Review
Pharmacology & Pharmacy
Tian Zhang, Shuai Guo, Fangzhou Li, Xinmiao Lan, Yaru Jia, Jinchao Zhang, Yuanyu Huang, Xing-Jie Liang
Summary: This review emphasizes the importance of timely and accurate assessment and diagnosis for various diseases, introduces the application of molecular imaging technology in disease diagnosis and treatment, and aims to promote the development of related technologies and fields.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Chemistry, Physical
Shira Ben-Shushan, Yifat Miller
Summary: Neurodegenerative diseases are characterized by amyloid deposits due to metal ion imbalance. Previous drug designs failed, while neuropeptides have shown neuroprotective effects and metal chelation abilities. This review suggests future studies on neuropeptides as potential metal chelators in neurodegenerative diseases.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Review
Pharmacology & Pharmacy
Yicheng Wang, Pengwei Wang, Cong Li
Summary: Neurodegenerative diseases (NDs) lead to the progressive degeneration of neurons, with mitochondrial dysfunction playing a crucial role in neuronal loss. Visualizing mitochondrial abnormalities using fluorescence microscopy can help understand ND progression and develop new therapeutic strategies.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Cell Biology
Yi-Yue Zhang, Xi-Sheng Li, Kai-Di Ren, Jun Peng, Xiu-Ju Luo
Summary: Metal homeostasis is crucial for normal brain function and disruptions can lead to neurodegenerative diseases. Metal ions play important roles in CNS development, metabolism, redox reactions, and neurotransmitter transmission. Dysregulation of metal homeostasis can cause neurooxidative stress, excitotoxicity, neuroinflammation, and nerve cell death. This review examines the physiological and pathophysiological functions of metal ions and their channels, as well as their involvement in neurodegenerative diseases. The potential therapeutic targets and current methods of modulating metal ions are discussed.
AGEING RESEARCH REVIEWS
(2023)
Review
Chemistry, Medicinal
Priya Singh, Deepika Singh, Pooja Srivastava, Gauri Mishra, Anjani K. K. Tiwari
Summary: The lack of information about in vivo impairments and tools for assessing brain penetrance and efficiency of newly designed drugs has hindered the development of treatments for new central nervous system diseases.
DRUG DEVELOPMENT RESEARCH
(2023)
Review
Geriatrics & Gerontology
Rae-Ling Lee, Kristen E. Funk
Summary: The blood-brain barrier regulates the passage of cells and molecules to and from the central nervous system. Alzheimer's disease is associated with the breakdown of the blood-brain barrier, allowing harmful substances to enter the brain. Recent studies have shown that subtle changes in the blood-brain barrier occur before the deposition of AD hallmark pathologies. These findings suggest that blood-brain barrier disruption may serve as an early diagnostic marker, although neuroinflammation can complicate the analysis.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Feng Chen, Huiyi Chen, Yanting Chen, Wenyan Wei, Yuanhong Sun, Lu Zhang, Lili Cui, Yan Wang
Summary: Communication between neurons relies on synaptic vesicle exocytosis, a process facilitated by the SNARE complex. Dysfunction of the SNARE complex in synapses may contribute to abnormal neurotransmission and lead to synaptic dysfunction. Research suggests that the SNARE complex could be a significant molecular target in neurological diseases.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Chemistry, Medicinal
Daniel J. Modemann, Andhika B. Mahardhika, Sabrina Yamoune, Anne-Katrin Kreyenschmidt, Frederike Maass, Sarah Kremers, Christian Breunig, Carsten-Oliver Sahlmann, Jan Bucerius, Dietmar Stalke, Jens Wiltfang, Yvonne Bouter, Christa E. Mueller, Caroline Bouter, Birgit Meller
Summary: The study aimed to develop a radiotracer for early diagnosis of neurodegenerative diseases by detecting the expression of cannabinoid subtype 2 receptor (CB2R) using positron emission tomography (PET). Several compounds were synthesized and evaluated, and the most promising candidate was radiolabeled and subjected to preclinical evaluation. The results showed promising potential for clinical application.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chris W. J. van der Weijden, Milena S. Pitombeira, Yudith R. A. Haveman, Carlos A. Sanchez-Catasus, Kenia R. Campanholo, Guilherme D. Kolinger, Carolina M. Rimkus, Carlos A. Buchpiguel, Rudi A. J. O. Dierckx, Remco J. Renken, Jan F. Meilof, Erik F. J. de Vries, Daniele de Paula Faria
Summary: Graph theoretical network analysis can be used to assess subtle changes in brain networks in multiple sclerosis (MS) patients. This study found that lesion filling can increase the detection rate of network alterations in MS, but it also introduces significant artifacts, suggesting that caution should be applied.
