Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer
出版年份 2013 全文链接
标题
Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer
作者
关键词
Insulin receptor, Insulin-like growth factor receptor, Cancer, Therapies
出版物
MEDICAL ONCOLOGY
Volume 31, Issue 1, Pages -
出版商
Springer Nature America, Inc
发表日期
2013-12-14
DOI
10.1007/s12032-013-0805-3
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma
- (2013) Marieke L Kuijjer et al. BMC CANCER
- Insulin Growth Factor-Receptor (IGF-1R) Antibody Cixutumumab Combined with the mTOR Inhibitor Temsirolimus in Patients with Refractory Ewing's Sarcoma Family Tumors
- (2012) A. Naing et al. CLINICAL CANCER RESEARCH
- Proinsulin Binds with High Affinity the Insulin Receptor Isoform A and Predominantly Activates the Mitogenic Pathway
- (2012) Roberta Malaguarnera et al. ENDOCRINOLOGY
- The Tyrphostin Agent AG490 Prevents and Reverses Type 1 Diabetes in NOD Mice
- (2012) Abdoreza Davoodi-Semiromi et al. PLoS One
- Effect of Insulin Analogues on Insulin/IGF1 Hybrid Receptors: Increased Activation by Glargine but Not by Its Metabolites M1 and M2
- (2012) Cécile Pierre-Eugene et al. PLoS One
- Insulin Receptor Isoforms A and B as well as Insulin Receptor Substrates-1 and -2 Are Differentially Expressed in Prostate Cancer
- (2012) Martin Heni et al. PLoS One
- Agonism and Antagonism at the Insulin Receptor
- (2012) Louise Knudsen et al. PLoS One
- Aldosterone Induces Vascular Insulin Resistance by Increasing Insulin-Like Growth Factor-1 Receptor and Hybrid Receptor
- (2011) Shamshad J. Sherajee et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Enhancement of doxorubicin cytotoxicity of human cancer cells by tyrosine kinase inhibition of insulin receptor and type I IGF receptor
- (2011) Xianke Zeng et al. BREAST CANCER RESEARCH AND TREATMENT
- Global cancer statistics
- (2011) Ahmedin Jemal et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Dual IGF-1R/InsR Inhibitor BMS-754807 Synergizes with Hormonal Agents in Treatment of Estrogen-Dependent Breast Cancer
- (2011) X. Hou et al. CANCER RESEARCH
- The role of the insulin-like growth factor signaling pathway in non-small cell lung cancer and other solid tumors
- (2011) Giorgio V. Scagliotti et al. CANCER TREATMENT REVIEWS
- 18FDG-PET Predicts Pharmacodynamic Response to OSI-906, a Dual IGF-1R/IR Inhibitor, in Preclinical Mouse Models of Lung Cancer
- (2011) E. T. McKinley et al. CLINICAL CANCER RESEARCH
- A Phase I Pharmacokinetic and Pharmacodynamic Study of Dalotuzumab (MK-0646), an Anti-Insulin-like Growth Factor-1 Receptor Monoclonal Antibody, in Patients with Advanced Solid Tumors
- (2011) F. Atzori et al. CLINICAL CANCER RESEARCH
- IGF1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin-responsive breast cancer
- (2011) Carly Jade Dool et al. ENDOCRINE-RELATED CANCER
- The insulin-like growth factor 1 pathway is a potential therapeutic target for low-grade serous ovarian carcinoma
- (2011) Erin R. King et al. GYNECOLOGIC ONCOLOGY
- Plasma and tissue insulin-like growth factor-I receptor (IGF-IR) as a prognostic marker for prostate cancer and anti-IGF-IR agents as novel therapeutic strategy for refractory cases: A review
- (2011) Emine Elif Ozkan MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Altered Expression of Insulin Receptor Isoforms in Breast Cancer
- (2011) Jiaqi Huang et al. PLoS One
- Insulin-like Growth Factor: Current Concepts and New Developments in Cancer Therapy
- (2011) Erin R. King et al. Recent Patents on Anti-Cancer Drug Discovery
- Clinical Phase I study with an Insulin-like Growth Factor-1 Receptor Inhibitor: Experiences in patients with squamous non-small cell lung carcinoma
- (2010) Simon Ekman et al. ACTA ONCOLOGICA
