Strategies for the Development of Conotoxins as New Therapeutic Leads

Ring-closing Metathesis in Peptides - the Sting is in the Tail!

(2017) Bianca J. van Lierop et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Conopeptides as novel options for pain management

(2014) N.L. Daly et al.   DRUGS OF THE FUTURE

Dicarba α-Conotoxin Vc1.1 Analogues with Differential Selectivity for Nicotinic Acetylcholine and GABAB Receptors

(2013) Bianca J. van Lierop et al.   ACS Chemical Biology

De novo design and synthesis of a μ-conotoxin KIIIA peptidomimetic

(2013) Ryan M. Brady et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Getting in Shape: Controlling Peptide Bioactivity and Bioavailability Using Conformational Constraints

(2012) Jonathan E. Bock et al.   ACS Chemical Biology

Distinct Disulfide Isomers of μ-Conotoxins KIIIA and KIIIB Block Voltage-Gated Sodium Channels

(2012) Keith K. Khoo et al.   BIOCHEMISTRY

Discovery of diphenyl lactam derivatives as N-type calcium channel blockers

(2012) George A. Doherty et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct

(2012) Hao Hu et al.   BMC GENOMICS

Engineering of Conotoxins for the Treatment of Pain

(2012) Bodil B. Carstens et al.   CURRENT PHARMACEUTICAL DESIGN

γ-Aminobutyric Acid Type B (GABAB) Receptor Expression Is Needed for Inhibition of N-type (Cav2.2) Calcium Channels by Analgesic α-Conotoxins

(2012) Hartmut Cuny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design of Bioactive Peptides from Naturally Occurring μ-Conotoxin Structures

(2012) Marijke Stevens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach

(2012) Aude Violette et al.   Journal of Proteomics

ω-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Cav2.2 Ion Channels

(2012) Charlotte Elisabet Tranberg et al.   Marine Drugs

An oral cyclic peptide drug to reverse kidney fibrosis?

(2012) Susan J. Allison   Nature Reviews Nephrology

Conotoxins Targeting Neuronal Voltage-Gated Sodium Channel Subtypes: Potential Analgesics?

(2012) Oliver Knapp et al.   Toxins

Synthesis and Activity of Thioether-Containing Analogues of the Complement Inhibitor Compstatin

(2011) Patrick J. Knerr et al.   ACS Chemical Biology

A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats

(2011) Victoria E. Scott et al.   BIOCHEMICAL PHARMACOLOGY

Peptidomimetics: modifying peptides in the pursuit of better vaccines

(2011) Nathan P Croft et al.   Expert Review of Vaccines

Lactam-Stabilized Helical Analogues of the Analgesic μ-Conotoxin KIIIA

(2011) Keith K. Khoo et al.   JOURNAL OF MEDICINAL CHEMISTRY

α-Conotoxin ImI Incorporating Stable Cystathionine Bridges Maintains Full Potency and Identical Three-Dimensional Structure

(2011) Zoltan Dekan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interactions of Key Charged Residues Contributing to Selective Block of Neuronal Sodium Channels by  -Conotoxin KIIIA

(2011) J. R. McArthur et al.   MOLECULAR PHARMACOLOGY

ConoServer: updated content, knowledge, and discovery tools in the conopeptide database

(2011) Q. Kaas et al.   NUCLEIC ACIDS RESEARCH

Ring-Closing Metathesis Approaches for the Solid-Phase Synthesis of Cyclic Peptoids

(2011) Sharaf Nawaz Khan et al.   ORGANIC LETTERS

Pyrrolinone-Based Peptidomimetics. “Let the Enzyme or Receptor be the Judge”

(2010) Amos B. Smith et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

(2010) Richard J. Clark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

μ-Conotoxin KIIIA Derivatives with Divergent Affinities versus Efficacies in Blocking Voltage-Gated Sodium Channels

(2010) Min-Min Zhang et al.   BIOCHEMISTRY

Structure–activity relationships of diphenylpiperazine N-type calcium channel inhibitors

(2010) Hassan Pajouhesh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice

(2010) Brid Callaghan et al.   Channels

Modulating Oxytocin Activity and Plasma Stability by Disulfide Bond Engineering

(2010) Markus Muttenthaler et al.   JOURNAL OF MEDICINAL CHEMISTRY

µ-Conotoxins as Leads in the Development of New Analgesics

(2010) Raymond S. Norton   MOLECULES

Cyclization of conotoxins to improve their biopharmaceutical properties

(2010) Richard J. Clark et al.   TOXICON

Structure of the Analgesic μ-Conotoxin KIIIA and Effects on the Structure and Function of Disulfide Deletion†‡

(2009) Keith K. Khoo et al.   BIOCHEMISTRY

ω-Conotoxin GVIA mimetics based on an anthranilamide core: Effect of variation in ammonium side chain lengths and incorporation of fluorine

(2009) Asa Andersson et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Low molecular weight non-peptide mimics of ω-conotoxin GVIA

(2009) Peter J. Duggan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Scaffold-based design and synthesis of potent N-type calcium channel blockers

(2009) Gerald W. Zamponi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Regioselective formation of interlocked dicarba bridges in naturally occurring cyclic peptide toxins using olefin metathesis

(2009) Andrea J. Robinson et al.   CHEMICAL COMMUNICATIONS

Structure and Activity of (2,8)-Dicarba-(3,12)-cystino α-ImI, an α-Conotoxin Containing a Nonreducible Cystine Analogue†

(2009) Christopher A. MacRaild et al.   JOURNAL OF MEDICINAL CHEMISTRY

χ-Conopeptide Pharmacophore Development: Toward a Novel Class of Norepinephrine Transporter Inhibitor (Xen2174) for Pain⊥

(2009) Andreas Brust et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of the Two Fundamental Conformations of Benzoylureas and Elucidation of the Factors That Facilitate Their Conformational Interchange

(2009) Guillaume Lessene et al.   JOURNAL OF ORGANIC CHEMISTRY

Left- and Right-Handed Alpha-Helical Turns in Homo- and Hetero-Chiral Helical Scaffolds

(2009) Nicholas E. Shepherd et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and Cav2.2 Binding Data for Non-Peptide Mimetics of ω-Conotoxin GVIA based on a 5-Amino-Anthranilamide Core

(2008) Peter J. Duggan et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Structurally Minimized μ-Conotoxin Analogues as Sodium Channel Blockers: Implications for Designing Conopeptide-Based Therapeutics

(2008) Tiffany S. Han et al.   ChemMedChem

Peptidomimetics, a synthetic tool of drug discovery

(2008) Josef Vagner et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Peptides Targeting Voltage-Gated Calcium Channels

(2008) Raymond Norton et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular Engineering of Conotoxins: The Importance of Loop Size to α-Conotoxin Structure and Function

(2008) Ai-Hua Jin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analgesic  -Conotoxins Vc1.1 and Rg1A Inhibit N-Type Calcium Channels in Rat Sensory Neurons via GABAB Receptor Activation

(2008) B. Callaghan et al.   JOURNAL OF NEUROSCIENCE

Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus

(2008) Mandë Holford et al.   TOXICON