Article
Food Science & Technology
Dandan Wang, Zequn Yin, Lan Han, Mengxue Zhang, Huaxin Li, Xiaoxiao Yang, Yuanli Chen, Shuang Zhang, Jihong Han, Yajun Duan
Summary: It has been reported that ascorbic acid partially inhibits non-alcoholic fatty liver disease by activating fatty acid beta-oxidation. This study reveals that ascorbic acid decreases lipid accumulation in hepatocytes by reducing LXRα nuclear translocation and activating AMPKα. In vivo, administration of ascorbic acid decreases triglyceride levels in serum and liver as well as FFA levels in the liver. These findings suggest that ascorbic acid is an effective and safe dietary supplement to ameliorate hypertriglyceridemia.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Pharmacology & Pharmacy
Shreya R. Savla, Kedar S. Prabhavalkar, Lokesh K. Bhatt
Summary: LXRs are important regulators of atherosclerosis and understanding their role is important for developing potential therapeutics. This review discusses the role of LXRs in atherosclerotic development, LXR agonists, and future research directions. It highlights the need for further research on specific agonist-targeted LXR isoforms and cell type-specific knockout models.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Article
Biochemistry & Molecular Biology
Hong Lu, Xiaohong Lei, Rebecca Winkler, Savio John, Devendra Kumar, Wenkuan Li, Yazen Alnouti
Summary: The down-regulation of HNF4 alpha and GR plays an important role in fatty liver and hyperlipidemia. They regulate hepatic gene expression, suppress lipogenesis, and induce lipid catabolism to protect the liver from fat accumulation.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Tomomi Yamazaki, Megumi Ihato
Summary: PPAR-alpha prevents fatty liver caused by excessive sucrose intake through regulating SREBP-1c target gene expression and liver TG accumulation. Gender differences may be related to the expression level of PPAR-gamma.
Article
Cell Biology
Xin Jin, Zhen Zhen, Zhaoxiong Wang, Xuejun Gao, Meng Li
Summary: Palmitic acid (PA) demonstrates dose-dependent effects on lipid synthesis in primary bovine mammary epithelial cells, mediated through the PI3K/PKCα-SREBP-1c pathway. Knockdown of GPRC6A almost completely blocks PA-induced phosphorylation of PI3K and PKCα, as well as the expression and maturation of SREBP-1c.
CELL BIOLOGY INTERNATIONAL
(2022)
Review
Gastroenterology & Hepatology
Lucia Parlati, Marion Regnier, Herve Guillou, Catherine Postic
Summary: Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease worldwide with no effective treatments currently available. Preclinical models have enhanced our understanding of its pathophysiology, and research on new therapeutic targets is ongoing.
Article
Pharmacology & Pharmacy
Thi Hoa Pham, Gi Ho Lee, Sun Woo Jin, Seung Yeon Lee, Eun Hee Han, Nam Doo Kim, Chul Yung Choi, Gil-Saeng Jeong, Sang Ki Lee, Hyung Sik Kim, Hye Gwang Jeong
Summary: This study found that sesamin can effectively reduce lipid accumulation, alleviate lipotoxicity, and improve lipid metabolism imbalance. Additionally, sesamin can regulate key factors involved in lipogenesis and lipolysis by activating specific signaling pathways. These findings suggest that sesamin may be a promising candidate for treating hepatic steatosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Maria E. Fernandez-Suarez, Lidia Daimiel, Gemma Villa-Turegano, Maria Vazquez Pavon, Rebeca Busto, Joan C. Escola-Gil, Frances M. Platt, Miguel A. Lasuncion, Javier Martinez-Botas, Diego Gomez-Coronado
Summary: Select estrogen receptor modulators (SERMs) have shown to impact cellular cholesterol metabolism by inhibiting intracellular trafficking of LDL-derived cholesterol, promoting SREBP-2 activation, and preventing LXR activation. These actions are independent of estrogen receptors and highlight the role of SERMs in regulating lipid homeostasis beyond their estrogen modulating effects.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Yue-Qiang Huang, Yi-Xi Tang, Bai-Hao Qiu, Milton Talukder, Xue-Nan Li, Jin-Long Li
