Review
Medicine, General & Internal
Jing Zhang, Long-Min Chen, Yuan Zou, Shu Zhang, Fei Xiong, Cong-Yi Wang
Summary: Type 1 diabetes (T1D) is an autoimmune disease caused by severe destruction of insulin-producing beta cells, with both genetic predisposition and environmental factors playing critical roles in its pathogenesis. Epigenetics serves as a bridge linking T1D risk genes and environmental exposures, modulating gene expression relevant to T1D development beyond DNA sequence changes.
CHINESE MEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Sanne D. D. van Otterdijk, Hagen Klett, Melanie Boerries, Karin B. B. Michels
Summary: This study examines the influence of folate and S-Adenosylmethionine (SAM) on placental DNA methylation. The study finds that maintaining sufficient levels of folate and SAM is particularly important for individuals carrying the MTHFR C677T polymorphism. The MTHFR genotype is associated with DNA methylation.
Article
Oncology
Arce Domingo-Relloso, Matthew O. Gribble, Angela L. Riffo-Campos, Karin Haack, Shelley A. Cole, Maria Tellez-Plaza, Jason G. Umans, Amanda M. Fretts, Ying Zhang, M. Daniele Fallin, Ana Navas-Acien, Todd M. Everson
Summary: This study investigated the association between blood DNA methylation and type 2 diabetes. The results suggest that differences in blood DNA methylation are related to markers of glucose metabolism and insulin activity, although no significant associations were found after multiple comparisons correction.
CLINICAL EPIGENETICS
(2022)
Review
Nutrition & Dietetics
Amira Kohil, Maha Al-Asmakh, Mashael Al-Shafai, Annalisa Terranegra
Summary: Type 1 Diabetes Mellitus (T1DM) is a complex autoimmune disease with increasing incidence worldwide. The interplay between genetic and environmental factors contributes to its pathogenesis. The relationship between diet and epigenetics plays a significant role in the development of T1DM.
FRONTIERS IN NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Gregory Alexander Raciti, Antonella Desiderio, Michele Longo, Alessia Leone, Federica Zatterale, Immacolata Prevenzano, Claudia Miele, Raffaele Napoli, Francesco Beguinot
Summary: Diabetes poses a serious threat to global health, especially for T2D patients facing severe complications. Improving care for T2D is crucial, and alterations in DNA methylation hold potential for predicting T2D risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Sine Knorr, Anne Skakkebaek, Jesper Just, Emma B. Johannsen, Christian Trolle, Soren Vang, Zuzana Lohse, Birgitte Bytoft, Peter Damm, Kurt Hojlund, Dorte M. Jensen, Claus H. Gravholt
Summary: Offspring born to women with pregestational type 1 diabetes (T1DM) show differences in DNA methylation and gene expression compared to controls, suggesting a potential link to increased risk of metabolic and vascular diseases in later life. Further research is needed to confirm these findings and explore underlying mechanisms.
Article
Genetics & Heredity
Kelsey Dawes, Willem Philibert, Benjamin Darbro, Ronald L. Simons, Robert Philibert
Summary: This study provides a new model for predicting T2D status in African Americans by evaluating the interaction between genes and methylation. The study found that certain gene-methylation interactions are associated with the development and complications of T2D, and correcting for genetic confounding improves the ability to detect T2D.
Review
Genetics & Heredity
Barbara Cugalj Kern, Katarina Trebusak Podkrajsek, Jernej Kovac, Robert Sket, Barbara Jenko Bizjan, Tine Tesovnik, Marusa Debeljak, Tadej Battelino, Natasa Bratina
Summary: Long-term hyperglycemia caused by type 1 diabetes has a significant impact on epigenetic marks in late complications, such as DNA methylation, histone modifications, and microRNAs.
Review
Genetics & Heredity
Ilaria Barchetta, Jeanette Arvastsson, Luis Sarmiento, Corrado M. Cilio
Summary: This article discusses the pathogenesis of organ-specific autoimmune diseases and the contribution of environmental factors, highlighting the role of epigenetic changes induced by maternal conditions in preventing type 1 diabetes through adjustment of the maternal environment.
