Article
Chemistry, Physical
Fei Qiu, Yijun Yan, Junlan Zeng, Jian-Ping Huang, Lingjiang Zeng, Wei Zhong, Xiaozhong Lan, Min Chen, Sheng-Xiong Huang, Zhihua Liao
Summary: The study on hyoscyamine dehydrogenase revealed the important role of the AbHDH gene in the biosynthesis of hyoscyamine and provided relevant biochemical and metabolic insights. AbHDH was found to enhance the production of hyoscyamine but did not significantly affect the biosynthesis of hyoscyamine, anisodamine, or scopolamine when suppressed.
Review
Biochemistry & Molecular Biology
Xiaolu Li, Tong Zhang, Nicholas J. J. Day, Song Feng, Matthew J. J. Gaffrey, Wei-Jun Qian
Summary: Protein S-glutathionylation (SSG) is a reversible post-translational modification that plays a critical role in redox signaling and regulation. This review summarizes current biochemical and analytical approaches for characterizing SSG and highlights recent examples of the functional and structural consequences of SSG modifications. The article also discusses future directions for research and the potential of computational methods in accelerating functional discovery.
Review
Agricultural Engineering
Hillol Chakdar, Mafruha Hasan, Sunil Pabbi, Helena Nevalainen, Pratyoosh Shukla
Summary: Eukaryotic microalgae are a valuable source of commercially important metabolites, but their genetic potential alone is often insufficient for high-level production of desired products. Understanding metabolic pathways and utilizing contemporary proteomic and metabolomic techniques can help redesign pathways to increase production of algal metabolites.
BIORESOURCE TECHNOLOGY
(2021)
Article
Astronomy & Astrophysics
Sukanta Panda, Abbas Altafhussain Tinwala, Archit Vidyarthi
Summary: We investigate the quantum stability of generalised Proca theories in curved spacetime treating gravity as a dynamical field. By evaluating the divergent part of the effective action at one-loop level using Vilkovisky-DeWitt formalism, we find that quantum corrections are suppressed by a UV cutoff parametrically higher than the Proca mass when the coupling constants are restricted to a certain range. Furthermore, we show that quantum corrections remain suppressed even at scales where classical non-linearities dominate over kinetic terms, allowing the Vainshtein mechanism to work effectively.
JOURNAL OF COSMOLOGY AND ASTROPARTICLE PHYSICS
(2022)
Review
Plant Sciences
Fatima Omari Alzahrani
Summary: Previous studies on engineering osmoprotectant metabolic pathway genes have focused on the performance of transgenic plants under salt stress conditions rather than elucidating the underlying mechanism(s), which are still unclear. Genetic engineering has been used to improve salt tolerance in plants by introducing preferred genes or modifying the expression of existing genes responsible for salt stress response, but there is no clear mechanistic model to explain how osmoprotectant accumulation in transgenic plants confers salt tolerance.
Article
Biochemistry & Molecular Biology
Syed Muhammad Shoaib, Samina Afzal, Ali Feezan, Muhammad Sajid Hamid Akash, Ahmed Nadeem, Tahir Maqbool Mir
Summary: Our study investigated the effects of arsenic-induced metabolic disorders, specifically disruptions in lipid metabolism, amino acid metabolism, and carbohydrate metabolism. We also assessed the potential therapeutic effects of resveratrol as a remedy for arsenic-induced diabetes. The findings showed significant changes in glucose levels, insulin resistance, inflammatory biomarkers, and liver and kidney function in mice exposed to arsenic. Additionally, enzyme levels related to carbohydrate metabolism and oxidative stress biomarkers were reduced in the arsenic-exposed group. The study also observed alterations in gene expression related to lipid and carbohydrate metabolism, as well as decreases in certain amino acids in arsenic-exposed mice. Metabolomics analysis identified disruptions in lipid metabolomes, amino acids, and arsenic metabolites. Histopathological observations revealed significant changes in liver architecture in the arsenic-exposed group.
Review
Biotechnology & Applied Microbiology
Haijie Xue, Wentao Sun, Ying Wang, Chun Li
Summary: Plant natural products are important secondary metabolites with various pharmacological activities and are widely used in pharmaceutical, food, perfume, and cosmetic industries. Traditional production methods relying on phytoextraction from natural plants have limitations in efficiency. The use of yeast cell factories for heterologous synthesis of plant natural products offers a promising alternative with strategies to enhance metabolic mass transfer for increased production efficiency.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eberhard O. Voit, Daniel V. Olivenca
Summary: Choosing the most suitable representations is crucial for biomedical systems analysis. Ordinary differential equations (ODEs) are the most prevalent choice due to their flexibility and ease of use. However, selecting a mathematical format for the equations is not trivial and often lacks objective guidance. Power-law approximations are simple and overcome limitations in describing nonlinear features of biomedical phenomena. Nonetheless, ODE models also have limitations, leading to the proposal of an alternative approach called discrete Biochemical Systems Theory (dBST).
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Physics, Multidisciplinary
Jonathan J. Heckman, Max Hubner, Ethan Torres, Hao Y. Zhang
Summary: The modern approach to m-form global symmetries in d-dimensional QFT involves specifying dimension d-m-1 topological generalized symmetry operators that link with m-dimensional defect operators. These defects originate from branes wrapped on non-compact cycles in a non-compact geometry X. The generalized symmetry operators associated with these defects arise from magnetic dual branes wrapped on cycles in partial differential X∂X.
