Article
Biophysics
Marie-Christin Viehauser, Erik Breslmayr, Stefan Scheiblbrandner, Franziska Schachinger, Su Ma, Roland Ludwig
Summary: The development of third generation biosensors relies on enzymes capable of direct electron transfer (DET), achieved by fusing a cytochrome domain to an enzyme. In this study, the chimeric enzyme NcCYT-GcGDH was successfully generated in large quantities, showing high catalytic activity and the ability to perform interdomain electron transfer and direct electron transfer via the fused cytochrome domain. The high current obtained on a simple, unmodified electrode at a relatively low redox potential provides a promising starting point for further optimization.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Physical
Pranjali Priyadarshini, Tomas Ricciardulli, Jason S. Adams, Yang Sik Yun, David W. Flaherty
Summary: The study investigates the impact of sodium bromide on the formation of H2O2 on Pd nanoparticle catalysts, revealing that sodium bromide can increase steady-state H2O2 selectivities without the need for additional liquid-phase bromide for at least 15 hours.
JOURNAL OF CATALYSIS
(2021)
Article
Biophysics
Manoharan Murphy, K. Theyagarajan, Kathavarayan Thenmozhi, Sellappan Senthilkumar
Summary: A novel biosensor was developed for monitoring hydrogen peroxide concentration, based on the covalent immobilization of hemoglobin on a newly developed NIBA-IL/MWCNT/GCE platform. The biosensor demonstrated effective direct electrochemistry of hemoglobin, with low detection limit, high sensitivity, good stability, and reliable reproducibility.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Physical
Zhu Jin, Yifeng Liu, Liang Wang, Chengtao Wang, Zhiyi Wu, Qiuyan Zhu, Lingxiang Wang, Feng-Shou Xiao
Summary: In this study, AuPd nanoparticles fixed within aluminosilicate zeolite crystals were used as catalysts for the direct synthesis of H2O2 in aqueous solution. The zeolite-assisted proton transfer process catalyzed the oxygen hydrogenation to form H2O2, leading to high productivity and selectivity of H2O2 in water. The findings highlight the potential of zeolite fixed structures for designing efficient catalysts in H2O2 synthesis.
Article
Chemistry, Analytical
Fanny Girard-Sahun, Pauline Lefrancois, Vasilica Badets, Stephane Arbault, Franck Clement
Summary: This study aims to detect the in situ production of reactive oxygen and nitrogen species (RONS), specifically superoxide anion (O-2(center dot-)), in aqueous buffer solutions exposed to cold atmospheric plasmas (CAPs). The production and accumulation of RONS in the liquids were found to depend on the plasma composition, with N-2-based shieldings providing the highest concentrations of superoxide. The study provides valuable insights into the interactions between CAPs and physiological solutions for biomedical applications.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Anca Aldea, Ricardo Jose Branco Leote, Elena Matei, Alexandru Evanghelidis, Ionut Enculescu, Victor C. Diculescu
Summary: Flexible electrodes obtained by electrospinning of poly(methyl methacrylate) fibers, coated with a gold layer, demonstrated superior performance in biosensing applications compared to planar gold electrodes. The electrodes showed increased current density values and sensitivity for hydrogen peroxide and glucose detection, with reduced interference and practical applicability in detecting glucose in artificial sweat and serum samples.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Koushik Barman, Xiang Wang, Rui Jia, Michael Mirkin
Summary: SECM is a powerful tool for mapping surface reactivity, but mapping electrocatalytic processes at the nanoscale is challenging. New SECM nanoprobes based on bimolecular electron transfer overcome this difficulty and can be used for mapping various electrocatalytic processes and as nanosensors.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Analytical
Viktorija Teiserskyte, Jaunius Urbonavicius, Dalius Ratautas
Summary: This study reported the construction of a direct electron transfer biosensor based on NAD-dependent formaldehyde dehydrogenase, achieving a fast, highly sensitive detection of formaldehyde with high stability and selectivity.