Article
Cell Biology
Rupal Dubey, Pranav Kumar Prabhakar, Jeena Gupta
Summary: Diabetes-related delayed wound healing is a multifactorial complication affected by genetic, dietary, and lifestyle factors, with epigenetic modifications recognized as key facilitators of gene-environment interactions. Dysfunctional epigenetic pathways caused by diabetes lead to changed gene expression in target cells, contributing to complications such as cardiomyopathy, nephropathy, and delayed wound healing. The role of epigenetic mechanisms in tissue repair, angiogenesis, and growth factors, as well as altered epigenetic events during diabetic wound healing, are important areas of study.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Cell Biology
Jianxin Deng, Yunxiu Liao, Jianpin Liu, Wenjuan Liu, Dewen Yan
Summary: Diabetic cardiomyopathy is characterized by diastolic relaxation abnormalities in its early stages and clinical heart failure in its later stages, contributing to high mortality and morbidity rates in diabetic populations. Diabetes is a complex condition influenced by genetic and environmental factors, with recent studies highlighting the role of epigenetics in its pathogenesis. Further research on epigenetic mechanisms could lead to novel therapeutic approaches for diabetic cardiomyopathy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Diana L. Juvinao-Quintero, Gemma C. Sharp, Eleanor C. M. Sanderson, Caroline L. Relton, Hannah R. Elliott
Summary: This study aimed to provide evidence for a causal relationship between DNA methylation (DNAm) and type 2 diabetes. The researchers used bidirectional two-sample Mendelian randomisation (2SMR) to evaluate the causality at 58 CpG sites. The results showed a strong causal effect of DNAm at cg25536676 (DHCR24) on the risk of type 2 diabetes.
Article
Oncology
Rachel G. Miller, Josyf C. Mychaleckyj, Suna Onengut-Gumuscu, Eleanor Feingold, Trevor J. Orchard, Tina Costacou
Summary: This study explored the potential of DNA methylation as an early marker for cardiovascular disease (CVD) in type 1 diabetes patients and how this association differs based on glycemic exposure. The study found that DNA methylation at loci involved in calcium channel activity and development may contribute to long-term CVD risk in type 1 diabetes patients, especially in individuals with higher glycemic exposure. These findings suggest the need for further research in this area.
CLINICAL EPIGENETICS
(2023)
Article
Biochemistry & Molecular Biology
Andy Madrid, Laura E. Borth, Kirk J. Hogan, Nithya Hariharan, Ligia A. Papale, Reid S. Alisch, Bermans J. Iskandar
Summary: The study investigates the distinct contributions of DNA methylation and hydroxymethylation to axonal regeneration in the spinal cord, highlighting the importance of distinguishing their independent roles in the central nervous system. The findings reveal unique functions of differential hydroxymethylated and methylated regions in the axonal regeneration phenotype, emphasizing discrete roles for DNA methylation modifications in spinal cord injury and regeneration in the context of transgenerational inheritance.
Article
Genetics & Heredity
Man Li, Litao Bao, Ping Zhu, Shuxia Wang
Summary: This study investigated the impact of metformin on the epigenetic age in subjects with type 2 diabetes mellitus (DM). The results showed an association between metformin intake and slower epigenetic aging.
FRONTIERS IN GENETICS
(2022)
Review
Food Science & Technology
Paula Jimenez, Paula Garcia, Vilma Quitral, Karla Vasquez, Claudia Parra-Ruiz, Marjorie Reyes-Farias, Diego F. Garcia-Diaz, Paz Robert, Cristian Encina, Jessica Soto-Covasich
Summary: Avocado, a native American fruit, produces a large amount of wastes during industrial processing, which contain bioactive compounds with antimicrobial, anti-inflammatory, anticancer properties. These compounds, including polyphenols, carotenoids, tocopherols, and phytosterols, have potential applications in food and pharmaceutical industries.
FOOD REVIEWS INTERNATIONAL
(2021)
Article
Pediatrics
Guisselle Arias-Bravo, Gustavo Valderrama, Jaime Inostroza, Marjorie Reyes-Farias, Diego F. Garcia-Diaz, Francisco Zorondo-Rodriguez, Loreto F. Fuenzalida
FRONTIERS IN PEDIATRICS
(2020)
Article
Food Science & Technology
J. Soto-Covasich, M. Reyes-Farias, R. F. Torres, K. Vasquez, L. Duarte, J. Quezada, P. Jimenez, M. T. Pino, L. Garcia-Nannig, L. Mercado, D. F. Garcia-Diaz
JOURNAL OF FUNCTIONAL FOODS
(2020)
Article
Integrative & Complementary Medicine
Angelica Ovalle-Marin, Claudia Parra-Ruiz, Francisca Rivas, Juan Francisco Orellana, Diego F. Garcia-Diaz, Paula Jimenez
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS
(2020)
Article
Biochemistry & Molecular Biology
Ariel Vivero, Manuel Ruz, Matias Rivera, Karen Miranda, Camila Sacristan, Alejandra Espinosa, Juana Codoceo, Jorge Inostroza, Karla Vasquez, Alvaro Perez, Diego Garcia-Diaz, Miguel Arredondo
Summary: The study found that zinc supplementation and strength exercise together improved insulin signaling and attenuated nonalcoholic liver disease in a T2D rat model.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Nutrition & Dietetics
Francisca Echeverria, Paula Andrea Jimenez Patino, Mauricio Castro-Sepulveda, Andres Bustamante, Paula Andrea Garcia Concha, Carlos Poblete-Aro, Rodrigo Valenzuela, Diego F. Garcia-Diaz
Summary: The study demonstrates that microencapsulated pomegranate peel extract can prevent high-fat diet-induced obesity in mice by preventing excessive weight gain and metabolic disturbances, potentially through activating complex IV activity and preserving mitochondrial cristae structure in brown adipose tissue.