- S961, an insulin receptor antagonist causes hyperinsulinemia, insulin-resistance and depletion of energy stores in rats
- (2010) Ajit Vikram et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The IGFR1 inhibitor NVP-AEW541 disrupts a pro-survival and pro-angiogenic IGF-STAT3-HIF1 pathway in human glioblastoma cells
- (2010) Marzia B. Gariboldi et al. BIOCHEMICAL PHARMACOLOGY
- Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one
- (2010) Upender Velaparthi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Differential Mechanisms of Acquired Resistance to Insulin-like Growth Factor-I Receptor Antibody Therapy or to a Small-Molecule Inhibitor, BMS-754807, in a Human Rhabdomyosarcoma Model
- (2010) F. Huang et al. CANCER RESEARCH
- The Insulin-like Growth Factor I Receptor/Insulin Receptor Tyrosine Kinase Inhibitor PQIP Exhibits Enhanced Antitumor Effects in Combination with Chemotherapy Against Colorectal Cancer Models
- (2010) S. A. Flanigan et al. CLINICAL CANCER RESEARCH
- High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti-IGF-IR Therapy
- (2010) B. C. Litzenburger et al. CLINICAL CANCER RESEARCH
- Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development
- (2010) T. M. Pitts et al. CLINICAL CANCER RESEARCH
- Combination mTOR and IGF-1R Inhibition: Phase I Trial of Everolimus and Figitumumab in Patients with Advanced Sarcomas and Other Solid Tumors
- (2010) R. Quek et al. CLINICAL CANCER RESEARCH
- Insulin Receptor (IR) Pathway Hyperactivity in IGF-IR Null Cells and Suppression of Downstream Growth Signaling Using the Dual IGF-IR/IR Inhibitor, BMS-754807
- (2010) Joseph E. Dinchuk et al. ENDOCRINOLOGY
- Anti-insulin-like growth factor 1 receptor antibody EM164 (murine AVE1642) exhibits anti-tumour activity alone and in combination with temozolomide against neuroblastoma
- (2010) Birgit Geoerger et al. EUROPEAN JOURNAL OF CANCER
- Compensatory Insulin Receptor (IR) Activation on Inhibition of Insulin-Like Growth Factor-1 Receptor (IGF-1R): Rationale for Cotargeting IGF-1R and IR in Cancer
- (2010) E. Buck et al. MOLECULAR CANCER THERAPEUTICS
- PI3K/PTEN/Akt pathway status affects the sensitivity of high-grade glioma cell cultures to the insulin-like growth factor-1 receptor inhibitor NVP-AEW541
- (2010) Daniel Hägerstrand et al. NEURO-ONCOLOGY
- Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation
- (2010) H Zhang et al. ONCOGENE
- Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program
- (2010) E. Anders Kolb et al. PEDIATRIC BLOOD & CANCER
- Treatment of biliary tract cancer with NVP-AEW541: Mechanisms of action and resistance
- (2010) Samuel Wolf WORLD JOURNAL OF GASTROENTEROLOGY
- Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer
- (2010) Marie-Claude Beauchamp et al. Journal of Oncology
- Myeloma cell growth inhibition is augmented by synchronous inhibition of the insulin-like growth factor-1 receptor by NVP-AEW541 and inhibition of mammalian target of rapamycin by Rad001
- (2009) Philipp Baumann et al. ANTI-CANCER DRUGS
- Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma
- (2009) Paul Haluska et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression
- (2009) Toru Mukohara et al. CANCER LETTERS
- Expression of Insulin Receptor Isoform A and Insulin-like Growth Factor-1 Receptor in Human Acute Myelogenous Leukemia: Effect of the Dual-Receptor Inhibitor BMS-536924 In vitro
- (2009) A. E. Wahner Hendrickson et al. CANCER RESEARCH
- Insulin Receptor Isoform A and Insulin-like Growth Factor II as Additional Treatment Targets in Human Osteosarcoma
- (2009) S. Avnet et al. CANCER RESEARCH
- Sequencing of Type I Insulin-Like Growth Factor Receptor Inhibition Affects Chemotherapy Response In vitro and In vivo
- (2009) X. Zeng et al. CLINICAL CANCER RESEARCH
