Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies

Effectiveness and tuberculosis-related safety profile of interleukin-1 blocking agents in the management of Behçet's disease

(2015) Luca Cantarini et al.   AUTOIMMUNITY REVIEWS

Efficacy and safety of biological agents in adult-onset Still’s disease

(2015) G Cavalli et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

BRAFV600E-mutation is invariably present and associated to oncogene-induced senescence in Erdheim-Chester disease

(2014) Maria Giulia Cangi et al.   ANNALS OF THE RHEUMATIC DISEASES

Long-term effectiveness and safety of interleukin-1 receptor antagonist (anakinra) in Schnitzler's syndrome: A french multicenter study

(2014) Antoine Néel et al.   AUTOIMMUNITY REVIEWS

Consensus guidelines for the diagnosis and clinical management of Erdheim-Chester disease

(2014) E. L. Diamond et al.   BLOOD

Early efficacy trial of anakinra in corticosteroid-resistant autoimmune inner ear disease

(2014) Andrea Vambutas et al.   JOURNAL OF CLINICAL INVESTIGATION

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

(2014) Scott W Canna et al.   NATURE GENETICS

Therapeutic Role of Anakinra, an Interleukin-1 Receptor Antagonist, in the Management of Secondary Hemophagocytic Lymphohistiocytosis/Sepsis/Multiple Organ Dysfunction/Macrophage Activating Syndrome in Critically Ill Children*

(2014) Surender Rajasekaran et al.   Pediatric Critical Care Medicine

Oncogene-Induced Senescence as a New Mechanism of Disease: The Paradigm of Erdheim–Chester Disease

(2014) Giulio Cavalli et al.   Frontiers in Immunology

Effects of Interleukin-1 Blockade With Anakinra on Adverse Cardiac Remodeling and Heart Failure After Acute Myocardial Infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) Pilot Study]

(2013) Antonio Abbate et al.   AMERICAN JOURNAL OF CARDIOLOGY

Effects of Interleukin-1 Blockade With Anakinra on Aerobic Exercise Capacity in Patients With Heart Failure and Preserved Ejection Fraction (from the D-HART Pilot Study)

(2013) Benjamin Wallace Van Tassell et al.   AMERICAN JOURNAL OF CARDIOLOGY

Results from systematic screening for cardiovascular risk in outpatients with rheumatoid arthritis in accordance with the EULAR recommendations

(2013) Jette Primdahl et al.   ANNALS OF THE RHEUMATIC DISEASES

The multifaceted clinical presentations and manifestations of Erdheim–Chester disease: comprehensive review of the literature and of 10 new cases

(2013) Giulio Cavalli et al.   ANNALS OF THE RHEUMATIC DISEASES

Anakinra treatment in drug-resistant Behcet’s disease: a case series

(2013) Luca Cantarini et al.   CLINICAL RHEUMATOLOGY

Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1  Antibody, in Patients With Type 2 Diabetes

(2013) J. Sloan-Lancaster et al.   DIABETES CARE

Erdheim–Chester disease with cardiac involvement successfully treated with anakinra

(2013) Ammar M. Killu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Successful treatment of Erdheim-Chester disease by interleukin-1 receptor antagonist protein

(2013) Audrey Courcoul et al.   JOINT BONE SPINE

Interleukin-1 blockade in refractory giant cell arteritis

(2013) Kim-Heang Ly et al.   JOINT BONE SPINE

Efficacy and safety of canakinumab in urticarial vasculitis: An open-label study

(2013) Karoline Krause et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rilonacept in the treatment of acute gouty arthritis: a randomized, controlled clinical trial using indomethacin as the active comparator

(2013) Robert A Terkeltaub et al.   ARTHRITIS RESEARCH & THERAPY

Topical Interleukin 1 Receptor Antagonist for Treatment of Dry Eye Disease

(2013) Francisco Amparo et al.   JAMA Ophthalmology

Effectiveness of First-Line Treatment With Recombinant Interleukin-1 Receptor Antagonist in Steroid-Naive Patients With New-Onset Systemic Juvenile Idiopathic Arthritis: Results of a Prospective Cohort Study

