Article
Endocrinology & Metabolism
Patricia Cristine Borck, Sarah Rickli, Jean Franciesco Vettorazzi, Thiago Martins Batista, Antonio Carlos Boschero, Elaine Vieira, Everardo Magalhaes Carneiro
Summary: Exposure to artificial light at night, especially in conjunction with a low-protein diet, can have negative effects on energy and glucose metabolism, potentially predisposing to metabolic disorders.
JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Bandish Kapadia, Soma Behera, Sireesh T. Kumar, Tapan Shah, Rebecca Kristina Edwin, Phanithi Prakash Babu, Partha Chakrabarti, Kishore V. L. Parsa, Parimal Misra
Summary: This study found that PIMT expression was upregulated in the livers of short-term fasted and obese mice. Modulating PIMT directly affected gluconeogenic gene expression and hepatic glucose output. Further investigations revealed that PKA regulated PIMT through phosphorylation and enhanced translation of TGS1 mRNA, thus promoting gluconeogenesis.
Review
Cell Biology
Huidong Liu, Ye-Guang Chen
Summary: TGF-beta signaling plays a critical role in metabolism and is closely related to the progression of various diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Alexandra Aliluev, Sophie Tritschler, Michael Sterr, Lena Oppenlaender, Julia Hinterdobler, Tobias Greisle, Martin Irmler, Johannes Beckers, Na Sun, Axel Walch, Kerstin Stemmer, Alida Kindt, Jan Krumsiek, Matthias H. Tschop, Malte D. Luecken, Fabian J. Theis, Heiko Lickert, Anika Boettcher
Summary: This study reveals that an obesogenic diet induces hyperproliferation of intestinal stem cells and progenitors in mice, leading to changes in intestinal cell identities and mucosal changes associated with obesity. The molecular mechanisms linking increased fatty acid synthesis, Ppar signaling, and the Insr-Igf1r-Akt pathway to these changes are described, shedding light on the pathogenesis of metabolic syndrome.
Article
Endocrinology & Metabolism
Ana P. Huerta Guevara, Sara J. McGowan, Melissa Kazantzis, Tania Rozgaja Stallons, Tokio Sano, Niels L. Mulder, Angelika Jurdzinski, Theo H. van Dijk, Bart J. L. Eggen, Johan W. Jonker, Laura J. Niedernhofer, Janine K. Kruit
Summary: The study demonstrated that persistent endogenous DNA damage accumulation in Ercc1(d/-) mice affects energy metabolism, insulin sensitivity, and beta-cell function, leading to improved insulin sensitivity and decreased insulin secretion.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Biochemistry & Molecular Biology
Akinobu Nakamura
Summary: SGLT2 inhibitors not only lower blood glucose levels but also have protective effects on organs such as the heart and kidneys. These inhibitors prevent beta-cell dysfunction by reducing glucose overload, leading to increased beta-cell proliferation and decreased apoptosis. Clinical and preclinical data support the protective effect of SGLT2 inhibitors on beta-cell mass and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Chuanxing Feng, Yuge Jiang, Guoqing Wu, Yonghui Shi, Yueting Ge, Bowen Li, Xiangrong Cheng, Xue Tang, Jianjin Zhu, Guowei Le
Summary: Methionine restriction improves glucose metabolism by promoting insulin secretion and enhancing glucose uptake and utilization in skeletal muscle. The key regulator H19 plays a crucial role in these processes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Yueting Ge, Bowen Li, Yuhui Yang, Chuanxing Feng, Xue Tang, Yonghui Shi, Guowei Le, Jin Sun
Summary: Consumption of pork with high levels of oxidative injury can lead to disorders of glucose metabolism in mice, characterized by hyperglycemia, hypoinsulinemia, impaired glucose tolerance, and impaired pancreatic insulin secretion. Protein oxidation plays a key role in this abnormal glucose metabolism induced by high oxidative injury pork intake.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Medicine, Research & Experimental
Martina Pauk, Vera Kufner, Viktorija Rumenovic, Ivo Dumic-Cule, Vladimir Farkas, Milan Milosevic, Tatjana Bordukalo-Niksic, Slobodan Vukicevic
Summary: The study found that adult Bmp6(-/-) mice showed progressive iron deposits in the exocrine pancreas, leading to pancreatic degeneration and injury, while blood glucose levels and islet structure remained unaffected, and insulin secretion was normal.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Nutrition & Dietetics
Thalles de Freitas Castro, Natalia Alves de Matos, Ana Beatriz Farias de Souza, Guilherme de Paula Costa, Luiza Oliveira Perucci, Andre Talvani, Silvia Dantas Cangussu, Rodrigo Cunha Alvim de Menezes, Frank Silva Bezerra
Summary: Maternal protein restriction during pregnancy has adverse effects on the lungs of offspring, including decreased body weight, inflammation and oxidative stress, and simplification of lung structure.
