期刊
MATERIALS LETTERS
卷 125, 期 -, 页码 111-115出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2014.03.084
关键词
Hydroxyapatite; Mesoporous microrods; Microstructure; Controlled release; Biomaterials
资金
- National Natural Science Foundation of China [21171051, 21271066, U1204516]
- Innovation Fund for Outstanding: Scholar of Henan Province [114200510004]
- Program for Science & Technology Innovation Talents in Universities of Henan Province [13HASTIT011]
- Henan Key Proposed Program for Basic and Frontier Research [112300410095]
- Key Young Teachers Project of Henan Province [2012GGJS-065]
In the present study, using chondroitin sulfate as morphology-directing matrix, hydroxyapatite-chondroitin sulfate hybrid mesoporous microrods were prepared successfully through a facile one-pot method under mild conditions. From the results, the antitumor drug doxorubicin hydrochloride (DOX center dot HCl) could be loaded into the as-prepared microrods efficiently owing to the large specific surface area and the presence of the mesopores. In addition, the loaded DOX center dot HCl could be controlled released with pH-dependent and sustained features. These suggest that the hybrid mesoporous microrods prepared in this study might be used as the potential targeted drug delivery carrier to treat the human tumors clinically with good specificity and long duration. (C) 2014 Elsevier B.V. All rights reserved.
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