FORTSCHRITTE DER PHYSIK-PROGRESS OF PHYSICS
(2023)
Article
Mathematics, Applied
Geoffrey Janssens
Summary: This paper investigates the exponential growth rate of finite dimensional Lie algebras with a generalized action, and constructs a graded Lie algebra with a non-integer exponential growth rate. Furthermore, it proves an analogue of Amitsur's conjecture for general algebra under certain conditions, which contrasts with the associative setting.
PROCEEDINGS OF THE AMERICAN MATHEMATICAL SOCIETY
(2022)
Article
Plant Sciences
Fabio D'Orso, Lionel Hill, Ingo Appelhagen, Tom Lawrenson, Marco Possenti, Jie Li, Wendy Harwood, Giorgio Morelli, Cathie Martin
Summary: Chlorogenic acid (CGA), the most abundant phenolic compound in Solanaceous plants, has protective properties and is mainly produced through the HQT pathway. CGA accumulates in the upper epidermis of tomato and acts as a protector against UV-B irradiation.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Astronomy & Astrophysics
Edward J. Shaya, R. Brent Tully, Daniel Pomarede, Alan Peel
Summary: The trajectories of galaxies systems since z=4 are studied through numerical action reconstructions. The distances are adjusted to minimize departures from observed redshifts. The best model has H(0)=73 km s(-1) Mpc(-1) and a density arising from interhalo matter as from halos. The fraction of matter in the interhalo medium matches that in n-body simulations.
ASTROPHYSICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Maria Kateri
Summary: This paper revisits the quasisymmetry (QS) model for square contingency tables, discussing more parsimonious QS-type models and models linked to local odds ratios (LOR). It also explores the expression of these models in an information-theoretic context and their closeness properties with respect to Kullback-Leibler (KL) divergence. Additionally, the paper introduces flexible classes of QS-type models and AMs based on different types of divergences, enriching the modeling options for better fit and interpretation.
Article
Computer Science, Information Systems
Jinghao Li, Huimin Wang
Summary: This paper focuses on the design problems of switching functions and fuzzy sliding mode controllers for T-S fuzzy descriptor systems. A generalized regular form of T-S fuzzy descriptor systems is defined and the design method of the linear switching function-based fuzzy sliding mode controller is developed. The relationship between the design parameter in the switching function and the gain matrix in the controller of T-S fuzzy systems is explored, and a new framework of switching function design for T-S fuzzy descriptor systems is formulated. The proposed fuzzy switching function-based method is shown to be less conservative than the linear switching function-based method in terms of the solvability of sliding mode control problems, which is verified through four illustrative examples.
INFORMATION SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Chang Dong, J. Carl Schultz, Wei Liu, Jiazhang Lian, Lei Huang, Zhinan Xu, Huimin Zhao
Summary: This study identified novel targets for enhancing SAM production through genome-scale engineering (GSE) and validated their effects in industrial yeast strains, leading to significant increases in SAM productivity. Transcriptomic and metabolomic analyses were conducted to investigate the molecular mechanisms for enhanced SAM accumulation.
METABOLIC ENGINEERING
(2021)
Article
Biology
Carlene Perpetua P. Arceo, Editha C. Jose, Alberto Marin-Sanguino, Eduardo R. Mendoza
MATHEMATICAL BIOSCIENCES
(2015)
Review
Genetics & Heredity
Nestor V. Torres, Guido Santos
FRONTIERS IN GENETICS
(2015)
Review
Biotechnology & Applied Microbiology
M. A. Valderrama-Gomez, D. Kreitmayer, S. Wolf, A. Marin-Sanguino, A. Kremling
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2017)
Article
Biochemistry & Molecular Biology
Daniel V. Guebel, Montserrat Perera-Alberto, Nestor V. Torres
MOLECULAR BIOSYSTEMS
(2016)
Article
Geriatrics & Gerontology
Daniel V. Guebel, Nestor V. Torres
FRONTIERS IN AGING NEUROSCIENCE
(2016)
Article
Physiology
Guido Santos, Mario Diaz, Nestor V. Torres
FRONTIERS IN PHYSIOLOGY
(2016)
Article
Genetics & Heredity
Hannes Loewe, Andreas Kremling, Alberto Marin-Sanguino
FRONTIERS IN GENETICS
(2016)
Article
Microbiology
Friedhelm Pfeiffer, Irina Bagyan, Gabriela Alfaro-Espinoza, Maria-A. Zamora-Lagos, Bianca Habermann, Alberto Marin-Sanguino, Dieter Oesterhelt, Hans J. Kunte
Article
Microbiology
Daniel V. Guebel, Nestor V. Torres
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Multidisciplinary Sciences
Guido Santos, Agustin Valenzuela-Fernandez, Nestor V. Torres
Article
Multidisciplinary Sciences
Viktoria Kindzierski, Silvia Raschke, Nicole Knabe, Frank Siedler, Beatrix Scheffer, Katharina Pflueger-Grau, Friedhelm Pfeiffer, Dieter Oesterhelt, Alberto Marin-Sanguino, Hans-Joerg Kunte
Editorial Material
Genetics & Heredity
Alberto Marin-Sanguino, Julio Vera, Rui Alves
FRONTIERS IN GENETICS
(2018)
Article
Multidisciplinary Sciences
Lukas Bromig, Andreas Kremling, Alberto Marin-Sanguino
Article
Education & Educational Research
Nestor Torres, Guido Santos
HIGHER EDUCATION PEDAGOGIES
(2017)
Article
Biochemistry & Molecular Biology
Christiana Sehr, Andreas Kremling, Alberto Marin-Sanguino