Article
Cell Biology
Eleonora Duregon, Maria Emilia Fernandez, Jorge Martinez Romero, Clara Di Germanio, Meaghan Cabassa, Romaniya Voloshchuk, Margaux R. Ehrlich-Mora, Jacqueline M. Moats, Sarah Wong, Oye Bosompra, Annamaria Rudderow, Christopher H. Morrell, Simonetta Camandola, Nathan L. Price, Miguel A. Aon, Michel Bernier, Rafael de Cabo
Summary: Emerging evidence suggests that prolonged fasting periods combined with calorie restriction (CR) and time-restricted feeding (TRF) have important health and survival benefits for male mice, but little is known about the effects of these feeding regimens in females. In this study, 14-month-old female mice were placed on five different dietary regimens, either CR or TRF with different feeding windows. The results showed that CR elicited a strong systemic response, unique serum metabolomics signature, and increased lifespan. These findings highlight the importance of daytime feeding with prolonged fasting periods initiated late in life for females.
Article
Multidisciplinary Sciences
Romana Bohuslavova, Valeria Fabriciova, Ondrej Smolik, Laura Lebron-Mora, Pavel Abaffy, Sarka Benesova, Daniel Zucha, Lukas Valihrach, Zuzana Berkova, Frantisek Saudek, Gabriela Pavlinkova
Summary: NEUROD1 is a transcription factor that plays an important role in pancreatic development and is crucial for the differentiation of endocrine cells. Its deficiency disrupts endocrine cell identity acquisition and compromises their differentiation and functional properties.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Philip Weber, Mads N. N. Thomsen, Mads Juul Skytte, Amirsalar Samkani, Martin Hansen Carl, Arne Astrup, Jan Frystyk, Jens J. J. Holst, Bolette Hartmann, Sten Madsbad, Faidon Magkos, Thure Krarup, Steen B. B. Haugaard
Summary: In a real-life setting, the benefits of a fully provided, hypocaloric, carbohydrate-reduced high-protein diet were not maintained when individuals with type 2 diabetes switched to self-prepared diets aiming for the same nutritional goals for 6 months.
Article
Medicine, Research & Experimental
Juliana Sales Rodrigues Costa, Graciene Fernandes Araujo Campos Fonseca, Natielle Cecilia dos Santos Ottone, Patrick Almeida Silva, Romulo Fernandes Antonaccio, Gabriela Silva, Maira da Silva Almeida Rocha, Candido Celso Coimbra, Elizabethe Adriana Esteves, Zachary A. Mang, Fabiano Trigueiro Amorim, Flavio de Castro Magalhaes
Summary: Strength training can improve insulin resistance and glucose tolerance through mitochondrial adaptation in skeletal muscle, increased skeletal muscle Hsp72, and reduced adipocyte size in visceral fat.
Article
Food Science & Technology
Seth H. Pincus, Alexi Kyro, Grace A. Maresh, Tami Peters, Jacob Kempa, Tamera K. Marcotte, Zhanguo Gao, Jianping Ye, Valerie Copie, Kejing Song
Summary: Injection of ricin toxin causes hypoglycemia in mice, accompanied by lymphopenia and cytokine secretion. Abnormal pancreatic and hepatic function may contribute to the hypoglycemia.
Review
Biochemistry & Molecular Biology
Fabiane Ferreira Martins, Vanessa Souza-Mello, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Summary: Brown adipose tissue (BAT) plays a role in thermogenesis and has the potential to be targeted for the treatment of obesity and its comorbidities. Brown adipokines (batokines) have effects on multiple organs and may be effective targets for treating obesity. This review discusses the importance of six emerging batokines and their interactions with other organs, focusing on their physiological significance and changes induced by diet.
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
(2023)
Article
Medicine, Research & Experimental
Fabiane Ferreira Martins, Thiago Santos-Reis, Thatiany Souza Marinho, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Summary: The aim of this study was to examine the effects of semaglutide on neuropeptide signaling in the hypothalamic energy metabolism of diet-induced obese mice. The results showed that semaglutide improved leptin sensitivity and anorexigenic signaling, while decreasing orexigenic signaling. Furthermore, semaglutide also affected biometric data and hypothalamic gene expressions. Therefore, semaglutide can activate anorexigenic signaling by restoring leptin, amylin, and POMC pathways in diet-induced obese mice.
