Synthesis, characterization, in vitro biocompatibility, and antimicrobial activity of gold, silver and gold silver alloy nanoparticles prepared from Lansium domesticum fruit peel extract

A cost-effective and eco-friendly method has been developed to form colloidal solutions of gold (AuNPs), silver (AgNPs), and gold-silver-alloy (Au-Ag-NPs) nanoparticles using Lansium domesticum (LD) fruit peel extract as a combined reducing and capping agent for the first time. The synthesized nanoparticles were characterized by various physic-chemical techniques. AgNPs and Au-Ag-NPs demonstrated potential antimicrobial activity. All these nanoparticles showed significant biocompatibility on C2C12 cell line. In addition, cellular and LDH activities supported our biocompatibility results. The outcomes of this study indicate that, these nanoparticles could be effectively utilized in pharmaceutical, biotechnological and biomedical applications. (C) 2014 Elsevier B.V. All rights reserved.