(2013) Sebastiaan J. Vastert et al.   Arthritis & Rheumatology

A pilot study of IL-1 inhibition in acute calcific periarthritis of the shoulder

(2012) Pascal Zufferey et al.   ANNALS OF THE RHEUMATIC DISEASES

Sustained efficacy of the monoclonal anti-interleukin-1 beta antibody canakinumab in a 9-month trial in Schnitzler's syndrome

(2012) Heleen D de Koning et al.   ANNALS OF THE RHEUMATIC DISEASES

A child with severe relapsing Kawasaki disease rescued by IL-1 receptor blockade and extracorporeal membrane oxygenation

(2012) Sophie Cohen et al.   ANNALS OF THE RHEUMATIC DISEASES

Blocking Interleukin-1 as a Novel Therapeutic Strategy for Secondary Prevention of Cardiovascular Events

(2012) Antonio Abbate et al.   BIODRUGS

Interleukin-1β Is Crucial for the Induction of Coronary Artery Inflammation in a Mouse Model of Kawasaki Disease

(2012) Youngho Lee et al.   CIRCULATION

Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes

(2012) C. Cavelti-Weder et al.   DIABETES CARE

Effect of anti-IL-1β antibody (canakinumab) on insulin secretion rates in impaired glucose tolerance or type 2 diabetes: results of a randomized, placebo-controlled trial

(2012) A. Rissanen et al.   DIABETES OBESITY & METABOLISM

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Enhanced Interleukin-1 Activity Contributes to Exercise Intolerance in Patients with Systolic Heart Failure

(2012) Benjamin W. Van Tassell et al.   PLoS One

Rilonacept (interleukin-1 trap) for prevention of gout flares during initiation of uric acid-lowering therapy: Results from a phase III randomized, double-blind, placebo-controlled, confirmatory efficacy study

(2012) H. Ralph Schumacher et al.   ARTHRITIS CARE & RESEARCH

Interleukin-1β-regulating antibody XOMA 052 (gevokizumab) in the treatment of acute exacerbations of resistant uveitis of Behçet's disease: an open-label pilot study

(2011) Ahmet Gül et al.   ANNALS OF THE RHEUMATIC DISEASES

Canakinumab reduces the risk of acute gouty arthritis flares during initiation of allopurinol treatment: results of a double-blind, randomised study

(2011) N. Schlesinger et al.   ANNALS OF THE RHEUMATIC DISEASES

Two-year results from an open-label, multicentre, phase III study evaluating the safety and efficacy of canakinumab in patients with cryopyrin-associated periodic syndrome across different severity phenotypes

(2011) J. B. Kuemmerle-Deschner et al.   ANNALS OF THE RHEUMATIC DISEASES

On-demand anakinra treatment is effective in mevalonate kinase deficiency

(2011) E. J. Bodar et al.   ANNALS OF THE RHEUMATIC DISEASES

Treatment of pediatric Erdheim-Chester disease with interleukin-1-targeting drugs

(2011) T. A. Tran et al.   ARTHRITIS AND RHEUMATISM

A phase II, multicenter, open-label study evaluating dosing and preliminary safety and efficacy of canakinumab in systemic juvenile idiopathic arthritis with active systemic features

(2011) Nicolino Ruperto et al.   ARTHRITIS AND RHEUMATISM

Efficacy of etanercept in the tumor necrosis factor receptor-associated periodic syndrome: A prospective, open-label, dose-escalation study

(2011) Ariel C. Bulua et al.   ARTHRITIS AND RHEUMATISM

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Efficacy and safety of the human anti-IL-1beta monoclonal antibody canakinumab in rheumatoid arthritis: results of a 12-week, phase II, dose-finding study

(2011) Rieke Alten et al.   BMC MUSCULOSKELETAL DISORDERS

Hyper-IgD syndrome or mevalonate kinase deficiency

(2011) Monique Stoffels et al.   CURRENT OPINION IN RHEUMATOLOGY

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Treatment with Anakinra Improves Disposition Index But Not Insulin Sensitivity in Nondiabetic Subjects with the Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study

(2011) Edwin J. P. van Asseldonk et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

IL-1  Is Overexpressed and Aberrantly Regulated in Corticosteroid Nonresponders with Autoimmune Inner Ear Disease

(2011) S. Pathak et al.   JOURNAL OF IMMUNOLOGY

IL-1  and IL-1  Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation

(2011) P. Rider et al.   JOURNAL OF IMMUNOLOGY

Dramatic beneficial effect of interleukin-1 inhibitor treatment in patients with familial Mediterranean fever complicated with amyloidosis and renal failure

(2011) K. Stankovic Stojanovic et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1 

(2011) Y. Berda-Haddad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1 Targeting Drugs in Familial Mediterranean Fever: A Case Series and a Review of the Literature

(2011) Ulrich Meinzer et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee

(2011) Stanley B Cohen et al.   ARTHRITIS RESEARCH & THERAPY

Sustained remission of symptoms and improved health-related quality of life in patients with cryopyrin-associated periodic syndrome treated with canakinumab: results of a double-blind placebo-controlled randomized withdrawal study

(2011) Isabelle Koné-Paut et al.   ARTHRITIS RESEARCH & THERAPY

Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat Gouty Arthritis by suppressing inflammation: results of a randomized, dose-ranging study

(2011) Naomi Schlesinger et al.   ARTHRITIS RESEARCH & THERAPY

Current Status of Understanding the Pathogenesis and Management of Patients With NOMID/CINCA

(2011) Raphaela Goldbach-Mansky   Current Rheumatology Reports

IL1-receptor antagonist anakinra provides long-lasting efficacy in the treatment of refractory adult-onset Still's disease

(2010) L Naumann et al.   ANNALS OF THE RHEUMATIC DISEASES

A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial)

(2010) P. Quartier et al.   ANNALS OF THE RHEUMATIC DISEASES

How interleukin-1β induces gouty arthritis

(2010) Charles A. Dinarello   ARTHRITIS AND RHEUMATISM

Efficacy of traditional and biologic agents in different clinical phenotypes of adult-onset Still's disease

(2010) Stefano Franchini et al.   ARTHRITIS AND RHEUMATISM

Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study

(2010) Alexander So et al.   ARTHRITIS AND RHEUMATISM

Engagement of fatty acids with toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis

(2010) Leo A. B. Joosten et al.   ARTHRITIS AND RHEUMATISM

Rationale and efficacy of interleukin-1 targeting in Erdheim-Chester disease

(2010) A. Aouba et al.   BLOOD

Anti-inflammatory Agents: Present and Future

(2010) Charles A. Dinarello   CELL

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Inflammasome and IL-1β-Mediated Disorders

(2010) Hal M. Hoffman et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Interleukin-1β modulation using a genetically engineered antibody prevents adverse cardiac remodelling following acute myocardial infarction in the mouse

(2010) Antonio Abbate et al.   EUROPEAN JOURNAL OF HEART FAILURE

The risk of tuberculosis related to tumour necrosis factor antagonist therapies: a TBNET consensus statement

(2010) I. Solovic et al.   EUROPEAN RESPIRATORY JOURNAL

Anakinra efficacy in a Caucasian patient with renal AA amyloidosis secondary to cryopyrin-associated periodic syndrome

(2010) Tassadit Aït-Abdesselam et al.   JOINT BONE SPINE

Follow-Up and Quality of Life of Patients with Cryopyrin-Associated Periodic Syndromes Treated with Anakinra

(2010) Loredana Lepore et al.   JOURNAL OF PEDIATRICS

Anti-Interleukin 1 Treatment for Patients with Familial Mediterranean Fever Resistant to Colchicine: Table 1.

(2010) SEZA ÖZEN et al.   JOURNAL OF RHEUMATOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Neurologic manifestations of the cryopyrin-associated periodic syndrome

(2010) J. L. Kitley et al.   NEUROLOGY

Differential release of chromatin-bound IL-1  discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

(2010) I. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Successful treatment of severe paediatric rheumatic disease-associated macrophage activation syndrome with interleukin-1 inhibition following conventional immunosuppressive therapy: case series with 12 patients

(2010) P. M. Miettunen et al.   RHEUMATOLOGY

Pneumonia in a patient with familial Mediterranean fever successfully treated with anakinra—case report and review

(2010) Stefanie Hennig et al.   RHEUMATOLOGY INTERNATIONAL

Erosive osteoarthritis of the hand: clinical experience with anakinra

(2009) L Bacconnier et al.   ANNALS OF THE RHEUMATIC DISEASES

Demyelinating events in rheumatoid arthritis after drug exposures

(2009) S. Bernatsky et al.   ANNALS OF THE RHEUMATIC DISEASES

The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study

(2009) R Terkeltaub et al.   ANNALS OF THE RHEUMATIC DISEASES

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1β receptor antagonist (anakinra): An unrecognized autoinflammatory disease?