INSIGHTS INTO IMAGING
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Marianne Chapleau, Leonardo Iaccarino, David Soleimani-Meigooni, Gil D. Rabinovici
Summary: This article provides an up-to-date overview of the application of amyloid PET in neurodegenerative diseases, including analysis of clinical, pathological, and imaging data, comparison with other available biomarkers, and review of its use in clinical trials and clinical utility studies.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Mukul Jain, Nil Patil, Gholamreza Abdi, Maryam Abbasi Tarighat, Arifullah Mohammed, Muhammad Rajaei Ahmad Mohd Zain, Khang Wen Goh
Summary: Polyglutamine diseases are congenital neurodegenerative diseases caused by genomic abnormalities in specific disease-related genes. Protein aggregates play a toxic role in these diseases and lead to neuronal death. Autophagy, the catabolic process responsible for removing damaged organelles and toxic protein aggregates, is affected in these diseases due to changes in gene expression. Increasing autophagy vesicles may be a result of either increased autophagy or decreased autophagy flux. Modulating autophagy has been shown to enhance the dissolution of toxic aggregates and delay disease progression. This review analyzes the interaction between autophagy and polyglutamine diseases and establishes a therapeutic approach using autophagy-inducing drugs.
Review
Biochemistry & Molecular Biology
Matilde Contardo, Roberta De Gioia, Delia Gagliardi, Giacomo Pietro Comi, Linda Ottoboni, Monica Nizzardo, Stefania Corti
Summary: In vivo cell reprogramming offers a promising approach to generate new neurons in the adult mammalian nervous system, with the successful conversion of glial cells into neurons through the repression of a single gene Ptbp1. However, concerns about the reliability of this strategy, particularly regarding the nature of converted neurons in vivo, necessitate further investigation with stringent lineage tracing methods.
Review
Clinical Neurology
Junjiao Zhang, Jianing Jin, Dongning Su, Tao Feng, Huiqing Zhao
Summary: This study conducted a systematic review and meta-analysis, which revealed that the accumulation of tau protein in the brains of Parkinson's disease patients is associated with cognitive impairment. The tau PET tracer shows potential as a biomarker for the diagnosis of Parkinson's disease cognitive impairment (PDCI).
