Review
Geriatrics & Gerontology
S. G. Chowdhury, S. Misra, Parimal Karmakar
Summary: Ageing is a multi-factorial phenomenon, and accumulation of DNA damage or mutations is a dominant theory which contributes largely to the development of ageing and age-related diseases. Obesity is a complex chronic disease that affects multiple organs and tissues, and it has been found to be associated with higher loads of DNA damage. The present review focuses on the involvement of DNA metabolism in the development of obesity and how it accelerates ageing in mammals.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Article
Obstetrics & Gynecology
Joop S. E. Laven
Summary: Recent studies have shown that genes involved in menopause are also involved in DNA repair pathways, and cumulative DNA damage can lead to cellular senescence and dysfunction. This also occurs in the ovaries, leading to a suppression of hormone production and eventual onset of menopause. Therefore, it seems that cellular aging is the primary driver for ovarian function loss in women, making menopause a result rather than a cause of aging.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Biochemistry & Molecular Biology
Le P. Ngo, Simran Kaushal, A. Isaac Chaim, Patrizia Mazzucato, Catherine Ricciardi, D. Leona Samson, D. Zachary Nagel, P. Bevin Engelward
Summary: By utilizing the CometChip, researchers uncovered significant variability in DNA repair efficiency among individuals, indicating its potential utility in future epidemiological and clinical studies.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Multidisciplinary Sciences
Bjoern Schumacher, Joris Pothof, Jan Vijg, Jan H. J. Hoeijmakers
Summary: Ageing is a complex process that affects every organ and tissue in the body, but the causal mechanism behind it remains unclear. Accumulating evidence suggests that DNA damage may play a central role in driving ageing, providing a potential unified approach to combat age-related diseases.
Article
Biotechnology & Applied Microbiology
Martina Fiumara, Samuele Ferrari, Attya Omer-Javed, Stefano Beretta, Luisa Albano, Daniele Canarutto, Angelica Varesi, Chiara Gaddoni, Chiara Brombin, Federica Cugnata, Erika Zonari, Matteo Maria Naldini, Matteo Barcella, Bernhard Gentner, Ivan Merelli, Luigi Naldini
Summary: Base and prime editors have shown potential for precise genetic engineering, but their cellular responses and genotoxicity are not well understood. This study compared the efficiency, toxicity, and genotoxicity between base and prime editors and Cas9 in human hematopoietic cells. The findings suggest that these editors can induce harmful effects and genotoxicity, raising concerns for their clinical applications.
NATURE BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Huishi Toh, Alexander Smolentsev, Ryan Sadjadi, Dennis Clegg, Jingqi Yan, Ron Stewart, James A. Thomson, Peng Jiang
Summary: Diabetic retinopathy is a common complication of long-term diabetes that can lead to vision loss. The early understanding and prevention of this condition are limited, with no effective methods until later stages. The study used a Nile rat model to examine the transcriptomic changes in retinal vascular development, aiming to better understand the early pathogenesis of diabetic retinopathy.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Huishi Toh, Alexander Smolentsev, Ryan Sadjadi, Dennis Clegg, Jingqi Yan, Ron Stewart, James A. Thomson, Peng Jiang
Summary: This study aims to understand the early pathogenesis of diabetic retinopathy by analyzing whole retinal vascular transcriptomic changes in a Nile rat model. The study identified the complex associations between acellular capillary density and factors like blood glucose, diet, and sex. A random forest regression model based on gene expression patterns was developed to predict acellular capillary density. Additionally, potential drugs that can attenuate early diabetic retinopathy were also identified.
SCIENTIFIC REPORTS
(2023)
Review
Endocrinology & Metabolism
Yan Wang, Mengrong Su, Yujie Chen, Xinyu Huang, Lian Ruan, Qizhuang Lv, Li Li
Summary: This study provides a systematic review of the role and mechanism of DNA damage repair in germ cell development. It summarizes the causes, detection methods, and repair methods of DNA damage, as well as the mechanism of DNA damage repair. It also discusses the causes of abnormal DNA damage repair in germ cells, the effects of germ cell damage, and the applications of DNA damage repair in reproductive diseases and related surgical treatments.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Environmental Sciences
Ericka Marel Quezada-Maldonado, Yesennia Sanchez-Perez, Yolanda I. Chirino, Claudia M. Garcia-Cuellar
Summary: This study analyzed the types of DNA damage and alterations in DNA repair pathways induced by PM exposure, showing that PM mainly causes oxidative stress and DNA damage through the formation of DNA adducts and DSBs, as well as deregulates the protein expression in DNA repair pathways. However, there are still limitations in the knowledge about the effects of PM on DNA repair pathways, and further research is needed to deepen our understanding.
