Article
Materials Science, Multidisciplinary
Shaohua Dong, Jiankai Xiang, Juan Ji, Yongjin Wang, Gang Zhang, Peng Fu, Jianwu Han, Li Li
Summary: The murals of Ming Dynasty North Mosque in Linqing, Shandong Province, Eastern China, are of significant cultural and historical importance. A comprehensive investigation of the painting materials of the murals was conducted using various analytical techniques. The study revealed the pigments used and the type of adhesive materials employed, as well as a possible restoration period. Furthermore, the mural materials used in the North Mosque were found to be similar to those found in other architectural murals in China.
Article
Chemistry, Analytical
Xin Wang, Gang Zhen, Xinying Hao, Ping Zhou, Zhan Wang, Jia Jia, Yan Gao, Shaohua Dong, Hua Tong
Summary: This study systematically analyzed the mineral pigments, adhesives, and painting techniques of the Eleven-Faced Guanyin statue in Tianjin, China during the Liao Dynasty, revealing the composition of pigments and types of adhesives used in different color areas, as well as the presence of gilding technique in the gold areas.
MICROCHEMICAL JOURNAL
(2021)
Article
Food Science & Technology
Marine Penland, Helene Falentin, Sandrine Parayre, Audrey Pawtowski, Marie-Bernadette Maillard, Anne Thierry, Jerome Mounier, Monika Coton, Stephanie-Marie Deutsch
Summary: During the production of Pe?lardon cheese, microbial diversity increases, with Lactococcus lactis identified as the main acidifying bacterium and playing a key role in amino acid metabolism alongside L. mesenteroides and Geotricium candidum. These three species dominate in the whey. Meanwhile, other species like L. paracasei, Enterococcus faecalis, Penicillium commune, and Scopulariopsis brevicaulis, which likely come from the cheese-making environment, are positively correlated with the unique aroma of Pe?lardon cheese.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Article
Polymer Science
Hye Hyun Yu, Jung-Ah Lim, Seung Wook Ham, Kang-Bong Lee, Yeonhee Lee
Summary: Researchers evaluated the compositions of Japanese and Vietnamese lacquers, and blends of the two, using various analytical techniques, providing quantitative results. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) offered quantitative results for blended lacquers and structural information, while pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) and high-performance liquid chromatography (HPLC) obtained linear calibration curves and gave essentially the same results for unknown mixtures.
Article
Polymer Science
Antia Lestido-Cardama, Patricia Vazquez-Loureiro, Raquel Sendon, Juana Bustos, Ma Isabel Santillana, Perfecto Paseiro Losada, Ana Rodriguez Bernaldo de Quiros
Summary: This study investigated polyester coatings intended for food contact. Various analytical techniques were used to identify the type of coating and investigate potential migrants. The results showed that certain polyester oligomers migrated, and there is currently no toxicological data or migration limits established for them.
