Review
Materials Science, Multidisciplinary
Meng Ding, Wei Zhao, Ling-Jie Song, Shi-Fang Luan
Summary: Bacterial biofilm infections pose a long-standing threat to human life and health, with traditional antibiotic therapies proving ineffective in eradicating them. Stimuli-responsive nanocarriers have gained attention for their smart drug release properties, with various stimuli such as enzymes, pH levels, and external triggers proving beneficial for biofilm treatment.
Article
Polymer Science
Muhammad Suhail, Chih-Wun Fang, Arshad Khan, Muhammad Usman Minhas, Pao-Chu Wu
Summary: The study aimed to develop CS/CBP-co-PAA hydrogels for controlled release of diclofenac sodium. Characterizations and experiments were conducted to understand drug release behavior at different pH levels. The prepared hydrogel showed controlled release of the drug according to the Korsmeyer-Peppas model.
Review
Polymer Science
Najla M. Salkho, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Summary: Chemotherapeutic drugs are effective in treating cancer but have side effects that lower the quality of life for patients. Smart nanocarriers can encapsulate these drugs and deliver them to tumors, reducing contact with healthy cells and minimizing side effects.
Review
Engineering, Biomedical
Jiayi Qin, Yangbo Zhu, Dongsheng Zheng, Qingwei Zhao
Summary: pH-sensitive smart polymeric nanocarriers are being developed in biomedicine to overcome the limitations of conventional chemotherapeutics delivery systems, by rapidly degrading in tumor acidic environments and achieving controlled drug release, pharmacokinetic improvements, and enhanced efficiency of antitumor biotherapeutic molecules compared to traditional polymers. The review also focuses on constructing smart drug delivery systems based on acid-labile linkers, including pH-sensitive polymeric prodrugs and copolymeric nanocarriers with acid-cleavable groups. Additionally, the article discusses advanced platforms for delivering special biotherapeutic molecules and reviews various acid-sensitive linkages for controlled pH-responsive drug delivery mechanisms and drug pharmacokinetics enhancement.
BIO-DESIGN AND MANUFACTURING
(2021)
Review
Engineering, Biomedical
Ziyang Cao, Dongdong Li, Junxia Wang, Xianzhu Yang
Summary: This review focuses on ROS-sensitive polymeric nanocarriers for improving drug delivery efficacy and highlighting their application in synergistic cancer therapy. The development of novel ROS-sensitive nanocarriers holds great potential for achieving synergistic anticancer efficacy by combining ROS-mediated therapy with other therapies.
ACTA BIOMATERIALIA
(2021)
Article
Polymer Science
Ji-Chao Hu, Qi-Hua Zhang, Qiu-Qin Mu, Yi-Yuan Tang, Zhen Wu, Guo-Jie Wang
Summary: This study reports a novel polymeric nanogel that can stably load cargo and release it under near-infrared (NIR) irradiation. The nanogels are formed through crosslinking reactions in microemulsions and have the ability to stably encapsulate hydrophobic guest molecules. They can respond to an oxidant, causing the disintegration of the crosslinked structure and releasing the cargo. Additionally, the nanogels can generate reactive oxygen species under NIR irradiation to release the cargo.
CHINESE JOURNAL OF POLYMER SCIENCE
(2023)
Article
Chemistry, Physical
Min Ji Son, Taelin Kim, Sang-Wha Lee
Summary: Fluorescent mesoporous silica nanoparticles were synthesized as a nanocarrier for the efficient delivery of Die molecules. The release rate of Die was pH-responsive, with the PEG-coated nanoparticles showing the most pronounced difference between pH 4.5 and pH 7.4. The double-layer-coated nanoparticles exhibited significantly delayed release rates compared to the coating-free and single-layer-coated analogs.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Review
Materials Science, Biomaterials
Panqin Ma, Qi Wang, Xi Luo, Liuzhou Mao, Zhanxiang Wang, Enyi Ye, Xian Jun Loh, Zibiao Li, Yun-Long Wu
Summary: This review summarizes the recent exploration of non-viral polymeric vectors with good biocompatibility as delivery systems for CRISPR/Cas nucleases. It discusses the advantages of stimulus-responsive polymeric delivery vectors (pH, redox, or enzymes) for controllable CRISPR/Cas9 genome editing system delivery and the advances in using stimulus-responsive CRISPR/Cas9 polymeric carriers for cancer treatment. The review also addresses the key challenges and promising development strategies of stimulus-responsive polymeric vector designs for CRISPR/Cas9 systems.
BIOMATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Chester E. Markwalter, Robert F. Pagels, Ava N. Hejazi, Kurt D. Ristroph, Jiping Wang, Ke Chen, Jian Li, Robert K. Prud'homme
Summary: This study introduces a scalable technique to encapsulate water-soluble therapeutics into polymeric nanocarriers, demonstrating improved therapeutic effect and reduced toxicity. The results establish the potential of this technique as a platform for nanocarrier delivery of water-soluble therapeutics, particularly in pulmonary administration.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Parisa Eslami, Martin Albino, Francesca Scavone, Federica Chiellini, Andrea Morelli, Giovanni Baldi, Laura Cappiello, Saer Doumett, Giada Lorenzi, Costanza Ravagli, Andrea Caneschi, Anna Laurenzana, Claudio Sangregorio
Summary: In this study, drug-loaded smart magnetic nanocarriers were successfully created using superparamagnetic iron oxide nanoparticles encapsulated in a dual pH- and temperature-responsive copolymer. These nanocarriers exhibited reversible hydration/dehydration transition at acidic conditions and/or temperatures above physiological body temperature, which could be triggered by magnetic hyperthermia. The effectiveness of the system was demonstrated by high encapsulation efficiency of the drug at neutral pH and the release of the drug under hyperthermia conditions. This study suggests that this multi-stimuli-sensitive nanoplatform has great potential for remote-controlled drug release combined with magnetic hyperthermia for cancer treatment.
Article
Chemistry, Physical
Roya Sedghi, Somayeh Ashrafzadeh, Bahareh Heidari
Summary: A new pH responsive CUR imprinted polymer GO@CUR-MIP was synthesized and showed high adsorption capacity and selectivity for CUR, with controlled and sustained release in response to environmental pH changes. The pH responsiveness of the system led to targeted drug delivery potential, while the inclusion complex improved drug interaction with the nanocomposite. The novel system has potential in separation and drug delivery processes.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Review
Biotechnology & Applied Microbiology
Neha Kaushik, Shweta B. Borkar, Sondavid K. Nandanwar, Pritam Kumar Panda, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: Nanocarriers (NCs) have attracted significant attention for their structural ability, good biocompatibility, and biodegradability. The development of NCs with stimuli-responsive properties has become a hot topic among scientists. These NCs can deliver drugs to tumors by regulating their pH, temperature, and enzyme responsiveness, thereby improving the accuracy of drug delivery and minimizing side effects. Material carriers for chemotherapeutic medicines are discussed in this review, with a focus on their structural properties and targeting methods that enhance therapeutic efficacy and trigger metabolic pathways. Overall, the development of NCs that respond to endogenous and exogenous stimuli in tumor regions and the understanding of their mechanisms have great potential for advancing tumor therapy and precision diagnosis in the future.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Wei Xiong, Zhengdong Guo, Baoyan Zeng, Teng Wang, Xiaowei Zeng, Wei Cao, Daizheng Lian
Summary: This study constructed multifunctional nanoparticles for the encapsulation of dacarbazine (DTIC) and targeted therapy of malignant melanoma (MM). In vitro and in vivo experiments showed that these nanoparticles had good release properties and exhibited strong anti-tumor effects with no side effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jiajia Tan, Zhengyu Deng, Chengzhou Song, Jie Xu, Yuben Zhang, Yong Yu, Jinming Hu, Shiyong Liu
Summary: The study presents a dual-responsive polyurethane nanoparticles containing external and built-in triggers that respond to weak pathological stimuli and degrade in a cycle amplification manner. These stimuli-responsive nanoparticles show high sensitivity to external stimuli and have promising applications in cancer therapy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Chemistry, Physical
Yiyuan Tang, Guojie Wang
Summary: This article reviews strategies for the design and fabrication of nanocarriers for NIR light-controlled release, based on three triggering mechanisms: photore-actions of chromophores, photothermal effect, and photo-oxidation. Challenges and perspectives for the future development of NIR light-sensitive nanocarriers are discussed.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS
(2021)
Article
Polymer Science
Ziquan Cao, Guojie Wang, Ying Chen, Fuxin Lang, Zhenzhong Yang
Article
Nanoscience & Nanotechnology
Ziquan Cao, Xiaoteng Zhou, Guojie Wang
ACS APPLIED MATERIALS & INTERFACES
(2016)
Article
Chemistry, Multidisciplinary
Zi-Quan Cao, Guo-Jie Wang
Article
Polymer Science
Ziquan Cao, Qingwei Li, Guojie Wang
Article
Polymer Science
Ziquan Cao, Qing Bian, Ying Chen, Fuxin Liang, Guojie Wang
Article
Polymer Science
Desheng Wang, Tingting Zhang, Bo Wu, Chunxiao Ye, Zhengyang Wei, Ziquan Cao, Guojie Wang