FRONTIERS IN NEUROLOGY
(2023)
Review
Immunology
Yinwei Chen, Jinghua Zhou, Li Wang
Summary: The human gut microbiome plays a crucial role in human health, and dysbiosis may lead to various chronic diseases. The mechanisms of its impact on neurodegenerative diseases, cardiovascular diseases, metabolic diseases, and gastrointestinal diseases are extremely complex.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lucja Justyna Walczak-Nowicka, Mariola Herbet
Summary: Acetylcholinesterase (AChE) plays a crucial role in the pathogenesis of neurodegenerative diseases, with ongoing research focusing on identifying new AChE inhibitors to potentially treat these diseases. The review highlights the importance of AChE inhibitors and their potential use in developing therapies for neurodegenerative diseases. Further investigations into designing and discovering new drugs targeting AChE may lead to effective treatments for neurodegenerative diseases in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Paul Gelfand, Randy J. Smith, Eli Stavitski, David R. Borchelt, Lisa M. Miller
ANALYTICAL CHEMISTRY
(2015)
Article
Endocrinology & Metabolism
Ryan D. Ross, Maleeha Mashiatulla, Alexander G. Robling, Lisa M. Miller, D. Rick Sumner
CALCIFIED TISSUE INTERNATIONAL
(2016)
Article
Biochemistry & Molecular Biology
Lisa M. Miller, Megan Gragg, Tae Gyun Kim, Paul S. -H. Park
Article
Endocrinology & Metabolism
Ryan D. Ross, Maleeha Mashiatulla, Alvin S. Acerbo, Jonathan D. Almer, Lisa M. Miller, Mark L. Johnson, D. Rick Sumner
CALCIFIED TISSUE INTERNATIONAL
(2016)
Article
Multidisciplinary Sciences
Yuanheng Cai, Kewei Zhang, Hoon Kim, Guichuan Hou, Xuebin Zhang, Huijun Yang, Huan Feng, Lisa Miller, John Ralph, Chang-Jun Liu
NATURE COMMUNICATIONS
(2016)
Article
Biophysics
Yizhi Meng, Meghan E. Faillace, Kathryn Dorst, Samantha J. Palmaccio, Lisa M. Miller, Yi-Xian Qin
Article
Multidisciplinary Sciences
Doga Gursoy, Young P. Hong, Kuan He, Karl Hujsak, Seunghwan Yoo, Si Chen, Yue Li, Mingyuan Ge, Lisa M. Miller, Yong S. Chu, Vincent De Andrade, Kai He, Oliver Cossairt, Aggelos K. Katsaggelos, Chris Jacobsen
SCIENTIFIC REPORTS
(2017)
Article
Chemistry, Multidisciplinary
Vito Graziano, Lisa Miller, Lin Yang
JOURNAL OF APPLIED CRYSTALLOGRAPHY
(2018)
Article
Multidisciplinary Sciences
Tiffany W. Victor, Lindsey M. Easthon, Mingyuan Ge, Katherine H. O'Toole, Randy J. Smith, Xiaojing Huang, Hanfei Yan, Karen N. Allen, Yong S. Chu, Lisa M. Miller
SCIENTIFIC REPORTS
(2018)
Article
Chemistry, Multidisciplinary
Tiffany W. Victor, Katherine H. O'Toole, Lindsey M. Easthon, Mingyuan Ge, Randy J. Smith, Xiaojing Huang, Hanfei Yan, Yong S. Chu, Si Chen, Doga Gursoy, Martina Ralle, Barbara Imperiali, Karen N. Allen, Lisa M. Miller
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Biochemistry & Molecular Biology
Ashwin Ambi, Aleksandra Stanisavljevic, Tiffany W. Victor, Adam W. Lowery, Judianne Davis, William E. Van Nostrand, Lisa M. Miller
Summary: Removing copper does not effectively decrease copper content in vascular amyloid deposits and may even increase the development of disease pathology in cerebral amyloid angiopathy (CAA).
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Adam W. Lowery, Ashwin Ambi, Lisa M. Miller, Jonathan B. Boreyko
Summary: This study demonstrates that using a hygroscopic ice frame in cryomicroscopy can effectively suppress frost growth and improve the visual clarity of specimens.
Article
Biochemistry & Molecular Biology
Tiffany W. Victor-Lovelace, Lisa M. Miller
Summary: X-ray fluorescence microscopy (XFM) is a widely used technique for imaging metal ion concentration and distribution in cells and tissues. To maximize its benefits in bioimaging, the metal ion distribution needs to be visualized within the subcellular context. Various approaches have been developed to create X-ray-sensitive tags for specific organelles or proteins. This review evaluates these tags, discusses scientific findings, and identifies future development needs.
Article
Biochemistry & Molecular Biology
Xiayoue Zhu, Tiffany W. Victor, Ashwin Ambi, Joseph K. Sullivan, Joshua Hatfield, Feng Xu, Lisa M. Miller, William E. Van Nostrand
Article
Chemistry, Analytical
Tiffany Victor, Natalie Delpratt, Sarah Beth Cseke, Lisa M. Miller, Leland James Cseke
ANALYTICAL CHEMISTRY
(2017)