Article
Biochemistry & Molecular Biology
Rosa Fontana, Daniela Guidone, Tiziana Angrisano, Viola Calabro, Alessandra Pollice, Girolama La Mantia, Maria Vivo
Summary: ARF phosphorylation may be a mechanism through which it promotes or counteracts autophagy, providing evidence of its dual role in cancer progression.
Article
Multidisciplinary Sciences
Gil Lola Oreff, Barbara Maurer, Ahmed N. ELKhamary, Iris Gerner, Veronika Sexl, Florien Jenner
Summary: An immortalized cell line was established using Ink4a/Arf deficient mice tenocytes, which has similar characteristics and proliferation potential as wild-type cells. These Ink4a/Arf(-/-) tenocytes can be a valuable tool for in vitro tendon research and an alternative to animal experiments.
SCIENTIFIC REPORTS
(2023)
Review
Pharmacology & Pharmacy
Dawid Dorna, Adriana Grabowska, Jaroslaw Paluszczak
Summary: Many natural products can exert anticancer or chemopreventive activity by interfering with the cellular epigenetic machinery, which can modulate cancer-related gene expression and functional changes, including reduced cell proliferation and migration, and enhanced apoptosis.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Collin M. Bantle, C. Tenley French, Jason E. Cummings, Shankar Sadasivan, Kevin Tran, Richard A. Slayden, Richard J. Smeyne, Ronald B. Tjalkens
Summary: Exposure to elevated levels of manganese during juvenile development could sensitize glial cells to more severe neuro-immune responses to influenza infection later in life through persistent epigenetic changes.
Article
Biochemistry & Molecular Biology
Julian Aldana, Miranda L. L. Gardner, Michael A. A. Freitas
Summary: A comprehensive multi-omics approach was used to study the effects of differential H3K27me3 deposition driven by EZH2 mutations. The study identified pathways involved in cellular proliferation, differentiation, and migration that are impacted by EZH2 GOF and LOF mutants. The results shed light on EZH2-mediated cell transformative processes from the epigenetic to the phenotypic level, providing insights for improved diagnostics and treatment in hematologic malignancies with mutated EZH2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Adva Hadar, Oxana Kapitansky, Maram Ganaiem, Shlomo Sragovich, Alexandra Lobyntseva, Eliezer Giladi, Adva Yeheskel, Aliza Avitan, Gad D. Vatine, David Gurwitz, Yanina Ivashko-Pachima, Illana Gozes
Summary: Activity-dependent neuroprotective protein (ADNP) is crucial for brain formation and function, and can interact with sirtuin 1 in key ways. This interaction may provide a new target for research on neurodegenerative diseases.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Hyun Ji An, Yun Kim, Soojeong Chang, Hakchun Kim, Jihwan Song, Hyunsung Park, Inhee Choi
Summary: The authors propose a high-spatial and colourimetric imaging method using plasmonic nanoparticles as probes to visualize heterochromatin histone markers in a single nucleus. By utilizing the distance-dependent coupling effect and spectral shifts of plasmonic nanoprobes, they observe reorganization of histone markers caused by oncogene-induced senescence. This plasmonic nanoprobe-based imaging provides an advanced way to study the dynamics of histone modifications for predicting disease progression or senescence.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Qiangsheng Zhang, Xinyi Chen, Xi Hu, Xianjie Duan, Guoquan Wan, Lu Li, Qiang Feng, Yiqian Zhang, Ningyu Wang, Luoting Yu
Summary: This study designed and synthesized a new series of compounds, among which SKLB-03176 was identified as a potent EZH2 covalent inhibitor. It was found that SKLB-03176 selectively bound to the SAM pocket of EZH2, exhibited weak activity against other targets, and inhibited the expression of H3K27Me3 in cells without cytotoxicity to normal cells.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Xiao Chen, Yinglu Li, Fang Zhu, Xinjing Xu, Brian Estrella, Manuel A. Pazos II, John T. McGuire, Dimitris Karagiannis, Varun Sahu, Mustafo Mustafokulov, Claudio Scuoppo, Francisco J. Sanchez-Rivera, Yadira M. Soto-Feliciano, Laura Pasqualucci, Alberto Ciccia, Jennifer E. Amengual, Chao Lu
Summary: Co-dependency mapping assays have identified genetic dependencies in cancer and can provide insights into chromatin crosstalk mechanisms. The authors developed a pipeline to integrate co-dependency mapping with molecular information in pan-cancer cell lines to uncover chromatin complexes and potential drug targets. This study sheds light on trans-regulatory interactions as mechanisms of chromatin regulation and potential synthetic lethality targets.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Shuqi Wu, Xiaochun Tian, Qian Mao, Chang Peng
Summary: This study aimed to explore whether azithromycin (AZM) attenuates post-inflammatory wheezing by inhibiting hypermethylation of histone H3K27me3 mediated by EZH2. The results showed that the expression levels of IL-6, IL-2, NF-kappa B P65, EZH2, and H3K27me3 in the BALF of wheezing cases were significantly increased, while IL-10 was decreased. AZM attenuated the overexpression of NF-kappa B P65, EZH2, and H3K27me3 in wheezing cases and shortened the time of wheezing.
