期刊
MICROBIAL CELL FACTORIES
卷 12, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1475-2859-12-127
关键词
Streptomyces; Two-component systems; Antibiotic production; Secondary metabolism
资金
- Spanish Comision Interministerial de Ciencia y Tecnologia (CICYT) [GEN2003-20245-C09-02]
- Junta de Castilla y Leon (JCyL) [SA072A07, CSI099A12-1]
- Spanish Ministerio de Ciencia e Innovacion (MICINN) [BFU2010-17551]
- Fundacion Ramon Areces
- CSIC
- Botin Foundation
Streptomyces, the main antibiotic-producing bacteria, responds to changing environmental conditions through a complex sensing mechanism and two-component systems (TCSs) play a crucial role in this extraordinary sensing device. Moreover, TCSs are involved in the biosynthetic control of a wide range of secondary metabolites, among them commercial antibiotics. Increased knowledge about TCSs can be a powerful asset in the manipulation of bacteria through genetic engineering with a view to obtaining higher efficiencies in secondary metabolite production. In this review we summarise the available information about Streptomyces TCSs, focusing specifically on their connections to antibiotic production.
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