Article
Rheumatology
Priyanka Ballal, Christine Peloquin, Cindy Germaine Boer, Tuhina Neogi
Summary: This study suggests that warfarin use is associated with a higher risk of knee and hip replacements compared to DOAC use. Furthermore, longer duration of warfarin use is linked to an increased risk of joint replacement.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Gastroenterology & Hepatology
Yiqing Wang, Yin Cao, Benjamin Lebwohl, Mingyang Song, Qi Sun, Peter H. R. Green, Edward L. Giovannucci, Walter C. Willett, Andrew T. Chan
Summary: The study found that gluten intake was not associated with the risk of digestive system cancers in adults without celiac disease, indicating that restricting dietary gluten may not be beneficial for the prevention of digestive system cancers in the general population.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Endocrinology & Metabolism
Nicola Veronese, Sinisa Stefanac, Ai Koyanagi, Nasser M. Al-Daghri, Shaun Sabico, Cyrus Cooper, Rene Rizzoli, Jean-Yves Reginster, Mario Barbagallo, Ligia J. Dominguez, Lee Smith, Stefania Maggi
Summary: The study found that sarcopenia is associated with a higher risk of symptomatic knee osteoarthritis in a large cohort of North American people, but not with radiographic knee osteoarthritis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Rheumatology
Eefje Martine van Helvoort, Christoph Ladel, Simon Mastbergen, Margreet Kloppenburg, Francisco J. Blanco, Ida K. Haugen, Francis Berenbaum, Jaume Bacardit, Pawel Widera, Paco M. J. Welsing, Floris Lafeber
Summary: The study aimed to describe the relationships between baseline clinical characteristics of IMI-APPROACH participants and their predicted probabilities for knee OA structural and/or pain progression. Participants with high structural progression scores had less structural damage compared to those with low progression scores, while participants with high pain progression scores experienced more pain compared to those with low progression scores. Overall, baseline characteristics had varying impacts on OA progression.
Article
Nutrition & Dietetics
Tao Meng, Johanna Wilson, Alison Venn, Flavia Cicuttini, Lyn March, Marita Cross, Terence Dwyer, Leigh Blizzard, Graeme Jones, Laura Laslett, Benny Antony, Changhai Ding
Summary: The study found that overall diet quality in adolescence and adulthood was not significantly associated with knee symptoms in adulthood, but certain diet components may affect later knee symptoms.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Multidisciplinary Sciences
Satoshi Hamai, Satoru Harada, Hidetoshi Tsushima, Ryutaro Kozuma, Satoshi Yamate, Shinya Kawahara, Yukio Akasaki, Tetsunari Harada, Yasuhiko Kokubu, Toshiki Konishi, Yasuharu Nakashima
Summary: This study aimed to evaluate the frequency of sleep disturbance at midterm after total knee arthroplasty (TKA) in a Japanese cohort and to identify intervening factors for sleep. The results showed that decreased functional capability, rather than residual knee pain, negatively interacted with sleep quality. The sleep disturbance rate was high during the middle postoperative period after TKA in the Japanese cohort.
SCIENTIFIC REPORTS
(2023)
Review
Biology
Eun-Hee Jang, Ye-Ji Han, Seong-Eun Jang, Seungmin Lee
Summary: This systematic review found that various diet qualities are significantly associated with a decreased risk of sarcopenia, especially the Mediterranean diet and Nordic diet. However, the results from non-European countries were inconsistent.
Article
Rheumatology
Andrea Dell'Isola, Clara Hellberg, Aleksandra Turkiewicz, Tom Appleyard, Dahai Yu, Geraint Thomas, George Peat, Martin Englund
Summary: This study examined the temporal trends in primary care visits, physiotherapy visits, and the use of NSAIDs and opioids in patients with knee osteoarthritis who have and have not undergone knee replacement surgery. The results showed that the management of these patients is largely similar, except for higher use of NSAIDs in knee replacement cases. Symptomatic treatments start to increase a few years before the surgery in knee replacement cases.