CLINICAL EPIGENETICS
(2023)
Review
Biochemistry & Molecular Biology
Aixin Hao, Yunxuan Wang, Daniel B. Stovall, Yu Wang, Guangchao Sui
Summary: Cancer therapies targeting epigenetic mechanisms, particularly involving EZH2, have shown significant progress. EZH2, a key component of PRC2, is elevated in cancers and associated with poor prognosis. In addition, studies have shown its involvement in both PRC2-dependent and independent transcriptional repression, while long non-coding RNAs have been identified as regulators of various oncogenic signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Abdulhameed Al-Ghabkari, Aru Narendran
Summary: EZH2 is a key player in pediatric leukemia, facilitating chromatin remodeling and gene silencing by catalyzing methylation of H3K27. Inhibition of EZH2 activity in THP-1 cells leads to increased apoptosis and suppression of AKT and ERK protein phosphorylation. Combining EZH2 inhibitors with selinexor may enhance treatment efficacy in pediatric AML.
CANCER BIOLOGY & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Wenjuan Zhang, Lihui Li, Lili Cai, Yupei Liang, Junfeng Xu, Yue Liu, Lisha Zhou, Chen Ding, Yanmei Zhang, Hu Zhao, Jun Qin, Zhimin Shao, Wenyi Wei, Lijun Jia
Summary: In this study, it was discovered that Prame recognizes p14/ARF for degradation. Inhibiting Prame expression and halting p14/ARF degradation can restrain tumor growth and induce G2/M phase cell cycle arrest.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Biochemistry & Molecular Biology
Ji-Yun Shang, Xue-Wei Cai, Yin-Na Su, Zhao-Chen Zhang, Xin Wang, Nan Zhao, Xin-Jian He
Summary: This study reveals a previously unknown mechanism for the regulation of DNA methylation, showing that ATX1-5 proteins play a crucial role in plant development, survival, and the regulation of DNA methylation. The redundant ATX paralogues promote the expression and H3K4me3 levels of both RNA-directed DNA methylation genes and active DNA demethylation genes to regulate DNA methylation.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Review
Oncology
Ru Wang, Hengwei Fan, Ming Sun, Zhongwei Lv, Wanwan Yi
Summary: BMI1 is a crucial factor in the occurrence and development of hepatocellular carcinoma (HCC), and its expression is correlated with prognosis and recurrence of HCC. Therefore, BMI1 is considered a potential therapeutic target for HCC.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Review
Cell Biology
Pawanrat Tangseefa, Sally K. Martin, Stephen Fitter, Paul A. Baldock, Christopher G. Proud, Andrew C. W. Zannettino
JOURNAL OF CELLULAR PHYSIOLOGY
(2018)
Article
Oncology
Ankit K. Dutta, J. Lynn Fink, John P. Grady, Gareth J. Morgan, Charles G. Mullighan, Luen B. To, Duncan R. Hewett, Andrew C. W. Zannettino
Article
Multidisciplinary Sciences
Agnieszka Arthur, Thao M. Nguyen, Sharon Paton, Ana Klisuric, Andrew C. W. Zannettino, Stan Gronthos
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Sally K. Martin, Stephen Fitter, Nadia El Khawanky, Randall H. Grose, Carl R. Walkley, Louise E. Purton, Markus A. Ruegg, Michael N. Hall, Stan Gronthos, Andrew C. W. Zannettino
SCIENTIFIC REPORTS
(2018)
Article
Hematology
Agnieszka Arthur, Thao M. Nguyen, Sharon Paton, Andrew C. W. Zannettino, Stan Gronthos
EXPERIMENTAL HEMATOLOGY
(2019)
Article
Genetics & Heredity
Dimitrios Cakouros, Sarah Hemming, Kahlia Gronthos, Renjing Liu, Andrew Zannettino, Songtao Shi, Stan Gronthos
EPIGENETICS & CHROMATIN
(2019)
Article
Cell & Tissue Engineering
Dongqing Yang, Stan Gronthos, Sandra Isenmann, Howard A. Morris, Gerald J. Atkins
STEM CELLS INTERNATIONAL
(2019)
Review
Clinical Neurology
Maria R. Gancheva, Karlea L. Kremer, Stan Gronthos, Simon A. Koblar
FRONTIERS IN NEUROLOGY
(2019)
Review
Biochemistry & Molecular Biology
Nicholas Smith, Suzanna Shirazi, Dimitrios Cakouros, Stan Gronthos
Summary: Many important epigenetic changes occur during early skeletal development and throughout life, influenced by factors such as aging, disease, and lifestyle. Epigenetics explores the heritable changes in gene expression resulting from environmental changes without any alterations in DNA sequence. Cellular epigenetic profiles are dynamic and regulated through mechanisms including histone modifications, non-coding RNA-associated gene silencing, and DNA methylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Geriatrics & Gerontology
Dimitrios Cakouros, Stan Gronthos
Meeting Abstract
Endocrinology & Metabolism
Esther Camp, Peter Anderson, Andrew Zannettino, Stan Gronthos
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Meeting Abstract
Biotechnology & Applied Microbiology
Thao M. Nguyen, Agnieszka Arthur, Stan Gronthos
JOURNAL OF GENE MEDICINE
(2018)
Meeting Abstract
Biotechnology & Applied Microbiology
Dimitrios Cakouros, Sarah Hemming, Clara Pribadi, Andrew Zannettino, Stan Gronthos
JOURNAL OF GENE MEDICINE
(2018)