Gut microbiota imbalance and chaperoning system malfunction are central to ulcerative colitis pathogenesis and can be counteracted with specifically designed probiotics: a working hypothesis

The Molecular Anatomy of Human Hsp60 and its Similarity with that of Bacterial Orthologs and Acetylcholine Receptor Reveal a Potential Pathogenetic Role of Anti-Chaperonin Immunity in Myasthenia Gravis

(2012) Antonella Marino Gammazza et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Intestinal microbiota determine severity of myocardial infarction in rats

(2012) Vy Lam et al.   FASEB JOURNAL

Effects of family history on inflammatory bowel disease characteristics in Japanese patients

(2012) Erika Kuwahara et al.   JOURNAL OF GASTROENTEROLOGY

Argentum–quarz solution in the treatment of anorectal fistulas: Is it possible a conservative approach?

(2012) Giovanni Tomasello et al.   MEDICAL HYPOTHESES

A complex microworld in the gut: Gut microbiota and cardiovascular disease connectivity

(2012) Michael R Howitt et al.   NATURE MEDICINE

The Odyssey of Hsp60 from Tumor Cells to Other Destinations Includes Plasma Membrane-Associated Stages and Golgi and Exosomal Protein-Trafficking Modalities

(2012) Claudia Campanella et al.   PLoS One

Abnormal expansion of segmented filamentous bacteria in the gut

(2012) Maurizio Bellavia et al.   REVIEWS IN MEDICAL MICROBIOLOGY

Possible relation between gut microflora composition and oncogenic risk

(2012) Giovanni Tomasello et al.   REVIEWS IN MEDICAL MICROBIOLOGY

The Role of Heat Shock Proteins in Antigen Cross Presentation

(2012) Ayesha Murshid et al.   Frontiers in Immunology

Differential Targeting of the E-Cadherin/β-Catenin Complex by Gram-Positive Probiotic Lactobacilli Improves Epithelial Barrier Function

(2011) Stephanie Hummel et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Impact of a probiotic fermented milk in the gut ecosystem and in the systemic immunity using a non-severe protein-energy-malnutrition model in mice

(2011) Carolina Maldonado Galdeano et al.   BMC GASTROENTEROLOGY

Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy

(2011) G. Tomasello et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Recent advances in understanding ulcerative colitis

(2011) Antonio Di Sabatino et al.   Internal and Emergency Medicine

Probiotics in the Treatment of Human Inflammatory Bowel Diseases

(2011) Bartolomeus Joannes Meijer et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Probiotic Sonicates Selectively Induce Mucosal Immune Cells Apoptosis through Ceramide Generation via Neutral Sphingomyelinase

(2011) Sandra Angulo et al.   PLoS One

Probiotic-Derived Polyphosphate Enhances the Epithelial Barrier Function and Maintains Intestinal Homeostasis through Integrin–p38 MAPK Pathway

(2011) Shuichi Segawa et al.   PLoS One

Convergent Sets of Data from In Vivo and In Vitro Methods Point to an Active Role of Hsp60 in Chronic Obstructive Pulmonary Disease Pathogenesis

(2011) Francesco Cappello et al.   PLoS One

Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases

(2011) P. A. Swanson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in Immunohistochemical Levels and Subcellular Localization After Therapy and Correlation and Colocalization With CD68 Suggest a Pathogenetic Role of Hsp60 in Ulcerative Colitis

(2011) Giovanni Tomasello et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Chaperonopathies of senescence and the scrambling of interactions between the chaperoning and the immune systems

(2010) Alberto J. L. Macario et al.   Annals of the New York Academy of Sciences

A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis

(2010) Lotte Wieten et al.   ARTHRITIS AND RHEUMATISM

Hsp60 and Hsp10 increase in colon mucosa of Crohn’s disease and ulcerative colitis

(2010) Vito Rodolico et al.   CELL STRESS & CHAPERONES

Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: A form of communication during injury, infection, and cell damage

(2010) Antonio De Maio   CELL STRESS & CHAPERONES

Disease association of antibodies to human and mycobacterial hsp70 and hsp60 stress proteins

(2010) A. ELSAGHIER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Stress for maintaining memory: HSP70 as a mobile messenger for innate and adaptive immunity