Article
Orthopedics
C. Xu, T. Liu, J. B. Driban, T. McAlindon, C. B. Eaton, B. Lu
Summary: The study found that following a Western dietary pattern was associated with an increased risk of knee osteoarthritis, while following a prudent pattern was associated with a reduced risk of knee OA. These associations were partially mediated through body mass index.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Nutrition & Dietetics
Guangfeng Ruan, Chengliang Yang, Tao Meng, Shuang Zheng, Yan Zhang, Jimin Zhu, Han Cen, Yuanyuan Wang, Zhaohua Zhu, Weiyu Han, Yujin Tang, Jia Liu, Benny Antony, Tania Winzenberg, Anita E. Wluka, Flavia Cicuttini, Changhai Ding
Summary: The study found that higher diet quality, particularly a vegetable-based diet quality, was associated with greater lower limb muscle strength, fewer depressive symptoms, and higher quality of life in knee osteoarthritis patients, rather than being related to knee joint structures and OA symptoms.
CLINICAL NUTRITION
(2021)
Article
Oncology
Mostafa Dianatinasab, Anke Wesselius, Amin Salehi-Abargouei, Evan Y. W. Yu, Mohammad Fararouei, Maree Brinkman, Piet van den Brandt, Emily White, Elisabete Weiderpass, Florence Le Calvez-Kelm, Marc J. Gunter, Inge Huybrechts, Maurice P. Zeegers
Summary: This study investigated the association between fat intake and bladder cancer risk using data from 11 cohort studies. It found an inverse association between mono-unsaturated fatty acids (MUFAs) intake and bladder cancer risk among women, and a positive association between higher dietary cholesterol intake and bladder cancer risk among men.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Orthopedics
M. T. Murphy, N. Wang, D. T. Felson, M. C. Nevitt, C. E. Lewis, L. Frey-Law, A. Guermazi, N. A. Segal
Summary: This study found that women had higher levels of knee flexor coactivation than men, and in men, knee flexor coactivation was more strongly associated with worsening cartilage morphology.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Rheumatology
Ying Ying Leung, Aizhen Jin, Kelvin Bryan Tan, Li-Wei Ang, Jian-Min Yuan, Woon-Puay Koh
Summary: This study found that total fibre intake was not associated with risk of TKR, while intake of legumes was associated with a lower risk in a dose dependent manner. Further research is needed to confirm these findings and explore the mechanisms behind the effects of dietary legumes on KOA.
Article
Orthopedics
Indiana Cooper, Peter Brukner, Brooke L. Devlin, Anjana J. Reddy, Melanie Fulton, Joanne L. Kemp, Adam G. Culvenor
Summary: This study aimed to evaluate the feasibility of a telehealth-delivered anti-inflammatory diet intervention for knee osteoarthritis. The results showed that the intervention was feasible, with high attendance rates and good self-reported dietary adherence. This study provides support for conducting a large-scale randomized controlled trial.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Nutrition & Dietetics
Ioanna Yiannakou, Martha R. Singer, Paul F. Jacques, Vanessa Xanthakis, R. Curtis Ellison, Lynn L. Moore
Summary: This study found that adherence to a Mediterranean-style diet is associated with a lower cancer risk, especially among women. Moderate or higher adherence to the MSDP can significantly decrease the risk of cancer.
Article
Rheumatology
Taro Kasai, Gen Momoyama, Yuichi Nagase, Tetsuro Yasui, Sakae Tanaka, Takumi Matsumoto
Summary: This study suggests that disease activity has an impact on recurrent deformities of the lesser toes in patients with rheumatoid arthritis after resection arthroplasty for forefoot deformities, while recurrent deformities of the hallux are associated with the severity of preoperative hallux deformity.
