Article
Microbiology
Amanda Fortes Francisco, Giovane R. Sousa, Mhairi Vaughan, Harry Langston, Archie Khan, Shiromani Jayawardhana, Martin C. Taylor, Michael D. Lewis, John M. Kelly
Summary: This study demonstrates the potential of the C3H/HeN:JR host:parasite combination as an experimental model for Chronic Chagas cardiomyopathy (CCC). The model exhibited cardiac abnormalities and inflammation, and could be used for screening new compounds and drugs to prevent or alleviate CCC development.
Review
Biochemistry & Molecular Biology
Danilo Martins, Leonardo Rufino Garcia, Diego Aparecido Rios Queiroz, Taline Lazzarin, Carolina Rodrigues Tonon, Paola da Silva Balin, Bertha Furlan Polegato, Sergio Alberto Rupp de Paiva, Paula Schmidt Azevedo, Marcos Ferreira Minicucci, Leonardo Zornoff
Summary: Cardiac remodeling refers to a series of molecular, cellular, and interstitial changes in the heart that occur after different stimuli, manifesting clinically as changes in size, mass, geometry, and function. Remodeling plays a crucial pathophysiological role in the onset and progression of ventricular dysfunction. The role of oxidative stress as a therapeutic target for cardiac remodeling has been gaining attention in recent years.
Review
Cell Biology
Zhenyu Zhai, Pengtao Zou, Fuxiang Liu, Zirong Xia, Juxiang Li
Summary: Ferroptosis, a recently discovered iron-dependent programmed cell death pathway, plays a significant role in cardiovascular diseases. Research has shown that blocking the ferroptosis pathways can alleviate myocardial injury. Therefore, ferroptosis may be a novel diagnostic and therapeutic target for patients suffering from cardiomyopathy in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Michael Gotthardt, Victor Badillo-Lisakowski, Victoria Nicole Parikh, Euan Ashley, Marta Furtado, Maria Carmo-Fonseca, Sarah Schudy, Benjamin Meder, Markus Grosch, Lars Steinmetz, Claudia Crocini, Leslie Leinwand
Summary: Alternative splicing plays a crucial role in determining the diversity of RNA transcripts in the heart. This review discusses its regulation in cardiac development, adaptation, and disease, as well as the advancements in technology and potential applications in cardiovascular medicine. The analysis of cardiac isoform expression can lead to improved diagnosis and therapy.
NATURE REVIEWS CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jingzhi Leng, Chuanzhi Wang, Zhide Liang, Fanghui Qiu, Shuangshuang Zhang, Yuan Yang
Summary: YAP is a downstream effector of the Hippo signaling pathway and plays a crucial role in cardiomyocyte survival. The Hippo/YAP axis potentially contributes to the development of cardiac, vascular, and renal injuries, and it is a key mediator of fibrosis in the infarcted heart.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Neurosciences
Mengtan Cai, Weihong Lin
Summary: NF-kappa B is a transcriptional regulator that plays important roles in inflammation, neuronal survival, and apoptosis. It is upregulated in epilepsy and causes functional changes in the central nervous system. Regulating NF-kappa B may be a safe and effective treatment strategy for epilepsy.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Jing Li, Bradley Richmond, TingTing Hong
Summary: cBIN1 and its organized microdomains play a crucial role in maintaining normal heart contraction, with abnormal remodeling of cBIN1-microdomains contributing to heart failure pathophysiology. A blood test cBIN1 score derived from plasma cBIN1 concentration can provide diagnostic and prognostic power for heart failure patients, while gene therapy introducing exogenous cBIN1 has shown potential in rescuing failing hearts by improving cardiac function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Menghua Zhou, Chaoqun Wang, Shounan Lu, Yanan Xu, Zihao Li, Hongchi Jiang, Yong Ma
Summary: Cholangiocarcinoma (CCA) is an aggressive and multifactorial malignancy of the biliary tract, with carcinogenesis associated with genomic and epigenetic abnormalities, as well as environmental effects. Tumor-associated macrophages (TAMs) in the tumor microenvironment interact closely with CCA cells by releasing protumor factors, promoting tumor growth, and exerting immunosuppressive and antichemotherapeutic effects. Targeting TAMs may offer insights into novel therapeutic approaches for CCA.