Summary: DEHP exposure can cause liver damage in quails, resulting in lipid metabolism disorders and inflammatory response.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mahdis Rahimi Naiini, Beydolah Shahouzehi, Shahrzad Azizi, Bentolhoda Shafiei, Mahdieh Nazari-Robati
Summary: Aging leads to impaired liver metabolic function, increasing the risk of liver and systemic diseases. Trehalose, a natural disaccharide, has shown potential in reducing dyslipidemia, hepatic steatosis, and glucose intolerance. This study aimed to investigate the effects of trehalose on lipid metabolism in aged liver.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Huazhen Liu, Yonger Chen, Yifan Wen, Shumin Zhu, Song Huang, Lian He, Shaozhen Hou, Xiaoping Lai, Shuxian Chen, Zhenhua Dai, Jian Liang
Summary: The study demonstrated that phloridzin can effectively alleviate nonalcoholic fatty liver disease by regulating lipid metabolism and insulin resistance through inhibiting the mTORC1/SREBP-1c pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biology
Neha Attal, Emilio Marrero, Kyle J. Thompson, Iain H. McKillop
Summary: Alcohol-induced metabolism through CYP2E1 inhibits AMPK alpha phosphorylation, leading to increased FFA accumulation and FABP4 protein secretion via an SREBP-1c dependent mechanism.
Article
Biochemistry & Molecular Biology
Mohammad Mohammadi, Roghayeh Abbasalipourkabir, Nasrin Ziamajidi
Summary: This study demonstrates that the combination of fish oils and chicoric acid can synergistically reduce lipid accumulation and regulate multiple signaling pathways, suggesting its potential therapeutic effect for NAFLD.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Sheng Qiu, Zerong Liang, Qinan Wu, Miao Wang, Mengliu Yang, Chen Chen, Hongting Zheng, Zhiming Zhu, Ling Li, Gangyi Yang
Summary: The study reveals that Nrf2 deficiency promotes hepatic lipid accumulation by enhancing SREBP-1c activity and attenuating autophagy. Additionally, the Nrf2-LAMP1 interaction plays a crucial role in regulating Nrf2-mediated hepatosteatosis.
Article
Endocrinology & Metabolism
Fei Luo, Chao Xing, Sumeet K. Asrani, Shili Li, Guosheng Liang, Helen H. Hobbs, Jonathan C. Cohen
Summary: This study identified a missense variant in the insulin receptor associated with fatty liver disease in a four generation family, but experiments in mice failed to show a causal relationship between this variant and the disease or any impact on hepatic triglyceride metabolism.
MOLECULAR METABOLISM
(2021)
Letter
Dermatology
S. Kumar, K. Vinay, D. Parsad, A. Bishnoi, T. Narang, S. K. Muthu, S. Dogra
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2020)
Article
Dermatology
Niharika Srivastava, Anuradha Bishnoi, Sakshi Mehta, Seema Rani, Ravinder Kumar, Supriya Bhardwaj, Muthu Sendhil Kumaran, Vinay Keshavamurthy, Sarika Gupta, Davinder Parsad
EXPERIMENTAL DERMATOLOGY
(2020)
Review
Dermatology
R. Kapoor, S. K. Dhatwalia, R. Kumar, S. Rani, D. Parsad
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2020)
Article
Dermatology
Anuradha Bishnoi, Keshavamurthy Vinay, Muthu Sendhil Kumaran, Davinder Parsad
Summary: The study demonstrates that both oral mycophenolate mofetil and dexamethasone oral mini-pulse effectively stabilize active vitiligo. Both treatments showed significant improvements in disease activity and new lesion numbers, but patients using mycophenolate mofetil had slightly higher Vitiligo Area Scoring Index at 270 days compared to those using dexamethasone oral mini-pulse.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2021)
Article
Dermatology
Hitaishi Kaushik, Deepak Kaul, Muthu Sendhil Kumaran, Davinder Parsad
JOURNAL OF DERMATOLOGICAL SCIENCE
(2020)
Article
Dermatology
Kiruthika Subburaj, Vishal Thakur, Muthu Sendhil Kumaran, Keshavamurthy Vinay, Niharika Srivastava, Davinder Parsad
Summary: Dermabrasion and cryoblister techniques have comparable efficacy in treating stable vitiligo, with dermabrasion showing superiority in terms of speed and color match. However, dermaroller has poorer repigmentation outcomes compared to dermabrasion and cryoblister in this study.
