期刊
MATERIALS LETTERS
卷 73, 期 -, 页码 172-175出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2012.01.049
关键词
Electrospinning; Gelatin; Ceramics; Adhesion; Bone tissue engineering
资金
- National Natural Science Foundation of China [81171000, 51073016]
- International Science and Technology Cooperation Program [2010DFA51500]
- National Basic Research Program of China [2012CB933904]
- Program of New Century Excellent Talents (NCET) of Universities in China
Gelatin/beta-TCP composite nanofibers were fabricated by incorporated different content of beta-TCP nanoparticles (0, 5, 10, and 20wt.%) into electrospun gelatin nanofibers. The morphology and chemical structure of the composite nanofibers were characterized by SEM, TEM, XRD, and TGA techniques. Especially, calcium ion release behaviors from the composite nanofibers were investigated in the cell culture medium and correlated to the osteoblastic behavior of MG-63 cells. The results demonstrated that the adhesion, spreading, proliferation and the early osteogenic differentiation of osteoblast-like MG-63 cells on the composite nanofibers depended positively on the content of incorporated beta-TCP nanoparticles and their dissolution behavior in the medium thereof. (C) 2012 Elsevier B.V. All rights reserved.
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