Article
Environmental Sciences
Zhi-Cong Wang, Pei-Gao Duan, Kai Wang
Summary: A Pyroprobe 5000 pyrolyzer connected to Py-GC-TOF-MS was used to analyze the decomposition behavior of waste tires. The study found that temperature and time had significant effects on the molecular composition and relative contents of the liquid products. The addition of zeolites also greatly affected the composition of the liquid products.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Bongekile Vilakati, V Sivasankar, Hlengilizwe Nyoni, Bhekie B. Mamba, Kiyoshi Omine, Titus A. M. Msagati
Summary: Wastewater treatment plants in South Africa, like most around the world, struggle to effectively remove microplastics, especially those less than 100 μm in size. A study in Gauteng Province found that the prevalent microplastics in wastewaters mainly consist of PVC, PA, PET, and PE, with potential additives making up a portion of the composition. SEM images showed the tangled fibrous nature of the microplastics, while FTIR and thermal studies revealed information about functional groups and residues in the samples.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Agricultural Engineering
Faezeh Jame-Chenarboo, Atousa Aliahmadi, Saba Khavari, Farhad Habibi, Rezvan Esmaeili, Alireza Ghassempour
Summary: In this study, a cell-free reaction for the production of (-)-menthol was introduced. Recombinant MMR protein was expressed in Escherichia coli and purified with high efficiency. The reductase activity and stereospecific activity of recombinant MMR were analyzed, and (-)-menthol with expected chirality was successfully synthesized.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Chemistry, Multidisciplinary
Rodica-Mariana Ion, Lorena Iancu, Ramona Marina Grigorescu, Sofia Slamnoiu-Teodorescu, Ioana Daniela Dulama, Ioan Alin Bucurica
Summary: Currently, around 70% of paintings in museum collections have been affected by the presence of metallic soaps, causing surface alterations such as exfoliation, cracking, and the formation of surface skins. This study investigates the icon paintings from Saint Mary Monastery in Romania, which have undergone restoration procedures. The presence of efflorescence and its correlation with the conversion of fatty acids into metallic soaps through the reaction of metals in the pigments and binder make this study highly significant. The analysis conducted using various microscopic techniques and spectroscopy methods provides insights into the identification and quantification of metallic soaps generated as white deposits.
APPLIED SCIENCES-BASEL
(2023)
Article
Agriculture, Multidisciplinary
Igor Moreira, Jessica Costa, Leonardo Vilela, Nelson Lima, Cledir Santos, Rosane Schwan
Summary: This study evaluated the impact of different starter cultures on the fermentation of different cocoa hybrids, showing that co-culturing S. cerevisiae and P. kluyveri can lead to the production of sweeter and more preferred chocolates. Analysis of volatile organic compounds (VOCs) and protein profiles during fermentation revealed significant changes, indicating the influence of microbial cultures on chocolate sensory characteristics. Further research is needed to understand the dynamics of protein degradation during inoculated fermentations.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Food Science & Technology
Weili Li, Huanzhen Zhou, Shanshan Yao, Ning Wang, Hui Zhu, Muhammad Aamer Mehmood, Tao Wu
Summary: This study comprehensively investigated the structural features of theabrownin in Tibetan tea using advanced analytical techniques. The results revealed the molecular weight and thermal degradation products of theabrownin, and highlighted the crucial role of hydrochloric acid and thiolysis hydrolysis techniques in elucidating its complex composition and structure.
Article
Polymer Science
Rosa Costantini, Luca Nodari, Jacopo La Nasa, Francesca Modugno, Lucia Bonasera, Sara Rago, Alfonso Zoleo, Stefano Legnaioli, Patrizia Tomasin
Summary: This study investigates the instability of polyurethane foam used in artworks, which requires careful conservation strategies. Various analytical techniques were used to characterize the main components and additives of the foam. Morphological changes and harmful environmental factors were also studied. The findings provide important insights for preventive conservation of these artworks.
Article
Chemistry, Analytical
Raquel Marques, Michel Sablier, Jaap J. Boon, Gauthier Rose, Leslie Carlyle, Isabel Pombo Cardoso, Laurence De Viguerie
Summary: This study analyzed brown bitumen oil paint reconstructions based on 19th century production records using thermal chemical analysis methods. It found that the asphalt markers in Trinidad Lake asphalt (TLA) were no longer detectable after heat processing, providing a possible explanation for the lack of evidence in previous studies.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Chao Han, Chaoqun Huang, Qinting Jiang, Li Chen, Yi Li, Chengjie Lou, Hailing Lu, Yan Shen
Summary: A novel and accurate method for the determination of folpet and phthalimide residues in tea has been developed, using solid-phase extraction combined with gas chromatography-tandem mass spectrometry. The method proposes converting all folpet to phthalimide prior to sample extraction and purification, and utilizes an isotopic internal standard for quantification. The study confirms the accurate determination of phthalimide content and its conversion to folpet content.