Article
Chemistry, Multidisciplinary
Jaejung Song, Je Min Yu, Jang Hyuk Ahn, Hyeonjin Cho, Jiyeon Oh, Yoon Seo Kim, Jieun Kim, Myohwa Ko, Seong-hun Lee, Tae Joo Shin, Hu Young Jeong, Changduk Yang, Jun Hee Lee, Ji-Wook Jang, Seungho Cho
Summary: The importance of hydrogen peroxide continues to rise globally. The oxygen reduction reaction (ORR) towards the 2e(-) pathway to form H2O2 is crucial for high productivity. However, existing catalysts made of carbon-containing materials have low stability, hindering their commercial applicability. In this study, layered double hydroxides (LDHs) are used as inorganic matrices for the first time. The developed LDH catalyst exhibits near-100% 2e(-) ORR selectivity and stably produces H2O2 with a high concentration.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Analytical
Chen Chen, Guanglian Zhou, Fengyun Sun, Jian Liu, Xiumei Liu
Summary: In this study, a new electron mediator was designed and synthesized, and a biosensor based on a modified electrode was developed for efficient detection of hydrogen peroxide in cells. The biosensor demonstrated high sensitivity and accuracy, making it a promising method for evaluating the activity of antitumor drugs.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Lei Gan, Hao Mei, Qingzhuo Lin, Jinlan Peng, Xinfei Ji, Rongbin Zhang, Xuewen Wang
Summary: A novel and efficient two-step crystal nucleation strategy was designed for constructing highly stable ternary ordered macroporous structures, exemplified by 3DOM NaTaO3 photocatalytic materials, showing significantly improved catalytic activity compared to nonporous counterparts. This construction enables faster reaction rates, participation of the bulk interior in photochemical reactions, and more options for later decoration.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Engineering, Environmental
Mengfan Luo, Hongyu Zhou, Peng Zhou, Leiduo Lai, Wen Liu, Zhimin Ao, Gang Yao, Heng Zhang, Bo Lai
Summary: This study compared and discussed the promotion effect of hydrogen peroxide (H2O2) in Fe(VI) and Fe(VI)-H2O2 processes, revealing that the Fe(VI)-H2O2 system exhibited better oxidation performance due to the catalytic role of H2O2. Additionally, the system showed satisfactory pollutant removal effects in real water conditions.
Article
Chemistry, Analytical
Yu Cai, Tingting Tu, Tianyu Li, Shanshan Zhang, Bin Zhang, Lu Fang, Xuesong Ye, Bo Liang
Summary: The study on the application of nanomaterials in glucose biosensors demonstrates excellent electrochemical performance, taking a step towards the development of the third-generation glucose biosensor.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Microbiology
Dawn E. Holmes, Jinjie Zhou, Toshiyuki Ueki, Trevor Woodard, Derek R. Lovley
Summary: The study demonstrates that the genetically tractable methanogen Methanosarcina acetivorans can grow via direct interspecies electron transfer (DIET) in coculture with Geobacter metallireducens. Transcriptomic analysis reveals higher expression of outer-surface multi-heme c-type cytochrome MmcA during DIET-based growth, while deletion of mmcA inhibits DIET. Additionally, the study provides insights into the potential role of aromatic amino acids in forming electrically conductive archaella and the involvement of membrane-bound complexes in energy production from carbon dioxide reduction during DIET.
Article
Engineering, Environmental
Junlin Wen, Daigui He, Tongye Zhuo, Wanqing Li, Jianbo Liu, Jialin Wu, Yurong Zhao, Yong Yuan
Summary: In this study, a simple and effective method for hydrogen peroxide (H2O2) detection using electroactive bacteria (EAB) as a whole-cell biosensor was proposed. The method utilized the multi-heme c-type cytochromes of Shewanella oneidensis MR-1 to catalyze the oxidation of tetramethylbenzidine in the presence of H2O2. The method showed a wide dynamic range and low detection limit for H2O2 detection, and when coupled with glucose oxidase, it also exhibited high sensitivity and broad linear range for glucose detection.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Mengfei Hou, Haiyang Su, Qinghe Wu, Wenshe Sun, Pengli Zhang, Yifei Jiang, Kun Qian, Chunfu Zhang
Summary: Altered cancer cell metabolism reshapes the tumor microenvironment, leading to glucose addiction and high antioxidant levels. Researchers have developed a Pd/Pt/Au tri-metallic nanoparticle coated with a pH-responsive tannic acid-iron ion network to reprogram nutrients and redox metabolisms in order to enhance radioimmunotherapy. This nanoparticle functions as a nanoreactor, consuming glucose and disrupting redox homeostasis in the tumor microenvironment to sensitize cancer cells to radiotherapy and inhibit tumor progression. Furthermore, it can promote the polarization of pro-inflammatory macrophages and suppress the proliferation of cancer-associated fibroblasts, overcoming immunosuppression caused by radiotherapy and inhibiting excessive tissue fibrosis, thus enhancing antitumor immunity and suppressing tumor metastasis.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Analytical
V. Sunil Kumar, Shekher Kummari, Gaelle Catanante, K. Vengatajalabathy Gobi, Jean Louis Marty, K. Yugender Goud
Summary: A label-free electrochemical impedimetric immunosensor was developed for rapid and sensitive detection of zearalenone (ZEN) using palladium nanoparticle embedded functionalized carbon nanotube-chitosan (SPCE/CS-CNT-Pd) modified electrode. The structure of the nanocomposite was analyzed and verified using X-ray diffraction, transmission electron microscopy, and energy dispersive X-ray spectroscopy. The coexistence of Pd nanoparticles with CNTs enhanced the conductivity and catalytic properties of the transducer surface, as well as improved antibody immobilization. The immunosensor showed high sensitivity and simplicity compared to conventional methods and successfully detected ZEN in corn samples with good recovery values.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Yuning Wang, Yu Liu, Shouzhi Yang, Jia Yi, Xiaoyu Xu, Kun Zhang, Baohong Liu, Kun Qian
Summary: A multifunctional self-assembled AuNPs array (MSANA)-based LDI-MS platform was developed for direct amino acids analysis and metabolic profiling in patient CSF samples. The platform demonstrated high selectivity and micromolar sensitivity for capturing and analyzing aromatic amino acids. It also exhibited excellent reproducibility (RSD < 10%) compared to the widely used direct matrix spotting approach (RSD < 44%). The platform was successfully used for metabolic profiling of CSF, enabling the discrimination of medulloblastoma patients from non-tumor controls within minutes. Overall, the MSANA-based LDI-MS platform shows potential clinical values for large-scale metabolic diagnostics and pathogenic mechanism study.