ENVIRONMENTAL POLLUTION
(2021)
Editorial Material
Cell Biology
Irene Franco, Gwladys Revechon, Maria Eriksson
Summary: The causal effects of somatic mutations in the aging process are still not clear due to technological and methodological weaknesses. Studying somatic mutagenesis in different experimental systems can help understand its functional role.
Article
Engineering, Environmental
Hongrui Guo, Yujuan Ouyang, Jiaqi Wang, Hengmin Cui, Huidan Deng, Xinyue Zhong, Zhijie Jian, Huan Liu, Jing Fang, Zhicai Zuo, Xun Wang, Ling Zhao, Yi Geng, Ping Ouyang, Huaqiao Tang
Summary: Copper is essential but over-exposure can lead to adverse health effects. CuSO4 was found to induce spermatogenesis disorder through oxidative stress-mediated DNA damage and apoptosis, impairing male reproductive function.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Inga R. Grin, Daria V. Petrova, Anton V. Endutkin, Chunquan Ma, Bing Yu, Haiying Li, Dmitry O. Zharkov
Summary: Base excision DNA repair is an important pathway in safeguarding the genome of plants, and understanding their repair mechanisms is crucial for developing new crop varieties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
S. Ahmad, M. L. Tan, Shahrul Hamid
Summary: Cardiovascular disease is a leading global cause of death, influenced by factors such as genetics, high-fat intake, smoking, hypertension, diabetes, and lifestyle. The disease is caused by the sudden production of reactive oxygen species, resulting in DNA damage and cell death. Various forms of DNA damage have been associated with cardiovascular disease. Therefore, reducing reactive oxygen species is crucial, and nutraceuticals and their bioactive compounds play a role in mitigating DNA damage.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Nutrition & Dietetics
Jingqian Su, Qiaofen Su, Shan Hu, Xinglin Ruan, Songying Ouyang
Summary: Aging is a cellular state characterized by a permanent cessation of cell division and evasion of apoptosis. DNA damage, metabolic dysfunction, telomere damage, and mitochondrial dysfunction are the main factors associated with senescence. Ginseng, a traditional Chinese medicine, has active components that have antioxidant, anti-apoptotic, neuroprotective, and age-delaying effects. This review focuses on the anti-aging mechanisms of the active ingredients of ginseng and expands the scope of ideas for further research on natural products and aging.
Review
Biochemistry & Molecular Biology
Harvey Boughey, Mateusz Jurga, Sherif F. El-Khamisy
Summary: As we age, DNA mutations can lead to cellular dysfunction and aging, while naked mole rats show minimal biological decline and neurodegeneration despite their long lifespan.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Rachel Abbotts, David M. Wilson
FREE RADICAL BIOLOGY AND MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
Mengxia Li, Xiao Yang, Xianfeng Lu, Nan Dai, Shiheng Zhang, Yi Cheng, Lei Zhang, Yuxin Yang, Yie Liu, Zhenzhou Yang, Dong Wang, David M. Wilson
NUCLEIC ACIDS RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Joo Sang Lee, Lital Adler, Hiren Karathia, Narin Carmel, Shiran Rabinovich, Noam Auslander, Rom Keshet, Noa Stettner, Alon Silberman, Lilach Agemy, Daniel Helbling, Raya Eilam, Qin Sun, Alexander Brandis, Sergey Malitsky, Maxim Itkin, Hila Weiss, Sivan Pinto, Shelly Kalaora, Ronen Levy, Eilon Barnea, Arie Admon, David Dimmock, Noam Stern-Ginossar, Avigdor Scherz, Sandesh C. S. Nagamani, Miguel Unda, David M. Wilson, Ronit Elhasid, Arkaitz Carracedo, Yardena Samuels, Sridhar Hannenhalli, Eytan Ruppin, Ayelet Erez
Article
Multidisciplinary Sciences
Lavinia C. Dumitrache, Mikio Shimada, Susanna M. Downing, Young Don Kwak, Yang Li, Jennifer L. Illuzzi, Helen R. Russell, David M. Wilson, Peter J. McKinnon
