期刊
JOURNAL OF NATURAL PRODUCTS
卷 73, 期 3, 页码 459-462出版社
AMER CHEMICAL SOC
DOI: 10.1021/np900603f
关键词
-
资金
- National Oceanic and Atmospheric Administration [NA05NOS4781194]
- U.S. Geological Survey [07ERAG0079]
A new dolastatin 13 analogue, molassamide (1), was isolated from cyanobacterial assemblages of Dichothrix utahliensis collected from the Molasses Reef, Key Largo, Florida, and from Brewer's Bay, St. Thomas, U.S. Virgin Islands. This is the first peptide reported from the cyanobacterial genus Dichothrix and the first natural product isolated from marine Dichothrix spp. Its planar structure was determined by NNR spectroscopic techniques, and the configurations of the asymmetric centers, were assigned after chiral HPLC analysis of the hydrolysis products. The depsipeptide I exhibited protease-inhibitory activity, with IC50 values of 0.032 and 0.234 mu M against elastase and chymotrypsin, respectively. There was no apparent inhibition of trypsin at 10 mu M the highest concentration tested.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据