Review
Chemistry, Multidisciplinary
Jianing Li, Wanyue Lu, Yannan Yang, Ruiqing Xiang, Yun Ling, Chengzhong Yu, Yaming Zhou
Summary: Nano-immunotherapy, a combination of nanotechnology and immunotherapy, is considered a highly promising strategy for cancer treatment. Hybrid nanomaterials, consisting of different organic and inorganic components, have been engineered with integrated functions and potential for boosting cancer immunotherapy. This review summarizes the use of hybrid nanomaterials in cancer immunotherapy, including metal-organic frameworks, metal-phenolic networks, organosilica nanoparticles, metallofullerene nanomaterials, polymer-lipid, and biomacromolecule-based hybrids. The review also discusses the combination of immunotherapy with different therapies based on hybrid nanomaterials, such as chemotherapy, photothermal therapy, and radiotherapy.
Article
Chemistry, Multidisciplinary
Tao Yang, Yaowei Jin, Yingchu Wang, Aiguo Kong, Yue Chen, Yingying Zou, Chao Liu, Guangfeng Wei, Chengzhong Yu
Summary: A covalent furan-benzimidazole-linked polymer (Furan-BILP) membrane is reported as a photocatalyst for the production of clean H2O2 in pure water. The membrane delivers clean H2O2 solution directly with a high production rate. The strategy of combining molecular engineering and macrostructural engineering may be applied to design other coordination organic polymer photocatalysts with improved performance.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ling Yuan, Chaoqi Zhang, Yingying Zou, Tong Bao, Jing Wang, Cheng Tang, Aijun Du, Chengzhong Yu, Chao Liu
Summary: Constructing MOF-on-MOF heterojunction with elaborate charge transfer and interface can greatly enhance the photocatalytic properties of MOFs. In this study, a Step-scheme (S-scheme) MIL125-NH2@CoFe Prussian blue analogue (PBA) heterojunction was reported for the first time. The designed MOF-on-MOF heterojunction demonstrated significantly enhanced photocatalytic activity for degrading various organic pollutants, which was attributed to the internal electric field and increased active site exposure.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Environmental Sciences
Jun Zhang, Sukitha Kothalawala, Chengzhong Yu
Summary: In the past decade, nanopesticides have been rapidly developed as effective and safe alternatives to conventional pesticides. Various nanotechnologies, such as pesticide nanoemulsions, polymer-based nanopesticides, and metal/metal oxide nanoparticle-based pesticides, have been extensively reviewed. Engineered silica nanomaterials (ESNs) have shown promising potential as carriers in nanopesticides for modern agriculture. However, there is limited research specifically on ESN-based nanopesticides. This comprehensive review provides an introduction to synthetic technology, formation mechanism, and surface engineering technology. The advantages of ESN-based pesticide formulation and their structure-function relationship are discussed in detail. Moreover, the challenges and future research in ESN-based nanopesticide development are also discussed.