- Development of the Monoclonal Antibody Figitumumab, Targeting the Insulin-like Growth Factor-1 Receptor, for the Treatment of Patients with Non–Small-Cell Lung Cancer
- (2009) Antonio Gualberto et al. Clinical Lung Cancer
- Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease
- (2009) Antonino Belfiore et al. ENDOCRINE REVIEWS
- Diabetes and cancer
- (2009) Paolo Vigneri et al. ENDOCRINE-RELATED CANCER
- Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor
- (2009) Mark J Mulvihill et al. Future Medicinal Chemistry
- BMS-536924 sensitizes human epithelial ovarian cancer cells to the PARP inhibitor, 3-aminobenzamide
- (2009) Marie-Claude Beauchamp et al. GYNECOLOGIC ONCOLOGY
- Discovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development
- (2009) Mark D. Wittman et al. JOURNAL OF MEDICINAL CHEMISTRY
- Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study
- (2009) David Olmos et al. LANCET ONCOLOGY
- BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR
- (2009) J. M. Carboni et al. MOLECULAR CANCER THERAPEUTICS
- Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions
- (2009) A Gualberto et al. ONCOGENE
- Insulin-Like Growth Factor 1 Receptor Targeted Therapeutics: Novel Compounds and Novel Treatment Strategies for Cancer Medicine
- (2009) Madeleine Hewish et al. Recent Patents on Anti-Cancer Drug Discovery
- A novel high-affinity peptide antagonist to the insulin receptor
- (2008) Lauge Schäffer et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Characterization of IRA/IRB hybrid insulin receptors using bioluminescence resonance energy transfer
- (2008) Christophe Blanquart et al. BIOCHEMICAL PHARMACOLOGY
- Multivalency: the hallmark of antibodies used for optimization of tumor targeting by design
- (2008) Sergey M. Deyev et al. BIOESSAYS
- The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells
- (2008) Patricia Maiso et al. BRITISH JOURNAL OF HAEMATOLOGY
- The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors
- (2008) F. Huang et al. CANCER RESEARCH
- Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis
- (2008) Christian Moser et al. EUROPEAN JOURNAL OF CANCER
- Preclinical Targeting of the Type I Insulin-Like Growth Factor Receptor in Adrenocortical Carcinoma
- (2008) Ferdous M. Barlaskar et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Cross-Talk Between the ErbB/HER Family and the Type I Insulin-Like Growth Factor Receptor Signaling Pathway in Breast Cancer
- (2008) Quanri Jin et al. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
- Association of Hypertension, Diabetes, Dyslipidemia, and Metabolic Syndrome with Obesity: Findings from the National Health and Nutrition Examination Survey, 1999 to 2004
- (2008) Ninh T. Nguyen et al. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
- Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: Lessons from the first clinical trials
- (2008) J. Rodon et al. MOLECULAR CANCER THERAPEUTICS
- Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program
- (2008) E. Anders Kolb et al. PEDIATRIC BLOOD & CANCER
- Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors
- (2008) C. Tarn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insulin receptor expression by human prostate cancers
- (2008) Michael E. Cox et al. PROSTATE
- Similarities and differences between insulin and IGF-I: Structures, receptors, and signalling pathways
- (2008) Haim Werner et al. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
- The role of insulin receptors and IGF-I receptors in cancer and other diseases
- (2008) Francesco Frasca et al. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
- Hyper-insulinaemia and cancer, meta-analyses of epidemiological studies
- (2008) Paola Pisani ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started