BRITISH JOURNAL OF NUTRITION
(2021)
Review
Endocrinology & Metabolism
Lissette Duarte, Naschla Gasaly, Carlos Poblete-Aro, Denisse Uribe, Francisca Echeverria, Martin Gotteland, Diego F. Garcia-Diaz
Summary: Dietary polyphenols, as plant secondary metabolites, can stimulate browning and thermogenesis of adipose tissue, prevent weight gain, and reduce systemic inflammation caused by high-fat diets. These effects are mediated by the gut microbiota, which can be modulated by polyphenols to regulate energetic metabolism and potentially control obesity through BAT activation.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Francisca Rivas, Carlos Poblete-Aro, Maria Elsa Pando, Maria Jose Allel, Valentina Fernandez, Angelica Soto, Pablo Nova, Diego Garcia-Diaz
Summary: Aging is a biological, irreversible, progressive process influenced by genetic and environmental factors, leading to a gradual decline in physical and mental capacity and increased risk of neurodegenerative diseases. Antioxidant therapy can reduce oxidative damage, and polyphenols have potential antioxidant properties to prevent harmful oxidative processes associated with neurodegenerative disorders.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Food Science & Technology
Nicolas Jeria, Sebastian Cornejo, Gabriel Prado, Andres Bustamante, Diego F. Garcia-Diaz, Paula Jimenez, Rodrigo Valenzuela, Carlos Poblete-Aro, Francisca Echeverria
Summary: The generation of agro-industrial by-products is a problem in terms of economics and the environment, but these materials can be a valuable source of bioactive compounds for various purposes. With the increasing prevalence of obesity and metabolic syndrome, there is a constant need for new strategies to prevent and treat these conditions. Revalorization of agro-industrial by-products for functional foods and nutraceutical development is gaining importance.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Jaime Zapata, Mauricio Castro-Sepulveda, Sandra Soto-Alarcon, Daniela Alvarez, Andres Bustamante, Guiselle Villarroel, Arturo Gallardo, Diego Fernando Garcia-Diaz, Rodrigo Valenzuela, Francisca Echeverria
Summary: Nonalcoholic fatty liver disease (NAFLD) has a high and growing prevalence globally. Mitochondria play a crucial role in regulating cell energy homeostasis, but their control mechanisms can be disrupted in the context of energy overload. Damaged mitochondria worsen NAFLD progression. Diet and lifestyle changes are the main recommendations for NAFLD prevention and treatment. Some polyphenols have shown promising effects in improving mitochondrial function in NAFLD and obesity models.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Cynthia Barrera, Valeska Castillo, Rodrigo Valenzuela, Carina A. Valenzuela, Diego F. Garcia-Diaz, Miguel Llanos
Summary: This study aimed to determine the effects of a nutritional intervention during pregnancy and lactation on metabolic alterations of obese female progenitors' offspring and on the involvement of the endocannabinoid system (ECS). The results showed that the intervention normalized some hormonal parameters and hepatic mRNA levels of ECS components, improving the condition of the obese offspring.
Article
Plant Sciences
A. Ovalle-Marin, M. Reyes-Farias, K. Vasquez, C. Parra-Ruiz, V. Quitral, P. Jimenez, L. Garcia, L. A. Ramirez, J. Quezada, P. Gonzalez-Muniesa, D. F. Garcia-Diaz
JOURNAL OF BERRY RESEARCH
(2020)
Article
Endocrinology & Metabolism
Lissette Duarte, Diego F. Garcia-Diaz, Francisco Perez-Bravo
ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2020)
Review
Nutrition & Dietetics
Claudia Parra-Ruiz, Gabriel Prado, Daniela Cerda, Javiera Fernandez, Catalina Mallea, Victoria Pardo, Vania Torres, Constanza Arredondo, Diego F. Garcia-Diaz
REVISTA CHILENA DE NUTRICION
(2019)
Article
Medicine, General & Internal
Javiera Abarzua, Williams Viloff C, Javiera Bahamondes, Yeritza Olivera P, Carlos Poblete-Aro, Tomas Herrera-Valenzuela, Carolina Oliva, Diego F. Garcia-Diaz
REVISTA MEDICA DE CHILE
(2019)