ENVIRONMENTAL POLLUTION
(2023)
Article
Chemistry, Multidisciplinary
Chaoqi Zhang, Ling Yuan, Chao Liu, Zimeng Li, Yingying Zou, Xinchan Zhang, Yue Zhang, Zhiqiang Zhang, Guangfeng Wei, Chengzhong Yu
Summary: An elaborate design enables the precise control of Zn/Co bimetallic zeolite imidazole frameworks (ZnCo-ZIFs) and makes them excellent 2e-ORR electrocatalysts. The control at both atomic and nano-scale regulates the role of water molecules and adjusts the coordination unsaturation degree of active sites. The optimized ZnCo-ZIF exhibits high 2e(-) selectivity and H2O2 yield, paving a new avenue for the development of multivariate MOFs as advanced 2e-ORR electrocatalysts.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Pharmacology & Pharmacy
Yue Zhang, He Xian, Ekaterina Strounina, Kimberley S. Gunther, Matthew J. Sweet, Chen Chen, Chengzhong Yu, Yue Wang
Summary: In this study, tetrasulphide bridged mesoporous organosilica nanoparticles (MONs) were found to have enhanced transfection performance of plasmid DNA (pDNA) in dendritic cell (DC) lines compared to conventional mesoporous silica nanoparticles (MSNs). This enhancement is attributed to the glutathione (GSH) depletion capability of MONs, which increases the activation of the mammalian target of rapamycin complex 1 (mTORc1) pathway and enhances translation and protein expression. The increased transfection efficiency was only observed in high GSH cell lines, validating the mechanism. This study provides a new design principle for nano delivery systems targeting pDNA delivery to DCs.
Review
Chemistry, Analytical
Jagadeeswara Rao Bommi, Shekher Kummari, Kavitha Lakavath, Reshmi A. Sukumaran, Lakshmi R. Panicker, Jean Louis Marty, Kotagiri Yugender Goud
Summary: Cancer is a significant global public health issue, accounting for the second highest number of deaths, especially in low- and middle-income countries. It has a huge economic burden of over a trillion dollars annually. Early detection plays a crucial role in effective treatment and improved survival rates, as a large percentage of cancers are diagnosed at late stages. Biosensors offer promise in the early screening of cancer biomarkers. This review highlights recent findings of novel cancer biomarkers, their advantages over traditional biomarkers, and innovative biosensing and diagnostic methods, aiding in early recognition and treatment monitoring of various human cancers.
Review
Chemistry, Analytical
Marjan Majdinasab, Marc Lamy de la Chapelle, Jean Louis Marty
Summary: Interleukin 6 (IL-6) is a pleiotropic cytokine that exerts pathological pro-inflammatory effects and plays important roles in various biological processes. The detection of IL-6 in small quantities with high selectivity is crucial in medical and biological fields. Conventional laboratory methods such as ELISAs and CLIAs are complex, expensive, and time-consuming, while biosensors offer a simple, rapid, economical, and user-friendly alternative due to their high sensitivity, quick detection time, ease of use, and miniaturization capability.
Article
Chemistry, Analytical
Ahlem Teniou, Ibrahim A. Madi, Riane Mouhoub, Jean Louis Marty, Amina Rhouati
Summary: In this study, a homogeneous technique was developed for sensitive and rapid quantification of hydrogen peroxide using hemoglobin as a bioreceptor. The chemiluminescence reagent luminol served as a peroxidase substrate and generated a chemiluminescent signal when oxidized by hemoglobin. The biosensor demonstrated high selectivity and a detection limit of 0.308 mM, making it a cost-effective and simple method for monitoring peroxidase substrates.
Review
Medicine, General & Internal
Pooyan Makvandi, Hao Song, Cynthia K. Y. Yiu, Rossella Sartorius, Ehsan Nazarzadeh Zare, Navid Rabiee, Wei-Xi Wu, Ana Claudia Paiva-Santos, Xiang-Dong Wang, Cheng-Zhong Yu, Franklin R. Tay
Summary: Fungi and bacteria cause numerous pathogen-related infections and diseases in humans. To specifically target and combat these pathogenic species, novel antimicrobials have been developed. This review highlights the cell wall features and antimicrobial mechanisms of these microorganisms, as well as the design of selective antimicrobials. The recent advances in antimicrobial immunomodulation strategy are also discussed.
MILITARY MEDICAL RESEARCH
(2023)
Review
Engineering, Biomedical
Ziyue Zhang, Shouzhi Yang, Haiyang Su, Kun Qian
Summary: This review provides an overview of the properties and synthesis methods of porous noble metal-based nanomaterials, as well as their applications in various fields of biomedicine. The unique physicochemical properties of porous noble metal-based nanomaterials and their potential in biomedical applications, particularly in optics, electrochemistry, and mass spectrometry, are highlighted.
ADVANCED NANOBIOMED RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Yihan Wang, Shunxiang Li, Kun Qian
Summary: Atmospheric pressure matrix assisted desorption/ionization mass spectrometry (AP MALDI MS) has been widely applied in biomolecular analysis and spatial visualization. Compared to conventional MALDI MS, AP MALDI has comprehensive advantages. Its applications include peptide and protein analysis, metabolite analysis, pharmaceutical analysis, and mass spectrometry imaging. Many advancements have driven the applications of AP MALDI in biomolecular analysis and spatial visualization.
NANOSCALE ADVANCES
(2023)
