期刊
MATERIALS LETTERS
卷 133, 期 -, 页码 171-174出版社
ELSEVIER
DOI: 10.1016/j.matlet.2014.06.181
关键词
Heterogeneous reaction; Thin film; Stimuli responsive; Chitosan; Hydrogel polymer; Deposition
资金
- Department of Chemical Engineering at the University of Rochester
- NSF [DGE 0966089]
- Ronald E. McNair Post-Baccalaureate Achievement Program
We report here a simple, versatile bi-cell-based platform for preparing crosslinked polymeric hydrogel thin films. Briefly, a nanoporous membrane is used to separate two solutions: one containing crosslinking molecules and the other containing oligomers. The crosslinking molecule diffuses through the membrane and reacts with the oligomer to form a polymeric film at the surface of the nanopore membrane. In this paper, a proof-of-concept experiment is described using crosslinkers with imidoester moieties (dimethyl 3,3'-dithiobispropionimidate (DTBP) or dimethyl suberimidate (DMS)) and chitosan oligomers. Crosslinking with DTBP or DMS also conferred degradability to the chitosan film. The film formation was confirmed and its morphology examined with electron microscopy. The chitosan film degradation was quantified by monitoring the transport of gold nanoparticles through the chitosan film after a degradation treatment. The film synthesis method presented here can potentially be used to prepare functional hydrogel thin films for biosensors, coatings and drug delivery systems in an inexpensive, high-throughput manner. (C) 2014 Elsevier B.V. All rights reserved.
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