(2009) Paolo Picco et al.   ARTHRITIS AND RHEUMATISM

Functional analysis of the osteoarthritis susceptibility-associatedGDF5regulatory polymorphism

(2009) Rainer J. Egli et al.   ARTHRITIS AND RHEUMATISM

Inflammatory arthritis in caspase 1 gene–deficient mice: Contribution of proteinase 3 to caspase 1–independent production of bioactive interleukin-1β

(2009) Leo A. B. Joosten et al.   ARTHRITIS AND RHEUMATISM

Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study

(2009) X. Chevalier et al.   ARTHRITIS AND RHEUMATISM

Long-term efficacy of the interleukin-1 receptor antagonist anakinra in ten patients with neonatal-onset multisystem inflammatory disease/chronic infantile neurologic, cutaneous, articular syndrome

(2009) Bénédicte Neven et al.   ARTHRITIS AND RHEUMATISM

Anti-IL-1 treatment for secondary amyloidosis in an adolescent with FMF and Behçet’s disease

(2009) Yelda Bilginer et al.   CLINICAL RHEUMATOLOGY

Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

(2009) C. M. Larsen et al.   DIABETES CARE

Lowering interleukin-1 activity with anakinra improves myocardial deformation in rheumatoid arthritis

(2009) I Ikonomidis et al.   HEART

Anakinra is a possible alternative in the treatment and prevention of acute attacks of pseudogout in end-stage renal failure

(2009) Nadia Announ et al.   JOINT BONE SPINE

In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromes

(2009) Helen J. Lachmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anakinra for Rheumatoid Arthritis: A Systematic Review

(2009) M. MERTENS et al.   JOURNAL OF RHEUMATOLOGY

The role of microparticles in the pathogenesis of rheumatic diseases

(2009) Christian Beyer et al.   Nature Reviews Rheumatology

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

(2009) Ivona Aksentijevich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Use of Canakinumab in the Cryopyrin-Associated Periodic Syndrome

(2009) Helen J. Lachmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Autoinflammatory Disease Due to Homozygous Deletion of theIL1RNLocus

(2009) Sreelatha Reddy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1  in human monocytes and multiple sclerosis

(2009) D. Burger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular inflammation: Underpinnings of aging and age-related diseases

(2008) Hae Young Chung et al.   AGEING RESEARCH REVIEWS

Successful treatment of resistant pseudogout with anakinra

(2008) Dennis McGonagle et al.   ARTHRITIS AND RHEUMATISM

The pattern of response to anti–interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis

(2008) Marco Gattorno et al.   ARTHRITIS AND RHEUMATISM

Persistent efficacy of anakinra in patients with tumor necrosis factor receptor–associated periodic syndrome

(2008) M. Gattorno et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of rilonacept (interleukin-1 trap) in patients with cryopyrin-associated periodic syndromes: Results from two sequential placebo-controlled studies

(2008) Hal M. Hoffman et al.   ARTHRITIS AND RHEUMATISM

Inhibition of Interleukin-1 by Anakinra Improves Vascular and Left Ventricular Function in Patients With Rheumatoid Arthritis

(2008) Ignatios Ikonomidis et al.   CIRCULATION

IL-1 blockade in Schnitzler syndrome: Ex vivo findings correlate with clinical remission

(2008) John G. Ryan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Successful treatment of familial Mediterranean fever with Anakinra and outcome after renal transplantation

(2008) C. Moser et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A case of macrophage activation syndrome successfully treated with anakinra

(2008) Alison Kelly et al.   Nature clinical practice. Rheumatology