MICROCHEMICAL JOURNAL
(2022)
Article
Engineering, Multidisciplinary
Na Wang, An Gu, Yong Lei
Summary: This study used a micro-UV/Py-GC/MS system to investigate the volatile products released by urushi lacquer film during aging under UV-irradiation and proposed parameters for evaluating its aging degree. The results showed that UV-irradiation caused degradation of polysaccharides and photo-oxidation of urushiol polymer in the lacquer, generating various oxidation products. The proposed parameters were further validated through the evaluation of urushi-contained samples collected from a carved lacquer panel in the Forbidden City.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Cosima Damiana Calvano, Ilario Losito, Tommaso Cataldi
Summary: This special issue focuses on the contribution of dysregulation of lipid signaling and metabolism to neurodegenerative diseases, including Alzheimer's and Parkinson's, summarizing three reviews and one research article.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Andrea Castellaneta, Ilario Losito, Davide Coniglio, Beniamino Leoni, Pietro Santamaria, Maria Antonietta Di Noia, Luigi Palmieri, Cosima Damiana Calvano, Tommaso R. Cataldi
Summary: An automated workflow named LIPIC is proposed for correcting isotopic interference in the analysis of phospholipid mixtures by liquid chromatography, improving accuracy through precise signal intensities prediction and correction.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2021)
Article
Agriculture, Multidisciplinary
Andrea Castellaneta, Ilario Losito, Beniamino Leoni, Pietro Santamaria, Cosima Damiana Calvano, Tommaso R. Cataldi
Summary: Microgreens are a special type of vegetal product with potentially high content of various nutrients, including glycerophospholipids. The study found that glycerophospholipids in different microgreens are rich in essential fatty acids, which can serve as additional sources in vegetarian/vegan diets.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemical Research Methods
Davide Coniglio, Giovanni Ventura, Cosima D. Calvano, Ilario Losito, Tommaso R. Cataldi
Summary: This study presents a new method to determine the carbon-carbon double bond positions of fatty acyl chains in water-soluble diacyl arsenosugar phospholipids (As-PL). Using this method, abundant unsaturated fatty acids were found in the brown alga wakame, confirming it as a good source of essential fatty acids with a balanced omega 6/omega 3 ratio.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Article
Biochemistry & Molecular Biology
Antonio Monopoli, Giovanni Ventura, Andrea Aloia, Fulvio Ciriaco, Angelo Nacci, Tommaso R. Cataldi, Cosima D. Calvano
Summary: This study explored the rational design of matrix for enhanced sensitivity and overall performance of matrix-assisted laser desorption/ionization mass spectrometry. Various matrices with different functionalities and substituents were synthesized and tested across different sample types. The results demonstrated improved performance in terms of ionization capability and interference-free spectra, especially for the analysis of phospholipids and neutral lipids.
Article
Chemistry, Analytical
Mariachiara Bianco, Giovanni Ventura, Cosima Damiana Calvano, Ilario Losito, Tommaso R. Cataldi
Summary: With the introduction of novel nutrient sources with high protein content in the consumer market, safety evaluation studies on potentially allergenic proteins are necessary. This study presents a method for establishing sequence-based homology between proteins of spirulina and chlorella micro-algae and known allergens through database searches. Several potentially allergenic proteins were identified, and further immunochemical tests are required to confirm their allergenicity.
