期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 42, 页码 28888-28896出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b10360
关键词
dual-cargo delivery; multistimuli responsiveness; nanogels; nanotechnology; selective release
资金
- National Natural Science Foundation of China [51373025, 21074010]
- Program for New Century Excellent Talents in University [NCET-11-0582]
- Fundamental. Research Funds for the Central Universities [FRE-TP-12-004B]
Highly stable multi-stimuli-responsive nanogels for selective release of simultaneously encapsulated hydrophobic and hydrophilic cargos in a spatiotemporally controlled manner are demonstrated here. The nanogel is composed of hydrophilic pH- and thermoresponsive poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA) and hydrophobic photocleavable o-nitrobenzyl (ONB) linkage. The hydrophobic cargos were noncovalently encapsulated into lipophilic interiors of the nanogels, while the hydrophilic cargos were chemically linked to the nanogel precursor polymer PDMAEMA through a redox-cleavable disulfide junction. For these dual-loaded nanogels, hydrophobic cargos can be released in response to temperature, pH, and UV light, while the hydrophilic cargos can be released in response to redox reagent. The stimuli-selective release of hydrophobic and hydrophilic cargos affords the system with great potential applications in combination chemotherapy, tissue engineering, anticorrosion, and smart nanoreactors.
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