(2010) Taoyong Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Microbial products from probiotic bacteria inhibit Salmonella enteritidis 857-induced IL-8 synthesis in Caco-2 cells

(2010) J. J. Malago et al.   FOLIA MICROBIOLOGICA

EC144, a Synthetic Inhibitor of Heat Shock Protein 90, Blocks Innate and Adaptive Immune Responses in Models of Inflammation and Autoimmunity

(2010) T. J. Yun et al.   JOURNAL OF IMMUNOLOGY

Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Delivers Heat Shock Protein 60-Fused Antigen into the MHC Class I Presentation Pathway

(2010) J. Xie et al.   JOURNAL OF IMMUNOLOGY

Hsp60 Is Actively Secreted by Human Tumor Cells

(2010) Anna M. Merendino et al.   PLoS One

Modulation of Intestinal Barrier Properties by Probiotics: Role in Reversing Colitis

(2009) Silvia C. Resta-Lenert et al.   Annals of the New York Academy of Sciences

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Mechanisms of Immune Complex–Mediated Neutrophil Recruitment and Tissue Injury

(2009) Tanya N. Mayadas et al.   CIRCULATION

The Role of the Gut Microbiota in Energy Metabolism and Metabolic Disease

(2009) Patrice Cani et al.   CURRENT PHARMACEUTICAL DESIGN

Leukocytapheresis in ulcerative colitis: A possible alternative to biological therapy?

(2009) K.O. Arseneau et al.   DIGESTIVE AND LIVER DISEASE

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

(2009) N. Buchon et al.   GENES & DEVELOPMENT

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

(2009) S. Brand   GUT

Probiotics

(2009) V Gupta et al.   Indian Journal of Medical Microbiology

Bacteria-free solution derived from lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function

(2009) Elaine O. Petrof et al.   INFLAMMATORY BOWEL DISEASES

Clinical Epidemiology of Ulcerative Colitis in Mexico

(2009) Jesús K. Yamamoto-Furusho   JOURNAL OF CLINICAL GASTROENTEROLOGY

Regulation of heat shock protein 60 and 72 expression in the failing heart

(2009) Y. Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Human Hsp10 and Early Pregnancy Factor (EPF) and their relationship and involvement in cancer and immunity: Current knowledge and perspectives

(2009) Simona Corrao et al.   LIFE SCIENCES

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Heat Shock Protein-Derived T-Cell Epitopes Contribute to Autoimmune Inflammation in Pediatric Crohn's Disease

(2009) Gisella L. Puga Yung et al.   PLoS One

Chlamydia trachomatis Infection and Anti-Hsp60 Immunity: The Two Sides of the Coin

(2009) Francesco Cappello et al.   PLoS Pathogens

Efficacy and Safety of Chaperonin 10 in Patients With Moderate to Severe Plaque Psoriasis: Evidence of Utility Beyond a Single Indication

(2008) Bronwyn Williams et al.   ARCHIVES OF DERMATOLOGY

Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis

(2008) John W. Rice et al.   ARTHRITIS AND RHEUMATISM

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

(2008) Ivaylo I. Ivanov et al.   Cell Host & Microbe

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Lactobacillus casei downregulates commensalsʼ inflammatory signals in Crohnʼs disease mucosa

(2008) Marta Llopis et al.   INFLAMMATORY BOWEL DISEASES

A comparative analysis of the products of GROEL-1 gene fromChlamydia trachomatisserovar D and the HSP60 var1 transcript fromHomo sapienssuggests a possible autoimmune response

(2008) C. Campanella et al.   International Journal of Immunogenetics

Methanogenic archaea in health and disease: A novel paradigm of microbial pathogenesis

(2008) E CONWAYDEMACARIO et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Results of a phase IIa clinical trial of an anti-inflammatory molecule, chaperonin 10, in multiple sclerosis

(2008) SA Broadley et al.   Multiple Sclerosis Journal

Extravasations and emigration of neutrophils to the inflammatory site depend on the interaction of immune-complex with Fc  receptors and can be effectively blocked by decoy Fc  receptors

(2007) R. Shashidharamurthy et al.   BLOOD