MODERN RHEUMATOLOGY
(2021)
Review
Endocrinology & Metabolism
Sakae Tanaka, Yoshiya Tanaka
Summary: RANKL plays a critical role in rheumatoid arthritis, with Denosumab being an effective therapeutic option.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Correction
Endocrinology & Metabolism
Sakae Tanaka, Yoshiya Tanaka
Summary: The original publication of the article contained an error in the title of the table, which should have been Baseline patient demographics and characteristics in DESIRABLE trial. This title was adopted from a reference with permission.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Review
Endocrinology & Metabolism
Sakae Tanaka, Toshio Matsumoto
Summary: Sclerostin negatively regulates canonical Wnt signaling pathways by binding to LRP5/6, while Romosozumab, a specific anti-sclerostin antibody, indirectly activates this pathway to promote bone formation.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Article
Endocrinology & Metabolism
Sakae Tanaka, Hideki Mizutani, Eri Tsuruya, Ryoko Fukuda, Kiyoka Kuge, Naoki Okubo
Summary: The study confirmed the long-term safety and effectiveness of denosumab in Japanese patients with osteoporosis in daily clinical practice. It showed significant improvements in bone density and reductions in bone turnover markers, with a low incidence of osteoporotic fractures over 3 years. No new safety signals were identified.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Article
Rheumatology
Uchio Akihiro, Takumi Matsumoto, Yuji Maenohara, Yasunori Omata, Hiroshi Takahashi, Mitsuyasu Iwasawa, Takuo Juji, Ichiro Nakamura, Sakae Tanaka
Summary: The study found that tofacitinib did not suppress the postoperative increase in body temperature and CRP level, but may lead to a decrease in lymphocyte count. The timing for resuming tofacitinib treatment after surgery should be carefully considered.
CLINICAL RHEUMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Takehiro Matsubara, Kazuhito Soma, Ikufumi Yamada, Hiroshi Fujita, Junya Yoshitani, Hiroyuki Oka, Hiroyuki Okada, Sakae Tanaka
Summary: Surgery for intertrochanteric fractures using intramedullary hip nails with an anterior offset (Best Fit Nail) has been found to be more effective in maintaining fragment reduction and proper lag screw position compared with conventional non-offset nails (Proximal Femoral Nail Antirotation), according to postoperative computed tomography evaluation.
Article
Medicine, General & Internal
Takuya Kawahara, Keiko Yamada, Ryohei Terashima, Ikumi Takashima, Sakae Tanaka, Toru Ogata, Hirotaka Chikuda, Hiromasa Miura, Kozo Nakamura, Takashi Ohe
Summary: Multiple imputation was found to be the preferable method for handling missing values in the GLFS-25 questionnaire. However, single imputation using subject average/subject domain average can be used with practically negligible bias as long as the number of missing items is up to 8 out of 25 items in each individual of the population.
Article
Rheumatology
Tsutomu Takeuchi, Sakae Tanaka, Mitsuru Murata, Yoshiya Tanaka
Summary: This study aimed to evaluate the efficacy and safety of TAS5315 in Japanese patients with refractory rheumatoid arthritis. The results showed numerical differences in disease activity improvement rates between the TAS5315 group and the placebo group at week 12, but the primary endpoint was not achieved. However, TAS5315 demonstrated advantages in disease activity and biomarker improvement, as well as higher risk of bleeding events within 36 weeks. Therefore, a risk-benefit analysis of TAS5315 should be considered.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Ryutaro Takeda, Takumi Matsumoto, Yasunori Omata, Hiroshi Inui, Shuji Taketomi, Yuichi Nagase, Takuji Nishikawa, Hiroyuki Oka, Sakae Tanaka
Summary: This study investigated the trend of joint destruction patterns on knee radiographs of patients with rheumatoid arthritis (RA) undergoing total knee arthroplasty (TKA) over the past 16 years. The results showed that radiographs of TKA recipients with RA are increasingly presenting osteoarthritic features in recent decades. The study also identified different clusters based on radiographic findings, indicating variations in joint space narrowing, spur formation, and alignment.
CLINICAL RHEUMATOLOGY
(2023)
Article
Orthopedics
H. Kobayashi, N. Ito, Y. Nakai, H. Katoh, K. Okajima, L. Zhang, Y. Tsuda, S. Tanaka
Summary: The aim of this study was to report the patterns of symptoms and insufficiency fractures in patients with tumour-induced osteomalacia (TIO) for early diagnosis. The study included 33 TIO patients treated between January 2000 and June 2022. Symptoms and radiological patterns of insufficiency fractures were investigated. The results showed that TIO patients experienced back pain, chest wall pain, and hip pain, with vertebral fractures being biconcave deformities and periarticular fractures involving subchondral insufficiency fractures and epiphyseal or metaphyseal fractures. The presence of these symptoms and insufficiency fractures in patients with a tumor should suggest TIO diagnosis.
