Tuning the dials of Synthetic Biology

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

(2013) Lei S. Qi et al.   CELL

Overcoming mutation-based resistance to antiandrogens with rational drug design

(2013) Minna D Balbas et al.   eLife

To the pore and through the pore: A story of mRNA export kinetics

(2012) Marlene Oeffinger et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data

(2012) Richard N. Smith et al.   BIOINFORMATICS

A modular cell-based biosensor using engineered genetic logic circuits to detect and integrate multiple environmental signals

(2012) Baojun Wang et al.   BIOSENSORS & BIOELECTRONICS

Designing Synthetic Regulatory Networks Capable of Self-Organizing Cell Polarization

(2012) Angela H. Chau et al.   CELL

Towards synthetic microbial consortia for bioprocessing

(2012) Jasmine Shong et al.   CURRENT OPINION IN BIOTECHNOLOGY

Engineering and ethical perspectives in synthetic biology

(2012) James Anderson et al.   EMBO REPORTS

Squeeze-and-breathe evolutionary Monte Carlo optimization with local search acceleration and its application to parameter fitting

(2012) M. Beguerisse-Diaz et al.   Journal of the Royal Society Interface

Predictive design of mRNA translation initiation region to control prokaryotic translation efficiency

(2012) Sang Woo Seo et al.   METABOLIC ENGINEERING

Genetic programs constructed from layered logic gates in single cells

(2012) Tae Seok Moon et al.   NATURE

Iterative plug-and-play methodology for constructing and modifying synthetic gene networks

(2012) Kevin D Litcofsky et al.   NATURE METHODS

Foundations for the design and implementation of synthetic genetic circuits

(2012) Adrian L. Slusarczyk et al.   NATURE REVIEWS GENETICS

De novo design of a synthetic riboswitch that regulates transcription termination

(2012) M. Wachsmuth et al.   NUCLEIC ACIDS RESEARCH

Comparison of mRNA features affecting translation initiation and reinitiation

(2012) Ilya A. Osterman et al.   NUCLEIC ACIDS RESEARCH

The Standard European Vector Architecture (SEVA): a coherent platform for the analysis and deployment of complex prokaryotic phenotypes

(2012) Rafael Silva-Rocha et al.   NUCLEIC ACIDS RESEARCH

Fine-tuning gene networks using simple sequence repeats

(2012) R. G. Egbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic switchboard for synthetic biology applications

(2012) J. M. Callura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Biology 2.0

(2012) Wendell A. Lim et al.   TRENDS IN CELL BIOLOGY

Automated Design of Genetic Toggle Switches with Predetermined Bistability

(2012) Shuobing Chen et al.   ACS Synthetic Biology

Genetic Circuits in Salmonella typhimurium

(2012) Arthur Prindle et al.   ACS Synthetic Biology

Tuning Promoter Strength through RNA Polymerase Binding Site Design in Escherichia coli

(2012) Robert C. Brewster et al.   PLoS Computational Biology

Codon usage: Nature's roadmap to expression and folding of proteins

(2011) Evelina Angov   Biotechnology Journal

Computational design approaches and tools for synthetic biology

(2011) James T. MacDonald et al.   Integrative Biology

The Role of Recombination for the Coevolutionary Dynamics of HIV and the Immune Response

(2011) Rafal Mostowy et al.   PLoS One

Growth-Rate Dependence Reveals Design Principles of Plasmid Copy Number Control

(2011) Stefan Klumpp   PLoS One

Fundamental relationship between operon organization and gene expression

(2011) H. N. Lim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid optimization of gene dosage in E. coli using DIAL strains

(2011) Joshua T Kittleson et al.   Journal of Biological Engineering

Synthetic Riboswitches That Induce Gene Expression in Diverse Bacterial Species

(2010) S. Topp et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Inteins, valuable genetic elements in molecular biology and biotechnology

(2010) Skander Elleuche et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Mathematical modeling of translation initiation for the estimation of its efficiency to computationally design mRNA sequences with desired expression levels in prokaryotes

(2010) Dokyun Na et al.   BMC Systems Biology

A comparative analysis of synthetic genetic oscillators

(2010) O. Purcell et al.   Journal of the Royal Society Interface

Switchable genetic oscillator operating in quasi-stable mode

(2010) N. Strelkowa et al.   Journal of the Royal Society Interface

In vivo imaging of labelled endogenous β-actin mRNA during nucleocytoplasmic transport

(2010) David Grünwald et al.   NATURE

Fundamental limits on the suppression of molecular fluctuations

(2010) Ioannis Lestas et al.   NATURE

Design, construction and characterization of a set of insulated bacterial promoters

(2010) J. H. Davis et al.   NUCLEIC ACIDS RESEARCH

Reengineering orthogonally selective riboswitches

(2010) N. Dixon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interdependence of Cell Growth and Gene Expression: Origins and Consequences

(2010) M. Scott et al.   SCIENCE

Defining Network Topologies that Can Achieve Biochemical Adaptation

(2009) Wenzhe Ma et al.   CELL

Growth Rate-Dependent Global Effects on Gene Expression in Bacteria

(2009) Stefan Klumpp et al.   CELL

Group I Introns and Inteins: Disparate Origins but Convergent Parasitic Strategies

(2009) R. Raghavan et al.   JOURNAL OF BACTERIOLOGY

Diversity-based, model-guided construction of synthetic gene networks with predicted functions

(2009) Tom Ellis et al.   NATURE BIOTECHNOLOGY

Automated design of synthetic ribosome binding sites to control protein expression

(2009) Howard M Salis et al.   NATURE BIOTECHNOLOGY

Emergent bistability by a growth-modulating positive feedback circuit

(2009) Cheemeng Tan et al.   Nature Chemical Biology

The second wave of synthetic biology: from modules to systems

(2009) Priscilla E. M. Purnick et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Delay-Induced Degrade-and-Fire Oscillations in Small Genetic Circuits

(2009) William Mather et al.   PHYSICAL REVIEW LETTERS

Design Parameters to Control Synthetic Gene Expression in Escherichia coli

(2009) Mark Welch et al.   PLoS One

Traceless protein splicing utilizing evolved split inteins

(2009) S. W. Lockless et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coding-Sequence Determinants of Gene Expression in Escherichia coli

(2009) G. Kudla et al.   SCIENCE

Design Principles for Riboswitch Function

(2009) Chase L. Beisel et al.   PLoS Computational Biology

Measuring the activity of BioBrick promoters using an in vivo reference standard

(2009) Jason R Kelly et al.   Journal of Biological Engineering

Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

(2008) Arjun Raj et al.   CELL

Intron length increases oscillatory periods of gene expression in animal cells

(2008) I. A. Swinburne et al.   GENES & DEVELOPMENT

Recognition of misfolded proteins by Lon, a AAA+ protease

(2008) E. Gur et al.   GENES & DEVELOPMENT

σ54-Promoter Discrimination and Regulation by ppGpp and DksA

(2008) Lisandro M. D. Bernardo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A fast, robust and tunable synthetic gene oscillator

(2008) Jesse Stricker et al.   NATURE

Refinement and standardization of synthetic biological parts and devices

(2008) Barry Canton et al.   NATURE BIOTECHNOLOGY

New pSC101-derivative cloning vectors with elevated copy numbers

(2008) James Peterson et al.   PLASMID

Small-scale copy number variation and large-scale changes in gene expression

(2008) Y. Mileyko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolving Lac repressor for enhanced inducibility

(2008) O. Satya Lakshmi et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Protein Translocation Across the Bacterial Cytoplasmic Membrane

(2007) Arnold J.M. Driessen et al.   Annual Review of Biochemistry