期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 371, 期 1-2, 页码 166-173出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2012.11.017
关键词
Adrenal cortex; N-POMC1-28; ACTH; Cyclin D; P27(kip); Proliferation
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Foundation for the Support of Research in the State of Sao Paulo)
- FAPESP
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, the National Council for Scientific and Technological Development)
- Pro-Reitoria de Pesquisa da Universidade de Sao Paulo (University of Sao Paulo Dean's Office for Research Projects)
The Adrenocorticotropic hormone (ACTH) and Pro-opimelanocortin (POMC) 1-28 N-terminal peptide (N-POMC1-28) have been shown to act as an adrenal mitogen in vivo. A possible role for cyclin E in the zona glomerulosa (ZG) proliferation, following ACTH and/or N-POMC1-28 administration, has been previously demonstrated. In this study, we investigated the effect of ACTH and N-POMC1-28 on the expression of adrenal cortex proteins related to cell cycle control such as cyclins D and P27(kip1). The administration of N-POMC upregulated cyclin D1 and D2 expression in the outer zone of the adrenal cortex; cyclin D3 expression was upregulated in the cortex inner zone even after administration of ACTH. Both ACTH and N-POMC peptides induced a decrease in the P27(kip1) expression in the ZG. These novel findings suggest that the POMC-derivate peptides, ACTH and N-POMC, promote proliferation in the adrenal cortex by upregulating the D2 and D3 cyclins and downregulating the P27(kip1) expression. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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