Editorial Material
Food Science & Technology
Cosima D. Calvano, Antonia Tamborrino
Article
Biochemical Research Methods
Andrea Castellaneta, Ilario Losito, Giovanni Cisternino, Beniamino Leoni, Pietro Santamaria, Cosima Damiana Calvano, Giuliana Bianco, Tommaso R. I. Cataldi
Summary: An analytical approach based on RPLC-ESI-(-)-FTMS was developed for the untargeted characterization of glucosinolates in the polar extracts of four Brassica microgreen crops. The method involved the systematic fragmentation of all ions generated in the electrospray source, followed by the acquisition of an FTMS spectrum. The identification of GSL was achieved by recognizing the best qualifying product ions and aligning the peaks detected in the EIC traces.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Article
Biochemistry & Molecular Biology
Nicola Giangregorio, Annamaria Tonazzi, Cosima Damiana Calvano, Ciro Leonardo Pierri, Giovanna Incampo, Tommaso R. I. Cataldi, Cesare Indiveri
Summary: The effect of mycotoxin patulin on the mitochondrial carnitine/acylcarnitine carrier was investigated. Patulin inhibited the transport function of the carrier in a competitive manner, interacting with a protein region including the substrate-binding area. Site-directed mutagenesis confirmed the key role of the C136 residue in the inhibition of patulin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Marco Bottin, Graziano Di Carmine, Olga Bortolini, Carmela De Risi, Monica Bertoldo, Tommaso R. I. Cataldi, Cosima D. Calvano, Alessandro Massi, Daniele Ragno
Summary: This article presents an alternative synthetic route to macrocyclic oligoesters (MCOs) using N-heterocyclic carbene (NHC) catalysis under highly diluted oxidative conditions. The method allows for the straightforward access to MCOs using commercial dialdehydes, without the use of toxic diacyl chlorides commonly employed in traditional processes. The method is metal-free, takes place in a green solvent, and uses a recyclable quinone oxidant.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Ramona Abbattista, Ilario Losito, Graziana Basile, Andrea Castellaneta, Giovanni Ventura, Cosima Damiana Calvano, Tommaso R. I. Cataldi
Summary: Reversed-phase liquid chromatography and electrospray ionization with Fourier-transform single and tandem mass spectrometry were used to characterize the structure of oleocanthal (OLEO) and oleacin (OLEA), two important bioactive compounds in extra virgin olive oil. The presence of multiple isoforms of OLEO and OLEA was observed, along with minor peaks of oxidized OLEO. The correlation between chromatographic peaks and specific isoforms was elucidated through H/D exchange experiments, revealing the prevalence of Open Forms II as the main isoforms.
Article
Materials Science, Multidisciplinary
Elena C. L. Rigante, Cosima D. Calvano, Rosaria A. Picca, Francesca Modugno, Tommaso R. I. Cataldi
Summary: In recent decades, modern murals and graffiti have gained attention as valuable artistic expressions that need to be preserved. Understanding the chemical composition of spray paints used in these artworks is crucial for their conservation. This study used various analytical techniques to investigate the composition of two yellow varnishes, revealing the use of acrylic and styrene-acrylic resins as binders, as well as the presence of silicone-based additives.
Article
Chemistry, Physical
Valentina Petrelli, Giuseppe Romanazzi, Cecilia Mortalo, Cristina Leonelli, Mauro Zapparoli, Elvira De Giglio, Cosima Damiana Calvano, Maria Michela Dell'Anna, Piero Mastrorilli
Summary: A nitrogen-doped polymer supported cobalt catalyst (Co-pol) was synthesized and used as an active and recyclable catalyst for nitroarene reduction. The catalysis was truly heterogeneous and prevented hydrodehalogenation. STEM and EDS analyses confirmed the presence of cobalt(0) nanoparticles as the active species. Nitrogen atoms in the catalytic support played a beneficial role in the catalytic activity.
MOLECULAR CATALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Giovanni Ventura, Davide Mesto, Davide Blasi, Tommaso R. I. Cataldi, Cosima Damiana Calvano
Summary: This study investigated the differences in the ethanolic extract of dried walnut shells obtained through hammer milling and ball milling grinding processes. The study analyzed the fatty acids and phenolic compounds in the extracts and found that the composition varied depending on the milling method used. The presence of potential active secondary metabolites was also explored, providing valuable information for potential applications in industries such as biorefinery and pharmaceuticals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Horticulture
Onofrio Davide Palmitessa, Andrea Castellaneta, Annalisa Somma, Adriano Didonna, Massimiliano Renna, Ilario Losito, Cosima Damiana Calvano, Tommaso R. I. Cataldi, Pietro Santamaria
Summary: Scopatizzo, a local variety of melon from Southern Italy, is consumed as an unripe melon alternative to cucumber due to its better quality profile and lack of cucurbitacins. However, recent analysis has found the presence of cucurbitacins in some bitter-tasting Scopatizzo fruits, raising concerns about potential genotypes not suitable for commercialization.
Article
Chemistry, Analytical
Michel Rocha Baqueta, Augusto Cesar Costa-Santos, Ana Paula Rebellato, Gisele Marcondes Luz, Juliana Azevedo Lima Pallone, Federico Marini, Alexsandro Lara Teixeira, Douglas N. Rutledge, Patricia Valderrama
Summary: This study reports the essential element composition of new Brazilian Canephora coffees and applies chemometric tools for analysis. The results demonstrate the suitability of this method for origin and species discrimination based on the inorganic fraction of coffee.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mengjie Li, Jiapeng Wang, You Zhou, Yang Chen, Lingying Xia
Summary: A novel photoelectrochemical biosensor based on gold nanoparticles and specific structures was developed for highly sensitive detection of mercury ion. The multiple sandwich structures hindered electron supply and light harvesting, resulting in a weakened PEC signal, while the specific structures extinguished the PEC signal, enabling quantitative detection of Hg2+. The sensor exhibited high selectivity and stability, with potential applications in environmental detection, biological analysis, and medical research.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mohamed A. Korany, Rasha M. Youssef, Marwa A. A. Ragab, Mostafa A. Afify
Summary: A stability-indicating fit-for-purpose method was developed for the determination of HC, TL, and PS in syrup dosage form. The method successfully separated CL from THY and quantified the analytes using HPLC-DAD. The robustness of the method was assessed through statistical analysis and self-validation.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Lingling Lin, Minyu Li, Ping Li, Chenqing Ye, Huanglong Zhuang, Shaohuang Weng, Feng Chen
Summary: This study developed a highly sensitive and selective electrochemical sensor for simultaneous detection of dopamine and uric acid. The sensor exhibited excellent anti-interference and stability, and could accurately measure dopamine and uric acid in human urine samples.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Peifang Chen, Caiyun Jiang, Zhouping Wang, Hong-zhen Lian, Xiaoyuan Ma
Summary: In this study, a high-performance SERS-active aptasensor was successfully developed for the quantitative analysis of AFB1 in cereal grains, which is of great significance in the field of food safety.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
E. Abas, C. Marina-Montes, C. Perez-Marin, J. Puimedon, J. Anzano
Summary: This study conducted a comprehensive measurement of natural and anthropogenic radionuclides in soil, water, and air in different locations around Deception Island in Antarctica. The results revealed significant levels of 210Pb and anthropogenic 137Cs in soil samples near old human settlements and facilities, as well as detectable levels of 137Cs and 60Co in water samples from old hunting areas. The findings also suggested potential resuspension processes based on higher-than-expected air quality results.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Joao Franciso Allochio, Nayara A. dos Santos, Nathalia dos S. Conceicao, Clara S. D. Baptista, Keyller B. Borges, Valdemar Lacerda Jr, Wanderson Roma
Summary: This study developed a fiber spray ionization mass spectrometry (FSI-MS) method, which shows great potential in detecting illicit drugs. Compared with paper spray ionization mass spectrometry (PSI-MS), FSI-MS demonstrates higher sensitivity in COC detection.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Dina A. Ahmed, Ola G. Hussein, Mamdouh R. Rezk, Mohamed Abdelkawy, Yasmin Rostom
Summary: The main goal of this study was to develop two green chromatographic techniques, HPLC and TLC, for the determination of alcaftadine (ALF) in pharmaceutical formulation and biological samples. The developed HPLC technique showed high efficiency and minimal environmental impact, successfully identifying ALF in the presence of its degradate. The TLC method provided a stability indicating study for ALF and was determined to be safe, green, and eco-friendly.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Abdullah Taner Bisgin
