A Practical Strategy to Discover New Antitumor Compounds by Activating Silent Metabolite Production in Fungi by Diethyl Sulphate Mutagenesis

Marine-Sourced Anti-Cancer and Cancer Pain Control Agents in Clinical and Late Preclinical Development

(2014) David Newman et al.   Marine Drugs

New and Highly Potent Antitumor Natural Products from Marine-Derived Fungi: Covering the Period from 2003 to 2012

(2013) Boris Pejin et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Industrial natural product chemistry for drug discovery and development

(2013) Armin Bauer et al.   NATURAL PRODUCT REPORTS

Classical and epigenetic approaches to metabolite diversification in filamentous fungi

(2013) Jacqueline Aparecida Takahashi et al.   PHYTOCHEMISTRY REVIEWS

Natural products as leads to antitumor drugs

(2013) David J. Newman et al.   PHYTOCHEMISTRY REVIEWS

Identification of a brevianamide F reverse prenyltransferase BrePT from Aspergillus versicolor with a broad substrate specificity towards tryptophan-containing cyclic dipeptides

(2012) Suqin Yin et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters

(2012) Kozo Ochi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Activation of the Dormant Secondary Metabolite Production by Introducing Gentamicin-Resistance in a Marine-Derived Penicillium purpurogenum G59

(2012) Yun-Jing Chai et al.   Marine Drugs

Purpurogemutantin and Purpurogemutantidin, New Drimenyl Cyclohexenone Derivatives Produced by a Mutant Obtained by Diethyl Sulfate Mutagenesis of a Marine-Derived Penicillium purpurogenum G59

(2012) Shi-Ming Fang et al.   Marine Drugs

Eurocristatine, a new diketopiperazine dimer from the marine sponge-associated fungus Eurotium cristatum

(2012) Nelson M. Gomes et al.   Phytochemistry Letters

Cytotoxic Pheofungins from an Engineered Fungus Impaired in Posttranslational Protein Modification

(2011) Kirstin Scherlach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Secondary metabolites of fungi from marine habitats

(2011) Mostafa E. Rateb et al.   NATURAL PRODUCT REPORTS

Dhilirolides A−D, Meroterpenoids Produced in Culture by the Fruit-Infecting FungusPenicillium purpurogenumCollected in Sri Lanka

(2011) E. Dilip de Silva et al.   ORGANIC LETTERS

Breeding cold tolerance strain by chemical mutagenesis in Volvariella volvacea

(2011) Zhu Liu et al.   SCIENTIA HORTICULTURAE

Fungal secondary metabolites – Strategies to activate silent gene clusters

(2010) Axel A. Brakhage et al.   FUNGAL GENETICS AND BIOLOGY

Epigenome manipulation as a pathway to new natural product scaffolds and their congeners

(2009) Robert H. Cichewicz   NATURAL PRODUCT REPORTS

Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12

(2009) Takeshi Hosaka et al.   NATURE BIOTECHNOLOGY

Hidden biosynthetic treasures brought to light

(2009) Christian Hertweck   Nature Chemical Biology

In Vivo and In Vitro Production Options for Fungal Secondary Metabolites

(2008) Patrick Schneider et al.   MOLECULAR PHARMACEUTICS

A chemical epigenetics approach for engineering the in situbiosynthesis of a cryptic natural product from Aspergillus niger

(2008) Jon C. Henrikson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY