期刊
JOURNAL OF THE ROYAL SOCIETY INTERFACE
卷 7, 期 48, 页码 1071-1082出版社
ROYAL SOC
DOI: 10.1098/rsif.2009.0487
关键词
synthetic biology; oscillatory gene networks; generalized repressilator; travelling waves; stochastic dynamics
资金
- Wellcome Trust [080711/Z/06/Z]
- Biotechnology and Biological Sciences Research Council [BB/F005210/1, BB/C519670/1, BB/F005210/2] Funding Source: researchfish
- BBSRC [BB/F005210/1, BB/F005210/2] Funding Source: UKRI
- Wellcome Trust [080711/Z/06/Z] Funding Source: Wellcome Trust
Ring topologies of repressing genes have qualitatively different long-term dynamics if the number of genes is odd (they oscillate) or even (they exhibit bistability). However, these attractors may not fully explain the observed behaviour in transient and stochastic environments such as the cell. We show here that even repressilators possess quasi-stable, travelling wave periodic solutions that are reachable, long-lived and robust to parameter changes. These solutions underlie the sustained oscillations observed in even rings in the stochastic regime, even if these circuits are expected to behave as switches. The existence of such solutions can also be exploited for control purposes: operation of the system around the quasi-stable orbit allows us to turn on and off the oscillations reliably and on demand. We illustrate these ideas with a simple protocol based on optical interference that can induce oscillations robustly both in the stochastic and deterministic regimes.
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