Summary: A green, speedy, and handy method for separation and determination of four commonly used food colorants was established using vortex assisted sequential-simultaneous liquid phase micro-extraction (VA-SS-LPME). The method does not require any instrumental chromatographic techniques. The procedure includes sequential separation steps using different extractants and simultaneous UV-vis spectrophotometric determination steps. The method is environmentally friendly and applicable for determination of colorants in food and pharmaceuticals.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Yifan Zhang, Tong Zhang, Wenjing Ba, Li Liu, Yuan Rao, Xiaodan Zhang, Hanhan Zhang, Xiu Jin
Summary: This paper proposes a novel spectral transfer modelling method based on neural network architecture searching for the asymptomatic prediction of Akizuki pear cork spot disorder. The experiments show that the model by this method is more effective, achieving an accuracy of 82.61%.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Krzysztof Greda, Maja Welna, Anna Szymczycha-Madeja, Pawel Pohl
Summary: For the first time, a dispersive micro-solid phase extraction (D-mu SPE) based on graphene oxide was used for the ultrasensitive determination of Cd. With this method, Cd can be efficiently extracted from a mixture of alkali and alkaline earth metals without the need for an elution step. The combination of D-mu SPE and SAGD OES significantly reduces matrix effects and improves the tolerance of Cd to alkali metals. The method shows simplicity in the measurement system and the commercially available nanosorbent used.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
P. K. Fathima Anjila, G. R. Tharani, Anand Sundaramoorthy, Venkat Kumar Shanmugam, Karthikeyan Subramani, Shanmugavel Chinnathambi, Ganesh N. Pandian, Vimala Raghavan, Andrews Nirmala Grace, Singaravelu Ganesan, Mangaiyarkarasi Rajendiran
Summary: This work proposes a rapid and sensitive spectroscopic method for detecting melamine in food products using rare-earth Terbium-doped Graphene Quantum Dots (Tb-GQDs) synthesized by microwave and simple chemical conjugation methods. The synthesized Tb-GQDs show a spherical shape with a size of approximately 6 nm and a quantum yield of 52%. The maximum detection limit for melamine concentration in milk and milk products is found to be 0.31 μM. The dual emitting Tb-GQDs provide a sensitive and effective platform for real-time detection of melamine in food samples, particularly in milk, and show promising potential in the food industry.
MICROCHEMICAL JOURNAL
(2024)
Review
Chemistry, Analytical
Piyush Dey, Mandeep Kaur, Akhil Khajuria, Dilmeet Kaur, Manpreet Singh, Hema Kumari Alajangi, Neha Singla, Gurpal Singh, Ravi Pratap Barnwal
Summary: Environmental issues, such as the uncontrolled release of dangerous pollutants, have significant impacts on human health. Traditional methods for detecting pollutants require specialized personnel and equipment, but nanotechnology has improved the performance of biosensors. This article discusses the use of nanotechnology in pollutant detection and the associated techniques.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Sa Dong, Qiuyun Shi, Lingjun Guan, Yulong Wang, Pengyan Liu, Cunzheng Zhang, Jianguo Feng
Summary: In this study, a highly sensitive indirect competitive chemiluminescence enzyme immunoassay (icCLEIA) method was developed for the determination of sodium pentachlorophenolate (PCP-Na) and its metabolite pentachlorophenol (PCP). The method showed high specificity and affinity with a detection limit of 0.0032 ng/mL for PCP-Na and 0.0192 ng/mL for PCP. The method had no cross reaction with other chlorophenols compounds except for PCP. The average recoveries in chicken, pork and fish samples were 81.3-105.8% with low coefficient of variation (CV).
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Palaniappan Ilayaraja, Murugan Manivannan, Paramasivam Parthiban
Summary: Nirmatrelvir, an antiviral drug used for the treatment of COVID-19, has been recommended by the World Health Organization. We developed an optimized analytical method for the quantification of Nirmatrelvir and its products, with high sensitivity and a wide linear range. The method also meets the requirements for greenness evaluation.
MICROCHEMICAL JOURNAL
(2024)