Review
Immunology
Chiara Agostinis, Andrea Balduit, Alessandro Mangogna, Gabriella Zito, Federico Romano, Giuseppe Ricci, Uday Kishore, Roberta Bulla
Summary: Endometriosis is a chronic disease characterized by the presence and proliferation of endometrial tissues outside the uterus, with symptoms depending on the location of involvement. The risk of developing endometriosis is influenced by complex interactions between genetic, immunological, hormonal, and environmental factors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Albert Katchborian-Neto, Mario Ferreira Conceicao Santos, Diego Fernandes Vilas-Boas, Elda Goncalves dos Santos, Marcia Paranho Veloso, Paula Carolina Pires Bueno, Ivo Santana Caldas, Marisi Gomes Soares, Danielle Ferreira Dias, Daniela Aparecida Chagas-Paula
Summary: Ayahuasca, composed mainly of Banisteriopsis caapi and Psychotria viridis, is a natural medicine used by indigenous communities in South America. It has shown potential against internal parasites and the Trypanosoma cruzi parasite. The compounds in Ayahuasca have multi-targeted effects, including controlling parasitaemia and modulating the immune response, making it beneficial for Chagas' disease treatment.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Multidisciplinary Sciences
Miyoung Lee, Jamie A. G. Hamilton, Ganesh R. Talekar, Anthony J. Ross, Langston Michael, Manali Rupji, Bhakti Dwivedi, Sunil S. Raikar, Jeremy Boss, Christopher D. Scharer, Douglas K. Graham, Deborah DeRyckere, Christopher C. Porter, Curtis J. Henry
Summary: This study reveals that adipocytes can induce the expression of Gal-9 in B-acute lymphoblastic leukemia cells, leading to chemoresistance. Antibody-mediated blockade of Gal-9 increases the survival rate in preclinical B-ALL murine models. This finding is important for developing targeted therapies for obese patients with leukemia.
NATURE COMMUNICATIONS
(2022)
Review
Oncology
Yujia Peng, Yiran Tao, Ya Zhang, Jiaxing Wang, Jinliang Yang, Yuxi Wang
Summary: CD25 is the alpha-chain of the heterotrimer IL-2 receptor, expressed on the surface of immune and non-immune cells with different frequencies. Its high expression in hematological malignancies and activated immune cells indicates its potential as a target for immunotherapy. The imbalanced ratio of effector T cells and regulatory T cells caused by Tregs infiltration in tumor microenvironment is associated with cancer progression. This paper summarizes the relationship between CD25 and tumors and discusses its important role in tumor therapy, as well as the recent progress of drugs targeting CD25.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Pharmacology & Pharmacy
Yan Wang, Jianliang Wei, Peng Zhang, Xin Zhang, Yifei Wang, Wenjing Chen, Yanan Zhao, Xiangning Cui
Summary: This article provides a summary of the role and mechanisms of NRG1 in cardiovascular diseases, discusses therapeutic approaches for cardiovascular diseases, and highlights future research directions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Lin Yang, Jiahao Liu, Sheng Li, Xiaoqiang Liu, Fuchun Zheng, Songhui Xu, Bin Fu, Jing Xiong
Summary: In this study, researchers identified 35 differential genes related to disulfidptosis and identified 4 ccRCC subtypes. The risk models based on these 13 genes predicted sensitivity to immunotherapy. The nomogram for predicting ccRCC prognosis has a high application value, with an AUC of 0.869. The key gene AJAP1 was found to have low expression in tumor cell lines and cancer tissues.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Amrutha Menon, Noraini Abd-Aziz, Kanwal Khalid, Chit Laa Poh, Rakesh Naidu
Summary: This review focuses on the role of miRNA in cancer, therapeutic approaches with miRNAs, and effective delivery into the system. Patents and ongoing clinical trials for miRNA therapy are also summarized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Katia Lino, Lilian S. Alves, Jessica Raposo, Thalia Medeiros, Cintia F. Souza, Andrea A. da Silva, Vanessa S. de Paula, Jorge R. Almeida
Summary: This real-world pilot study aimed to understand the frequency and clinical impact of HHV-6 coinfection in moderate to critically ill patients hospitalized due to COVID-19. Despite the high frequency of HHV-6 coinfection in SARS-CoV-2 positive cases, it did not impact general mortality. More extensive prospective studies are suggested to further elucidate the influence of HHV-6 reactivation in COVID-19 cases, focusing on specific clinical outcomes and viral reactivation mechanisms.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Iury Amancio Paiva, Debora Familiar-Macedo, Jessica Badolato-Correa, Fabiana Rabe Carvalho, Helver Goncalves Dias, Alex Pauvolid-Correa, Caroline Fernandes dos Santos, Andrea Alice Silva, Elzinandes Leal de Azeredo, Renata Artimos de Oliveira Vianna, Claudete Aparecida Araujo Cardoso, Alba Grifoni, Alessandro Sette, Daniela Weiskopf, Luzia Maria de-Oliveira-Pinto
Summary: High levels of Th17-related cytokines, associated with a regulatory environment during pregnancy, may create a favorable milieu for the differentiation of CD4+Th17 cells. Our study found a higher frequency of Th1Th17 cells in mothers and children with Zika virus infection, indicating that the activation of Th1Th17 cells may play a significant role in the development of Zika-related brain abnormalities.
