Translational readthrough potential of natural termination codons in eucaryotes – The impact of RNA sequence

CRISPR-Cas9: a new and promising player in gene therapy

(2015) Lu Xiao-Jie et al.   JOURNAL OF MEDICAL GENETICS

Translation initiation factor eIF3 promotes programmed stop codon readthrough

(2015) Petra Beznosková et al.   NUCLEIC ACIDS RESEARCH

New insights into stop codon recognition by eRF1

(2015) Sandra Blanchet et al.   NUCLEIC ACIDS RESEARCH

Programmed Translational Readthrough Generates Antiangiogenic VEGF-Ax

(2014) Sandeepa M. Eswarappa et al.   CELL

Ataluren treatment of patients with nonsense mutation dystrophinopathy

(2014) Katharine Bushby et al.   MUSCLE & NERVE

Evidence of efficient stop codon readthrough in four mammalian genes

(2014) Gary Loughran et al.   NUCLEIC ACIDS RESEARCH

Selenoproteins: Molecular Pathways and Physiological Roles

(2014) Vyacheslav M. Labunskyy et al.   PHYSIOLOGICAL REVIEWS

OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation

(2014) R. S. Singleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy

(2014) C. Loenarz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosomal Readthrough at a Short UGA Stop Codon Context Triggers Dual Localization of Metabolic Enzymes in Fungi and Animals

(2014) Alina C. Stiebler et al.   PLoS Genetics

In vitro read-through of phenylalanine hydroxylase (PAH) nonsense mutations using aminoglycosides: a potential therapy for phenylketonuria

(2013) Gladys Ho et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Long-term nonsense suppression therapy moderates MPS I-H disease progression

(2013) Gwen Gunn et al.   MOLECULAR GENETICS AND METABOLISM

Structure of the mammalian ribosomal pre-termination complex associated with eRF1*eRF3*GDPNP

(2013) A. des Georges et al.   NUCLEIC ACIDS RESEARCH

Phase 2a Study of Ataluren-Mediated Dystrophin Production in Patients with Nonsense Mutation Duchenne Muscular Dystrophy

(2013) Richard S. Finkel et al.   PLoS One

Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster

(2013) Joshua G Dunn et al.   eLife

L-MPZ, a Novel Isoform of Myelin P0, Is Produced by Stop Codon Readthrough

(2012) Yoshihide Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryptic peroxisomal targeting via alternative splicing and stop codon read-through in fungi

(2012) Johannes Freitag et al.   NATURE

Pharmaceutical therapies to recode nonsense mutations in inherited diseases

(2012) Hui-Ling Rose Lee et al.   PHARMACOLOGY & THERAPEUTICS

The Elongation, Termination, and Recycling Phases of Translation in Eukaryotes

(2012) T. E. Dever et al.   Cold Spring Harbor Perspectives in Biology

Statistical Analysis of Readthrough Levels for Nonsense Mutations in Mammalian Cells Reveals a Major Determinant of Response to Gentamicin

(2012) Célia Floquet et al.   PLoS Genetics

Chronic ataluren (PTC124) treatment of nonsense mutation cystic fibrosis

(2011) M. Wilschanski et al.   EUROPEAN RESPIRATORY JOURNAL

Evidence of abundant stop codon readthrough in Drosophila and other metazoa

(2011) I. Jungreis et al.   GENOME RESEARCH

Efficiency of translation termination in humans is highly dependent upon nucleotides in the neighbourhood of a (premature) termination codon

(2011) F. Pacho et al.   JOURNAL OF MEDICAL GENETICS

A high-resolution map of human evolutionary constraint using 29 mammals

(2011) Kerstin Lindblad-Toh et al.   NATURE

Stimulation of stop codon readthrough: frequent presence of an extended 3′ RNA structural element

(2011) Andrew E. Firth et al.   NUCLEIC ACIDS RESEARCH

Aminoglycoside-induced suppression of CYP2C19*3 premature stop codon

(2011) Mateus Fuchshuber-Moraes et al.   Pharmacogenetics and Genomics

Readthrough of Premature Termination Codons in the Adenomatous Polyposis Coli Gene Restores Its Biological Activity in Human Cancer Cells

(2011) Célia Floquet et al.   PLoS One

Characterization of the stop codon readthrough signal of Colorado tick fever virus segment 9 RNA

(2011) S. Napthine et al.   RNA

Ataluren (PTC124) Induces Cystic Fibrosis Transmembrane Conductance Regulator Protein Expression and Activity in Children with Nonsense Mutation Cystic Fibrosis

(2010) Isabelle Sermet-Gaudelus et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rescue of non-sense mutated p53 tumor suppressor gene by aminoglycosides

(2010) Célia Floquet et al.   NUCLEIC ACIDS RESEARCH

Structural insights into eRF3 and stop codon recognition by eRF1

(2009) Z. Cheng et al.   GENES & DEVELOPMENT

Restoration of APC gene function in colorectal cancer cells by aminoglycoside- and macrolide-induced read-through of premature termination codons

(2009) A. Zilberberg et al.   GUT

Delivery of a read-through inducing compound, TC007, lessens the severity of a spinal muscular atrophy animal model

(2009) Virginia B. Mattis et al.   HUMAN MOLECULAR GENETICS

Tandem Stop Codons in Ciliates That Reassign Stop Codons

(2009) Marie Adachi et al.   JOURNAL OF MOLECULAR EVOLUTION

Suppression of Nonsense Mutations in Rett Syndrome by Aminoglycoside Antibiotics

(2009) Cornelia Brendel et al.   PEDIATRIC RESEARCH

A meta-analysis of nonsense mutations causing human genetic disease

(2008) Matthew Mort et al.   HUMAN MUTATION

Effectiveness of PTC124 treatment of cystic fibrosis caused by nonsense mutations: a prospective phase II trial

(2008) Eitan Kerem et al.   LANCET