being used. Testing the HPA axis, imaging, and ruling out systemic causes are necessary for the diagnosis, and cancer treatment with immune checkpoint inhibitors is an emerging cause that requires close follow up.
Article
Endocrinology & Metabolism
Yu Cheng, Jie Li, Jingtao Dou, Jianming Ba, Jin Du, Saichun Zhang, Yiming Mu, Zhaohui Lv, Weijun Gu
Summary: This study describes three cases of hypercortisolism secondary to ectopic production of ACTH from adrenal medulla, with two cases showing Cushingoid features and all cases presenting marked hypokalemia. Surgical treatment resulted in significant decrease in cortisol levels postoperatively, highlighting the importance of controlling hypercortisolism in such patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Eleonora Lauteri, Jole Mariella, Francesca Beccati, Ellen Roelfsema, Carolina Castagnetti, Marco Pepe, Tanja Peric, Olimpia Barbato, Marta Montillo, Stefanie Rouge, Francesca Freccero
Summary: The study compared adrenal gland ultrasound measurements and hormone concentrations in healthy newborn Thoroughbred and Standardbred foals, finding differences between the two breeds in adrenal gland measurements, cortisol, and adrenocorticotropic hormone concentrations.
Article
Cell Biology
Kimberly Wellman, Rui Fu, Amber Baldwin, Juilee Rege, Elisabeth Murphy, William E. Rainey, Neelanjan Mukherjee
Summary: The study compared the gene expression dynamics of adrenal steroid hormone production in H295R cells and primary cultures of adult adrenocortical cells stimulated with ACTH or AngII. It was found that the magnitude of expression dynamics elicited by ACTH was greater than AngII in primary cells. While most of the stimulus-induced expression dynamics in H295R cells were recapitulated in primary cells, there were some expression responses unique to primary cells.
Review
Endocrinology & Metabolism
Georgia Pitsava, Constantine A. Stratakis
Summary: Pediatric adrenocortical hyperplasias are rare conditions characterized by Cushing syndrome and genetic defects affecting the adrenal cortex. Most cases are caused by defects in the cyclic AMP/protein kinase A (cAMP/PKA) pathway, while a few cases have unidentified genetic defects. Congenital adrenal hyperplasia, mainly due to steroidogenic enzyme deficiencies, is another cause of adrenal hyperplasia in childhood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Theo Charnay, Gregory Mougel, Cyril Amouroux, Iva Gueorguieva, Florence Joubert, Morgane Pertuit, Rachel Reynaud, Anne Barlier, Thierry Brue, Alexandru Saveanu
Summary: Isolated ACTH deficiency (IAD) is a life-threatening condition, particularly in the neonatal period. TBX19 mutations account for over 60% of neonatal cases of IAD and can lead to cognitive impairment in survivors. A new variant of the TBX19 gene has been identified, which is assumed to be pathogenic and is found in multiple families from the same region, suggesting a founder effect. Early diagnosis, treatment, and education can ensure normal development and quality of life in patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biology
M. M. Franca, N. P. Abreu, T. A. M. Vrechi, C. F. Lotfi
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2015)
Article
Biotechnology & Applied Microbiology
Monica Malheiros Franca, Bruno Ferraz-de-Souza, Antonio Marcondes Lerario, Maria Candida Barisson Villares Fragoso, Claudimara Ferini Pacicco Lotfi
BIOMED RESEARCH INTERNATIONAL
(2015)
Review
Endocrinology & Metabolism
Claudimara Ferini Pacicco Lotfi, Pedro O. R. de Mendonca
FRONTIERS IN ENDOCRINOLOGY
(2016)
Article
Endocrinology & Metabolism
Joao A. B. Pedroso, Pedro O. R. de Mendonca, Marco A. S. Fortes, Igor Tomaz, Vitor L. Pecorali, Thais B. Auricino, Ismael C. Costa, Leandro B. Lima, Isadora C. Furigo, Debora N. Bueno, Angela M. Ramos-Lobo, Claudimara F. P. Lotfi, Jose Donato
JOURNAL OF ENDOCRINOLOGY
(2017)
Article
Anatomy & Morphology
Daniella S. Battagello, Giovanne B. Diniz, Paulo L. Candido, Joelcimar M. da Silva, Amanda R. de Oliveira, Kelly R. Torres da Silva, Claudimara F. P. Lotfi, Jose A. de Oliveira, Luciane V. Sita, Claudio A. Casatti, David A. Lovejoy, Jackson C. Bittencourt
FRONTIERS IN NEUROANATOMY
(2017)
Article
Oncology
Elaine Silveira, Isadora Pontes Cavalcante, Jean Lucas Kremer, Pedro Omori Ribeiro de Mendonca, Claudimara Ferini Pacicco Lotfi
CANCER CELL INTERNATIONAL
(2018)
Article
Cell Biology
Isadora P. Cavalcante, Mirian Nishi, Maria Claudia N. Zerbini, Madson Q. Almeida, Vania B. Brondani, Maria Luiza Anhaia de Arruda Botelho, Fabio Y. Tanno, Victor Srougi, Jose Luis Chambo, Berenice B. Mendonca, Jerome Bertherat, Claudimara F. P. Lotfi, Maria Candida B. V. Fragoso
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2018)
Article
Endocrinology & Metabolism
Barbara dos Santos Passaia, Matheus Henrique Dias, Jean Lucas Kremer, Sonir Roberto Rauber Antonini, Madson Queiroz de Almeida, Maria Candida Barisson Villares Fragoso, Claudimara Ferini Pacicco Lotfi
FRONTIERS IN ENDOCRINOLOGY
(2018)
Article
Cell Biology
Pedro O. R. de Mendonca, Cleber W. Liria, Maria Teresa Machini, Claudimara F. P. Lotfi
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2013)
Article
Cell Biology
Monica Malheiros Franca, Bruno Ferraz-de-Souza, Mariza Gerdulo Santos, Antonio Marcondes Lerario, Maria Candida Barisson Villares Fragoso, Ana Claudia Latronico, Rork D. Kuick, Gary D. Hammer, Claudimara F. P. Lotfi
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2013)
Article
Multidisciplinary Sciences
Pedro Omori Ribeiro de Mendonca, Ismael Cabral Costa, Claudimara Ferini Pacicco Lotfi
Review
Medicine, General & Internal
Maria Candida Barisson Villares Fragoso, Isadora Pontes Cavalcante, Amanda Meneses Ferreira, Beatriz Marinho de Paula Mariani, Claudimara Ferini Pacicco Lotfi
Review
Medicine, General & Internal
Claudimara Ferini Pacicco Lotfi, Jean Lucas Kremer, Barbara dos Santos Passaia, Isadora Pontes Cavalcante
Article
Medicine, General & Internal
Monica Malheiros Franca, Antonio M. Lerario, Maria Candida B. V. Fragoso, Claudimara Ferini Pacicco Lotfi
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)