Article
Medicine, Research & Experimental
Matheus Ajackson, Brenda A. Nagagata, Ilitch A. Marcondes-de-Castro, Carlos A. Mandarim-de-Lacerda, Marcia Barbosa Aguila
Summary: The aim of this study was to investigate the effects of melatonin supplementation in the liver of adult offspring from obese mothers during pregnancy and lactation. The results showed that supplementation of melatonin reduced body weight and liver lipid levels in offspring from high-fat diet-fed mothers. Additionally, melatonin supplementation improved lipid metabolism, inflammation, oxidative stress, and endoplasmic reticulum stress in the offspring's liver.
Article
Endocrinology & Metabolism
Ilitch Aquino Marcondes-de-Castro, Thamiris Ferreira Oliveira, Renata Spezani, Thatiany Souza Marinho, Luiz Eduardo Macedo Cardoso, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Summary: Cotadutide has anti-obesity effects and can improve glucose intolerance and insulin resistance. It also shows beneficial effects on liver lipid metabolism and mitigates steatosis, inflammation, and ER stress. Therefore, Cotadutide could be a potential treatment for type 2 diabetes and associated obesity.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Luiz E. M. Cardoso, Thatiany Souza Marinho, Fabiane Ferreira Martins, Marcia Barbosa Aguila, Carlos A. Mandarim-de-Lacerda
Summary: In this study, the effects of a glucagon-like peptide type 1 receptor agonist, semaglutide, on the turnover of islet extracellular matrix (ECM) components in an obese mouse model were investigated. The results showed that semaglutide improved the turnover of ECM components and reduced the formation of amyloid deposits.
Article
Endocrinology & Metabolism
Daiana Araujo Santana-Oliveira, Henrique Souza-Tavares, Aline Fernandes-da-Silva, Flavia Maria Silva-Veiga, Gustavo Casimiro-Lopes, Patricia Cristina Lisboa, Carlos Alberto Mandarim-de-Lacerda, Vanessa Souza-Mello
Summary: This study shows that high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) can prevent obesity by modulating gut microbiota and inflammatory signals. These exercise modalities restore body weight, improve glucose tolerance, and reduce insulin levels in high-fat-fed mice. Furthermore, they prevent gut dysbiosis and maintain the integrity of the gut barrier, leading to decreased inflammatory signals to brown adipose tissue. These findings are important for understanding the impact of exercise on obesity and metabolic health.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Renata Spezani, Thatiany Souza Marinho, Luiz E. Macedo Cardoso, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Summary: Obesity and type 2 diabetes mellitus cause morphofunctional alterations in pancreatic islet alpha and beta cells. A new GLP-1/Glucagon receptor dual agonist cotadutide may benefit islet cell arrangement and function. The study found that cotadutide led to weight loss, reduced insulin resistance, and improved markers of transdifferentiation, proliferation, apoptosis, and ER stress in obese mice.
Article
Public, Environmental & Occupational Health
Brenda A. Nagagata, Matheus Ajackson, Fernanda Ornellas, Carlos A. Mandarim-de-Lacerda, Marcia Barbosa Aguila
Summary: Supplementing obese mothers with melatonin during gestation and lactation has benefits for the pancreatic islet cellular composition and beta-cell function in adult male offspring. The study found that melatonin supplementation improved glucose metabolism and weight loss in both mothers and offspring, while reducing pro-inflammatory markers and endoplasmic reticulum stress. Additionally, antioxidant enzymes were improved, beta-cell mass and hyperinsulinemia were reduced, and beta-cell maturity and identity gene expressions were enhanced in the offspring. Overall, melatonin supplementation in obese mothers helps preserve pancreatic islets and functioning beta cells in their offspring.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Anatomy & Morphology
Patricia de Castro De Paiva, Thatiany Souza Marinho, Carlos Alberto Mandarim-De-Lacerda, Marcia Barbosa Aguila
Summary: High-Intensity Interval training (HIIT) has positive effects on myokines and endoplasmic reticulum (ER) stress in obese mice, reducing weight gain and improving muscle function. The study suggests that HIIT can prevent chronic inflammation and muscle dysfunction associated with obesity.
INTERNATIONAL JOURNAL OF MORPHOLOGY
(2023)