Links between recognition and degradation of cytoplasmic viral RNA in innate immune response

Cellular 5′-3′ mRNA Exonuclease Xrn1 Controls Double-Stranded RNA Accumulation and Anti-Viral Responses

(2015) Hannah M. Burgess et al.   Cell Host & Microbe

Viral RNA detection by RIG-I-like receptors

(2015) Mitsutoshi Yoneyama et al.   CURRENT OPINION IN IMMUNOLOGY

Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses

(2015) Delphine Goubau et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

DDX60L Is an Interferon-Stimulated Gene Product Restricting Hepatitis C Virus Replication in Cell Culture

(2015) Oliver Grünvogel et al.   JOURNAL OF VIROLOGY

RIOK3-Mediated Phosphorylation of MDA5 Interferes with Its Assembly and Attenuates the Innate Immune Response

(2015) Ken Takashima et al.   Cell Reports

DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation

(2015) Hiroyuki Oshiumi et al.   Cell Reports

OASL—a new player in controlling antiviral innate immunity

(2015) Jianzhong Zhu et al.   Current Opinion in Virology

Antagonism of the Phosphatase PP1 by the Measles Virus V Protein Is Required for Innate Immune Escape of MDA5

(2014) Meredith E. Davis et al.   Cell Host & Microbe

Advances in understanding the role of type I interferons in systemic lupus erythematosus

(2014) Mary K. Crow   CURRENT OPINION IN RHEUMATOLOGY

The eukaryotic RNA exosome

(2014) Kurt Januszyk et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Antiviral Activity of Human OASL Protein Is Mediated by Enhancing Signaling of the RIG-I RNA Sensor

(2014) Jianzhong Zhu et al.   IMMUNITY

Protective Role of LGP2 in Influenza Virus Pathogenesis

(2014) Mustapha Si-Tahar et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular Imprinting as a Signal-Activation Mechanism of the Viral RNA Sensor RIG-I

(2014) Bin Wu et al.   MOLECULAR CELL

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates

(2014) Delphine Goubau et al.   NATURE

Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I

(2014) Alys Peisley et al.   NATURE

The SKIV2L RNA exosome limits activation of the RIG-I-like receptors

(2014) Sterling C Eckard et al.   NATURE IMMUNOLOGY

Helicase proteins DHX29 and RIG-I cosense cytosolic nucleic acids in the human airway system

(2014) N. Sugimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiviral innate immunity and stress granule responses

(2014) Koji Onomoto et al.   TRENDS IN IMMUNOLOGY

DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation

(2014) Ji-Seung Yoo et al.   PLoS Pathogens

Dephosphorylation of the RNA Sensors RIG-I and MDA5 by the Phosphatase PP1 Is Essential for Innate Immune Signaling

(2013) Effi Wies et al.   IMMUNITY

Respiratory virus–induced EGFR activation suppresses IRF1-dependent interferon λ and antiviral defense in airway epithelium

(2013) Iris F. Ueki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential expression of ISG20 in chronic hepatitis B patients and relation to interferon-alpha therapy response

(2013) Xi Lu et al.   JOURNAL OF MEDICAL VIROLOGY

MDA5 Localizes to Stress Granules, but This Localization Is Not Required for the Induction of Type I Interferon

(2013) M. A. Langereis et al.   JOURNAL OF VIROLOGY

Encephalomyocarditis Virus Disrupts Stress Granules, the Critical Platform for Triggering Antiviral Innate Immune Responses

(2013) C. S. Ng et al.   JOURNAL OF VIROLOGY

STING Recognition of Cytoplasmic DNA Instigates Cellular Defense

(2013) Takayuki Abe et al.   MOLECULAR CELL

RIG-I Forms Signaling-Competent Filaments in an ATP-Dependent, Ubiquitin-Independent Manner

(2013) Alys Peisley et al.   MOLECULAR CELL

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus

(2013) H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

(2013) T. Kondo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune Responses

(2013) Hiroyuki Oshiumi et al.   PLoS Pathogens

Inhibition of Hepatitis B Virus Replication by the Host Zinc Finger Antiviral Protein

(2013) Richeng Mao et al.   PLoS Pathogens

SKIV2L Mutations Cause Syndromic Diarrhea, or Trichohepatoenteric Syndrome

(2012) Alexandre Fabre et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

(2012) Bin Wu et al.   CELL

The Mitochondrial Targeting Chaperone 14-3-3ε Regulates a RIG-I Translocon that Mediates Membrane Association and Innate Antiviral Immunity

(2012) Helene Minyi Liu et al.   Cell Host & Microbe

Antagonism of the Interferon-Induced OAS-RNase L Pathway by Murine Coronavirus ns2 Protein Is Required for Virus Replication and Liver Pathology

(2012) Ling Zhao et al.   Cell Host & Microbe

A Common Strategy for Host RNA Degradation by Divergent Viruses

(2012) M. M. Gaglia et al.   JOURNAL OF VIROLOGY

Correction: Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity

(2012) Koji Onomoto et al.   PLoS One

Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication

(2012) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ski2-like RNA helicase structures

(2012) Sean J. Johnson et al.   RNA Biology

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein

(2012) Ricardo Rajsbaum et al.   PLoS Pathogens

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling

(2011) M. Miyashita et al.   MOLECULAR AND CELLULAR BIOLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy

(2011) Joachim Lupberger et al.   NATURE MEDICINE

DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-β-inducing potential

(2010) Hiroyuki Oshiumi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Oligoadenylate Synthetase Family: An Ancient Protein Family with Multiple Antiviral Activities

(2010) Helle Kristiansen et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses

(2010) Sumio Hayakawa et al.   NATURE IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

(2010) T. Satoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiviral activities of ISG20 in positive-strand RNA virus infections

(2010) Zhi Zhou et al.   VIROLOGY

The Influenza Virus Enigma

(2009) Rachelle Salomon et al.   CELL

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

(2009) Martin Schlee et al.   IMMUNITY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

Recognition of viral single-stranded RNA by Toll-like receptors☆

(2008) S DIEBOLD   ADVANCED DRUG DELIVERY REVIEWS

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

RNA recognition and signal transduction by RIG-I-like receptors

(2008) Mitsutoshi Yoneyama et al.   IMMUNOLOGICAL REVIEWS

Riplet/RNF135, a RING Finger Protein, Ubiquitinates RIG-I to Promote Interferon-β Induction during the Early Phase of Viral Infection

(2008) Hiroyuki Oshiumi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Stress granules: the Tao of RNA triage

(2008) Paul Anderson et al.   TRENDS IN BIOCHEMICAL SCIENCES

The exosome: a multipurpose RNA-decay machine

(2008) Manfred Schmid et al.   TRENDS IN BIOCHEMICAL SCIENCES