DERMATOLOGIC THERAPY
(2021)
Article
Oncology
Naveed Pervaiz, Harjot Kaur, Davinder Parsad, Ravinder Kumar
Summary: The study investigated the effects of lenalidomide on vitiligo mouse models, showing that lenalidomide could suppress the development of vitiligo lesions by reducing levels of pro-inflammatory cytokines and increasing levels of anti-inflammatory cytokines, modulating the immune response towards an anti-inflammatory profile.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Review
Oncology
Vishal Thakur, Anuradha Bishnoi, Keshavamurthy Vinay, Sendhil M. Kumaran, Davinder Parsad
Summary: This is an exciting phase of vitiligo research as understanding of vitiligo pathogenesis has led to successful treatment. Vitiligo originates from autoimmunity with contributions from factors like oxidative stress and melanocyte defects. Treatment aims to rescue melanocytes to arrest depigmentation and replenish them for successful repigmentation, while also focusing on maintaining stability to prevent relapse, especially in non-segmental vitiligo.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Letter
Dermatology
Hitaishi Mehta, Anuradha Bishnoi, Keshavamurthy Vinay, Muthu Sendhil Kumaran, Davinder Parsad
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Sushma Tanwar, Vishal Thakur, Alka Bhatia, Davinder Parsad
Summary: This study evaluated the levels of catecholamines and gene expression changes in active vitiligo patients. The results showed elevated levels of catecholamines in the perilesional skin of patients, indicating oxidative stress, inflammation, and immune response.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Review
Dermatology
Hitaishi Kaushik, Vinod Kumar, Davinder Parsad
Summary: Mitochondria plays a role in melanocyte function and can be associated with certain diseases, such as Duchenne muscular dystrophy and vitiligo. The exact mechanism of melanocyte destruction in vitiligo is still unknown, but studies suggest that mitochondrial function, inter- and intra-organellar communications, and melanosome association may be involved. Understanding the role of mitochondria in vitiligo could lead to new treatments for the disease.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Quentin Marin Dit Bertoud, Clemence Bertold, Khaled Ezzedine, Amit G. Pandya, Marie Cherel, Alejandro Castillo Martinez, Marie-Anne Seguy, Marwa Abdallah, Jung Min Bae, Markus Boehm, Davinder Parsad, David Rosmarin, Albert Wolkerstorfer, Philippe Bahadoran, Manon Blaise, Pierre-Michel Dugourd, Valerie Philippo, Jean-Michel Delaval, Thierry Passeron
Summary: The study developed an algorithm called Vitil-IA to assess depigmentation on standardized facial ultraviolet (UV) pictures in vitiligo patients. The algorithm showed excellent reproducibility and high agreement with the assessment by raters. The study also revealed the limitations of the F-VASI score when performed by non-experts for homogeneous vitiligo depigmentation and in the case of heterogeneous depigmentation.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Shikha Shah, Narayanan Baskaran, Keshavamurthy Vinay, Anuradha Bishnoi, Davinder Parsad, Muthu S. Kumaran
Summary: Acquired dermal macular hyperpigmentation (ADMH) is an umbrella concept that unifies various acquired pigmentary disorders characterized by dermal pigmentation. The treatment of ADMH remains challenging.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Deepak Kumar, Vishal Thakur, Kiruthika Subburaj, Anuradha Bishnoi, Keshavamurthy Vinay, Muthu Sendhil Kumaran, Davinder Parsad
Summary: This study found that the application of 0.1% tacrolimus ointment can effectively prevent the appearance of new lesions and promote repigmentation in unstable acral vitiligo. Moreover, using the ointment on both affected and unaffected skin yields better results.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Naveed Pervaiz, Harjot Kaur, Davinder Parsad, Ravinder Kumar
DERMATOLOGIC THERAPY
(2020)