Article
Immunology
Camila de Paula Martins, Fabiana Rabe Carvalho, Renan Faustino, Thalia Medeiros, Natalia Fonseca do Rosario, Christiane Mello Schmidt, Ana Paula Barbosa, Ana Paula Quintanilha dos Santos, Caio Pluvier Duarte Costa, Hugo Henrique Kegler dos Santos, Karina Yuriko Yaginuma, Elisangela Costa da Silva, Afranio Lineu Kritski, Clemax Couto Sant'Anna, Claudete Aparecida Araujo Cardoso, Andrea Alice Silva
Summary: This study aimed to investigate the efficacy of immune mediators in diagnosing PTB and LTBI in pediatric patients. The study found that certain immune mediators were significantly higher in PTB patients, and immune mediators were able to distinguish PTB from LTBI. VEGF and IL-1Ra were identified as promising biomarkers.
Article
Immunology
Barrios Leda Castano, Andrea Alice Silva, Lina L. Hernandez-Velasco, Ana Paula Da Silva Pinheiro, Daniel Gibaldi, Jose Roberto Mineo, Neide Maria Silva, Joseli Lannes-Vieira
Summary: Toxoplasma gondii infection can cause behavioral and neurocognitive changes, such as anxiety, depression, and memory loss. Treatment with a specific drug can reduce brain cyst load, neuroinflammation, and blood-brain barrier disruption, and improve these behavioral and neurocognitive changes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Katia Lino, Lilian Santos Alves, Natalia Trizzotti, Jessica Vasques Raposo, Cintia Fernandes Souza, Andrea Alice da Silva, Vanessa Salete de Paula, Jorge Reis Almeida
Summary: Members of the Herpesviridae family, particularly EBV, HSV-1, and CMV, are common in SLE patients and may be associated with renal dysfunction, although the underlying mechanisms are not well understood.
JORNAL BRASILEIRO DE NEFROLOGIA
(2022)
Article
Infectious Diseases
Paula Finamore-Araujo, Gabriel Lucio Silva da Fonseca, Cecilia Stahl Vieira, Daniele Pereira de Castro, Otacilio Cruz Moreira
Summary: In this study, a new Real-Time PCR with Reverse Transcription (RT-qPCR) was developed to determine T. cruzi viability in R. prolixus samples. The amplification signals of DNA and mRNA were compared to analyze the colonization kinetics of T. cruzi in experimentally infected R. prolixus. The results suggest that RNA can serve as a molecular viability marker for parasite activity and contribute to understanding the dynamics of parasite infection in invertebrate hosts.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Natalia Lins da Silva-Gomes, Leonardo Alexandre de Souza Ruivo, Claudia Moreira, Marcelo Meuser-Batista, Cristiane Franca da Silva, Denise da Gama Jaen Batista, Stenio Fragoso, Gabriel Melo de Oliveira, Maria de Nazare Correia Soeiro, Otacilio C. Moreira
Summary: In this study, genetically modified strains of Trypanosoma cruzi were used to evaluate the role of NTPDases in parasite infectivity. The results showed that parasites overexpressing TcNTPDase-1 had higher infectivity, while hemi-knockout parasites had lower infectivity and no significant electrocardiographic changes. These findings highlight the potential of NTPDases as a therapeutic target for Chagas disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Israel de Souza Pinto, Bruno Leite Rodrigues, Thais de Araujo-Pereira, Paloma Helena Fernandes Shimabukuro, Daniela de Pita-Pereira, Constanca Britto, Reginaldo Pecanha Brazil
Summary: Using DNA barcoding, we identified different species of sand flies in forest fragments in Brasileia, state of Acre, Brazil. We generated new COI sequences for 11 species, which had not been sequenced before, and found hidden diversity of five species. The DNA barcoding approach proved to be useful for molecular identification of sand flies and detecting cryptic diversity.
Article
Microbiology
Carolina Valenca-Barbosa, Paula Finamore-Araujo, Otacilio Cruz Moreira, Marcus Vinicius Niz Alvarez, Andre Borges-Veloso, Silvia Ermelinda Barbosa, Lileia Diotaiuti, Rita de Cassia Moreira de Souza
Summary: This study characterizes the parasitic and epidemiological aspects of the sylvatic population of Triatoma melanica in rural areas of Minas Gerais, Brazil. The findings highlight the need for surveillance and control measures for this vector species.