BONE & JOINT JOURNAL
(2023)
Article
Cell & Tissue Engineering
Takeshi Oichi, Joe Kodama, Kimberly Wilson, Hongying Tian, Yuka Imamura Kawasawa, Yu Usami, Yasushi Oshima, Taku Saito, Sakae Tanaka, Masahiro Iwamoto, Satoru Otsuru, Motomi Enomoto-Iwamoto
Summary: Long bone growth in the growth plate relies on endochondral ossification through the accumulation and synthesis of matrix scaffold by chondrocytes. Nutritional restriction increases the number of chondroprogenitors in the resting zone and inhibits their differentiation, while nutrient recovery promotes their differentiation and contributes to accelerated growth. Furthermore, the phosphorylation of Akt in the resting zone is reduced under nutrient deprivation, and exogenous IGF-1 restores the phosphorylation of Akt and stimulates the differentiation of chondroprogenitor cells, leading to a decrease in their numbers.
Article
Endocrinology & Metabolism
Yasunori Omata, Hiroyuki Okada, Steffen Uebe, Naohiro Izawa, Arif B. Ekici, Kerstin Sarter, Taku Saito, Georg Schett, Sakae Tanaka, Mario M. Zaiss
Summary: Bone turnover is regulated by a variety of bone cells, including osteoblasts, osteoclasts, and osteocytes. The differentiation and maturation of osteoclasts are crucial for maintaining skeletal homeostasis. Through single-cell RNA sequencing, researchers identified RAB38 as a key molecule involved in osteoclast differentiation and maturation.
Article
Endocrinology & Metabolism
Hisato Watanabe, Hiroyuki Okada, Jun Hirose, Yasunori Omata, Takumi Matsumoto, Morio Matsumoto, Masaya Nakamura, Taku Saito, Takeshi Miyamoto, Sakae Tanaka
Summary: We investigated the role of hematopoietically expressed homeobox protein (Hhex) in osteoclast development. Our findings suggest that Hhex acts as an inhibitor of osteoclast differentiation through epigenetic regulation and modulation of the cell cycle of osteoclast precursors. Hhex expression is reduced during RANKL-induced osteoclastogenesis, and overexpression or suppression of Hhex affects the development of osteoclasts in vitro. Conditional deletion of Hhex in osteoclast-lineage cells promotes osteoclastogenesis and reduces cancellous bone volume in mice.
Article
Rheumatology
Haruka Tsuchiya, Mineto Ota, Shuji Sumitomo, Kazuyoshi Ishigaki, Akari Suzuki, Toyonori Sakata, Yumi Tsuchida, Hiroshi Inui, Jun Hirose, Yuta Kochi, Yuho Kadono, Katsuhiko Shirahige, Sakae Tanaka, Kazuhiko Yamamoto, Keishi Fujio
Summary: Objectives: Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation in the synovium, where synovial fibroblasts (SFs) play a major role. This study aimed to understand the genetic contribution to molecular regulatory networks in SFs under inflammatory conditions. Methods: SFs from RA and osteoarthritis (OA) patients were stimulated with various cytokines and immune cell subsets were analyzed. Integrative analyses including mRNA expression, histone modifications, 3D genome architecture, and genetic variations were performed. Results: Unstimulated SFs from RA patients showed differences in transcriptome and epigenome compared to OA SFs. Most responses to stimulations were shared between the diseases. SFs expressed pathogenic genes and chromatin remodeling in activated SFs revealed enrichment of RA risk loci in clusters of enhancers induced by proinflammatory cytokines. A RA risk SNP formed 3D contact with the promoter of a gene related to arthritis, and inhibition of this gene suppressed cytokine and chemokine production in SFs. Conclusions: This study identified potential therapeutic targets associated with genetic risk of RA and established a dynamic landscape of activated SFs.
ANNALS OF THE RHEUMATIC DISEASES
(2021)