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Teruaki Iyama, Mustafa N. Okur, Tyler Golato, Daniel R. McNeill, Huiming Lu, Royce Hamilton, Aishwarya Raja, Vilhelm A. Bohr, David M. Wilson
SCIENTIFIC REPORTS
(2018)
Review
Genetics & Heredity
Vinod Tiwari, David M. Wilson
AMERICAN JOURNAL OF HUMAN GENETICS
(2019)
Review
Genetics & Heredity
Daniel R. McNeill, Amy M. Whitaker, Wesley J. Stark, Jennifer L. Illuzzi, Peter J. McKinnon, Bret D. Freudenthal, David M. Wilson
Article
Multidisciplinary Sciences
Tunc Morova, Daniel R. McNeill, Nada Lallous, Mehmet Gonen, Kush Dalal, David M. Wilson, Attila Guersoy, Ozlem Keskin, Nathan A. Lack
NATURE COMMUNICATIONS
(2020)
Article
Oncology
Koen D. Flach, Manikandan Periyasamy, Ajit Jadhav, Dorjbal Dorjsuren, Joseph C. Siefert, Theresa E. Hickey, Mark Opdam, Hetal Patel, Sander Canisius, David M. Wilson, Maria Donaldson Collier, Stefan Prekovic, Marja Nieuwland, Roelof J. C. Kluin, Alexey Zakharov, Jelle Wesseling, Lodewyk F. A. Wessels, Sabine C. Linn, Wayne D. Tilley, Anton Simeonov, Simak Ali, Wilbert Zwart
Review
Cell Biology
Behnaz Banimohamad-shotorbani, Houman Kahroba, Hadi Sadeghzadeh, David M. Wilson, Hamid Maadi, Nasser Samadi, Mohammad Saeid Hejazi, Hekmat Farajpour, Behzad Nemati Onari, Mohammad Reza Sadeghi
AGEING RESEARCH REVIEWS
(2020)
Review
Biochemistry & Molecular Biology
David M. I. I. I. I. I. I. Wilson, Ashley M. Deacon, Matthew A. J. Duncton, Patricia Pellicena, Millie M. Georgiadis, Andrew P. Yeh, Andrew S. Arvai, Davide Moiani, John A. Tainer, Debanu Das
Summary: Cancer affects over one-third of the population directly. The DNA Damage Response (DDR) plays a central role in cancer etiology and therapy, with therapeutic approaches targeting DDR advancing through combinatorial treatments and synthetic lethality. While many DDR proteins are undruggable, Fragment- and Structure-Based Drug Discovery (FBDD, SBDD) have led to the development of therapeutic agents and FDA-approved medicines.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Berna Somuncu, Selcuk Keskin, Fatma Merve Antmen, Yesim Saglican, Aysegul Ekmekcioglu, Tugce Ertuzun, Mustafa Bilal Tuna, Can Obek, David M. Wilson, Umit Ince, Ali Riza Kural, Meltem Muftuoglu
SCIENTIFIC REPORTS
(2020)
Review
Biochemistry & Molecular Biology
Jan Spaas, Lieve van Veggel, Melissa Schepers, Assia Tiane, Jack van Horssen, David M. Wilson, Pablo R. Moya, Elisabeth Piccart, Niels Hellings, Bert O. Eijnde, Wim Derave, Rudy Schreiber, Tim Vanmierlo
Summary: Oligodendrocyte precursor cells (OPCs) play a crucial role in various neurodegenerative disorders, with oxidative/carbonyl stress potentially impacting their differentiation and function, contributing to disease progression. Investigating how oxidative/carbonyl stress disrupts OPC differentiation may offer new directions for therapeutic strategies in neurodegenerative disorders.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Oncology
Katia A. Mesquita, Reem Ali, Rachel Doherty, Michael S. Toss, Islam Miligy, Adel Alblihy, Dorjbal Dorjsuren, Anton Simeonov, Ajit Jadhav, David M. Wilson, Ian Hickson, Natalie J. Tatum, Emad A. Rakha, Srinivasan Madhusudan
Summary: Increased expression of FEN1 in ovarian cancer is associated with poor survival outcomes, while inhibition of FEN1 can enhance platinum sensitivity and exhibit synthetic lethality in BRCA2 and POL beta deficient cells. These findings suggest that FEN1 is a promising target for ovarian cancer therapy.
Review
Biochemistry & Molecular Biology
Elle E. M. Scheijen, Sven Hendrix, David M. Wilson
Summary: Oxidative stress plays a crucial role in spinal cord injury (SCI), causing damage to proteins, nucleic acids, lipids, cytoskeleton, and organelles. Oxidative DNA damage is likely a major contributor to the pathogenesis of SCI, although the evidence supporting this hypothesis is limited. Improved analysis methods are needed to uncover the role of DNA damage and repair in SCI.