Article
Medicine, General & Internal
Luciane Almeida Amado, Wagner Luis da Costa Nunes Pimentel Coelho, Arthur Daniel Rocha Alves, Vanessa Cristine de Souza Carneiro, Otacilio da Cruz Moreira, Vanessa Salete de Paula, Andreza Salvio Lemos, Larissa Araujo Duarte, Elisa Gouvea Gutman, Fabricia Lima Fontes-Dantas, Joao Paulo da Costa Goncalves, Carlos Henrique Ferreira Ramos, Carlos Henrique Ferreira Ramos Filho, Marta Guimaraes Cavalcanti, Marisa Pimentel Amaro, Rafael Lopes Kader, Roberto de Andrade Medronho, Dmitry Jose de Santana Sarmento, Soniza Vieira Alves-Leon
Summary: Since the declaration of COVID-19 as a pandemic, Brazil has been severely affected. The second wave of COVID-19, caused by a new SARS-CoV-2 variant, has led to an increase in severe cases and a higher need for invasive respiratory support. Laboratory biomarkers related to various bodily functions were significantly associated with severe COVID-19.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ana Carolina Oliveira, Amanda Roberta Revoredo Vicentino, Daniele Andrade, Isabela Resende Pereira, Leonardo Saboia-Vahia, Otacilio da Cruz Moreira, Carla Eponina Carvalho-Pinto, Julia Barbalho da Mota, Leonardo Maciel, Glaucia Vilar-Pereira, Joao B. Pesquero, Joseli Lannes-Vieira, Pierre Sirois, Antonio Carlos Campos de Carvalho, Julio Scharfstein
Summary: We investigated the role of B1R receptor in the development of Chagas disease caused by Trypanosoma cruzi. Our findings suggest that blocking the B1R receptor can reduce heart parasitism and cardiac injury in acute and chronic Chagas disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Otacilio C. Moreira, Alice Gomes Fernandes, Natalia Lins da Silva Gomes, Carolina Messias dos Santos, Thiago Jacomasso, Alexandre Dias Tavares Costa, Lucas de O. Rossetti Nascimento, Alejandro Marcel Hasslocher-Moreno, Pedro Emmanuel Alvarenga Americano do Brasil, Luis Gustavo Morello, Fabricio Klerynton Marchini, Marco Aurelio Krieger, Constanca Britto
Summary: In the absence of validated biomarkers, PCR-based diagnosis is being used for an early indication of therapeutic failure in Chagas disease. The NAT Chagas kit, based on qPCR, has been validated as an excellent alternative for molecular diagnosis in both public and private diagnostic centers. It showed 100% sensitivity and specificity in comparison to the in-house real-time PCR assay.
Article
Biochemistry & Molecular Biology
Vanessa Cristine de Souza Carneiro, Otacilio da Cruz Moreira, Wagner Luis da Costa Nunes Pimentel Coelho, Beatriz Chan Rio, Dmitry Jose de Santana Sarmento, Andreza Lemos Salvio, Soniza Vieira Alves-Leon, Vanessa Salete de Paula, Luciane Almeida Amado Leon
Summary: In patients co-infected with COVID-19 and HHV-6, miRNA is associated with neurological manifestations and may serve as potential biomarkers for diagnosis and therapeutic strategies of neurological disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Gabriel Macedo Costa Guimaraes, Renan Faustino, Any Caroline Oliveira, Lilian Santos Alves, Fabiana Rabe Carvalho, Katia Lino Baptista, Karina Yuriko Yaginuma, Hugo Henrique Kegler dos Santos, Jorge Reis Almeida, Thalia Medeiros, Andrea Alice Silva
Summary: This study aimed to evaluate the relationship between hematological and coagulation parameters and clinical outcomes of COVID-19. Hematological and coagulation parameters at admission were found to be useful predictors of disease severity and mortality. A logistic regression model combining all parameters showed the best performance with an AUC of 0.89, sensitivity of 84.84%, and specificity of 77.41%.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Parasitology
Joseli Lannes-Vieira, Glaucia Vilar-Pereira, Leda Castano Barrios, Andrea Alice Silva
Summary: Patients with chronic Chagas disease (CD) may experience mental disorders such as anxiety, depression, and memory loss, possibly due to social, psychological, and biological stress. There is a debate on the existence of a chronic neurological form of CD, but preclinical models have shown that brain atrophy, parasite persistence, oxidative stress, and cytokine production are associated with behavioral disorders.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2023)